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8318906 EMP2 antibodies and their therapeutic uses  
The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a...
8313940 Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics  
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic...
8315818 Methods of diagnosing inflammatory bowel disease  
The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD) or a clinical subtype...
8309313 Glycated peptides and methods of use  
The invention provides glycated peptides and glycated fragments and glycated variants thereof, antibodies and aptamers which bind thereto, compositions and kits comprising the same, related...
8309688 Monkey homolog of human oncostatin M and methods of use thereof  
Cytokine oncostatin M nucleic acids from Cynomolgus monkey are useful for expression of oncostatin M proteins that are functional homologs of human oncostatin M. The nucleic acids and proteins...
8309304 Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes  
The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex...
8310679 Apparatus and methods for sensing or imaging using stacked thin films  
Technologies are generally described for methods and systems for sensing or imaging. The apparatus includes a stack of a plurality of thin films, such as polymer thin films. The stack has a...
8309695 Marking reagents bearing diazo and nitro functions, methods for the synthesis of such reagents and methods for detecting biological molecules  
The present invention relates to a labeling reagent of formula: in which: R1 represents at least one detectable label,L and A are each a linker arm,n is an integer equal to 1, andu is an integer...
8309315 Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods  
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are...
8309314 Agonists of bitter taste receptors and uses thereof  
The present invention relates to agonists of the human bitter-taste receptors hTAS2R14, hTAS2R10 and hTAS2R4 and their role in bitter taste transduction. The invention also relates to methods for...
8304201 Autoantibody enhanced immunoassays and kits  
The present disclosure provides immunoassays and kits for detection or quantification of an analyte of interest in a test sample that potentially contains endogenously produced autoantibodies...
8304197 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor  
The present invention concerns methods for detecting a hepcidin precursor in a sample from a patient and involves contacting the sample with an antibody or fragment thereof that specifically binds...
8298781 Compositions and methods for characterizing and regulating olfactory sensation  
The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell...
8298777 Method of identifying transmembrane protein-interacting compounds  
A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins...
8298783 Detecting molecules  
Disclosed are processes to increase the relative abundance of a molecule that is present in a test sample at relatively low abundance. The process includes fractionating a sample and immunizing...
8293490 Method for high spatial resolution stochastic examination of a sample structure labeled with a substance  
A method for high spatial resolution stochastic examination of a biological sample structure labeled with a labeling substance is described. The method comprises providing a biological sample...
8293541 Thyroid analyte measurement  
A non-radioisotopic method measures Free T3 and/or Free T4 in a sample of a non-human species, which can be a canine.
8293492 Lenalidomide and thalidomide immunoassays  
Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and...
8293489 Methods for detection of biological substances  
Methods and compositions are provided for detection of biological substances in nasal specimen.
8288115 Method for enriching a prokaryotic DNA  
A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of...
8288171 Biochip and apparatus for detecting biomaterial using biochip  
Provided is a biochip and an apparatus for detecting a biomaterial. The biochip includes a metal thin film on the surface of a substrate, restraining autofluorescence of the substrate, and a...
8287939 Method for manufacturing substrate for biochip  
A substrate for biochips is manufactured so that the substrate has a substrate surface having a reaction region capable of reacting with biological substances and a non-reaction region not...
8288116 Methods and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof  
The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the...
8283131 Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock  
The present invention provides for the in vitro establishing of a prognosis for a subject in severe sepsis with at least two organ failures or in septic shock with at least two organ failures....
8283126 Voltage sensor domains of voltage-dependent ion channel proteins and uses thereof  
A composition of matter suitable for use in identifying chemical compounds that bind to voltage-dependent ion channel proteins, the composition comprising a screening protein that comprises an ion...
8283169 Differential gradient separation of cells  
A device and method in which cells of a heterogeneous population are separated through a column partially packed with antibody coated beads. The antibody coated beads may be placed in a gradient...
8283182 Agglutination based sample testing device  
A sample testing device for testing for the presence of a component of interest in a liquid sample comprises: (a) at least one capillary pathway which has an upstream end and a downstream end and...
8283128 Methods and compositions for monitoring and risk prediction in cardiorenal syndrome  
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods...
8283127 Detection system and uses therefor  
A system for the detection of molecular associations, the system comprising: i) a first agent, comprising a first interacting group coupled to a first reporter component; ii) a second agent,...
8277808 Mucosal vascular addressins and uses thereof  
The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a...
8273542 Human T2R receptors for acetaminophen, ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators  
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine,...
8268568 Methods and compositions for categorizing patients  
The disclosure provides, among other things, molecular markers for categorizing the neoplastic state of a patient, methods for using the molecular markers in diagnostic tests, nucleic acid and...
8268635 Methods of identifying agents that selectively activate p38 and/or NKkB signaling  
The present invention relates to a method of selectively modulating a signalling pathway of interest controlled by a cell receptor involved in signalling through multiple pathways. The method...
8268886 Pyrenyloxysulfonic acid fluorescent agents  
The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by...
8263415 Method of determining analyte concentration  
A method of determining the total concentration of an analyte in a fluid sample, wherein at least part of the analyte is present as a complex with an analyte-binding species. The methods includes...
8263416 Turbidimetric immunoassay for assessing human Cystatin C  
There is a demand for improved turbidimetric immunoassays for human Cystatin C in biological samples, especially in human clinical samples of body fluids. The present invention provides a...
8263348 Abnormal prion protein binder, and method for detection of abnormal prion protein  
Disclosed are: a method for detecting pathogenic isoform of prion protein as distinguished from normal prion protein in a simple manner, rapidly, with a high degree of sensitivity and...
8262874 Biosensor coating composition and methods thereof  
The disclosure provides for reagent compositions for biosensors comprising release polymers, methods of making such biosensors and films of reagent compositions comprising release polymers. The...
8263352 Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor  
The present invention concerns a method of detecting hepcidin, prohepcidin or fragments thereof, by contacting the sample with an antibody or fragment thereof that specifically binds to one or...
8257934 Screening methods using sitosterolemia susceptibility gene (SSG) polypeptides  
The present invention provides nucleic acids encoding a novel ABC family cholesterol transporter, SSG. The herein-disclosed sequences can be used for any of a number of purposes, including for the...
8252604 Selection of particles in laminar flow  
The invention relates to a method for selecting charged particles possessing a predetermined property from a population of a multiplicity of different particles, and also to a device which is...
8252544 Diagnosis and risk stratification of cardiac insufficiency by means of natriuretic peptides for NYHA I patients  
The invention relates to a method for the diagnosis, and/or risk stratification, and/or outcome prognosis of cardiac insufficiency for NYHA I patients, wherein a determination of the proANP...
8247219 Device and method for multiple analyte detection  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
8246911 Optical amplification of molecular interactions using liquid crystals  
Interactions between molecules that are components of self-assembled monolayers and other molecules can be amplified and transduced into an optical signal through the use of a mesogenic layer. The...
8241860 Cell free methods for detecting protein-ligand binding  
Provided are rapid and sensitive cell-free assay methods for detecting and/or measuring specific bimolecular or higher order interactions via reassembly of a split monomeric reporter protein, and...
8241861 Methods and compositions for diagnosis or prognosis of cardiovascular disease  
The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop or is suffering from, cardiovascular disease. In one embodiment, the method...
8236570 Methods for identifying nucleic acid ligands  
The present invention generally relates to methods for identifying nucleic acid ligands of a target molecule. In certain embodiments, the invention provides methods for identifying a nucleic acid...
8236511 Quantitation of cellular DNA and cell numbers using element labeling  
Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to...
8236513 Determining and reducing immunoresistance to botulinum toxin therapy using botulinum toxin A peptides  
The present invention provides BoNT/A peptide compositions, tolerogizing compositions, BoNT/A immune response inducing compositions and antibody compositions, as well as methods of determining...
8236575 Carrier for analysis of an analyte and process for producing the same  
A first reactant, which is provided with a reaction site for specific binding with an analyte, and a fluorescent label site, and a second reactant, which is provided with a reaction site for...