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8105478 Method for measuring the concentration or change in concentration of a redox-active substance and corresponding device  
In order to follow the change in concentration of a redox-active substance, potential suitable for a reducing process or oxidation process are applied to the working electrode of a measuring...
8105787 Applications of nucleic acid fragments  
The present invention relates to a method of isolating fragments of nucleic acid according to the density of CpG dinucleotides and subsequent procedures for producing a library and/or an array or...
8105842 Interleukin-13 as a cardiovascular disease marker  
The present invention relates to use of interleukin-13 as a cardiovascular disease marker. The therapeutic composition and diagnostic composition of the invention for cardiovascular diseases are...
8101368 Quantitation of cellular DNA and cell numbers using element labeling  
Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to...
8101369 Diagnose device for measuring the ratio of proteins with similar structure  
The present invention relates to a diagnostic device for measuring the ratio of similar structural proteins among the proteins secreted in a liquid test sample taken from diagnosis subject. In...
8101180 Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof  
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR) and/or the insulin/IGF-I hybrid receptor (hybrid-R)...
8097422 Kir channel modulators  
Provided is a three-dimensional structure of an alcohol bound to an alcohol-binding site of an inwardly rectifying potassium (Kir) channel, Kir channel alcohol modulators and methods for...
8097457 Liquid crystalline substrates for culturing cells  
The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for...
8097427 Direct mass spectrometric analysis of drug candidates targeting protein complexes  
The invention relates to a method of using high mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the qualitative and quantitative analysis of the effect of drug...
8097425 Multiplex protein fractionation  
The invention provides methods, compositions, and kits for multiplex fractionation of proteins in a sample. Protein-binding molecules, such as small epitope antibodies or small epitope aptamers,...
8097461 Interference control panel for evaluation of analytical assays for samples derived from blood  
The invention relates to quality control of analytical assays, particularly NAT assays of blood samples containing nucleic acids. A control panel containing quantified amounts of substances known...
8097423 MN/CA IX and breast cancer therapy  
Herein disclosed are methods that are predictive of resistance to endocrine therapy in an estrogen receptor-positive (ER-positive) breast cancer patient. An exemplary method comprises detecting...
8092825 Glycan binding proteins as therapeutic targets for retinal disorders and treatment methods based thereon  
Disclosed are novel methods of treatment for retinal diseases and conditions including age-related macular degeneration, genetic-based retinal degenerations and retinal detachment. A novel glycan...
8093013 Claudins as markers for early detection, diagnosis, prognosis and as targets of therapy for breast and metastatic brain or bone cancer  
Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the...
8093005 Preparation and use of a reactive solid support surface  
A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of...
8093063 Assay for detecting genetic abnormalities in genomic nucleic acids  
The present invention provides methods of detecting unamplifed genomic nucleic acid anchored to a solid support. The methods are useful for the detecting genetic abnormalities associated with...
8093065 Microbead optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS  
An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor...
8088594 Risperidone immunoassay  
Novel conjugates and immunogens derived from risperidone and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of risperidone and...
8088587 Genetic variants increase the risk of age-related macular degeneration  
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as...
8088586 Method of producing a body fluid sample depleted of anti-MHC antibodies  
The invention provides a method of depleting anti-MHC antibodies in a sample comprising contacting said sample with one or more recombinant MHC molecules or functionally equivalent variants,...
8088381 Methods of treatment of cardiovascular disease using anti-CTGF agents  
The present invention relates to methods for treating impaired cardiac function. Methods for treating various physiological and pathological features associated with cardiac dysfunction by...
8080382 Monitoring immunologic, hematologic and inflammatory diseases  
This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, e.g., immunologic, hematologic, vascular, or infectious diseases or conditions, by...
8082109 Computer-aided discovery of biomarker profiles in complex biological systems  
The invention relates to computational methods, systems and apparatus useful in the analysis of sets of biomolecules in an accessible body fluid or tissue sample from a patient, which biomolecules...
8076092 Nonseparation assay methods  
Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support...
8076159 Ligand-regulable transactivation systems, methods of use thereof, methods of detecting estrogen receptor ligands, and methods of differentiating estrogen receptor ligand agonists and antagonists  
Briefly described, embodiments of this disclosure include ligand-regulable transactivation systems, methods of producing ligand-regulable transactivation systems, methods of using ligand-regulable...
8076095 Method for enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates  
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody...
8076088 Method of detecting human β-defensins  
A method of detecting β-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between β-defensin and negatively charged moieties in the bodily sample prior to...
8075854 Microfluidic chips for rapid multiplex ELISA  
A microfluidic chip comprises a substrate and a channel or multiple channels in the substrate. Each channel includes a tortuous path section or multiple tortuous path sections. A receptor for the...
8076160 Drug monitoring assay  
A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is...
8076083 Screening methods involving the detection of short-lived proteins  
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
8071320 Use of specific T2R taste receptors to identify compounds that block bitter taste  
Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to...
8073630 Pharacogenetic method for prediction of the efficacy of methotrexate monotherapy in recent-onset arthritis  
Pharmacogenetic methods for determining a predicting responsiveness to antifolate therapy for subjects that present with recent-onset undifferentiated arthritis. The methods are based on the...
8071815 CTIP2 expression in squamous cell carcinoma  
The present disclosure provides methods of diagnosing and staging squamous cell carcinomas, for instance head and neck (HNSCC), by detecting chicken ovalbumin upstream promoter-transcription...
8071054 Microfluidic magnetophoretic device and methods for using the same  
A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally...
8071323 Human monoclonal antibodies that bind human insulin like growth factors and their use  
Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided.
8071734 Nucleic acid-based detection  
The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer...
8067187 Cross-β structure binding compounds  
The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structure...
8067185 Methods of quantifying taste of compounds for food or beverages  
Methods of quantifying the taste of compounds for food and beverages are provided. These methods comprise contacting the compounds with an isolated heteromeric receptor comprising at least one...
8067188 Analyte detection  
The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods...
8062854 Method for enriching a prokaryotic DNA  
A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of...
8062595 Nucleic acid analysis chip integrating a waveguide and optical apparatus for the inspection of nucleic acid probes  
A chip for nucleic acid analysis includes a body (2, 9), in which a detection chamber (7) is formed for accommodating nucleic acid probes (12, 12′). A waveguide (8) is integrated in the body (2,...
8062855 Assay methods and materials  
The invention relates to assays in which complexes between an analyte and a binding agent specific for the analyte are detected by a reporter molecule, which is capable of binding to the binding...
8062859 Method for screening anticancer substances, set or kit for implementing said method  
A method for screening anticancer substances comprising the following steps: a) obtaining a culture of tumour cells which do not express E-cadherin on their cell membrane;b) bringing the cells...
8062857 H-FABP as early predictor of myocardial infarction  
The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac troponin level which is detectable but lower...
8062856 System for cell-based screening  
The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently...
8062906 B-lymphocyte stimulator binding polypeptides and methods based thereon  
Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or...
8058014 Method of diagnosing or predicting disease states in a subject using omentin 1 and omentin 2  
The present invention is directed to methods of diagnosing a disease or predicting an increased risk of a disease, such as obesity, obesity-dependent subacute inflammation, atherosclerosis,...
8053206 Antagonists of HMG1 for treating inflammatory conditions  
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
8053204 Beta-2 microglobulin as a biomarker for peripheral artery disease  
The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
8053203 Methods and device for the detection of occult blood  
The present invention relates generally to detection of occult blood. In particular, the present invention provides a device and methods for the simultaneous detection of hemoglobin and...