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8232069 Antibody directed against PAP2a and use thereof for diagnostic and therapeutic purposes  
The present invention aims at developing a gene delivery system which has a high selectivity to a target cell and can introduce and express a gene with high efficiency, particularly developing...
8231862 RBP4 in insulin sensitivity/resistance, diabetes, and obesity  
Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of...
8232067 Disrupting FCRN-albumin interactions  
Provided herein are, inter alia, methods for identifying a candidate compound for treating the toxic effects of compounds or molecules that bind to albumin in a subject. The methods include...
8232066 Peptide antibody depletion and its application to mass spectrometry sample preparation  
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant...
8232065 Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets  
Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets,...
8232584 Nanoscale sensors  
Various aspects of the invention relate to nanoscale wire devices and methods of use for detecting analytes. In one aspect, the invention relates to a nanoscale electrical sensor array device,...
8232068 Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays  
The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic...
8232064 Detection and quantitation of cyclodextrins  
The invention relates to the detection and quantitation of cyclodextrins and cyclodextrin derivatives in solutions comprising a protein. The invention further relates to methods of evaluating...
8227201 BETA2-microglobulin and C reactive protein (CRP) as biomarkers for peripheral artery disease  
The present invention relates to use of β-2-microglobulin (B2M or β2M) and C-reactive protein (CRP) levels as biomarkers of peripheral artery disease and/or atherosclerosis.
8227194 Monoclonal antibodies with binding specificity for response gene to complement 32 (RGC-32)  
The invention relates to antibodies that bind to a fragment of the Response Gene to Complement-32 (RGC-32), as well as methods of using these antibodies. Particular methods of using the antibodies...
8227203 Method for testing or screening protein synthesis inhibitors  
This invention provides methods for screening an inhibitor of protein synthesis by measuring the level of relocalization of an SMN complex component from the cytoplasm to the nucleus....
8227200 Methods for identifying kremen polypeptide binding partners  
The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g....
8221751 Tumor-targeting monoclonal antibodies to FZD10 and uses thereof  
The present invention relates to an antibody or a fragment thereof which is capable of binding to a Frizzled homologue 10 (FZD10) protein, such as a mouse monoclonal antibody, a chimeric antibody...
8221987 Methods of identifying modulators of bitter taste using hT2R50 receptors  
The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e.,...
8221990 Screening GPR12 receptor for substances having Nesfatin-1-like action, or which regulate Nesfatin-1 action  
An object of the present invention is to identify a Nesfatin-1 receptor, and to provide a method for screening or designing a Nesfatin-1-action regulating substance or a Nesfatin-1-like action...
8216793 Detection of antibody that binds to water soluble polymer-modified polypeptides  
The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble...
8211630 Diagnostic agent and therapeutic agent for pancreatic cancer  
The present invention provides a novel diagnostic or therapeutic method for pancreatic cancer employing a blood marker. The present invention provides a diagnostic or therapeutic drug for...
8211655 Wild-type receptor assays  
A method for determining ligand activation of receptors using cells expressing genetic constructs of a fusion protein of at least a binding domain of an auxiliary protein and a fragment of...
8211657 Capillary-column-based bioseparator/bioreactor with an optical/electrochemical detector for detection of microbial pathogens  
The present invention is directed to satisfying the need to detect microbial contamination of food products. The described bioseparator/bioreactor coupled with an optical/electrochemical biosensor...
8211656 Biological targeting compositions and methods of using the same  
Modified red blood cells are described. In an embodiment, the modified red blood cell includes a target-binding agent. Targeted delivery of imaging agents, drugs, and peptide and protein...
8211649 Methods of diagnosing and prognosing hodgkin's lymphoma  
The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha...
8206907 SCD fingerprints  
This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through...
RE43497 Anti-MIF antibodies  
The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to...
8206989 Method of generating a dosing schedule using gamma secretase notch biomarkers  
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity...
8202510 Biomarkers for amyotrophic lateral sclerosis  
The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining...
8198034 Immuno-based botulinum toxin serotype A activity assays  
The present specification discloses SNAP-25 compositions, methods of making α-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site...
8197757 Electrical insulation of devices with thin layers  
A novel, economical electrical insulation method for the production of ultra-thin insulation layers using a solution coating method. Thin hydrophobic self-assembled bi-functional layers of less...
8192720 Compositions and methods for detection, prevention, and treatment of anthrax and other infectious diseases  
Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals...
8192762 Preparation of soluble and colloidal molecularly imprinted polymers by living polymerization  
The present invention describes a method for synthesis of relatively low molecular weight imprinted polymers using living polymerization, and their application in analytical chemistry,...
8187822 Methods to identify modulators  
Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose, and an inhibitor, are provided.
8183001 Methods and compositions related to GABA receptor subunits  
Disclosed are compositions and methods related to GABAA receptors.
8183002 Autoantibody enhanced immunoassays and kits  
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies...
8183003 Polymer end group detection  
Provided herein are processes of detecting and quantifying the number of polymer end groups in a sample. In particular instances provided herein are processes of detecting.
8183056 Assay  
A method for determining the risk of an individual of suffering from inflammation, opportunistic infection or disruption of immunoglobulin metabolism, comprising (a) determining the level of...
8178344 System and method for antigen structure-independent detection of antigens captured on antibody arrays  
The present invention provides a system and method for detecting antigens captured on an antibody array. The method comprises the following steps of providing the antibody array having at least...
8178066 Method for stabilizing calcium phosphates fine particles, method for manufacturing calcium phosphates fine particles by using the method, and use thereof  
The present invention provides a method for stabilizing fine particles of calcium phosphates without lowering their solid phase forming activity. It is possible to stabilize the fine particles of...
8173379 Method of determining a concentration of analytes of interest in a sample  
A method of determining a concentration of analytes of interest in a sample reaction mixture is disclosed. The method can include measuring intensities of the polarized fluorescence of at least...
8173376 Method for identifying compounds for treatment of pain  
Methods and products for the attenuation or treatment of pain and the reduction of nociception are described. The methods and products are based on the modulation of CNS intracellular chloride...
8173380 Metering technique for lateral flow assay devices  
A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane...
8173436 Biosensor utilizing a resonator having a functionalized surface  
Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In...
8173443 Multiplex screening for lysosomal storage disorders (LSDs)  
A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of...
8168756 Levetiracetam immunoassays  
Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of...
8168395 Taste receptors of the T1R family from domestic dog  
The present invention relates to the discovery of several genes of the domestic dog (Canine familiaris) associated with taste perception. The invention provides, inter alia, the nucleotide...
8168403 Agonists of bitter taste receptors and uses thereof  
The present invention relates to agonists of the human bitter-taste receptor hTAS2R40 and their role in bitter taste transduction. The invention also relates to assays for screening molecules that...
8163475 Methods for diagnosis and prognosis of psychotic disorders  
The invention features methods diagnostic of a psychotic disorder such as bipolar disorder or schizophrenia. The methods include obtaining a cell sample from a subject, subjecting a cell from the...
8163502 Method for predicting the risk of disease based on lectin binding  
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole...
8163508 Methods for predicting pregnancy outcome in a subject by hCG assay  
The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present...
8163499 Drug selection for breast cancer therapy using antibody-based arrays  
The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of...
8163562 Photon reducing agents for fluorescence assays  
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based...
8163511 Methods for the identification of LRRK2 interacting molecules  
The invention features methods for the identification of leucine-rich kinase 2 (LRRK2) inhibitors using indol ligand 91. Generally, these methods include identifying compounds that compete with...