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7785536 Photon reducing agents for fluorescence assays  
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based...
7785810 Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof  
The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the...
7785809 Nucleic acids and proteins of insect Or83b odorant receptor genes and uses thereof  
The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes...
7785803 Antibody diagnostic kits and methods of use  
Disclosed herein are VEGF-D antibody diagnostic kits and methods of using such kits for the detection of VEGF-D in a biological sample.
7785805 MAN2As as modifiers of the IGFR pathway and methods of use  
Human MAN2A genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR...
7781172 Method for extending the dynamic detection range of assay devices  
A flow-through assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a detection zone and compensation zone within which are...
7781181 Human T1R2 polypeptide functional assays  
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
7781169 Diagnosis of gluten sensitive enteropathy and other autoimmunopathies  
Method for diagnosis of autoimmune diseases of the GSE-type or associated with gluten sensitive enteropathy comprising taking a sample and testing the sample for antibodies against human tissue...
7781226 Particle on membrane assay system  
Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable...
7776558 Human G protein-coupled receptor and modulators thereof for the treatment of cell death-related disorders  
The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain...
7776617 Signal enhancement system with multiple labeled-moieties  
Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with...
7776561 Use of specific T2R receptors to identify compounds that block bitter taste  
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to...
7776538 Method for diagnosing methamphetamine dependence  
Disclosed is useful means for the therapy or diagnosis of a mental disorder. A method for screening for a compound which is effective for a mental disorder, comprising the steps of (1) providing a...
7771928 Immunoassay device and immunoassay method using the same  
Disclosed are an immunoassay device which comprises a labeled substance dotting portion and a specimen dotting portion provided thereon, and an immunoassay method using the device.
7771957 Method for diagnosing alzheimer's disease  
The invention relates to method of diagnosing Alzheimer's disease or detecting a predisposition to Alzheimer's disease including providing a test cell sample from a subject, exposing the test cell...
7771958 Method for predicting response to epidermal growth factor receptor-directed therapy  
This invention provides methods for determining or predicting response to cancer therapy in an individual.
7772363 Two helix binders  
An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein....
7767401 Diagnostic method for stroke  
Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample...
7767407 Elemental analysis of tagged biologically active materials  
Methods for the detection and measurement of tagged (labeled) biologically active materials in a sample are described. The tagged biologically active materials are detected using an atomic mass or...
7763418 Detection of Rho proteins  
The present invention provides methods of detecting activated Rho GTPase proteins by contacting a solid support with a sample comprising an activated Rho GTPase protein. The solid support is...
7763429 Compound containing farnesyl diphosphate for modulating TRPV3 function and use thereof  
The present invention relates to a method for activating TRPV3 (transient receptor potential vanilloid 3) using FPP (farnesyl diphosphate) and a method for screening a TRPV3 activity inhibitor....
7759073 Electronic methods for the detection of analytes  
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
7759074 Immunological latex turbidimetry method and reagent therefor  
An immunological latex turbidimetry method for analyzing an antigen or antibody in a sample, comprising the steps of: (1) bringing a sample which may contain the antigen or antibody to be analyzed...
7759133 Method of detecting and/or quantifying a specific IgE antibody in a liquid sample  
Methods of detecting and/or quantifying an IgE antibody present in a liquid sample. The IgE antibody is specific to a ligand in the form of an antigen, an antibody, or a hapten. These methods can...
7759075 Molecules for the treatment of lung disease involving an immune reaction to connective tissue found in the lung  
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In...
7759069 Compositions and methods for measuring nuclear receptor ligands  
Disclosed herein are compositions and methods used for detecting and measuring ligands for nuclear receptors and intracellular lipid binding proteins in both in vitro and in vivo samples.
7761242 Metabonomic methods to assess health of skin  
The present invention relates to methods of assessing the health of skin. Biomarkers are used to evaluate skin samples. Using metabonomics approaches, samples taken from different skin sites or at...
7754438 Solid state NMR method for screening cell membrane protein binding drug candidates  
Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum...
7754436 Diagnostic assay for stroke  
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using a anti-H-FABP...
7754907 Allosterically catalyzed signal amplification in chemical and biological sensing  
Coordination complexes having at least two structural conformations are disclosed. The coordination complexes contain at least one metal center and at least one hemi-labile ligand, and change...
7754495 Methods for early diagnosing of an increased risk of preeclampsia  
Methods are provided for the diagnosis and treatment of patients with increased risk of preeclampsia. The methods involve measuring levels of TGF-β3, receptors of cytokines of the TGβ family, or...
7749695 PRO polypeptides for diagnosis of systemic lupus erythematosis  
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
7749774 Arrays formed of encoded beads having ligands attached  
A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
7749712 Non-competitive immunoassay for small analytes  
A non-competitive immunoassay for small analytes, wherein the analyte is reacted with two binding partners. The first binding partner binds to the analyte to form a complex between the first...
7749776 Liquid flow assays utilising a combined detection and control zone  
The invention relates to liquid flow assays widely applicable to target analytes, including haptens, which employ a detection zone which is a single combined analyte detection and control zone in...
7749713 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor  
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof,...
7745127 Molecular diagnostic method for dementia with lewy bodies  
The present invention describes methods of molecular diagnosis of a concrete form of a-synucleinopathy, the dementia with Lewy bodies (DLB), associated to the levels of ubiquitin carboxy-terminal...
7745128 Ras mutation and compositions and methods related thereto  
Disclosed are newly discovered Ras mutations and combinations of mutations, proteins and peptides and fusion proteins containing these mutations, nucleic acid molecules encoding such proteins,...
7745153 Pyrocatechol violet-metal protein assay  
A method for protein determination utilizing a pyrocatechol violet-metal complex, a composition used in the protein determination assay, and a kit.
7741055 Prostatic growth factor  
The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and...
7741128 Cooperative reporter systems, components, and methods for analyte detection  
The present invention relates to methods and compositions to detect analytes in a sample using antibody molecules that are transformed into nanoscale “self-signaling” biosensors. It relates in...
7741102 Analyte detection and apparatus therefor  
The present invention relates to sensitive SE(R)RS based methods for detecting analytes such as explosives and drugs, which may be present in a sample at extremely low levels. The methods may be...
7741064 Materials and methods relating to G-protein coupled receptor oligomers  
The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are...
7736623 CSF biomarker dilution factor corrections by MRI imaging and algorithm  
A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated...
7736857 Caries risk test for predicting and assessing the risk of disease  
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole...
7736862 Human T2R63 receptor and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R63 that responds to particular bitter compounds The present invention...
7739056 Biomarkers for aging  
A statistical and functional correlation strategy to identify changes in cellular pathways specifically linked to impaired cognitive function with aging. Analyses using the strategy identified...
7732151 Use of IRS-polypeptides for identifying of pharmaceutically active compounds  
An assay for determining the ability of an enzyme, functional fragment, or functional derivative thereof to modify the phosphorylation status of a biotinylated polypeptide.
7732153 Nonseparation assay methods  
Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support...
7732133 Screening methods for biologically active ligands  
In the case when there are two objective biological activities, and the aim is to isolate a compound having at least one biological activity, the present inventors developed an assay method...