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7615529 |
Methods and compositions for modulating hyperstabilized c-met
The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.
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7615380 |
Methods for modulating an immune response by modulating KRC activity
This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation,...
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7615379 |
Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer
A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is...
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7611904 |
Serpentine transmembrane antigens expressed in human cancers and uses thereof
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
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7611848 |
Method for selecting allosteric regulators of class III G protein-coupled receptors
A method for identifying and selecting a compound acting as an allosteric regulator of a GPCR-III is described. A method comparing the activity level of a recombinant GPCR-III (GPCR-III-Δ),...
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7611847 |
Method for identifying an intestinal phenotype
The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the...
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7608412 |
P62 as a diagnostic tool for alzheimer's disease
The p62 protein has been analyzed and identified as the significant contributor to several metabolic pathways that lead to metabolic syndrome, Alzheimer's Disease, and other related diseases. The...
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7608408 |
Methods of identifying compounds that inhibit Notch cleavage
In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying γ-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are...
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7608407 |
Fluorescence polarization assay for determining histidine decarboxylase activity
The present invention relates to fluorescence polarization assays for determining the HDC modulating activity of a candidate compound including providing a reaction mixture comprising a HDC,...
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7608406 |
Diagnostic markers of stroke and cerebral injury and methods of use thereof
The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and...
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7608405 |
Method of selectively assaying adiponectin multimers
Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of...
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7608404 |
Disease determination method, data generation method for disease determination and data generation system for disease determination
Supernatant of the urinary sample (SP 1 ) was mixed with an acid or alkali and heated (SP 2 ) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP 3 )....
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7605004 |
Test strip for a lateral flow assay for a sample containing whole cells
A test strip for conducting a lateral flow assay for detection of an analyte in a sample that contains cells and fluid is provided, as well as methods for making and using the test strip. This test...
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7604954 |
Method for evaluating kidney function in a feline
Methods for ( 1 ) evaluating feline kidney function by determining ghrelin level in feline tissue or biofluid and correlating the ghrelin level directly to kidney function and ( 2 ) diagnosing...
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7604948 |
Biomarkers for diagnosing an autism spectrum disorder
The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using...
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7604946 |
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
Assay systems and specialized antibodies for the detection and quantitation of troponin I and troponin T in body fluids as an indicator of myocardial infarction. Since troponin I and T exist in...
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7601831 |
Methods, kits and assay system for detecting drug-resistant mycobacterium tuberculosis
The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces...
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7601684 |
Diagnosis and treatment of disorders of iron metabolism
The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The...
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7601540 |
Gamma secretase notch biomarkers
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity...
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7601509 |
Biotype diets system: predicting food allergies by blood type
The invention is a diet-typing system for humans, including novel methods for diagnosis and treatment of food allergies and hypersensitivities. The diagnostic method correlates blood types...
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7601507 |
Electronic methods for the detection of analytes
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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7601506 |
Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
The invention provides a simple method for diagnosing a non-symptomatic or symptomatic human or animal with transmissible spongiform encephalopathy.
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7601504 |
Protein achieving improved blocking efficiency
It is intended to provide a method of conveniently screening a novel protein or a novel partial sequence protein having a blocking ability based on amino acid sequence data; and a protein achieving...
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7601301 |
Multiplexed active biologic array
A method and apparatus for addressing and driving an electrode array includes addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect, a value...
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7598352 |
Method of identifying polypeptide monobodies which bind to target proteins and use thereof
A method of identifying a polypeptide monobody having target protein binding activity, said method comprising: providing a host cell comprising (i) a reporter gene under control of a 5′...
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7598051 |
Compositions and methods for the therapy and diagnosis of ovarian cancer
Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic...
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7598050 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7598048 |
Screening methods for identifying agents that modulate output of a circadian pacemaker
The invention provides a method for screening for a compound for modulating circadian rhythm. The method involves (a) providing a compound that is a Prokineticin 2 (PK2) receptor antagonist or...
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7598044 |
Procedure and device for determining the concentrations of at least two ligands
In a procedure for determining the concentrations of ligands contained in a sample wherein a first ligand is bond-specific to a first receptor and a second ligand is bond-specific to a second...
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7598031 |
Method for the detection of gene transcripts in blood and uses thereof
The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR analysis performed on a drop of blood for detecting, diagnosing and...
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RE40929 |
Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
Methods and compositions for staining based upon nucleic acid sequence that employ nudeic nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for...
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7595495 |
Microreactor device and microchannel cleaning method
A microreactor device includes: a microchannel; magnetic particles that are introduced into the microchannel; and a magnet that is arranged on an outside of the microchannel and exerts a magnetic...
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7595202 |
Analysis method using reporter (label) intermolecular interaction
The present invention provides a method for controlling the spatial arrangement of an energy donor and an energy acceptor in a reaction complex in order to carry out the measurement with good...
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7592187 |
Method of calibrating ligand specificity
A method to determine specificity of ligand binding includes comparing a solid phase carrier first extract obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a...
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7592148 |
Method for examining human kidney disease by detecting the fatty acid binding protein
Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the...
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7592146 |
Protocol for detecting proteins in a culture containing an embryo
The present invention provides methods to determine the sex of an embryo by detecting the presence of a protein associated with the Y chromosome in a sample of culture medium obtained by sampling a...
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7591997 |
Method for determining the susceptibility of a subject to infection
A method for determining the susceptibility of a subject to infection, which method comprises: (i) providing a sample from said subject; (ii) detecting any LL-37 present in said sample; (iii)...
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7588902 |
Methods and compositions for diagnosing hepatocellular carcinoma
Methods for the diagnosis of hepatocellular carcinoma (HCC) are set forth. Improved assay methods and scanning methods are included that employ non-cell-associated and cell-associated HCC related...
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7588900 |
Mammalian sweet and amino acid heterodimeric taste receptors
The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R...
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7588898 |
Biomarker for gestational trophoblastic disease
A relatively specific trophoblastic-associated biomarker, HSD3B1, is disclosed. A method for screening gestational trophoblastic disease using HSD3B1 is also disclosed.
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7585641 |
Immunoassay and method of use
A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The...
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7582443 |
Method for the detection and measurement of Hapten-conjugated biological binding entities by western and dot-blot using anti-hapten antibodies
The invention is a procedure for measuring the binding of an entity (ligand) to a surface by using a hapten-conjugated version of the ligand (hapten-ligand). An excess of the hapten-ligand is...
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7579159 |
Assays, antibodies, and standards for detection of oxidized and MDA-modified low density lipoproteins
Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the...
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7579156 |
Fluorescent phospholipase assay, phospholipase A2 inhibitor and stimulator, and the use thereof
A fluorescent phospholipase assay is disclosed. Further disclosed are the identification of alpha-1-antitrypsin as a phospholipase A 2 stimulator and phospholipase C inhibitor and the...
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7575877 |
Method of diagnosing tuberculosis
The present invention relates to a method of diagnosing tuberculosis in a subject, said method comprising steps of: detecting anti- Mycobacterium tuberculosis (M.tb.) isocitrate dehydrogenase...
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7575876 |
Biomarkers for neurodegenerative disorders
The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene...
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7575875 |
Method of tacrolimus extraction and quantification using aqueous detergents
The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in...
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7575874 |
Method and probes for the detection of a tumor specific fusion protein
This invention relates to the detection of fusion proteins. The invention provides a set of at least a first and a second molecular probe, each probe provided with a dye wherein the dyes together...
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7575862 |
Assay systems, kits and methods for detecting microorganisms
The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis ) of suspected patient. The present invention also relates to an...
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7572596 |
Modulation of the neuroendoctrine system as a therapy for motor neuron disease
The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a...
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