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8053244 Magnetic oscillator based biosensor  
A biosensor is described. The biosensor includes a fixed multilayer stack providing a magnetization oscillation, a voltage source electrically coupled to the fixed multilayer stack, and a binding...
8053194 Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance  
Disclosed is a labeling substance capable of reversibly immobilizing (reversible detachment) to a solid surface and to reliably and accurately identify a target biological substance interacting...
8048641 Micropatterning of biological molecules using laser ablation  
The present invention employs the natural hydrophilic properties of a macromolecular film such as a hydrogel and in combination with localized photo-ablation of monolayers created with the...
8048635 Measurement of soluble Tweak levels for evaluation of lupus patients  
Methods of treating patients and evaluating patients for disease stage and/or severity are disclosed.
8048683 Insect repellent and process for identifying other insect repellent molecules  
This invention is based on the identification of the role played by the receptor mX on certain insects through the behavior evinced in the taste sensory reactions of these insects. The invention...
8043820 Diagnostic methods for the detection of risk of autistic spectrum disorder  
The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of...
8043824 Methods for determining the redox status of proteins  
A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine...
8039223 Method of selectively assaying adiponectin multimers  
Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through...
8039222 Treatment and prevention of tissue damage  
A method for the treatment or prevention of tissue damage in a subject having an inflammatory and/or tissue damaging condition, which comprises administering to the subject an effective amount of...
8039225 Method to identify patients at risk for lung transplant rejection  
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In...
8039271 Assays employing randomly distributed microbeads with attached biomolecules  
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
8034574 Screening method for prokinetic agent  
The present invention provides a screening tool and screening method for obtaining a substance useful as a prophylactic and/or therapeutic drug for diseases associated with 5-HT...
8036831 Ligand searching device, ligand searching method, program, and recording medium  
The present invention is directed to serve ligand screening apparatuses, ligand screening methods, programs and a recording medium for studying the binding analysis between a receptor including an...
8034578 PKP3 oncogene as a prognostic indicator for lung cancer  
The present invention provides the method of predicting an non-small cell lung cancer (NSCLC) prognosis.
8034575 Screening systems utilizing RTP801  
RTP801 represents a unique gene target for hypoxia-inducible factor-1 (HIF-1). Down-regulation of the mTOR pathway activity by hypoxia requires de novo mRNA synthesis and correlates with increased...
8034576 Xanthurenic acid derivative pharmaceutical compositions and methods related thereto  
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
8030009 Human T2R67 taste receptor and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R67 that responds to particular bitter compounds The present invention...
8030097 Lipocalin-2 as a prognostic and diagnostic marker for heart and stroke risks  
Methods and apparatus are disclosed for the measurement of lipocalin-2 in body fluids (including but not limited to blood, serum, plasma, urine, saliva, tear, etc.) by an assay such as an...
8030010 Method for detecting a biomarker of oxidative stress in a biological sample  
A method for characterizing oxidative stress. The method includes dosing a ratio of HNE-to-DHN-protein in blood; comparing the ratio of HNE-to-DHN-protein in blood to a predetermined interval of...
8030008 Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use...
8030011 Biomarkers and assays for myocardial infarction  
Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional...
8030014 Detecting agent and therapeutic agent for highly malignant breast cancer  
A detection agent for high malignancy breast cancer includes an antibody against collagen XIV, or a variant or derivative or fragment of the antibody. A therapeutic agent for high malignancy...
8026072 Method of identifying compounds that bind BAFF-R  
Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and...
8026075 Method for stabilizing coenzyme and composition thereof  
Disclosed is a sugar and/or a sugar alcohol as a substance for suppressing dephosphorylation reaction of a phosphorylated coenzyme. Also disclosed is a method for stabilizing a phosphorylated...
8026107 Agglutination inhibition assay method and reagent  
Provided are an agglutination-inhibition assay and a reagent for agglutination-inhibition assay, which can be used for measuring a ligand in a sample at high sensitivity in a wide range from the...
8021837 Detection of chromosomal abnormalities associated with breast cancer  
Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to...
8021849 Methods and kits for the determination of sirolimus in a sample  
Methods and kits for determining sirolimus in a sample known or suspected to contain sirolimus are provided. The methods and kits according to the invention use one or more antibodies generated...
8021893 Molecular recognition polymer enabling reconstruction of recognition field for target molecule and method of producing the same  
A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which is produced by applying the molecular imprinting method is disclosed. A molecular...
8021891 Methods and compositions for protein detection using nanoparticle-fluorescent polymer complexes  
Compositions, methods and related apparatus, as can be used for selective protein detection and identification.
8021895 Markers of renal transplant rejection and renal damage  
The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said...
8019557 Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same  
Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit...
8012705 Nonseparation assay methods  
Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support...
8012762 Test device, and related methods  
Test device for detection and visual indication of a specific analyte in a liquid sample such as a body fluid. The device includes a biodegradable housing, a test strip and a lid. The device is...
8012703 Microarrays and uses therefor  
Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding...
8012694 Assay for the detection of phosphorylated PTH  
Antibodies for a variant of intact parathyroid hormone (PTH) or its fragments which have at position 17 the amino acid serine which is phosphorylated [p(17) PTH] and methods of producing the same....
8012701 Agonists of bitter taste receptors and uses thereof  
The present invention relates to agonists of the human bitter-taste receptor hTAS2R3 and its role in bitter taste transduction. The invention also relates to assays for screening molecules that...
8012769 Thyroid analyte detection and measurement  
A non-radioisotopic method of detecting thyroid analytes comprising detecting T3, Free T3, T4, Free T4 and thyroglobulin autoantibody in a sample of a non-human species. Each one of these analytes...
8008092 CCR3 inhibition for ocular angiogenesis and macular degeneration  
Provided are methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization. Administration of inhibitors of the CCR3 receptor or its ligands eotaxin...
8008032 Tagged ligands for enrichment of rare analytes from a mixed sample  
Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand...
8008025 Biomarkers for neurodegenerative disorders  
The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of...
8008021 N-terminal truncation of cardiac troponin subunits and their roles in cardiovascular disease  
Methods for diagnosing, determining the likelihood of developing cardiac disease by measuring the level of a truncated form of cardiac Troponin T are provided. Also provided are methods for...
8005627 Bioinformatic approach to disease diagnosis  
A multivariate diagnostic method based on optimizing diagnostic likelihood ratios through the effective use of multiple diagnostic tests is disclosed. The Neyman-Pearson Lemma provides a...
8003338 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor  
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof,...
8003337 Method for detecting lysosomal storage diseases  
A method for detecting lysosomal storage diseases including the steps of performing an assay for a single species of glycosaminoglycan contained in a specimen and correlating results of the assay...
8003406 Methods for detecting attention-deficit/hyperactivity disorder  
The invention provides a method of determining a susceptibility of a subject for development of ADHD. The method comprises obtaining a sample from the subject, analyzing the sample for an ADHD...
8003339 Method for determining endoglycosidase (heparanase) enzyme activity  
The present invention provides a method for determining endoglycosidase activity, and in particular of the heparanase type, in a sample, and also a method for detecting compounds that modulate the...
7998744 Methods for determining dysregulation of methylation of brain expressed genes on the X chromosome to diagnose autism spectrum disorders  
The discovery that alterations in methylation, which can cause one or more genes on the single X chromosome in males to be partially silenced or overexpressed, constitute a predisposition to...
7998691 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor  
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a...
7998693 Gene specific to cancer and diagnosis kit using the same  
The present invention provides a new additional identification of a gene related to cancer expression and a diagnostic kit using the same.
7998692 Agonists of bitter taste receptors and uses thereof  
The present invention relates to agonists of the human bitter-taste receptor hTAS2R7 and its role in bitter taste transduction. The invention also relates to assays for screening molecules that...