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8883427 Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments  
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting...
8883985 Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier  
The present invention provides an antibody-immobilized carrier that can be used in antibody screening, a method of producing the antibody-immobilized carrier, and use of the antibody-immobilized...
8883086 Apparatus and method for measuring biomedical data and measurement strip  
Disclosed herein are an apparatus and method for measuring biomedical data and a measurement strip. The apparatus includes a plurality of detection units arranged within a strip reception area on...
8883425 Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts  
The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a...
8883428 Methods to determine atherosclerosis regression, plaque stabilization and cardiovascular risk  
Provided herein are compositions and methods for examining the progression, regression or risk of individuals at risk for developing coronary artery disease (CAD).
8883516 Click chemistry on heterogeneous catalysts  
The present invention relates to new methods and reagents for coupling molecules by a Click reaction using a heterogeneous catalyst system. Further, the present invention refers to novel devices...
8877516 Detection of biomarkers and biomarker complexes  
The invention features methods and devices for the detection of biomarker complexes and their components and for the sequential detection of multiple epitopes of a biomarker. The invention also...
8877450 Dual path immunoassay device  
Systems include test cells with sorbent material in a T-shape and defining a first flow path for a solution and a second flow path for a sample, and a test line or test site with immobilized...
8877441 Methods and kits for performing in situ hybridization  
The invention relates to methods and kits for performing in situ hybridization on a biological sample on a solid surface using nucleic acid probes that are embedded in or sorbed to a dry, fibrous...
8877514 Aqueous solution for use as medium for the specific binding reaction of a binding pair  
The present invention refers to an aqueous solution for use as medium for the specific binding reaction of a binding pair, wherein a first binding member recognizes its complementary second...
8871448 Diagnosis of preeclampsia  
The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples...
8871453 Method of predicting acute appendicitis  
Embodiments of the invention provide method and devices for predicting the likelihood of acute appendicitis without invasive exploratory medical procedures. Several protein biomarkers:...
8871452 Methods for treatment of cardiovascular disease  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8871454 Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)  
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal...
8865164 Detecting complement activation  
Methods of detecting complement activation including steps of detecting in a sample from a subject a level of iC3b wherein the detecting involves specific interaction between the iC3b and a...
8865424 Anti-FDP monoclonal antibody, FDP measurement reagent and reagent kit using same, and FDP measurement method  
The present invention relates to an anti-FDP monoclonal antibody selected from the first, second and third monoclonal antibodies having different reactivity towards FDP. The present invention also...
8865425 Reagent and reagent kit for measurement of FDP, and measurement method  
The present invention relates to a reagent for the measurement of FDP comprising a carrier sensitized with at least two monoclonal antibodies selected from three monoclonal antibodies having...
8865413 Pancreatic cancer targets and uses thereof  
The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or...
8865418 Immunoanalytical method and system using mass spectrometry technology  
An immunoanalytical system in which, after a sample such as a patient's serum is subjected to a pretreatment by an immunological pretreatment device, the sample is subjected to light detection by...
8859294 Method for binding a protein consisting of protein A or consisting of at least one domain of the A to E domains of the protein A to the substrate  
The object of the present invention is to provide a method for immobilizing the SpA protein on the surface of a substrate with high density without causing dimerization. The following method...
8859212 Method of extracting food component, food inspection method and food inspection kit  
Provided is a technique of extracting a component in a food from the food by using a reducing agent that is inexpensive and has a mild reducing action. A component in a food is extracted by mixing...
8859214 PAS kinase assays  
The present invention is directed towards methods for measuring and assaying PAS Kinase activity. The methods are useful, for example, for detecting PASK activity in a cell, and for screening for...
8858949 Antibodies that specifically bind to a beta oligomers and use thereof  
The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological...
8859215 Cell binding assay  
The present invention relates to a fluorescent cell binding assay combining pre-labeling and Western blotting. Intact cells are incubated with pre-labelled binders preferably followed by SDS PAGE...
8859295 System and method to measure dissociation constants  
A system and method for determining the dissociation constant for a particular ligand is disclosed. In accordance with certain embodiments, the method creates a chemical denaturation curve of a...
8859216 Method for noninvasive prediction or diagnosis of inflammation and infection in amniotic fluid of patients with premature rupture of membranes  
Provided is a method for noninvasive prediction or diagnosis of inflammation and/or infection in amniotic fluid leaked through the cervix into the vagina to predict the concentration of...
8852954 Nucleic acid molecule having binding affinity to rodent-derived IgG antibody, binder, detection reagent, and detection kit  
The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or...
8852953 Immunodetection and quantification of pyrazolopyrimidine sedatives  
The invention relates to novel immunogens, antibodies, methods and kits for use in immunoassays to detect and quantify zaleplon, metabolites of zaleplon and indiplon. These are the first described...
8852956 Method for diagnosing primary biliary cirrhosis (PBC) using novel autoantigens  
Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
8853154 Fibronectin based scaffold domain proteins that bind to myostatin  
The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat...
8852877 Apparatus and method for identifying a hook effect and expanding the dynamic range in point of care immunoassays  
The present invention relates to systems and methods for the rapid in situ determination of the existence of a hook effect and expansion of the dynamic range of a point of care immunoassay. For...
8846319 Lateral flow strip assay with immobilized conjugate  
The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are...
8846412 Multiple substances-responsive gel, method for producing same, and utilization of same  
A multiple-substance-responsive substance is disclosed, which is capable of simultaneously detecting a plurality of detection target substances by a single measurement. By a...
8846324 In vitro method for diagnosing or predicting hypertension and/or early-stage cardiovascular end-organ damage by determining the concentration of soluble prorenin receptor  
A method for diagnosis and/or prediction of hypertension and/or cardiovascular end-organ damage is disclosed. The method disclosed comprises the determination of the presence of soluble pro-renin...
8846932 Small molecules modulator of epigenetic regulation and their therapeutic applications  
Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to...
8846326 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Chimeric T1R taste receptor polypeptides and nucleic acid sequences encoding and cell lines that express said chimeric T1R polypeptides
 
The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric...
8846411 Derivatives, reagents, and immunoassay for detecting levetiracetam  
Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase...
8846413 Method for determining the concentration of the adipocytic form of the fatty acid binding protein (A-FABP, FABP4, P2)  
Products and methods for the research, diagnosis, risk assessment, course monitoring, treatment and prophylaxis of various metabolic disorders and their early forms, concomitant diseases and...
8841136 Levetiracetam immunoassays  
Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of...
8840896 Anti-HER2 antibody variants  
The present invention concerns novel antibody variants, particularly anti-HER2 antibody variants having substitutions at positions within the variable domains of the heavy and light chains.
8835122 Methods and system for the automated determination of immunofluorescent foci using a cell-based immunofluorescence assay using synthetic calibration particles  
The invention relates to a method for automated determination of immunofluorescent foci by means of an immunofluorescence assay using synthetic calibration particles, in addition to a system and...
8835125 Methods and compositions for selective labeling of different biotinylated targets within multicolor or multilabel assays  
Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within...
8835183 Determination of sFlt-1:angiogenic factor complex  
Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or...
8835121 Modified method of agglutination to detect infections caused by microorganisms  
Provided herein is a modified method of agglutination to detect infections caused by microorganisms including the steps of staining the test serum, plasma or blood or purified antibodies with a...
8828666 Method for measuring bonding activity of antibody which mimics antibody-dependent cell medicated cytotoxic activity  
The present invention provides a simple method which is capable of evaluating the binding activities of an antibody to both an antigen and an Fe receptor. Disclosed is a method of measuring the...
8828741 Method and device for the detection of molecular interactions  
The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes,...
8822231 Assay method and device  
A method for the analysis of at least two analytes in a liquid sample, in which a substrate is provided wherein at least two different types of capturing molecules are immobilized on the substrate...
8822165 Method for producing cAMP using chimeric olfactory receptor  
A method for producing cAMP using a chimeric olfactory receptor. The method includes a step of preparing a reaction system comprising a first layer, a lipid bilayer membrane, and a second layer,...
8815528 Methods and systems for detecting MHC class I binding peptides  
The present invention is based on the discovery that MHC heavy chain monomers immobilized to a solid surface are still capable of forming detectable conformational epitopes and being detected by...
8815156 Sensor housing and reagent chemistry  
A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the...