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8815159 Luminescent nanostructured materials for use in electrogenerated chemiluminescence  
A nanostructured particulate material, which includes a redox active luminescent organic and/or ionic compound, is provided herein. The nanostructured particulate material may be used for...
8815525 Binding and functional assays that use the T1R3 receptor to screen for taste modulatory compounds  
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
8802381 Methods for predicting pregnancy outcome in a subject by HCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8802382 Cobalamin assay  
The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the...
8802379 T1R3 binding assays  
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
8802380 Method for testing or screening protein synthesis inhibitors  
This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus....
8795975 Methods and compositions for diagnosis and risk prediction in heart failure  
The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention...
8796039 Method for measuring inhibitory activity on ligand-receptor binding  
A method for measuring the presence or absence and/or strength of the inhibitory activity of a test substance on binding between a ligand and a receptor thereof, which comprises the following...
8790882 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays  
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic...
8790933 Screening  
A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a...
8785210 Detection of an analyte in aqueous media  
Test kit for the detection of an analyte in an aqueous solution, including chromatographic test strips for a hapten-antihapten complex and first and second standardized vessels for receiving and...
8785134 Glycoprotein vesicles and their methods of use  
Provided are methods of collecting, detecting and altering cells and molecular entities using glycoprotein micelles and vesicles. Glycoprotein vesicles comprising a glycoprotein micelle, at least...
8785139 Modification-dependent activity assays  
Disclosed herein are methods, systems and kits to measure the presence and/or activity of recombinant polypeptides comprising a modification.
8778845 Composition, device and associated method  
A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a...
8778699 Detection of degradation products of canine NT-proBNP  
A method for determining the amount of NT-proBNP in blood samples from animals. The method includes detecting degradation products of NT-proBNP by various methods, including using antibodies, kits...
8778697 Method of measuring the affinity of biomolecules  
The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length...
8778846 Composition, device and associated method  
A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the...
8771698 Modulation of UL24 interactions with protein targets and uses thereof for inhibition of herpesvirus infection  
Methods and uses for the treatment of herpesvirus infection based on the inhibition of the interaction between herpesvirus UL24 and non-muscle myosin type IIa (NM2a) are described.
8771964 Compositions and methods for detection of methadone metabolite  
Methods and reagents are disclosed for conducting assays for EDDP. The reagents include a moiety selected from the group consisting of poly(amino acid) label moieties, non-poly (amino acid) label...
8771972 Clozapine immunoassay  
Novel conjugates and immunogens derived from clozapine and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of clozapine in biological fluids.
8771963 Method of diagnosing esophageal cancer  
In order to identify the molecules involved in esophageal carcinogenesis and those to be useful for diagnostic markers as well as targets for new drugs and immunotherapy, a cDNA microarray...
8771969 Peptide antibody depletion and its application to mass spectrometry sample preparation  
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant...
8772467 Methods and apparatus for screening and detecting multiple genetic mutations  
An assay system and methods are described where patient samples containing genomic DNA are analyzed for the presence of known genetic polymorphisms using a universal reporter strategy. In a...
8771708 Biologically-active radiolabeled Cry1Fa and receptor binding assay methods  
Cysteine-specific radiolabeled Cry1Fa protein retains insecticidal activity against insect pests and binds to insect brush border membrane vesicle receptors in a saturable manner. The...
8771968 Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereof  
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...
8765643 Composition, device and associated method  
The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first...
8765487 Detection of amniotic fluid in vaginal secretions of pregnant women due to premature rupture of fetal membranes  
A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More...
8765950 Reagents for biomolecular labeling, detection and quantification employing raman spectroscopy  
The present disclosure provides isotopically substituted compounds of the formula (II): wherein T, U, V, W, X, Y, Z, R0, R3, R4, R5 and R6 are as defined in the detailed description. The method...
8753829 Monoclonal antibodies against HER2 antigens, and uses therefor  
The present invention provides and includes monoclonal antibodies (mAbs) preferentially selective for HER2 antigens, hybridoma lines that secrete these HER2 antibodies or antibody fragments, and...
8748351 Method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands  
The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a...
8748195 Molecular markers for urinary tract infections  
The invention relates to an in vitro method for determining procalcitonin levels in plasma and urine as a diagnostic marker to identify patients with urinary tract infections, in vitro methods to...
8748113 Methods for detecting and monitoring circulating cancer stem cells  
Provided herein are compositions, methods, and kits useful for detecting whether a subject has or is likely to develop a cancer and for monitoring, staging and examining a cancer patient. Also...
8748116 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8748182 Mutant proteins and methods for producing them  
Aspects of the invention relate to methods of producing a mutant GPCR with increased stability relative to its parent GPCR.
8741586 Antibodies against HER2 truncated variant CTF-611  
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the...
8741663 Enhanced detection sensitivity with piezoelectric sensors  
A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's...
8741585 Electronic methods for the detection of analytes  
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
8741813 Composition, device and associated method  
A composition includes a first probe capable of binding to a first analyte and a first initiator bonded to the first probe. The composition further includes a second probe capable of binding to a...
8735081 T1R hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds  
The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric...
8734769 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8735062 Chemiluminescence proximity nucleic acid assay  
This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a sample and the methods of use thereof. The detection system includes a...
8735170 Method for measuring concentration of antigen contained in test solution  
A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for...
8728828 Purification of immunoglobulins  
The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilized, wherein the ligand density is in the range of...
8731839 Method and system for robust classification strategy for cancer detection from mass spectrometry data  
A robust classification method for cancer detection from mass spectrometry data includes inputting the mass spectrometry data, preprocessing the spectrometry data, conducting robust feature...
8728829 Compositions for binding to assay substrata and methods of using  
Compositions and methods for binding to assay substrata in a stable and protective manner, thereby enhancing assay performance, are provided. The compositions comprise lyotropic materials (for...
8728823 Methods for detecting lung cancer and monitoring treatment response  
A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer....
8722349 Methods and kit for endometriosis screening  
Methods of screening a bodily sample for endometriosis are provided. The bodily sample is preferably saliva. According to one embodied method, the bodily sample is subjected to a denaturing...
8722628 Autophagy-inducing peptide  
An autophagy-inducing compound comprises an autophagy-inducing peptide comprising beclin-1 residues 269-283 and a heterologous moiety that promotes therapeutic stability or delivery of the...
8722350 Methods and compositions for categorizing patients  
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and...
8715946 Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the...