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7090989 |
Recombinant human SM-11044-binding receptor proteins exhibiting ligand-binding activities, and their uses
Transformed cells designed to express a recombinant human SMBP at an elevated level to the extent that its ligand-binding activity can be measured, and cellular membrane fractions thereof;...
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7087395 |
Vitamin D assay
The present invention features a kit and a method of using the kit for determining a concentration of a vitamin D component. The kit comprises a releasing composition and a detecting composition....
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7083983 |
Inhibitors of the interaction between P53 and MDM2
The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds,...
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7083914 |
Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
A method and apparatus for the physico-chemical encoding of a collection of beaded resin (“beads”) to determine the chemical identity of bead-anchored compounds by in-situ interrogation of...
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7081344 |
Methods for screening compounds that bind human COE-2
The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic...
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7081348 |
Immunoassay of human medullasin and diagnosis of multiple sclerosis using the same
There is provided an immunoassay by which the amount of human medullasin present inside granulocytes, which are one leukocyte component in blood, can be determined with high accuracy and with good...
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7081347 |
Method for predicting cardiovascular events
A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is...
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7078224 |
Cell concentration and lysate clearance using paramagnetic particles
Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of...
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7078511 |
Class BI and CI scavenger receptors
Two distinct scavenger receptor type proteins having high affinity for modified lipoproteins and other ligands have been isolated, characterized and cloned. HaSR-BI, an AcLDL and LDL binding...
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7078494 |
Antibodies to human IL-13bc and methods of their use in inhibiting IL-13 binding
Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods...
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7074576 |
Protein biopolymer markers indicative of alzheimer's disease
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7074620 |
Controlling protein levels in eucaryotic organisms
Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having...
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7071004 |
14094, a novel human trypsin family member and uses thereof
The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in...
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7070941 |
Methods and compositions for tagging via azido substrates
The invention provides methods and compositions for azide tagging of biomolecules. In one embodiment of the invention, proteins are tagged by metabolic incorporation of prenylated azido-analog...
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7067324 |
Photon reducing agents for fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon...
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7067266 |
Modulators of leukocyte activation, Hck compositions and methods of use
The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte...
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7063953 |
Human voltage gated sodium channel β1A subunit and methods of use
DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been...
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7063951 |
Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The...
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7063954 |
Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors
Screening methods for identifying compounds that bind to or activate corticotropin releasing factor 2 receptors (CRF 2 R) and regulate or potentially regulate skeletal muscle mass or function in...
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7060451 |
Methods for screening GABA-modulatory compounds for specified pharmacological activities
Methods are provided that are useful in assaying compounds for cognitive enhancing properties, anxiolytic properties, hypnotic properties, or antidepressant properties. These methods involve...
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7060507 |
Targeted molecular bar codes and methods for using the same
Targeted molecular bar codes and methods for using the same are provided. The subject targeted molecular bar codes include a molecular bar code and a member of a specific binding pair, where the...
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7056665 |
Screening methods involving the detection of short-lived proteins
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
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7056508 |
Receptor-type phosphotyrosine phosphatase-kappa antibodies
A novel receptor-type protein tyrosine phosphatase-κ (RPTPκ) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTPκ protein or...
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7057028 |
14273 Receptor, a novel G-protein coupled receptor
The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The...
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7056682 |
Immunoassay method and immunoassay reagent kit to be used therein
In step St 1 shown in FIG. 1 , a reaction system including a sample for which the content of a subject substance is to be measured, a specific-binding substance specifically binding to the...
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7052852 |
CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker in alzheimer's disease
Methods for assessing the risk of developing Alzheimer's Disease (AD), for diagnosing AD, and for measuring the progression of AD in a patient by determining CD45 isoform expression of blood cells...
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7052650 |
Apparatus and method for the manipulation and testing of molecules, and in particular of DNA
Apparatus for the manipulating and testing of molecules and in particular of DNA comprising a surface on which the molecule is anchored on multiple points at one end and a paramagnetic bead on...
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7052854 |
Application of nanotechnology and sensor technologies for ex-vivo diagnostics
Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination...
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7052850 |
Isolated human EDG-4 receptor
A novel, isolated EDG receptor that upon activation results in increased induction of IL-8 or NF-κB. Preferably, the EDG receptor is a human EDG-4 receptor, which has an amino acid sequence shown...
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7052833 |
Absorptive hypercalciuria locus on human chromosome 1
Disclosed is a region on human chromosome 1 that provides a genetic basis for absorptive hypercalciuria. The genes, proteins, and other biological materials provided are envisioned for use in...
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7052858 |
Diagnostic assays for detection of Cryptosporidium parvum
This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and...
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7049080 |
Process for detecting serine/threonine kinase activity
The present invention describes a process for detecting threonine or serine kinase activity in an immunoassay using a pre-phosphorylated substrate.
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7048889 |
Dynamically controllable biological/chemical detectors having nanostructured surfaces
A biological/chemical detector is disclosed that is capable of manipulating liquids, such as reagent droplets, without relying on microchannels. In a first embodiment, fluid flow is passed through...
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7049079 |
Coupling factor 6 inhibitor and potentiator and use thereof
Methods of measuring the presence/absence of a coupling factor 6, which is a subunit of H + -transporting ATP synthase→H + ATP synthase present in the mitochondrial inner membrane, in the blood...
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7049081 |
Diagnostic methods based on human BTG-2 and BTG-3 polypeptides
The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and...
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7045367 |
Nano-scaled dendrimer-based colorimetric biosensors
Molecular chemical and/or biological sensors that exhibit a very high density of sensing functionality and which are applicable to a wide variety of different analytes, and enable rapid, convenient...
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7045097 |
Biologic electrode array with integrated optical detector
A biologic electrode array is formed on a semiconductor substrate. A matrix of electrode sites is disposed on the semiconductor substrate. A matrix of optical detectors is disposed beneath the...
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7045363 |
Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide
A nucleic acid-bound polypeptide produced by binding a nucleic acid to a polypeptide, a method of producing the nucleic acid-bound polypeptide, and applications of the nucleic acid-bound...
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7045287 |
Method for contacting fluid components with moieties on a surface
An improved method is provided for conducting chemical or biochemical reactions on a substrate surface in which the reactions take place in an enclosed chamber between components of a fluid and...
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7045310 |
Redox reversible bipyridyl-osmium complex conjugates
Novel bipyridyl-osmium complex conjugates and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials...
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7045361 |
Analyte sensing via acridine-based boronate biosensors
Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address...
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7045610 |
Modified oligonucleotides for mismatch discrimination
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
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7041458 |
Methods and reagents for determining protein S
The present invention relates to an assay for free protein S comprising the addition of a ligand specific for free protein S to a biological fluid sample to form a protein S/ligand complex, and...
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7037663 |
Human zona pellucida protein 3 and uses thereof
The present invention provides a method to determine sperm activity comprising the steps of: (a) contacting an appropriate concentration of human zona pellucida protein 3 with an appropriate amount...
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7037726 |
Methods for forming recombined nucleic acids
Described herein are methods for generating recombined nucleic acids. In one method, fragments of a sequence are provided wherein the fragments have non-extendable 3′ ends. A primer is provided...
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7033766 |
Construction and screening of lantibody display libraries
A sublancin peptide variant (lantibody) having a spacer region and a subtilin leader peptide fused to the C-terminal end of the mature sublancin peptide provide an anchoring means for inserting and...
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7033760 |
Metallic solid supports modified with nucleic acids
The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization...
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7033841 |
Process and compounds for use in detecting analytes by measurement of residual magnetism, and the use of the said compounds
The invention relates to a process for quantitative detection of analytes in liquid and solid phases with the aid of binding remanence measurement, compounds that are suitable for this purpose, and...
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7033765 |
Site-specific drug delivery
Compounds and methods which are useful for the site-specific delivery and localization of drugs are provided. The compounds can be represented by the formula: A-L-D wherein A is an anchoring...
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7033773 |
Screening assays for G protein coupled receptor agonists and antagonists
Parathyroid hormone (PTH) and its closely related peptide, PTHrP, share the same receptor, PTHR. LLC-PK1 cells are porcine renal epithelial cells which do not normally express PTHR. The...
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