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7125676 |
Expression system for human brain-specific voltage-gated sodium channel, type 1
Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A...
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7125678 |
Protein biopolymer markers predictive of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7125668 |
Electrodes linked via conductive oligomers to nucleic acids
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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7122382 |
Method for detecting proteins under mutual interaction
A method for detecting proteins under mutual interaction which comprises mixing a protein having a label for detection synthesized by a cell-free protein synthesis method with another protein...
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7122327 |
Biopolymer markers indicative of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7122639 |
Chemokine alpha-2 antibodies
Human chemokine Alpha-2-polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are...
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7122383 |
Fluorescent polymer superquenching-based bioassays
A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering...
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7118873 |
Polynucleotides encoding cellular transporters and methods of use thereof
This disclosure encompasses the Indy gene, polypeptides encoded by the Indy gene and fragments thereof. This disclosure also encompasses homologs of the Indy gene both from Drosophila and other...
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7118875 |
Analyte determination using a general purpose structure of an analytical element
The invention concerns an analytical element for the determination of an analyte containing in or on material which enables liquid transport between zones, a sample application zone and a detection...
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7118853 |
Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile...
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7118862 |
Induction of apoptosis by cellular stress
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such...
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7118908 |
On-spot selectively activated hydrophobic slide and preparation thereof
An on-spot selectively activated hydrophobic slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic...
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7119189 |
Metabotropic GABA [B] receptors, receptor-specific ligands and their uses
The present invention provides purified GABA B receptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic...
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7115377 |
Cell-based assays for G-protein-coupled receptor-mediated activities
Disclosed are compositions and methods for their use, such as in identifying G-protein-coupled receptors, ligands and compounds that modulate the activities of G-protein-coupled receptors. The...
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7115361 |
Detection of CD8+ T cell responses to M. tuberculosis
A method of detecting an anti-mycobacterial CD8 T cell response comprising contacting a population of CD8 T cells of an individual with one or more peptides selected from the peptides represented...
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7112667 |
Sequences of an Ih ion channel and use thereof
The present invention relates to a nucleic acid, preferably a DNA, comprising at least a part of the sequence of an I h ion channel. Said sequence may e.g. be derived from a human DNA, a rat DNA,...
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7109041 |
Display of receptors and analysis of binding interactions and drug libraries
A display and method of preparing 7-transmembrane and other receptors for real-time kinetic analysis of binding interactions. The invention includes display on beads and in micelles for multi-well...
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7109044 |
Method of detection and disease state management for renal diseases
The present invention relates to a method of detection of an early-stage renal disease, comprising determining the concentration of human lipocalin-type prostaglandin D synthase in a body fluid...
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7108988 |
Methods of identifying agents for inhibiting lentivirus replication
The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the...
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7108983 |
Tissue inhibitor of matrix metalloproteinases type-1 (TIMP-1) as a cancer marker
The present invention describes a method for determining whether an individual is likely to suffer from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples...
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7105650 |
T2R taste receptors and genes encoding same
Newly identified mammalian taste-cell-specific G Protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed...
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7105301 |
Detecting molecular binding by monitoring feedback controlled cantilever deflections
The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached...
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RE39282 |
Nucleic acid derivatives
This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment.
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7105340 |
On-spot selectively activated hydrophobic slide and preparation thereof
An on-spot selectively activated hydrophobic slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic...
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7105488 |
G protein-coupled receptor antagonists
G-protein coupled receptors (GPCR) generally contain seven transmembrane helices. The present invention provides synthetic peptides derived from these transmembrane helices. The peptides inhibit...
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7105303 |
Antibodies to hepatitis C virus asialoglycoproteins
Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal...
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7105154 |
Method of treatment using interferon-tau
A method for treating a condition responsive to interferon therapy in a human subject is described. The method includes orally administering interferon-tau to the intestinal tract in an amount...
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7101674 |
Anti-idiotypic anti-TNF antibodies and related immunoassay methods
Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as...
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7101717 |
Addressable biologic electrode array
An addressable biologic electrode array includes an array of electrodes disposed on a support, the array of electrodes being selectively addressed and driven using a memory associated with each...
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7102752 |
Systems to view and analyze the results from diffraction-based diagnostics
An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of...
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7097966 |
Detection of survivin in the biological fluids of cancer patients
The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising...
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7097983 |
Method for detecting the presence of an analyte in a sample
The invention features a method of determining whether one or more members of an analyte family are present in a sample. The method makes use of a test zone binder, e.g., a receptor that can bind...
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7097969 |
Non-endogenous, constitutively activated known G protein-coupled receptors
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known...
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7097989 |
Complement C3 precursor biopolymer markers predictive of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7097991 |
Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the...
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7097809 |
Combinatorial synthesis system
The present invention provides a microfluidic device for synthesizing an array of compounds and methods for using the same. In particular, the microfluidic device of the present invention comprises...
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7097988 |
Methods for screening for substances that bind opioid receptors
The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor...
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7097838 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7094556 |
Diagnosis and treatment of malignant neoplasms
The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl)...
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7094593 |
Method for improving the function of heterologous G protein-coupled receptors
This invention relates to mutant G protein-coupled receptors with improved G-protein coupling and receptor response, yeast cells expressing such receptors, vectors useful for making such cells, and...
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7094550 |
Method to determine TGF-beta
A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I):
wherein Z is C═O or a covalent bond; Y is H or O(C 1 –C 4 )alkyl, R 1 and R 2...
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7094549 |
Fibronectin biopolymer marker indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time- of-flight detection procedures to maximize the diversity of biopolymers...
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7091047 |
Methods and kits for diagnosing tumorigenicity
Methods and kits for diagnosing tumorigenicity by measuring the concentration of GP88 in blood, plasma, serum, saliva, urine and other biological fluids. The methods and kits detect GP88 in...
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7090975 |
Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
Processes are disclosed using the depolymerization of a nucleic acid hybrid and incorporation of a suitable nucleotide to qualitatively and quantitatively analyze for the presence of predetermined...
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7090834 |
Vascular endothelial cell growth factor variants and uses thereof
The present invention provides VEGF variants having one or more amino acid mutations in the KDR and/or FLT-1 receptor binding domains in the native VEGF sequence and selective binding affinity for...
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7090989 |
Recombinant human SM-11044-binding receptor proteins exhibiting ligand-binding activities, and their uses
Transformed cells designed to express a recombinant human SMBP at an elevated level to the extent that its ligand-binding activity can be measured, and cellular membrane fractions thereof;...
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7087395 |
Vitamin D assay
The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition....
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7083983 |
Inhibitors of the interaction between P53 and MDM2
The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds,...
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7083914 |
Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of...
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7081344 |
Methods for screening compounds that bind human COE-2
The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic...
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