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7608465 |
Multi-analyte diagnostic test for thyroid disorders
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and...
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7385022 |
Polythiocarbonate polythiol
Disclosed is a polythiocarbonate polythiol including repeating units represented by the chemical formula (I):
in which formula (I), R represents a divalent hydrocarbon group, which hydrocarbon...
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7358341 |
Beta-like glycoprotein hormone polypeptide and heterodimer
Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods...
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7252961 |
Competitive immunoassay using complexed analyte derivatives
The invention relates to a method for the detection of an analyte in a competitive immunoassay in the presence of an analyte derivative and first and second receptor molecules, and to a kit for...
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7217505 |
Method for determining whether condition is symptom of metabolic syndrome
The use of cortisol agonist for preparing a system for diagnosis of the metabolic syndrome and related conditions as belly fatness, insulin resistancy including increased risk of developing senile...
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7199097 |
Peptide fragments having cell death inhibitory activity
The present invention provides a peptide fragment or a series of peptide fragments having a cell death-inhibitory activity, having the amino acid sequence consisting of 103 amino acid residues at...
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7083986 |
Near infrared chemiluminescent acridinium compounds and uses thereof
A method for the detection or quantitation of an analyte in a biological sample is disclosed. The method comprises the steps of selecting a biological sample suspected of containing a target...
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7056655 |
Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism
The present invention relates to novel methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism. One determines and...
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7041441 |
Phage display of intact domains at high copy number
Disclosed is a phage display system in which the molecules to be displayed (i.e., molecules of interest) are bound to dispensable capsid polypeptides such as SOC (small outer capsid) and HOC...
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7037664 |
Apoptosis marker antibodies and methods of use
Disclosed are antibodies that specifically recognize the new amino terminus of a protein cleaved by a protease during apoptosis. Methods of using and making the antibodies are also provided. The...
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6974793 |
Method for treating primary hyperparathyroid disorders
A method for treating hypoparathyroidism and/or hypocalcemia by local administration of a neurotoxin, such as a botulinum toxin, to a parathyroid gland, thereby reducing an inhibitory effect upon...
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6924154 |
Hydrophilic chemilumescent acridinium labeling reagents
In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid,...
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6869805 |
Electrical connection passing through a dividing wall
An electrical connection passing through a dividing wall contains a contact plate ( 2 ) having a base piece ( 4 ) covering a surface, and a contact piece ( 8 ) connected to the base piece via a...
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6777197 |
Method and test kit for measuring immunoglobulins reactive with amylase as indication of crohn's disease
A method for diagnosing Crohn's disease by detecting the presence of immunoglobulins, reactive with an amylase, in a specimen by an immunologic or enzymologic method using the amylase, and a test...
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6756233 |
Method for measuring free ligands in biological fluids, and assay kits for measuring same
A method for measuring free ligands in biological fluids in the presence of bound ligand and endogenous binding proteins, without disturbing the equilibrium between the free ligand and the...
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6749846 |
Interferon-beta use in the treatment of ewing's family of tumors
The invention relates to the use of interferon-beta for the treatment of Ewing's family of tumors in mammals. A method for treating Ewing's family of tumors in a mammal comprising administering to...
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6660482 |
Inter-alpha-trypsin inhibitor as a marker for sepsis
The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under...
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6613583 |
Electrochemiluminescent label based on multimetallic assemblies
Electrochemiluminescent label compounds containing multimetallic centers separated by bridging ligands are described. An example of a multimetallic electrochemiluminescent label suitable for use in...
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6608178 |
5-hydroxytryptophol (5-HTOL) derivatives, antibodies, immunoassays and detection of recent alcohol consumption
Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the β-glucuronide between the 5-hydroxy group of 5-HTOL...
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6586194 |
Method for assaying creatine kinase isozyme activity and assay reagent
A method for measuring the activity of creatine kinase MB (CK-MB) isozyme which is accurate, high in specificity, convenient, by inhibiting the activity of a mitochondria localized creatine kinase...
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6548309 |
Procedure for assay of liquids containing undissolved solids, semisolids or colloids
In qualitative or quantitative assays which employ a test device comprising a test strip pretreated for detection of a specified target analyte dissolved in a liquid medium, the presence of solid,...
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6537760 |
Receptor binding assay for detecting TSH-receptor auto-antibodies
In a competitive receptor binding assay for detecting TSH-receptor auto-antibodies in a biological sample, the sample is reacted in a reaction mixture which contains (i) a TSH-receptor or...
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6500925 |
Human thyroid protein ZSIG45
The present invention relates to polynucleotide and polypeptide molecules for zsig45, a novel human protein expressed in thyroid. The polypeptides, and polynucleotides encoding them, may be used...
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6423549 |
Phycoerythrin labeled thyronine analogues and assays using labeled analogues
The invention provides fluorescent analogues of thyroid hormones T 3 and T 4 . Also provided are assays for thyroid hormones utilizing the compounds of the invention. The assays of the invention...
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6420188 |
Screening assay for the identification of inhibitors for macrophage migration inhibitory factor
The present invention encompasses assays to identify compounds that inhibit the enzymatic activity of MIF which catalyzes the tautomerization of MIF-substrates, such as D-dopachrome to DHICA. In...
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6410339 |
Preparation for diagnosis of the metabolic syndrome and diseases including the syndrome
The use of cortisol agonist for preparing a system for diagnosis of the Metabolic Syndrome and related conditions as belly fatness, insulin resistance including increased risk of developing senile...
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6355803 |
Near infrared chemiluminescent acridinium compounds and uses thereof
This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional...
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6344331 |
Water immiscible solvent based binding systems
A biphase immunoassay method is provided in which a water immiscible liquid is qualitatively or quantitatively measured by mixing a sample of the water immiscible liquid with an aqueous solution...
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6323321 |
Antibody 97A6
The present invention relates to a monoclonal antibody binding an antigen on the megakaryocytic cell line UT-7. The invention further relates to hybridoma cells producing such an antibody.
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6316272 |
Methods of diagnosis of colorectal cancer and methods of screening for colorectal cancer modulators
Described herein are methods that can be used for diagnosis and prognosis of colorectal cancer. Also described herein are methods that can be used to screen candidate bioactive agents for the...
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6228597 |
Polypeptides having thyrotropin-receptor activity, nucleic acid sequences coding for such receptors and polypeptides, and applications of these polypeptides
The invention concerns a polypeptide possessing thyrotropin receptor activity characterized in that it comprises the amino acid sequence shown in FIG. 11 (i.e., SEQ ID NO: 59) and cDNA molecules...
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6226378 |
Method and system for anonymously testing for a human malady
An anonymous testing system for taking a sample of body fluid to be tested, the sample is acquired in private and sent for analyzation to obtain results. The system comprises a test kit for...
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6197533 |
Chemical modification of antibodies and antigens
There is described a method for the chemical modification of antibodies and/or antigens in order to minimise sample interference in immunoassays, an immunoassay method in which chemically modified...
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6154706 |
Apparatus and method for kinetic analysis of the intraoperative assay for parathyroid hormone
An apparatus for predicting a residual hormone concentration in a patient after a removal of a portion of the patient's glandular tissue which secretes the hormone, includes an input device...
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6153442 |
Reagents and methods for specific binding assays
The present invention relates to compounds that are bis-biotins. These compounds comprise two biotinyl radicals connected by a chain of atoms, usually at least 16 atoms in length. The bis-biotin is...
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6153440 |
Simultaneous measurement of free triiodothyronine and free thyroxine by equilibrium dialysis and immunoassay
The present invention provides methods for the simultaneous measurement of triiodothyronine (T 3 ) and thyroxine (T 4 ) in biological fluids such as serum by direct equilibrium dialysis and...
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6121056 |
Random detection of antigens with antibodies immobilized on soluble submicron particles
Methods, compositions and articles of manufacture are provided for conducting specific binding assays to determine the concentration or presence of at least one analyte in a sample. At least two...
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6103486 |
Process and test kit for determining free active compounds in biological fluids
A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active...
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6037185 |
Non-competitive immunoassay with blocking of unoccupied specific binding sites on solid phase
A non-competitive method for the determination of analytes. Initially the analyte is bound to a specific binding partner, after which the unoccupied binding sites of the binding partner are...
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6013461 |
APC mutation associated with familial colorectal cancer in Ashkenazi Jews
During routine screening of a patient with a family history of colorectal cancer for truncating APC mutations, a novel missense mutation was identified. Upon further evaluation, it was found that...
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5981296 |
Stabilization of particle reagents
Stabilized particle reagents suitable for use in turbidimetric immunoassays are disclosed. The stabilized particle reagents contain functionalized polymer particles in which the surface of the...
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5958789 |
Reduction in positive bias in wet assays due to splashing
A method of preventing false detection of signal due to splashing of reagent liquid used to produce such signal, when dispensing at least one such liquid from a metering tip into a second liquid,...
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5919632 |
Use of polyclonal human anti-HTG autoantibodies as a reagent for the clinical diagnosis of thyroid autoimmune diseases and reagent additive for detecting anti-HTG autoantibodies in patient sera
Use of polyclonal human autoantibodies against thyroglobulin (anti-hTg autoantibodies), in particular in the form of an affinity-purified IgG fraction, as a specific binding reagent in an...
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5898005 |
Rapid detection of analytes with receptors immobilized on soluble submicron particles
Methods are provided for conducting specific binding assays to determine the concentration or presence of at least one analyte in a sample. Dendrimer-reagent preparations with particular analyte...
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5879896 |
Method of screening for inhibitors of human thyrotropin releasing hormone (TRH) receptor
A human receptor protein capable of binding TRH, a DNA coding for said protein, use of the proetein and DNA, a method for preparing said protein, and antibodies to the protein are described. The...
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5861319 |
Immobilization of specific binding assay reagents
Methods and compositions are provided for specific binding assays in which specific binding reagents are immobilized on a solid phase. Immobilization is facilitated by covalently coupling specific...
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5854008 |
Europium and terbium chelators for the time-resolved fluorometric assays
Fluorogenic chelators for Eu 3 + and Tb 3 + are provided, they form highly fluorescent complexes with Eu 3 + and Tb 3 +. In all cases, the fluorescence observed was lanthanide-specific, long-lived...
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5851840 |
Biotinsilane compounds and a binding matrix containing these compounds
The invention concerns a binding matrix containing a carrier material with an oxidic surface and a solid phase reactant covalently bound thereto via anchor groups which is capable of binding to at...
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5851777 |
Homogeneous sol-sol assay
The present invention provides methods for detecting the presence of or determining the amount of a ligand in a fluid sample. The methods comprise providing a first reagent comprising a sol...
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5847088 |
Antibodies specific for platelet-activating factor acetylhydrolase
The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the...
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