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8377643 Split flow device for analyses of specific-binding partners  
The present invention provides an analyte detection system for detecting a target analyte in a sample. In particular, the invention provides a detection system capable of one-step amplification of...
8372596 Asbestos detection method, asbestos detection agent, asbestos detection kit, method for screening candidate for agent aiming at preventing or treating disease for which asbestos is causative or worsening factor  
The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a...
8372660 Quantitative analyzing method  
This invention discloses an analyzing method for detecting a specific analyte in a fluid sample. The method comprises the following steps. First, a substrate is provided. The substrate has a...
8372593 Method for detecting misfolded proteins and prions  
The invention provides methods and kits for detecting conformationally altered proteins, such as prions or other proteins associated with disease states, in a sample. The methods comprise...
8372658 Chemical analytic apparatus and chemical analytic method  
A chemical analytic apparatus of the present invention is the one which proposes that a miniaturization, a making low-cost and portability are possible and also the operation of each process of...
8372591 MCM6 and MCM7 monoclonal antibodies and methods for their use in the detection of cervical disease  
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that...
8372594 Secreted phospholipase A2 biomarkers for arthritis  
The present invention relates to the use of protein expression profiles of sPLA2 isoforms with clinical relevance to osteoarthritis (OA). In particular, the invention provides methods for...
8372652 Luminescent nanostructured materials for use in electrogenerated chemiluminescence  
A nanostructured particulate material, which includes a redox active luminescent organic and/or ionic compound, is provided herein. The nanostructured particulate material may be used for...
8367356 Gelsolin binding agent compositions and uses of same  
The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination,...
8367349 Methods for identifying modulators of LRRK2  
A method for assessing the effect of a test compound on LRRK2 in a cell-based system, the method comprising the steps of a) assessing the effect of exposing the cell-based system comprising LRRK2...
8367351 Methods for determining signal transduction activity in tumors  
The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is...
8367353 Method for improved diagnosis of dysplasias  
The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly...
8367354 Methods for determining the levels of TGF-β in a composition  
A novel method for determining the levels of TGF-β1 or TGF-β2 in a sample of milk, raw protein source, or nutritional composition is provided. The method involves, in some cases, reconstituting...
8367399 Method for measuring molecular interactions by measurement of light reflected by planar surfaces  
A procedure for the quantitative determination of interactions of ligands with receptors adsorbed or immobilized on the surface of a solid material which can be functionalized, transparent and...
8361735 Interference control panel for evaluation of analytical assays for samples derived from blood  
The invention relates to quality control of analytical assays, particularly NAT assays of blood samples containing nucleic acids. A control panel containing quantified amounts of substances known...
8361729 Detection of cells expressing T1R2 taste receptor  
Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or...
8361808 Capillary flow solid phase assay  
Methods, materials, apparatus and systems are described for performing capillary flow assay. In one aspect, a system includes a sample collection unit to collect a sample liquid and a sample...
8362201 Insecticidal compounds and methods for selection thereof  
A series of potent and highly specific insecticidal toxins characterized by an amino acid sequences SEQ ID NO: 2-35.
8361734 Xanthurenic acid derivative pharmaceutical compositions and methods related thereto  
The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I: or a prodrug or pharmaceutically acceptable salt...
8364418 Software integrated cytometric assay for quantification of the human polymorphonuclear leukocyte FCγRI receptor (CD64)  
The invention relates a method of quantifying CD64 and CD163 expression in leukocytes and, specifically to a kit for use with a flow cytometer including a suspension of quantitative fluorescent...
8357497 Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets  
Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets,...
8357500 Methods of diagnosing non-alcoholic steatohepatitis (NASH)  
Non-invasive methods for detecting non-alcoholic fatty liver disease (NAFLD) and identifying the presence or absence of non-alcoholic steatohepatitis (NASH) in a subject utilize one or more...
8357499 Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify smell modulators  
The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention...
8354250 Neurotransmitter sensors and methods of using the same  
Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit...
8354280 Reusable detection surfaces and methods of using same  
The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte.
8354237 Anti-methylation-controlled j protein antibodies and uses thereof  
This application includes, in part, methods of preparing antibodies that specifically bind to methylation-controlling J (MCJ) polypeptide. In some aspects, the application also includes, hybridoma...
8354242 Quantitation of cellular DNA and cell numbers using element labeling  
Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to...
8354236 Detection of neurodegenerative disease  
Provided are methods of assessing the absence or presence of a neurodegenerative disease in a subject comprising characterizing TDP-43 in a tissue sample of the subject. Also disclosed are methods...
8349621 Ligand molecule-immobilized polymer, ligand molecule-immobilized particle, method of detecting target substance, and method of separating target substance  
A ligand molecule-immobilized polymer has a structure represented by the following general formula (1). In the general formula (1), R1 represents a ligand molecule-containing group, R2 represents...
8349573 Methods and device for the detection of occult blood  
The present invention relates generally to detection of occult blood. In particular, the present invention provides a device and methods for the simultaneous detection of hemoglobin and...
8349619 Method for detecting and analyzing protein interactions in-vivo  
The invention relates to various methods of detecting and analyzing protein interactions in a cell, which methods involve the appearance of a specific protein interaction being converted to a...
8349571 High content screening  
A high content screening (HCS) assay for rapidly screening one or more compounds to determine functional response or pharmacological properties thereof, comprising: i) priming a cell or cell...
8349616 Assays  
A method for assaying a sample for each of multiple analysis is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test...
8344104 Screening systems utilizing RTP801  
RTP801 represents a unique gene target for hypoxia-inducible factor-1 (HIF-1). Down-regulation of the mTOR pathway activity by hypoxia requires de novo mRNA synthesis and correlates with increased...
8343776 Immunoassay method  
Provided is an immunoassay method that can reduce the effort of establishing an immunoassay system due to not needing two or more antibodies, and that is applicable to not only high molecular...
8338097 Method and apparatus for combined electrochemical synthesis and detection of analytes  
Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for...
8338579 Homogeneous analyte detection  
The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of...
8338189 Detection of biomarkers and biomarker complexes  
The invention features methods and devices for the detection of biomarker complexes and their components and for the sequential detection of multiple epitopes of a biomarker. The invention also...
8334105 Methods for treating cardiac disease by modifying an N-terminal domain of troponin I  
The invention provides methods for identifying modulators of cardiac troponin I activity as well as methods for using N-terminally truncated forms of cTnI to monitor the function of the...
8334107 Detection systems utilizing supported lipid bilayers  
The invention relates to lipid bilayer coated beads and methods of using those beads in immunoassays, in analytical assay and the like.
8329397 Chemiluminescence proximity nucleic acid assay  
This invention relates to the detection and quantitation of target nucleic acids in a heterogeneous mixture in a Sample and the methods of use thereof. The detection system includes a...
8329104 Measurement device with at least one sensor  
A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the...
8329875 Antibodies to an epitope of AGR2, assays and hybridomas  
Provided is a monoclonal antibody, or an antigen binding fragment thereof, which binds specifically to an epitope within the sequence KPGAKKDTKDSRPKL (Sequence ID No. 2) of AGR2. Such monoclonal...
8329872 Drug monitoring assay  
A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is...
8323914 Analyte detection  
The present invention relates to analyte detection test systems, including test systems for the oral detection of analytes in saliva. The present invention also provides compositions and methods...
8323943 Screening method for anticancer drug  
The screening method for an anticancer drug comprises selecting a compound which blocks the kinase activity of TNIK, or blocks the combination of TNIK with β-catenin/TC4 transcription complex.
8318509 Two-phase optical assays for analytes of no intrinsic opitcal contrast  
Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized...
8318105 Systems and methods for biomarker analysis  
Systems and methods of biomarker analysis. In at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound the present disclosure, the system comprises a...
8318420 Heated assays for influenza  
Methods of increasing specific binding, decreasing non-specific binding, and reducing false-positive interaction in solid phase assays for influenza are disclosed. In the methods, the solid phase...
8318137 Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts  
The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a...