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7175828 |
Modulators of β-amyloid peptide aggregation comprising D-amino acids
Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely...
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7176181 |
Compositions and methods of using galectin-8 as an inhibitor of tumor cell growth
The present invention provides compositions that enhance or inhibit the interactions of galectin-8 and galectin-8-like proteins with other extracellular matrix proteins or cell surface receptors,...
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7172876 |
Method of screening therapeutic agents for nerve degeneration associated diseases
By using a G protein-coupled receptor protein containing an amino acid sequence, which is the same or the substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:10,...
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7172907 |
Cyanine dye labelling reagents with meso-substitution
Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1):
in which groups R 3 and R 4 are attached to...
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7172858 |
Blood-based assay for dysferlinopathies
It has been discovered that dysferlin is expressed in blood and that individuals who lack dysferlin in muscle also lack it in CD14(+) cells. Based on these discoveries, blood-based tests for...
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7169582 |
Multifunctional recombinant phycobiliprotein-based fluorescent constructs and phycobilisome display
The invention provides multifunctional fusion constructs which are rapidly incorporated into a macromolecular structure such as a phycobilisome such that the fusion proteins are separated from one...
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7169564 |
FKBP51/52 and CyP40-mediated mammalian hair growth
The present invention relates to drug screening assays designed to identify non-immunosuppressive agents that modulate hair growth and the use of such agents for modulation of hair growth.
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7166423 |
Direct selection of cells by secretion product
Cells can be labeled with products which they secrete and release in an efficient manner by coupling the cells at their surface to a specific binding partner for the product and allowing the...
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7163799 |
Neuromedin U receptor NMUR2 and nucleotides encoding it
A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain....
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7163800 |
Methods of screening compositions for G protein-coupled receptor desensitization inhibitory activity
The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition...
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7160733 |
Ligand specific to β2-glycoprotein I and use thereof
The cholesterol derivative, represented by the following formula (1):
wherein R represents a C3–C23 saturated or unsaturated aliphatic hydrocarbon residue having an optional substituent, and,...
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7160677 |
Transcription factor DP-1
The invention provides a polynucleotide in substantially isolated form which includes a contiguous sequence of nucleotides which is capable of selectively hybridizing to SEQ ID NO: 1 or the...
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7157269 |
On-spot hydrophilic enhanced slide and preparation thereof
The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a...
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7157234 |
Detection of very low quantities of analyte bound to a solid phase
A microscale binding assay, analyte binding array, and kits are disclosed, which exploit the mass action law to harvest analyte from a liquid sample. This is achieved by fabrication of sorbent...
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7157286 |
Method for immunologically measuring RCAS1 and kit for measuring the same
RCAS1 in a specimen is measured by a immunologically method consisting of a step of reacting a specimen with a first anti-RCAS1 antibody capable of specifically binding to RCAS1, a step of labeling...
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7153700 |
Methods and compositions for diagnosing and predicting the behavior of cancer
The present invention relates to methods for detecting the presence of SIX1 protein or nucleic acid in a biological sample in which a biological sample is contacted with an agent capable of...
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7153935 |
Tumor suppressor gene
A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA...
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7154007 |
Luminous compounds and labeling reagents using the same
This invention provides: a compound represented by formula (I):
R—Y—(—X-Phe-COCH 2 COC n F 2n+1 ) m (I)
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7150974 |
Parathyroid hormone receptor binding method
DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone...
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7151082 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7150856 |
On-spot selectively activated hydrophobic slide and preparation thereof
An on-spot selectively activated hydrophobic slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic...
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7150997 |
Multiplexed active biologic array
A method of addressing and driving an electrode array includes the step of addressing one or more electrodes within the array using a plurality of row and column lines. In one aspect of the method,...
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7148016 |
Immunoassays to detect diseases or disease susceptibility traits
Disclosed are immunoassay methods for the diagnosis/prognosis of diseases and disease susceptibility traits associated with gene mutations that cause protein truncation or allelic loss. The levels...
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7144705 |
Diagnostic assay for stroke
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using anti-H-FABP or...
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7144997 |
Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that...
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7144996 |
Nucleic acid encoding human suppressor of fused
The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of the Drosophila melanogaster fused protein and to nucleic acid molecules encoding those...
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7141434 |
Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing an adenosine kinase
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds...
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7141437 |
Solid-state colorimetric biosensors comprised of dendritic polymer networks
Solid-state colorimetric biosensors having sensory groups and interdendritic cross-linking segments of alternating conjugated double and triple bonds are prepared by intermolecular polymerization...
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7141377 |
Process for discrimination of nucleic acid sequence variants
A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from...
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7141435 |
Monoclonal antibodies against human apoptosis inhibitory protein NAIP and method for assaying the NAIP
An anti-NAIP monoclonal antibody recognizing a human apoptosis inhibitory protein NAIP having the amino acid sequence of SEQ ID NO: 1, which is produced from hybridoma prepared by fusing a myeloma...
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7138492 |
Method of treating dopaminergic and GABA-nergic disorders
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that...
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7138240 |
Methods of assaying receptor activity
Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G Protein-coupled...
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7138249 |
Screening method
The screening method for a compound or a salt thereof that alters the binding property between Neuromedin U or a salt thereof and TGR-1 or a salt thereof, characterized by using Neuromedin U, a...
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7138246 |
Methods for identifying or screening for agents that modulate 17β-HSD3
Methods for determining whether a test agent inhibits a 17β-HSD3, the methods comprising: obtaining a recombinant host cell that expresses the 17β-HSD3; obtaining a reaction mixture comprising...
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7138121 |
Biosensors utilizing dendrimer-immobilized ligands and there use thereof
The present invention is directed to methods and compositions useful as biosensors that specifically interact with various pathogens and other target analytes. The biosensor itself, comprises...
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7138500 |
Antibodies to human 4-1BB
Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences,...
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7138239 |
Method and reagent for testing for multiple organ failure in SIRS by cytochrome C measurement
A method for testing for multiple organ failure in SIRS, which comprises determining cytochrome C in body fluid and using the determined result as an index of the multiple organ failure, and a...
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7138541 |
Surface coating agents
Compounds useful as surface coating agents, including compounds of the formula:
wherein X 1 comprises a first photoreactive species; X 2 comprises a second photoreactive species; Y...
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7138241 |
Hybridoma, an antibody resistant to an interfering substance, and a kit for immunological analysis
The present invention provides for a method of selecting an antibody against a target substance to be measured, which comprises selecting the antibody against the target substance by...
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7135311 |
Means for detecting and treating pathologies linked to FGFR3
The invention relates to a method for detecting carcinomas in a biological sample, comprising identifying FGFR3 mutations.
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7135296 |
Elemental analysis of tagged biologically active materials
Improved methods for the detection and quantitation of labeled biological materials in a sample using elemental spectroscopic detection are described. Element-labeled biologically active materials,...
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7135143 |
Detecting compounds with liquid crystals
A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer...
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7135280 |
Assay to determine efficacy of treatment for mycobacterial infection
Method of determining the efficacy of treatment for mycobacterial infection in an individual comprising determining in samples from the individual whether the level of T cells specific for a...
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7135340 |
Tetrameric antibody complexes for blocking non-specific labeling of antigens
A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody...
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7135176 |
VMP-like sequences of pathogenic Borrelia
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia , the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded...
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7132508 |
Mammalian chemokine reagents
A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also...
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7129040 |
Tumor suppressor designated TS10q23.3
A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene...
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7129039 |
Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
Novel genes expressed selectively by long-term dendritic cell (DC) lines (XS series) from murine epidermis which retain important features of resident epidermal Langerhans cells (LC) are provided....
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7129203 |
Site specific protein modification
Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of...
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7125592 |
Detecting interactions at biomimetic interfaces with liquid crystals
A method of forming a liquid crystal device, includes: contacting an aqueous solution comprising a surfactant and a receptor molecule with a top surface of a liquid crystal. The liquid crystal is...
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