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8652789 Diagnosis and prognosis of dipeptidyl peptidase-associated disease states  
A method is provided for the diagnosis or prognosis of a disease state, involving the measurement of a parameter of discriminated dipeptidyl dipeptidases from a patient sample, and the correlation...
8647833 Method for in vitro assay of the circulating tissue factor, and use in the detection of coagulation diseases  
The invention concerns the field of hemostasis, in particular blood coagulation disorders linked to an abnormal expression of tissue factor, and to physiopathological phenomena correlated with...
8647887 Measuring G protein coupled receptor activation  
The present invention relates to methods and polypeptides for detecting a compound in a sample. In particular, the present invention relates to the use of a cell-free composition comprising at...
8647830 Method for determining amino-terminal proANP in patients having a cardiac disease or being suspected of developing or having a cardiac disease  
The present invention relates to an in vitro method for medical diagnosis, prognosis and therapy follow-up for patients having a cardiac disease or being suspected of developing or having a...
8647829 Switchable affinity binders  
Methods and kits for binding and releasing biological targets, comprising, a binder comprising an environmentally reactive molecular switch that can switch between a high affinity state, to bind...
8647831 Cobalamin assay  
The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the...
8647832 Methods for determining the risk of prenatal complications  
The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain...
8642283 Screening assay for agents that alter target of rapamycin activity  
The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate...
8642032 Method for screening of patient to be administered with pharmaceutical agent comprising anti-cancer antibody as active ingredient  
The present invention provides a method for screening a patient to be administered with a pharmaceutical composition which comprises an anti-cancer antibody as an active ingredient, said method...
8642534 Proteins and polynucleotides of Vibrio cholerae  
Therapeutic, diagnostic and environmental monitoring methods employing proteins encoded by the rbmBCDEF gene cluster and by bap1.
8637325 Method and apparatus for pyrolysis-induced cleavage in peptides and proteins  
A method and apparatus for conducting the rapid pyrolysis of peptides, proteins, polymers, and biological materials. The method can be carried out at atmospheric pressures and takes only about 5...
8637270 Fluidized bed detector for continuous, ultra-sensitive detection of biological and chemical materials  
The present invention is generally directed to a fluidized bed detector for continuous detection of biological and chemical materials comprising a fluidized bed of detecting elements suspended in...
8637264 Microarrays and uses therefor  
Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding...
8637471 Fertilization prediction and promotion  
The outcome of an in vitro fertilization (IVF) of a woman in terms of chances of successful pregnancy or the fertility status of a woman is predicted based on nucleotide analysis of the...
8637256 Immunoassay for determining the release of neurotensin into the circulation  
The invention relates to an immunodiagnostic method for determining the release of neurotensin into the circulation of mammals based on the selective determination of an immunoreactivity of the...
8632776 Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for Parkinson's disease, dementia with lewy bodies and other α-synucleinopathies  
Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified Complementarity...
8633307 Dark quenchers for donor-acceptor energy transfer  
The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially...
8632986 Methods and kits for detection of toxemia  
Various embodiments of methods and kits are disclosed for prognosis, detection, and/or diagnosis of toxemia in a subject patient by analyzing an aliquot of the subject patient's extracellular...
8628978 Responsive luminescent lanthanide complexes  
A compound of formula (I) is provided: wherein: R1 is an optionally substituted 2-(1-azathiaxanthone);each —R2 is independently of the formula —CH2—C(═O)—R4, wherein R4 is an amino acid or a salt...
8628933 Homogeneous detection method  
The invention relates to a kit for a homogenous detection method for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogenous...
8628931 mTOR pathway theranostic  
This invention relates, e.g., to a method for predicting a subject's response to a chemotherapeutic agent and/or the subject's prognosis, comprising measuring the phosphorylation state of at least...
8629251 Specific detection and quantification of phosphatidic acid using an Arabidopsis trigalactosyldiacylglycerol-4 (TGD4) protein  
The present invention is related to the field of phospholipid detection. In particular, certain embodiments provide the detection of phosphatidic acid. For example, certain proteins are capable of...
8628916 Method for isolating hepatitis A virus or spring viremia of carp virus  
A method for isolating Hepatitis A virus or Spring viremia of Carp virus. A virus probe is prepared by linking a magnetic bead-conjugated Protein G with an anti-HAV (Hepatitis A Virus) antibody or...
8628979 MCAM as a biomarker for fluid homeostasis  
The application discloses MCAM as a new biomarker for fluid homeostatic imbalance; methods for predicting, diagnosing, prognosticating and/or monitoring fluid homeostatic imbalance based on...
RE44693 Beads bound to a solid support and to nucleic acids  
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are...
8623639 Thermostable proteins and methods of making and using thereof  
The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also...
8623605 Diagnostic assay for spongiform encephalopathies  
The invention provides a method of diagnosis of a spongiform encephalopathy in a diagnostic sample of a valid body tissue taken from a subject, which comprises detecting an increased proteolytic...
8623666 Method for detecting erythropoietin (EPO) receptor using anti-human EPO receptor antibodies  
Herein is reported an antibody that specifically binds to human EPO receptor, wherein the antibody binds to EPO receptor fragment LPGPGGSVDIV (SEQ ID NO: 01) but that does not specifically bind to...
8623610 Chondroitin sulfate binding proteins and modulators thereof  
Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further,...
8617906 Identification and screening of triptolide target molecules  
The identification of triptolide target molecules is described. Also described are methods of screening triptolide-related compounds for binding to these molecules, including screening for...
8617803 Non-specific adsorption inhibitor, probe-bonded particles, and method for producing the same  
A method for producing a non-specific adsorption inhibitor includes reacting (A) a tosylated compound of polyoxyethylene monomethyl ether with (B) a polyamine having either an amino group or imino...
8617826 TSH immunoassays employing scavenging reagents for cross-reacting endocrine glycoprotein hormone analogues  
Thyroid Stimulating Hormone (TSH) immunoassays are performed using an ELISA sandwich assay that employs scavenging or sacrificial beads for reducing interference caused by cross-reacting endocrine...
8614065 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof  
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or...
8609349 Drug selection for breast cancer therapy using antibody-based arrays  
The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of...
8609353 Diagnostics and methods for removal and detection of interferents  
Described herein are substrates, methods, articles, and kits that are useful for removing interferents from samples for diagnostic purposes. The interferents are removed with phosphocellulose and...
8609436 Method  
The invention provides a method of detecting the presence of anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent...
8609334 Biomarkers for painful intervertebral discs and methods of use thereof  
The present disclosure provides methods of diagnosing painful intervertebral discs. The present disclosure also provides methods of treating a painful intervertebral disc.
8603758 Prostate carcinogenesis predictor  
A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or...
8603762 Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor TAS2R46  
TAS2R46 was identified as a dextromethorphan-binding bitter taste receptor. Novel methods to identify modulators and in particular inhibitors to the bitter taste of dextromethorphan are provided.
8603765 Immunoassay reagents and methods of use thereof  
The present invention provide reagents and methods of using the reagents, for example, on automated staining devices, that facilitate detection of two or more antigens in a sample simply and...
8597896 Methods to identify modulators using TAS2R bitter taste receptor  
Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided.
8597577 Swept-frequency semiconductor laser coupled to microfabricated biomolecular sensor and methods related thereto  
An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described....
8597878 Device and procedure for automated isolation and purification of nucleic acids from complex starting materials of the users choice  
A reaction unit containing a bottom part and a top part for pipetting a liquid, wherein the bottom part contains a reaction cavity with a permeable filter grid insert and the top part contains a...
8597958 IL1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8597899 Method for automated tissue analysis  
The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts...
8594948 Apparatus and methods for medical testing  
Apparatus and methods for practicing telemedicine in the form of software systems acting over a network and kits containing laboratory supplies and equipment to organize the laboratory operations...
8592224 Biochip for archiving and laboratory-medical analysis of biological sample material, process for its production, and its use in diagnostic methods  
A biochip for diagnostic purposes comprises a sample carrier made of a solid matrix, on the surface of said sample carrier is bound the sample material to be analysed which originates from a...
8592223 Use of periostin as a novel biomarker  
The invention provides, in certain embodiments, a method of assaying an indicator of, and treating, renal injury or renal disease. The method entails assaying a urine sample for periostin, wherein...
8586321 Method for enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates  
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody...
8586387 Methods of triggering activation of encapsulated signal-generating substances and apparatus utilising activated signal-generating substances  
A method of performing a bioassay comprising activating capsules containing a signal precursor that is hydrolysable from a latent form in which substantially no signal is generated to a form in...