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8586349 Moving droplet diagnostic assay  
The present invention concerns a method for the detection of an analyte in a droplet of fluid comprising the steps of providing a solid phase with a hydrophobic surface comprising at least one...
8580529 Diagnosis of collagen IX destruction  
A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of...
8580577 Method for detecting an analyte in a sample  
The present invention relates to a method for detecting an analyte in a sample comprising the steps of providing detection probes being labeled with a first reporter, which detection probes are...
8574858 Autoantibody enhanced immunoassays and kits  
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies...
8574856 Methods for determining the efficiency of a therapeutic  
Methods for determining the efficiency of a therapeutic. In at least one embodiment of a method of determining the efficacy of a therapeutic compound, the method comprises the steps of treating a...
8574861 PPM1E proteins and nucleic acids as targets for neurodegenerative diseases  
1. Use of (v) a gene coding for a protein phosphatase 1 E having SEQ ID NO:1 or SEQ ID NO:2, and/or(vi) a transcription product of the gene coding for a protein phosphatase 1 E having SEQ ID NO:1...
8568999 Diagnosis and treatment of preeclampsia  
The present invention relates to biomarkers for preeclampsia as well as treatment of this disease. In particular, the invention relates to methods for diagnosis or aiding in the diagnosis of...
8568995 Methods for assessing modified LDL immune complexes in subjects having or at risk of coronary artery disease  
The present invention relates to the analysis of modified LDL in the context of immune complexes. In particular, ox-LDL and AGE-LDL are shown to predict the development of coronary artery disease...
8568997 Detection system and uses therefor  
A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent,...
8568990 Methods for identifying compounds that modulate sensory signaling through the taste cell specific G-protein coupled receptor GPCR-B4  
The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids...
8569000 Immunoassays using antibodies specific to carbamazepine  
The present disclosure is directed to antibodies specific to carbamazepine, immunogens used to produce the antibodies, and immunoassay kits and methods for using the antibodies.
8568996 MMP activation peptide detection in biological samples  
A method is provided along with related reagent kits for aiding the diagnosis of IPF or other interstitial lung diseases, as well as for potential monitoring of disease progression or therapeutic...
8569074 Analyte-releasing beads and use thereof in quantitative elispot or fluorispot assay  
A method of quantifying analyte secreted by a cell or released from a drug delivery vehicle, typically by ELISpot or fluorispot assay is described. Quantification is possible through the use of an...
8568993 Detection of glycopeptides and glycoproteins for medical diagnostics  
A diagnostic method for determining the absence or presence of a disease is provided. The method includes assaying the amount and/or types of glycopeptides in a sample from a subject, and...
8569001 Method for detecting lysosomal storage diseases  
A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay...
8563713 Antibodies specific to carbamazepine  
The present disclosure is directed to antibodies specific to carbamazepine, immunogens used to produce the antibodies, and immunoassay kits and methods for using the antibodies.
8563259 Complement-mediated thrombophilic assay  
A method for assessing the presence of an acquired thrombophilia disorder in a patient exhibiting hypercoagulation is disclosed.
8563476 Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders  
A method for detecting an inflammatory disease in a subject is disclosed. The method comprises the steps of (a) detecting a level of expression of one or more inflammatory disease markers in a...
8557534 Method and compositions for specifically detecting physiologically acceptable polymer molecules  
The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of...
8557601 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides  
The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous...
8557606 Immunological test for detecting autoantibodies against testicular antigens  
The present invention discloses an immunological test for the detection and specific determination of autoantibodies against testicular antigens which are associated with inflammation-related...
8557602 Method for detecting and distinguishing intrahepatic cholangiocarcinoma  
Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a...
8557530 Use of a TAS2R7 nucleic acid sequence to identify modulators  
TAS2R7 was identified as a menthol-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of menthol are provided.
RE44539 Rapid classification of biological components  
A method is disclosed for analyzing a biological sample by antibody profiling for identifying forensic samples or for detecting the presence of an analyte. In an illustrative embodiment of the...
8557526 Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury  
Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2,...
8551786 Systems and methods for enhancing fluorescent detection of target molecules in a test sample  
Systems and methods for enhancing fluorescent detection of target molecules in a test sample are for use with an irradiating device. First fluorophores are provided for absorption of EMF...
8551719 Endotoxin detection method  
The invention relates to a method for detecting endotoxins in a sample.
8551717 Method for determining sumoylation  
The present invention relates to a method for determining SUMOylation and utilizing said SUMOylation patterns for identifying specific interaction between different binding partners. In another...
8551768 Split DNA enzyme for visual single nucleotide polymorphism typing  
A probe that changes solution color in the presence of only one of the two DNA sequences, which differ by a single nucleotide, is reported. The probe consists of two oligodeoxyribonucleotides,...
8551789 Frizzled-binding agents and their use in screening for WNT inhibitors  
Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors...
8546085 Methods of identifying modulators of the bitter taste receptor TAS2R44  
Steviol glycosides have been discovered to bind the bitter taste receptor TAS2R44. Novel methods of identifying modulators and in particular inhibitors to the bitter taste of steviol glycosides...
8546148 Composition for use as an assay reagent  
A composition for use as an assay reagent comprises a solid support comprising a member of a signal producing system and a coating of a synthetic copolymer. The synthetic copolymer comprises a...
8546084 Device and method for identifying and determining blood groups  
A device for the determination and/or the detection of erythrocyte blood groups from a whole blood sample, and a process that implements this device, as well as a kit for the determination and the...
8546089 CMYBP-C and MLC2 as diagnostic markers of cardiac injury  
The invention relates to markers for acute myocardial infarction (AMI), particularly markers that may be used in the rapid and accurate diagnosis of AMI or reinfarction. A method of diagnosing...
8541244 In situ heat induced antigen recovery and staining apparatus and method  
Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction...
8541183 Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof  
The invention provides biomarkers and combinations of biomarkers that are useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also...
8541242 Device and method for detection of analytes  
The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane...
8541240 Colorimetric and fluorimetric fluoride sensing  
The present invention generally relates to fluoride receptor reagent compounds that are derived from one or more N-aryl or heteroaryl substituted 1,4,5,8-naphthalenetetracarboxydiimide (NDI)...
8541243 Method for assessment of folate phenotypes, disease risk and response to therapy  
The invention provides a method for measuring the levels of 5-methyltetrahydrofolate (5-MTHF), tetrahydrofolate (THF), and 5,10-MTHF in a biological sample. The method includes employing an...
8535896 Biomarkers for inflammation of the liver  
The invention relates to a method for the diagnostic investigation of biological samples from a person for inflammation of the liver, in particular hepatic fibrosis and/or cirrhosis of the liver,...
8536118 Methods and compositions for modulating hyperstabilized c-met  
The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.
8535891 Method of predicting acute appendicitis  
Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers:...
8530245 Methods and compositions related to acetylocholine receptor conjugates  
Disclosed are methods, compositions, and diagnostic kits for detecting acetylcholine receptor (AchR) autoreactive immune cells in a subject. The methods comprise detecting the binding of...
8530152 Methods of reducing non-specific interaction in metal nanoparticle assays  
The present invention discloses methods of reducing non-specific interactions of interfering species present in a sample in metallic nanoparticle-based assays, thereby increasing the sensitivity...
8530177 Chloral hydrate detection  
The invention relates to an immunoassay method and kit for the indirect detection of chloral hydrate. The invention is underpinned by a novel immunogen that produces an antibody that is specific...
8524504 Sensor  
This invention relates to a method for detecting an analyte in a sample, comprising the steps of exposing the sample to a transducer which is capable of transducing a change in energy to an...
8524507 Method for detecting a target molecule in a biological sample  
A method is provided for detecting a target molecule in a biological sample. One step of the method includes immobilizing the biological sample on a membrane. Next, the membrane-bound biological...
8524464 Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use...
8524462 Methods and compositions for diagnosis and prognosis of renal artery stenosis  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS)....
8524465 Agonists of bitter taste receptors and uses thereof  
The present invention relates to agonists of the human bitter-taste receptors hTAS2R14, hTAS2R10 and hTAS2R4 and their role in bitter taste transduction. The invention also relates to methods for...