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8524231 Antigen binding polypeptides  
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on the conventional antibody repertoire...
8524463 Diagnosis and risk classification of acute coronary syndrome by means of CT-proET-1 in combination with NT-proBNP  
The invention relates to a method for diagnosis and/or risk classification for acute coronary syndrome (ACS), in particular for acute myocardial infarct (AMI) and angina pectoris (AP) and/or a...
8518656 Procollagen C-proteinase enhancer (PCPE) biomarker for bone formation  
A method of diagnosing fibrosis in a subject is provided, comprising the steps of: determining a level of PCPE in a body fluid sample obtained from said subject; and detecting an increased level...
8518710 Photon reducing agents for fluorescence assays  
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based...
8512966 Method for sensing a chemical  
The present invention relates to a method for detecting an analyte (10) in a sample, comprising the steps of: providing a transducer comprising a pyroelectric or piezoelectric element and...
8513001 Method and apparatus for target detection using electrode-bound viruses  
A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer...
8512960 88kDa tumorigenic growth factor and antagonists  
This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an...
8507294 Method and system for analyte monitoring using surface plasmons with a refreshable surface  
The present technology provides an illustrative method for analyte monitoring using surface plasmons with a refreshable surface. The method includes placing a solution to be monitored in contact...
8506934 Methods for detection of biological substances  
The invention is directed to a method of detecting a biological substance in the nasal secretion and diagnosing a disease following the detection of the biological substance wherein the biological...
8510057 Summarizing an aggregate contribution to a characteristic for an individual  
Summarizing an aggregate contribution to a characteristic for an individual is disclosed, including determining the characteristic to be evaluated, identifying one or more markers associated with...
8507259 Dual path immunoassay device  
The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the...
8507215 Diagnostics for membranous nephropathy  
The invention provides immunoassays for detecting serum auto-antibodies reactive against a phospholipase A2 receptor (PLA2R) and uses thereof for diagnosis and prognosis evaluation of idiopathic...
8501420 Biomarkers for prediction of major adverse cardiac events and uses thereof  
The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac...
8501421 Method for high throughput peptide/protein assay generation and assays generated therewith  
The invention relates to a method for the determination of an MRM or SRM assay for a protein of interest, a peptide of interest, or a group of proteins/peptides of interest or a whole proteome. It...
8501423 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays  
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic...
8501422 Methods of detecting and treating pulmonary disease and markers thereof  
The present invention relates to the treatment of pulmonary diseases. More specifically, the invention relates to new methods of detecting and treating chronic obstructive pulmonary disease...
8501669 Systems and methods of screening biomarkers in bodily fluids  
Systems and methods of screening biomarkers in bodily fluids. According to at least one embodiment of the system for analyzing stabilizing agents of the present disclosure, the system comprises a...
8497080 Methods for determining signal transduction activity in tumors  
The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is...
8497078 Biomarkers for myocardial ischemia  
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial...
8497106 Immobilisation of biological molecules  
A method of immobilising a biological molecule on a substrate comprises: (i) covalently attaching a substantially three-dimensional polysilane polymer to a substrate; and (ii) attaching a...
8497079 Glucagon detection and quantitation by mass spectrometry  
Methods are described for measuring the amount of glucagon in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying glucagon in a sample.
8492107 Neural proteins as biomarkers for nervous system injury and other neural disorders  
The present invention identifies biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree...
8492136 Fluidic indicator device  
Disclosed is a fluidic assay device for assaying at least one property of a liquid sample comprising: a liquid sample application region; at least one test flow path in liquid flow communication...
8486346 Gas scrubber for automated clinical analyzer  
A device and method for extending the useful life of a bulk liquid used in an automated clinical analyzer. Air from the atmosphere surrounding the automated clinical analyzer that displaces the...
8486648 Methods of detecting ovarian cancer  
The present invention provides methods of detecting ovarian cancer using biomarkers.
8486647 Neuropeptide release assay for sodium channels  
Methods and compositions for using genetically modified non-human animals are provided, wherein the genetic modification comprises a humanization of the one or more extracellular pore loops of a...
8486716 Method for detection of basic peptide and reagent for detection of basic peptide  
The present invention provides a method for detection of a basic peptide by mixing a sample suspected to contain the basic peptide and a reagent containing denatured albumin and detecting...
8486719 Multiplex assay methods and compositions  
Luminescence assays and compositions for assay of biomolecular interaction and activity and detection of modulators of biomolecular interaction and activity are provided. Technology described...
8486640 Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease  
A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of...
8481326 Apparatus for measuring cholesterol and method thereof  
A microfluidic device and method for measuring a level of cholesterol therewith are provided. The cholesterol measurement apparatus includes a microfluidic device including a plurality of chambers...
8481273 Perlecan fragments as biomarkers of bone stromal lysis  
A method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit...
8481680 Mutant smoothened and methods of using the same  
The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, we describe a...
8481277 Alzheimer's diagnosis  
Evaluation of VLP-I levels in combination with at least one of amyloid-β peptide (AB), hyperphosphorylated tau (pTau) or total tau (tTau) levels in samples of biological fluid improves the...
8476081 Assay for evaluating affinity and specificity of ligand-albumin binding  
A method for identifying a ligand or compound which binds to albumin comprises the steps of contacting a reaction mixture comprising a site-specific probe and albumin in the presence and the...
8476461 Dipyrromethene-boron hydrophilic fluorescent compounds  
Dipyrromethene-boron hydrophilic fluorescent compounds The invention concerns fluorescent and hydrophilic compounds meeting following formula (I): wherein: S1 is a group of formula —C≡C-L′-A where...
8476077 Urine and serum biomarkers associated with diabetic nephropathy  
Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic...
8476443 Fluorescent dyes  
The present invention provides dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles....
8470535 Two stage nucleic acid amplification using an amplification oligomer  
This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic...
8470548 Diagnosis of depression  
The present invention relates to the use of p11 as a drug target as well as a tool for the diagnosis, treatment and development of p11/5-HT receptor related disorders. The invention further...
8470607 Inhibition of angiogenesis  
The present invention is directed to novel methods of inhibiting angiogenesis using chlorotoxin agents. In some embodiments, the inventive methods include intravenous, intraocular, intravitreal,...
8466090 Development and use of fluorescent probes of unbound analytes  
A method for high throughput screening of probes is described. These probes are useful for characterization and measurement of unbound metabolites in a fluid sample, particularly characterization...
8467974 System, method, and computer software for the presentation and storage of analysis results  
A computer program product, and related systems and methods, are described that processes emission intensity data corresponding to probes of a biological probe array. The computer program includes...
8465980 Urine and serum biomarkers associated with diabetic nephropathy  
Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic...
8465989 Method and system for detecting a target within a population of molecules  
A method (800) of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target...
8465935 Detection and quantitation of cyclodextrins  
The invention relates to the detection and quantitation of cyclodextrins and cyclodextrin derivatives in solutions comprising a protein. The invention further relates to methods of evaluating...
8460885 Binding of pathological forms of prion proteins  
A process for the selective binding of an aggregating abnormal form of a protein in the presence of the nonaggregating normal form of the protein, including contacting under selective binding...
8460889 Methods and compositions for diagnosis or prognosis of cardiovascular disease  
The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method...
8463553 Methods for diagnosing irritable bowel syndrome  
The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the...
8460943 Detection and monitoring of liver damage  
A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3...
8455202 Affinity selector based recognition and quantification system and method for multiple analytes in a single analysis  
A multi-dimensional method for simultaneously analyzing multiple analytes within a sample solution, comprising adding affinity selectors to a sample solution containing analytes to be measured,...