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6797482 |
Methods for the high-resolution identification of solvent-accessible amide hydrogens in protein binding sites
The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The...
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6794149 |
GABA B receptors
The invention relates to polypeptides which exert the biological activity of GABA B receptors, and to nucleic acids which encode these polypeptides, and in particular to their use for finding...
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6794144 |
Methods and materials for generating SH3 domains with tailored binding properties
The present invention relates to controlled modification of Src homology region 3 (SH3) domains by using random manipulation of the non-conserved region of SH3 RT-loop. Consequently, the invention...
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6794128 |
Methods of selecting internalizing antibodies
This invention provides methods of selecting antibodies that are internalized into target cells. The methods generally involve contacting target cells with one or more members of an antibody phage...
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6790662 |
Method of isolating CD8&plus cells, and related hybridoma cells antibodies and polypeptides
This invention provides a method of isolating CD8 + cells which employs an antibody which specifically binds to CD8 molecules present on the surface of CD8 + cells but does not activate the CD8 +...
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6790611 |
Assay for directly detecting a RS virus related biological cell in a body fluid sample
The present invention relates to a kit and an assay method for rapidly and directly detecting a predetermined respiratory syncytial virus-related biological cell in a sample, even when present in...
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6790652 |
Method and apparatus for high density format screening for bioactive molecules
A method and apparatus for screening an array of test compounds for bioactivity by contacting an array of test compounds with a detector layer capable of detecting bioactivity, and detecting a...
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6787317 |
Method of identifying missing domains in receptors
A method for searching, with a predetermined predictability and more ease, for new physiologically active substances is disclosed. In one method for searching for physiologically active substance...
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6780650 |
Ligand binding assays for vanilloid receptors
The present invention describes an assay in which pH alters RTX affinity to VR1 receptors. The RTX affinity was increased with increasing pH from 4.1 to 8.6. Both the RTX affinity and apparent...
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6780605 |
Method of diagnosing cardiovascular disease and early atherosclerosis
The present invention provides a method of diagnosing cardiovascular disease and increased risk of early atherosclerosis in a human wherein the presence and/or concentration of antibodies to...
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6777190 |
Crosstalk inhibitors and their uses
Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample....
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6773895 |
Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases
The present invention relates to substances which modulate receptors involved in inflammatory processes and whose modulated functions positively influence inflammatory diseases.
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6773892 |
Methods of identifying and determining the effectiveness of therapeutic processes or agents for the treatment of schizophrenia and related disorders
Methods for detecting schizophrenia or related neuropsychiatric disorders based on modifications of the contribution of the D 4 receptor to phospholipid methylation levels are described herein....
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6770489 |
Method for an immunoassay with a magnetic label and an apparatus for the same
The present invention relates to an immunoassay and an apparatus for the same. A method of the present invention comprises following processes: (1) an analyte is labeled to detect antigen-antibody...
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6767888 |
Neuroprotective methods and reagents
One aspect of the present application relates to a method for limiting damage to neuronal cells by ischemic or epoxic conditions, e.g., such as may be manifest by a reduction in brain infarct...
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6767709 |
Immunoassay of human medullasin and diagnosis of multiple sclerosis using the same
There is provided an immunoassay by which the amount of human medullasin present inside granulocytes, which are one leukocyte component in blood, can be determined with high accuracy and with good...
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6764858 |
Methods for creating a compound library
A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for...
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6759206 |
System for cell-based screening
The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent...
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6759200 |
Thymidine phosphorylase gene sequence variances having utility in determining the treatment of disease
The present disclosure describes the use of genetic variance information for folate transport or metabolism genes or pyrimidine transport or metabolism genes in the selection of effective methods...
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6756233 |
Method for measuring free ligands in biological fluids, and assay kits for measuring same
A method for measuring free ligands in biological fluids in the presence of bound ligand and endogenous binding proteins, without disturbing the equilibrium between the free ligand and the...
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6753154 |
Human AZU-1 gene, variants thereof and expressed gene products
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of...
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6750344 |
Amine compounds and combinatorial libraries comprising same
The present invention provides monocyclic, bicyclic and oligomeric amine compounds with at least two sites of diversity. These compounds are formed from monocyclic scaffolds which can be cyclized...
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6749756 |
Reaction and separation methods
A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second...
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6750027 |
Human ubiquitin-conjugating enzyme homologs
The invention provides human ubiquitin-conjugating enzyme homologs (UCEH) and polynucleotides which identify and encode UCEH. The invention also provides expression vectors, host cells, antibodies,...
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6747143 |
Methods for polymer synthesis
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
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RE38525 |
Optical sensor for in situ measurement of analytes
An implantable sensor for use in the detection of quantitative measurement of an analyte in subcutaneous fluid, the sensor being biodegradable or hydrolysable in vivo. The sensor incorporates an...
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6743638 |
Detection system using liposomes and signal modification
A process for detecting an analyte which process comprises (a) contacting a sample suspected of containing said analyte with a containment means comprising a barrier which separates signal...
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6743586 |
Rapid fluorescence detection of binding to nucleic acid drug targets labelled with highly fluorescent nucleotide base analogs
The present invention is a method of identifying ligands that interact will cellular processes involved in the life-cycle of HIV. In particular, an oligonucleotide, corresponding to specific RNA...
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6740735 |
DNA encoding human apoB48R: a monocyte-macrophage apolipoprotein B48 receptor gene and protein
The present invention provides an isolated DNA molecule that codes for a cell-surface binding protein in human monocytes and macrophages. In addition, an amino acid sequence derived from the...
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6740500 |
Method of screening for non-steroidal neuropsychiatric agents
A method of screening for non-steroidal neuropsychiatric agents includes determining the ability of a candidate non-steroidal agent to selectively regulate or alter the central nervous system...
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6740485 |
Anti-bacterial methods and materials
Staphylococcus aureus virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and provision of...
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6733982 |
Method for screening compounds for alpha1B adrenergic receptor antagonist and analgesic activity
A method for identifying compounds that can be useful for producing analgesia is disclosed. In particular, the method involves providing preparation of a cell, that expresses an alpha 1B ...
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6730482 |
Modified SELEX processes without purified protein
This invention is directed towards a method for obtaining nucleic acid ligands against target proteins without directly purifying the target proteins. The method used in the invention is called...
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6730905 |
Scanning probe microscopy, method of producing the probe, and molecular processing method using the scanning probe microscope
There is provided a probe for a scanning probe microscope, comprising: a proximal end; and a distal tip portion, wherein the distal tip portion has a tip surface which faces a fixed sample, and at...
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6727072 |
EGF-r detection kit
A kit containing the reagents necessary for the qualitative or quantitative demonstration of epidermal growth factor receptor (EGFR) in formalin-fixed, paraffin-embedded tissue sections. A...
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6728641 |
Method and system for selecting a best case set of factors for a chemical reaction
A method selects a best case set of factors of a chemical reaction by defining a chemical experimental space by (i) identifying relationships between factors of a candidate chemical reaction space;...
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6723518 |
Detection and treatment of breast disease
An isolated chemokine is disclosed. The isolated chemokine is expressed preferentially in breast tissue or can be detected in breast milk. It includes from about 100 to about 132 amino acids, has a...
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6723570 |
Methods of use for anti-CCR1 antibodies
The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 1 (CCR1) or a portion of the receptor and blocks binding...
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6720190 |
Methods for screening compound libraries
Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target...
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6716640 |
Stabilization and amplification of electrochemiluminescence signals
The invention concerns the stabilization and amplification of electrochemiluminescence signals in detection methods.
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6713267 |
Biochemical assay to monitor the ubiquitin ligase activities of cullins
The present invention is based on the discovery of a simplified assay for identifying modulators of ubiquitin ligase activity. This assay allows detection of compounds that affect ubiquitination...
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6710164 |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting...
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6710163 |
Peptide nucleic acid synthons
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands...
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6709832 |
Method of early diagnosis of carcinomas
The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a...
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6706482 |
Conditional-selex
The invention provides method for producing nucleic acid ligands that generate a signal, or cause a decrease in the level of a signal, in the presence of a target molecule or an environmental...
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6706490 |
Method for detecting rheumatoid arthritis employing the CB10 peptide of mammalian type II collagen as an antigen
A predictive test for rheumatoid arthritis comprises the detection of antibodies to collagen in a biological sample from a patient by contacting the biological sample with an antigen comprising the...
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6706539 |
Enzyme substrate delivery and product registration in one step enzyme immunoassays
One-step enzyme immunoassays in which enzyme-antibody conjugate or label and enzyme substrate are separated until separation of bound and free enzyme conjugate or label is complete. This separation...
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6706486 |
Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides
The present invention relates to a method for the quantitative release of natural or recombinant proteins, polypeptides (thermostable immunoligands) able to bind to the Fc-part of immunoglobulins...
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6699843 |
Method for treatment of tumors using nucleic acid ligands to PDGF
A method is provided for treating solid tumors comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using...
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6699677 |
Tethered ligands and methods of use
The invention provides methods, reagents and devices for analysis of receptor ligand interactions, determining the profile of receptor expression in cells and cell populations, and diagnostic and...
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