Match Document Document Title
8158372 Agonists of a bitter taste receptor and uses thereof  
The present invention relates to agonists of the hTAS2R14 bitter taste receptor and its role in bitter taste transduction. The invention also relates to assays for screening molecules that...
8158441 Method for detecting aggregate-forming circulating protein forms using an agent for aggregating said forms and an agent for capturing formed aggregates  
The present invention concerns a method for detecting aggregate-forming circulating protein forms in a biological sample of human origin that may contain said aggregate-forming circulating protein...
8158340 Methods for detecting conformational changes in bioentities  
Described herein are methods for detecting conformational changes in bioentities.
8158442 Antagonists of bitter taste receptors and uses thereof  
The present invention relates to antagonists of the human bitter-taste receptors hTAS2R38. The invention also relates to methods for identifying further molecules that suppress hTAS2R38 mediated...
8158659 Dual-acting imidazole antihypertensive agents  
The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds...
8158374 Quantitative diagnostic methods using multiple parameters  
Materials and Methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to...
8158443 Turbidimetric immunoassay for assessing human Cystatin C  
There is a demand for improved turbidimetric immunoassays for human Cystatin C in biological samples, especially in human clinical samples of body fluids. The present invention provides a...
8153387 Method for immobilizing glycoprotein  
A method for immobilizing glycoprotein is disclosed. A surface is provided. Next, a boronic acid is contacted to the surface. The boronic acid is represented as Y—R—B—(OH)2 and includes a boronic...
8153442 Stabilization of signal generation in particles used in assays  
Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support includes...
8153386 Human T2R64 taste receptor and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R64 that responds to particular bitter compounds The present invention...
8153594 Tacrolimus standard and methods of using same  
A composition and kit useful as a tacrolimus standard solution for immunoassays, and methods for making and using same. The composition and kits include a known amount of tacrolimus or a...
8148095 Methods for predicting psychotropic drugs which elicit weight gain  
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that...
8148083 Methods of screening for TRPM4 modulators of insulin secretion  
The invention relates to methods useful in identifying candidate agents that modulate insulin secretion from an insulin secreting cell, where such molecules modulate TRPM4 activity and expression...
8148088 Regulation of autophagy pathway phosphorylation and uses thereof  
The invention relates to polypeptides and proteins known to function in the autophagy pathway that have novel phosphorylation sites. The invention also relates to antibodies specific to these...
8148093 Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk  
This invention relates to a method for assessing risk of prostate cancer. Specifically, it relates to utilizing both Pro108 and Prostate Specific Antigen (PSA) in combination to determine the risk...
8143011 MAGE-C2 antigenic peptides and uses thereof  
This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the...
8143071 Method and device for extracting an analyte  
The invention provides columns and methods for the purification and concentration of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample...
8137616 System for multi color real time PCR  
The invention is directed to a system for performing multi-color real time PCT, comprising a flexible real time PCT instrument and a specific composition or reaction mixture for performing...
8138319 Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein  
The present invention provides an aptamer or pool of aptamers (nucleic acid sequences) that bind(s) to a target molecule on the surface, accessible from the surface or inside of a mammalian sperm...
8133693 Measurement of binding rate of a binding substance and an analyte  
A method of measuring the rate of binding of a binding substance and an analyte, for example in an assay such as an immunoassay, uses an initial step of performing ultrasonication sufficient to...
8133689 Members of the capsaicin/vanilloid receptor family of proteins and uses thereof  
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The...
8133692 Methods of predicting responsiveness to chemotherapeutic agents and selecting treatments  
Methods are provided for predicting responsiveness of cancer cells to chemotherapy by measuring the level of phosphorylated Stat or the level of expression of Survivin in a cancer and comparing...
8129123 Methods for assessing atherogenesis by determining oxidized phospholipid to apolipoprotein B ratios  
The present invention relates to the analysis of oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary...
8128907 CSF biomarker dilution factor corrections by MRI imaging and algorithm  
A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated...
8124359 Use of additives for the reduction of non-specific binding in assays  
A method for reducing non-specific binding in an assay is provided herein. The method includes (a) providing a reaction mixture, which includes or is suspected to include a first component and a...
8124424 Single molecule-format bioluminescent probe  
The claimed invention comprises a single molecule-format bioluminescent probe for detecting a target-specific ligand in a living cell, which comprises, a ligand-binding molecule of which...
8124361 Methods of screening for sweet taste modulators  
We have discovered a method to enhance sweetness comprising the use of a sweetener at a sub- to near-threshold concentration which is used in combination with a suprathreshold concentration of...
8124362 Nonseparation assay methods  
Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support...
8124365 Identification of genotype-selective anti-tumor agents  
The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human...
8119423 Device and method for multiple analyte detection  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
8119420 Absorption pad for immunoassay, strip for immunoassay, and immunoassay apparatus  
Providing an absorption pad which shows remarkable water absorptivity and can shorten a detection time when employed for an immunoassay apparatus. A water absorption pad for the immunoassay...
8119358 Diabetes-related biomarkers and methods of use thereof  
The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify...
8119421 Methods to identify compounds useful for the treatment of proliferative and differentiative disorders  
The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention...
8114624 Use of the ornithine transcarbamylase (OTC), as a marker for diagnosing brain damages  
The present invention pertains to the domain of brain diseases, and provides novel markers and methods for diagnosing a brain alteration in an individual, especially in patients suffering from...
8114594 Crude biological derivatives competent for nucleic acid detection  
The invention relates generally to the fields of making biological unit lysates or admixtures of body fluids and of RNA analysis. More specifically, it relates to direct methods for the detection...
8114615 Method for automated tissue analysis  
The invention provides an improved method for identifying and interpreting tissue specimens and/or cells derived from tissue specimens. A panel of cell-based reagents provides a number of readouts...
8114621 Lenalidomide and thalidomide immunoassays  
Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and...
8114620 Diagnostic and therapeutic target PRKX proteins for neurodegenerative diseases  
The present invention discloses a dysregulation of a PRKX gene and the protein products thereof in Alzheimer's disease patients and individuals being at risk of developing Alzheimer's disease....
8114661 Electronic methods for the detection of analytes  
The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
8114617 Method for quantifying phosphokinase activity on proteins  
The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those...
8114618 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays  
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic...
8114616 Methods for diagnosing irritable bowel syndrome  
The invention provides an ELISA assay for the determination of serum mast cell β-tryptase levels using rabbit anti-tryptase as the capture antibody and alkaline phosphatase conjugated G3 as the...
8114593 Cancer biomarker genes and gene products and methods for using the same  
Using gene expression analysis, specific biomarker genes and gene products have been identified which are activated in transformed cells, but suppressed in nontransformed cells; or suppressed in...
8110079 Electrochemical sensor  
Disclosed herein is an electrochemical sensor for detecting an analyte. The sensor comprises an electrode, a redox active species that is electrochemically accessible to the electrode, and a...
8110366 Method for evaluating cell populations  
The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of...
8110656 Compositions and methods of a phosphatidic acid binding protein  
TGD2 proteins of Arabidopsis are proposed to be a substrate binding component of a lipid transfer complex in the inner chloroplast envelope membrane. Loss of function of this protein or other...
8110365 Compositions and methods for detecting and treating renal injury and inflammation  
Renal injury and inflammation is diagnosed by detecting an elevation in GSK3b level or activity. Inflammation of bodily tissues such as renal tissue is inhibited by administration of GSK3b...
8110374 Method for predicting the risk of transplant rejection and immunological testkit  
The invention relates to a method and an immunological test kit for predicting the risk of transplant rejection by detecting anti-AT1 receptor auto-antibodies in biological materials of a patient...
8105788 Mucopolysaccharidosis (MPS) diagnostic methods, systems, kits and assays associated therewith  
Methods, systems, kits and assays for diagnosing, monitoring or screening for mucopolysaccharidosis (MPS) and methods and systems for assaying test compounds for therapeutic activity are...
8105794 Rapid nasal assay kit  
The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an...