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6699675 |
Marker for inflammatory conditions
Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
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6696303 |
Identifying substances using cells that express p75NTR
Methods for evaluating the risk of an individual to develop Alzheimer's disease using cultured neural crest-derived melanocytes are described. Also described are methods of therapy for Alzheimer's...
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6692915 |
Sequencing a polynucleotide on a generic chip
The present invention describes methods and devices for sequencing a polynucleotide by determining subsets of composite subsequences present in nucleic acid subsamples generated from the sample...
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6692696 |
Biosensor
Apparatus comprising G-protein coupled receptor (GPCR) for detecting ligands or substances in liquid or vapor media. The GPCR is based on in a cell or in a synthetic membrane or polymer system, and...
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6692926 |
Recombinant human SM-11044-binding receptor proteins exhibiting ligand-binding activities, and their use
Transformed cells designed to express a recombinant human SMBP at an elevated level to the extent that its ligand-binding activity can be measured, and cellular membrane fractions thereof;...
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6692921 |
Method for measurement of total analyte
A method of assaying for an analyte which occurs at least partially bound as a complex with its soluble receptor or binding protein, the method comprising the steps of: i) mixing a biological...
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6693184 |
DNA molecules encoding splice variants of the human melanocortin 1 receptor protein
The present invention relates to DNA molecules encoding splice variants of the melanocortin-1 receptor (MC-R1) protein belonging to the rhodopsin sub-family of G-protein coupled receptors,...
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6692923 |
Tapasin-like protein
The invention provides a cDNA which encodes tapasin-like protein. It also provides for the use of the cDNA, protein, and antibody in the diagnosis, prognosis, treatment and evaluation of therapies...
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6693168 |
Chiral cyanoamines and methods of preparation
Methods for preparing chiral non-racemic cyanoamines are provided. The methods are useful, e.g., for preparing chiral amino acids.
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6689613 |
Method for preparing and screening catalysts
A combinatorial method is provided for the preparation and screening of heterogeneous catalysts. The method comprises the steps of: (I) providing a library of elemental catalysts; (II) reacting the...
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6689316 |
Holographic sensors and their production
A method for the production of a holographic sensor wherein the holographic recording material forming the sensitive element is a polymer matrix, which comprises diffusing into the matrix one or...
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6689569 |
Saliva test for detection of food allergy, candidiasis, microflora imbalance, intestinal barrier dysfunction and humoral immunodeficiencies
A method for determining a cause for digestive and immune disorders is disclosed. The method determines the levels of antibodies against normal intestinal microflora and food antigens. It then...
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6689568 |
Capture arrays using polypeptide capture agents
A method of evaluating for the presence of a polypeptide in an analyte, using an addressable array of capture agents linked to a substrate. The analyte is exposed to the array and a set of fixed...
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6686146 |
Prognostic methods for prediction of progression of normal and hyperplastic mammary cells to carcinoma
The present invention encompasses methods for determining the likelihood that benign hyperplastic breast tissue or normal breast tissue adjacent to carcinoma tissue will become malignant. The...
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6686209 |
Reagents for detecting cannabinoids
In this disclosure, novel caanabinol-based tracers suitable for use in immunoassays that detect cannabinoids in a biological sample are disclosed. These cannabinol-based tracers are particularly...
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6686164 |
Low allergenic protein variants
The present invention relates to a method of selecting a protein variant having reduced immunogenicity as compared with the parent protein. This method includes the steps of screening a random...
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6682936 |
Addressable biologic electrode array
A biologic electrode array assembly is formed on an integrated circuit chip that includes an array of electrodes. At least one metal oxide semiconductor (MOS) switch is coupled to at least one of...
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6682898 |
High-throughput screening assays for modulators of STAT4 activity
This invention provides receptor peptides that have a high affinity for STAT4 and STAT6 polypeptides. Also provided are assays that are useful for identifying compounds that modulate the...
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6682893 |
Gel pad arrays and methods and systems for making them
Gel pads and gel pad arrays, and methods for making and using them, are disclosed. The gel pads preferably comprise an intelligent gel.
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6680377 |
Nucleic acid-based detection
The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer...
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6680207 |
Detection of molecules in samples
Disclosed is a method of detecting the presence in a sample of a polypeptide exogenously administered to a mammalian subject from whom the sample is obtained, and distinguishing between such an...
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6677164 |
Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds
The present invention provides biologically active linear polypeptides that possess a plurality of biologically active groups, methods employing such peptides to target molecules to cells, and...
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6677123 |
Process for detecting increased risk of fetal chromosomal abnormality
An increased risk of a fetal chromosomal abnormality, for example, fetal Down syndrome can be detected by separating or discriminating α-fetoproteins present in the body fluid of a pregnant woman,...
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6673562 |
Differential immunoassay
The invention provides assay methods and kits that in general measure the level of a first analyte in a sample reduced by the level of a second analyte present in the same sample. In one...
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6675103 |
Visualizing high dimensional descriptors of molecular structures
The distribution of chemical compounds in high-dimensional molecular descriptor space can be viewed in two dimensions by applying the projection method of this invention. This method has particular...
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6673558 |
Drug compositions to prevent desensitization of cellular receptors
Drug compositions combining antagonists with agonists to prevent desensitization of cellular receptors. An agonist is a substance or drug that produces a maximal or nearly maximal response, whereas...
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6673632 |
Method for measuring urinary trypsin inhibitor
The present invention provides a method by which UTI concentration can be measured easily with high precision and good reproducibility. The measurement is performed by adding free anti-UTI...
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6673561 |
Diagnostic test for thrombotic or thromboembolic disease
Thrombotic or thromboembolic disease is detected or monitored by determining the presence or amount B in a urine sample.
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6670198 |
Test piece and system for reading out image information from the test piece
A test piece for use in biological analyses includes a plurality of different known specific binding substances disposed in predetermined positions on a substrate. The specific binding substances...
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6670115 |
Devices and methods for detecting analytes using electrosensor having capture reagent
The present invention relates to devices comprising electrosensors containing capture reagents, their preparation thereof, and their use for detecting, preferably, quantitative measurement, of...
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6670465 |
Retinal calcium channel (alpha)1F-subunit gene
This present invention relates to calcium channel compositions. In particular, this invention relates to a mammalian gene, herein referred to as CACNA1F, encoding an (alpha) 1 F-subunit of a...
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6670332 |
Complex cationic lipids having quarternary nitrogens therein
Cationic lipids having a derivatized quaternary ammonium head group that provide improved cell targeting ability and enhanced transfective efficacy for introducing molecules into cells are provided.
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6670137 |
Differential diagnosis of neurological diseases
The present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus and individual suffering from another neurological disease. More...
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RE38352 |
Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy....
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6664378 |
Urogenital carcinoma anti-TLP peptide antibodies, related kits and methods
An antibody that binds to a specific urogenital carcinoma tumor liberated protein (TLP) epitope, wherein the TLP comprises GlyProProGluValGlnAsnAlaAsn, is described. Also described are kits...
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6664372 |
Azatide peptidomimetics
Peptidomimetic azatides and combinatorial oligoazitide libraries are produced by means of a stepwise synthesis. Combinatorial library construction of this new biomimetic polymer provides a means to...
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6660466 |
Di-nitrogen heterocycle compositions
Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as...
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6660533 |
Attaching a biological molecule to a support surface
The invention concerns a method for fixing a biological molecule, associated with a specific binding site, on the surface of a support made of silica or metal oxide. The invention also concerns a...
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6660274 |
Surface antigens and proteins useful in compositions for the diagnosis and prevention of lyme disease
A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi...
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6660532 |
Modular assembly for reagentless affinity separation and detection of analyte
The invention provides a reagentless assay kit for analyte in a sample comprising a modular affinity assembly including at least one sensor unit comprising a ligand having binding affinity for the...
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6660484 |
Colorimetric glycopolythiophene biosensors
The present invention relates to methods and compositions for the direct detection of analytes using observable spectral changes in biopolymeric systems. In particular, the present invention allows...
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6660482 |
Inter-alpha-trypsin inhibitor as a marker for sepsis
The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under...
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6656694 |
Method for identifying a ligand for a biological substrate
A method of identifying a ligand for a second binding site ( 5 ) on a biological substrate ( 1 ) is disclosed. The method comprises determining the effect of a candidate compound ( 9 ) on the...
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6653087 |
Convergent synthesis of combinatorial library
Targeted C2-symmetric and unsymmetric chemical libraries for use in protein and receptor homodimerization and heterodimerization are constructed by solution phase methodologies. Exemplary libraries...
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6653147 |
Apparatus and method for chemiluminescent assays
Disclosed herein are methods for the chemiluminescent assay of a variety of analytes of interest. The methods are adaptable to the determination of microbial species in both liquid samples and on...
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6649344 |
Assay to indicate the presence of non-fertilizable ova
The present invention relates to an assay for at least one predictive marker in a sample from a mammal wherein a specific reaction for at least one predictive marker indicates when non-fertilizable...
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6645725 |
Diagnostic assay for endometriosis
The present invention provides a method for detecting endometriosis in a patient and is an improvement over invasive and expensive surgical procedures. The method employs immunoassays which detect...
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6645733 |
Fluorescent intensity method for assaying binding between proteins or peptides
A method for assaying specific binding between a fluorophore-labeled probe and an unlabeled target is provided. The method includes detecting a quenching effect on fluorescence emitted by the...
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6642001 |
Generic SBE-FRET protocol
The present invention is drawn to methods for detection, quantitation and analysis of nucleotides of interest in nucleic acid sequences of interest using single base extension and fluorescence...
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6641997 |
Assays for screening compounds which interact with cation channel proteins, mutant prokaryotic cation channel proteins, and uses thereof
Assays for screening potential drugs or agents that can interact and potentially bind to cation channel proteins, and potentially have uses in treating conditions related to the function of cation...
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