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8715943 Methods for improving inflammatory bowel disease diagnosis  
The present invention provides methods and systems to predict and diagnose inflammatory bowel disease (IBD) and subtypes such as ulcerative colitis (UC) and Crohn's disease (CD) by detecting the...
8715948 Granzyme A and granzyme B diagnostics  
A method for identifying a subject being at risk for or having a chronic inflammatory disease, fibrillinopathy, atherosclerosis, or coronary artery disease is provided. The method may include...
8716029 Carbon nanotube sensors employing synthetic multifunctional peptides for surface functionalization  
A biosensor that utilizes carbon nanotubes functionalized with a protein sequence. One domain of the multifunctional peptide sequence noncovalently binds to the surface of single-walled carbon...
8715942 Methods for the detection of glycated hemoglobin  
Provided herein are methods for detecting glycated hemoglobin in, for example, human whole blood, that are not affected by the presence of variation in amino acid sequence that can exist in...
8709733 Methods for diagnosing irritable bowel syndrome  
The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the...
8709722 Methods for detecting DNA-binding proteins  
There is provided a method for detecting binding of a DNA-binding protein to a target recognition sequence. The method comprises mixing in a reaction buffer a first set of metal nanoparticles, a...
8709734 Method for identifying modulators of GPCR GPR1 function  
The invention relates to the identification of Humanin and derivatives thereof as ligands of the GPR1 GPCR (G-protein coupled receptor). The invention encompasses the use of the interaction of...
8712696 Methods of prognosing a rheumatoid arthritis remission phenotype  
A method for prognosing a rheumatoid arthritis phenotype using the outcomes of selected single nucleotide polymorphisms (SNPs) and clinical variables. A method for genotyping multiple rheumatoid...
8710180 VEGF-specific capture agents, compositions, and methods of using and making  
The present application provides biligand and triligand protein-catalyzed capture (PCC) agents that specifically bind VEGF, as well as the use of these capture agents as detection, diagnosis, and...
8709735 β-2 microglobulin as a biomarker for peripheral artery disease  
The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
8703413 Detection of human somatic cell reprogramming  
The methods and kits described herein are based, in part, to the discovery phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits...
8703503 Methods and compositions for inhibition of BCL6 repression  
Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods or blocking corepressor binding to the BCL6 lateral groove. Additionally,...
8703428 Single-cell label-free assay  
The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution...
8704037 Targeted cell death  
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or...
8703441 Monoclonal antibodies against PCBP-1 antigens, and uses therefor  
The present invention provides and includes monoclonal antibodies (MoAbs or mAbs) specific or preferentially selective for PCBP-1 antigens, hybridoma lines that secrete these PCBP-1 antibodies or...
8703435 Peptide biomarkers of cardiovascular disease  
The presently-disclosed subject matter provides methods for diagnosing a cardiovascular disease in a subject by determining an amount of one or more peptide biomarkers disclosed herein in a...
8697373 Reagents and methods for use in cancer diagnosis, classification and therapy  
Methods and reagents for classifying HER2+ breast tumors and for identifying new HER2+ breast tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen...
8697370 Biomarker for diagnosis, prediction and/or prognosis of sepsis and uses thereof  
Methods for the diagnosis, prognosis and prediction of sepsis in a subject using the expression levels of the biomarkers Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) and TREM-like...
8697729 Small molecules modulator of epigenetic regulation and their therapeutic applications  
Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to...
8697372 Method for determining the binding of a given compound to a membrane receptor  
The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed...
8697356 Single-molecule-format probe and utilization thereof  
A single-chain probe of the present invention for detecting a ligand, comprises: a ligand binding protein for binding the ligand; a recognition protein for recognizing that the ligand is bound by...
8694265 Bioinformatic approach to disease diagnosis  
A kit and test panel utilizing a multivariate diagnostic method based on optimizing diagnostic likelihood ratios through the effective use of multiple diagnostic tests is disclosed. The...
8691766 Biglycan and related therapeutics and methods of use  
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with...
8691585 Methods for predicting pregnancy outcome in a subject by hCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8691593 Agglutination based sample testing device  
A sample testing device for testing for the presence of a component of interest in a liquid sample includes: (a) a capillary pathway having an upstream end and a downstream end and incorporating a...
8685656 Methods for diagnosing and treating encephalitis or epilepsy  
This invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of...
8685666 ARL-1 specific antibodies and uses thereof  
This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides...
8685399 PAX 5 monoclonal antibody  
The present invention relates to anti-human PAX 5 antibodies capable of binding to one or more epitopes located within the C-terminal regulatory domain of PAX 5. In particular the invention...
8685752 Ex vivo flow cytometry method and device  
The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a...
8685655 Dissociation method and dissociation agent for avidin and biotin derivatives  
A method for dissociating avidin or streptavidin efficiently from a biotin derivative, thereby making it possible to isolate a target material efficiently under a mild condition in a short period,...
8679769 Detection of endometrial secretion markers for assessment of endometriosis  
The present invention refers to a group of biomarkers and to non-invasive in vitro methods for the diagnosis or prognosis of endometriosis, as well as to a kit to perform said methods.
8673823 Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia  
The present invention relates to a method of identifying a compound involved in pain, the use of Epsti1 nucleic acid or Epsti1 protein for identifying a compound involved in pain as well as...
8673582 Methods for determining the risk of prenatal complications  
The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain...
8673652 Immunoassay with extended detection window  
The immunoassay method and kit are provided for the detection and/or the determination of zolpidem. The disclosure provides novel antibodies, derived from a novel immunogen, that are highly...
8673579 Peptide probes for diagnostics and therapeutics  
Disclosed are agents and methods that may be used to diagnose and treat a variety of diseases associated with conformationally-altered proteins. The agents and methods may be used to identify and...
8673581 sCD40L and placental growth factor (PLGF) as biochemical marker combinations in cardiovascular diseases  
The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools...
8669120 High capacity solid phase  
A high capacity solid phase for bioaffinity assays and other solid phase applications prepared by coating a solid support with an analyte-specific biomolecule in the presence of a zwitterionic...
8669066 Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays  
This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste...
8663938 Methods for detection of biological substances  
Methods and compositions are provided for detection of biological substances in nasal specimen.
8663942 Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities  
The present invention pertains to the field of tools for ensuring manufacture of polypeptides and quality control. Specifically, it relates to a method for determining the amount of processed...
8663576 Detection of intraamniotic infection  
The present invention concerns the identification of biomarkers and groups or combinations of biomarkers that can be used for non-invasive diagnosis of intra-amniotic infection, and diagnostic...
8663930 Methods and means for treatment of osteoarthritis  
The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and...
8658382 Proteins with pteridine glycosyltransferase activity and analysis method using the same  
The present invention relates to proteins with pteridine glycosyltransferase activity and an analysis method using the same. Since the proteins glycate tetrahydrobiopterin selectively through an...
8658374 Binding of aggregated forms of proteins  
Aggregating proteins such as IgG, are bound selectively in the presence of the non-aggregated protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine...
8658384 Biomarkers for prediction of major adverse cardiac events and uses thereof  
The present invention relates to combinations of biomarkers and levels thereof that may be used, for example, in the determination of risk associated with the occurrence of a major adverse cardiac...
8658774 Meditopes and related meditope-monoclonal antibody delivery systems, synthesis and therapeutic uses thereof  
Meditope variants and methods for their use are provided herein. A meditope variant as described herein comprises a peptide having a sequence CQFDLSTRRLKC (SEQ ID NO:1) or CQYNLSSRALKC (SEQ ID...
8658762 Polypeptides that inhibit dopamine D2 receptor-DISC1 interaction and methods of use thereof  
The present invention provides compounds, compositions and methods for inhibiting D2R-DISC1 interaction. Specifically, the present invention provides a polypeptide comprising the amino acid...
8658381 Detection conjugate  
The invention relates to a detection conjugate composed of a filament fragment, e.g. a cytoskeletal filament such as actin filaments or microtubules, and recognition elements bound to this...
8652790 Conformational entropy in molecular recognition  
The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may...
8652851 Multi-acceptor molecular probes and applications thereof  
An oligonucleotide-based molecular probe includes at least one pin loop, the pin loop including a loop sequence complementary to a target sequence. A first stem sequence is attached to one end of...