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8455203 Immuno-based retargeted endopeptidase activity assays  
The present specification discloses SNAP-25 immune response inducing compositions, methods of making α-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a...
8450077 Quantitative diagnostic methods using multiple parameters  
Materials and methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to...
8450071 Biomarker and method for detecting a chronic inflammatory-associated disease  
The present invention in one embodiment uses detection of isoforms of CAP37 as an early detection marker for a chronic inflammatory-associated disease. Chronic inflammatory-related diseases may...
8444932 D-dimer, troponin, and NT-proBNP for pulmonary embolism  
The present invention relates to a method of diagnosing acute pulmonary embolism (PE) in a subject including a) determining the amount of fibrin-fibrinogen degradation products, in particular...
8445719 Method of stabilizing heme protein and storage solution therefor  
A method of stabilizing a hem protein which is effective against the denaturation and degradation of a hem protein typified by hemoglobin and a storage solution therefor. A method of stabilizing a...
8445218 Device and methods for the immunological identification of cerebrospinal fluid  
The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample by the detection of one or more antigens that are enriched in CSF compared to their...
8445219 Method of determination of receptor binding saturation effected by monoclonal antibodies  
The invention relates to the determination of the degree of membrane receptor binding by specific monoclonal antibodies. This method is notably beneficial for monoclonal antibodies that are used...
8440188 Therapeutic and diagnostic anti-HSP70 antibodies  
Methods and compositions for the detection, prevention and treatment of infectious diseases, primary and metastatic neoplastic diseases, including, but not limited to human sarcomas and carcinomas...
8440418 Metabolic syndrome and HPA axis biomarkers for major depressive disorder  
Materials and methods for using combinations of metabolic syndrome and HPA axis biomarkers for monitoring major depressive disorder.
8440463 Predicting renal failure in diabetes patients based on placental growth factor and soluble FLT-1  
Disclosed is a method for predicting the risk of developing renal failure or mortality for a subject suffering from diabetes mellitus. More specifically, a method is disclosed for predicting the...
8431405 Hyperglycosylated hCG detection device  
The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a...
8426154 Immunoassay for venom detection including noninvasive sample collection  
Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from...
8426150 Process for differential polypeptides detection and uses thereof  
Provided herein is an affinity media and the construction and use thereof. The affinity media may be used, for example, for the detection of differential proteins/peptides by depletion of...
8426220 Utilization of shield effect for dopamine detection and reagent development  
The present invention relates to fusion proteins of monoamine oxidase B (MAO B)-green fluorescent protein (GFP) and utilizes “shield effect” to detect the dopamine under physiological condition,...
8426149 Granzyme A and granzyme B diagnostics  
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include...
8428886 Genotype calling  
Determining a genetic sequence for a particular site on an individual's genome is disclosed, including: receiving a measurement associated with a particular sequence for the particular site on the...
8426151 Systems and methods for the detection of biomarkers  
System and methods for the detection of biomarkers. In at least one embodiment of a system for the detection of a diagnostic marker in a body fluid of the present disclosure, the system comprises...
8420339 Methods for predicting pregnancy outcome in a subject by hCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8420093 Anti-ADDL monoclonal antibody and use thereof  
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can...
8420336 Method of bioassaying yokukansan  
An in-vitro bioassay method for yokukansan, involving competitively binding a labeled ligand and yokukansan with cells or cell membranes expressing glutamate receptors, measuring the binding...
8420310 Method for detection of idiopathic interstitial pneumonia  
The present invention provides a method for detecting idiopathic interstitial pneumonia, which comprises measuring the expression level of a periostin gene or the amount of a periostin protein in...
8420338 Serum MG53 as a diagnostic marker for tissue injury  
Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a...
8420333 G-protein coupled receptor-associated sorting protein 1 as a cancer biomarker  
A method for determining whether early stage cancer is present in a subject comprises detecting the expression level of GASP-1 in the subject by detecting the amount of GASP-1 peptide fragments...
8420335 Inhibition of GASC1  
The present invention provides a method of testing the ability of a test compound to bind to and optionally modulate the activity of a protein of the JMJD2 subfamily of Jumonji proteins. The...
8423296 Method for analyzing gene expression data  
The invention provides a method for selecting one or more genes from among a predetermined group of genes whose expression level is significantly different among a first group of individuals in a...
8420337 Lipoprotein-associated markers for cardiovascular disease  
The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an...
8420326 Method of evaluating performance of activation gas deactivating antigenic substance and apparatus for generating processed antigenic substance used as evaluation sample of the evaluating method  
A method of evaluating performance of an activation gas deactivating an antigenic substance including the steps of causing the antigenic substance and the activation gas to react with each other,...
8420321 Method for the identification of a risk for a thrombogenic disorder by determining the TAFI-Ile347 polymorphism  
The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit...
8415112 COPD diagnosis  
The present invention relates to a method for diagnosing chronic obstructive pulmonary disease (COPD) in a human subject or the risk of a human subject to develop COPD comprising the steps of:...
8409874 Reversible binding surface  
The present invention relates to a method to treat a product which product comprises a surface which surface includes a plasma polymer of an organic monomer wherein immobilized on said plasma...
8409815 sCD40L and placental growth factor (PLGF) used as a biochemical marker combination in cardiovascular diseases  
The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools...
8409816 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
8409878 Detection and monitoring of liver damage  
A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3...
8409875 Measurement of binding kinetics with a resonating sensor  
A subject material in a fluid sample is detected using a resonating sensor immersible in the fluid sample. Binding kinetics of an interaction of an analyte material present in the fluid sample are...
8404455 Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides  
The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric...
8404459 Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof  
The invention pertains to a method of measuring Aβ protofibrils in a sample. The method includes the steps of (a) providing a labeled monoclonal antibody or fragment thereof that binds wildtype Aβ...
8399210 Autoantigenes for improved diagnosis, prognosis and treatment of inflammatory neurological diseases  
According to the invention, autoantibodies, the appearance of which is characteristic of neurological autoimmune diseases, especially multiple sclerosis, are detected and the respective...
8399209 Homogeneous detection method  
The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the...
8394601 Peptide biomarkers predictive of renal function decline and kidney disease  
Methods and kits are provided for diagnosing a kidney disease, or the risk thereof, in a subject. The methods include determining an amount of at least one peptide biomarker disclosed herein in a...
8394646 Method for the quality control of molecules or targets  
A method for quality control of species used in analytical or diagnostic or therapeutic procedures includes immobilization of a model of the malignancy to a solid support (121), contacting the...
8394597 Endotoxin detection method  
The invention relates to a method for detecting endotoxins in a sample.
8389225 Bio-silica chip comprising silica binding protein and method for fabricating the same  
The present invention relates to a bio-silica chip comprising a silica-binding protein and a fabrication method thereof, and more particularly to a bio-silica chip in which a fusion protein of a...
8389227 Method for diagnosing cancers expressing the HER2 receptor or its truncated variants  
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognizes an epitope of a...
8389224 Assay for analysis of free drug in samples  
Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding...
8383356 Electronic methods for the detection of analytes  
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
8383349 Bone morphogenetic protein antagonist and uses thereof  
The present invention relates to the use of proteins that are differentially expressed in tumor associated stromal cells, as compared to normal stromal, as biomolecular targets for tumor treatment...
8383360 Methods of diagnosing and treating autism  
The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother...
8378115 Monomethine dyes  
Monomethine dyes that have no or minimal fluorescence in buffer or in the presence of single stranded DNA or RNA, but strongly fluoresce in the presence of double-stranded DNA. In one embodiment,...
8377646 Beta-2 microglobulin as a biomarker for peripheral artery disease  
The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
8377647 Nonseparation assay methods  
Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support...