Matches 151 - 200 out of 326 < 1 2 3 4 5 6 7 >
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4506019 Activated polymer container means and assay method employing the same  
Novel activated polyamide polymer container or test tube means and a method for the determination of ligand or analyte content in aqueous samples, are provided. The surfaces of the container tubes...
4493793 Soluble immunoassay reagent comprising lectin covalently bonded to reactive component  
A lectin is covalently bonded to an immunological conjugate such as an antibody-antigen or its equivalent. Then, the lectin-conjugate is isolated from the reaction product mixture by one of a...
4489165 Chromogenic tracers for use in an assay  
A chromogen, in particular, a fluorescent compound, is conjugated to a ligand through an amino acid spacer radical, which includes a free carboxyl group. The tracers are particularly suitable for...
4481298 Pre-precipitated double antibody immunoassay method  
An immunoassay process for the detection of an antigen in a sample, which comprises: (a) forming a mixture of the sample with (1) a preformed complex of a primary antibody and a secondary binding...
4480042 Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays  
Novel particle reagents for light scattering immunoassays are provided. The particle reagents are high refractive index shell-core polymers covalently bonded to compounds of biological interest or...
4480041 Use of phosphotriester intermediates for preparation of functionalized liposomes  
A method of forming an analyte-functionalized liposome for use in immunoassay techniques employs a phosphotriester intermediate of a phospholipid derivatized with the desired analyte in a process...
4478945 Method for evaluating thyroid function  
Clinical method for evaulating thyrometabolic function by determination of clinically important thyroxine concentrations and thyroxine binding protein capacities in plasma. The method employs a...
4477576 Antigen assay method and kit  
A method of determining the concentration of an antigen in a sample solution comprising (a) coating an antigen-protein conjugate onto a solid matrix, (b) conjugating an enzyme to an antibody...
4477578 Method and apparatus for performing assays  
Method and apparatus are provided for carrying out multiple simultaneous transfers of fluid. The method and apparatus are particularly directed toward immunoassays wherein immunologically active...
4476229 Substituted carboxyfluoresceins  
This disclosure relates to a method and reagents for determining ligands in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. This disclosure also relates to a novel...
4476228 Determination of unsaturated thyroxine binding protein sites using fluorescence polarization techniques  
This invention encompasses a method for measuring unsaturated thyroxine binding protein sites in a sample comprising intermixing with the sample an effective amount of fluorescent labeled tracer...
4474891 Mini-iodinated polypeptide hormone tracer and method for its use  
This invention relates to a highly-sensitive mini-iodinated radioactive hormone tracer which has both initial low iodine-to-hormone molar ratios and low specific activity. This invention also...
4472508 Test for detecting and measuring the graves' disease-specific immunoglobulins  
An immunoassay for a specific antibody, particularly Graves' disease-specific antibody, in which interfering reactions by the reactive ends of similar antibodies are eliminated by the step of...
4472498 Analysis film and a method of analysis using the same  
An analysis film comprises a reagent layer composed of a porous material which contains an antibody but does not substantially contain a complex of an analyte or a labelled antigen with the...
4469787 Immunoassay involving soluble complex of second antibody and labeled binding protein  
A method and kit for determining the presence of a polyvalent ligand in an aqueous fluid. The method involves incubating the fluid with an immobilized antibody to the ligand to form an immobilized...
4468469 Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays  
An improved immunoassay method, reagent means, and test kit for determining an iodothyronine, e.g., thyroxine (T-4), in a biological fluid, usually serum or plasma, wherein fenclofenac and related...
4467030 Determination of the thyroxine-binding index in serum  
A method for the determination of the thyroxine-binding index in serum, which method comprises mixing the serum sample to be determined with a defined amount of thyroxine and a defined amount of a...
4456689 Competitive protein binding assay using an organosilane-silica gel separation medium  
An improved competitive protein binding assay comprising; incubating an analyte in the presence of labeled analyte and a protein binder suitable for competitive binding activity by the analyte and...
4454231 Method and device for mass transfer operation in immunoassays and other applications  
The present invention relates to a new technique and device for mass transfer of one or more components from one liquid phase to another liquid phase, involving a physical separation of said two...
4442218 Method of measuring degree of partitioning  
A method of measuring the degree of partitioning of a labeled species between free and bound states which involves the use of an insoluble porous monolith having a means for binding a portion of...
4432907 Diamine acid fluorescent chelates  
Species-linked diamine triacetic acids of the formula ##STR1## wherein T is an organic species containing at least one amine, hydroxyl, or thio functional group, L is the residue of at least one of...
4431741 Hypothyroid control serum  
A hypothyroid control serum for use in assay of thyroid function of serum with a reagent antiserum, said control comprising (a) serum from which triodothyronine and thyroxine have been stripped and...
4430263 Hapten-inhibitor immunoassay  
A specific binding assay method employing, as a labeling substance, a reversible trypsin inhibitor for the detection of a hapten. Competition between the hapten to be determined and hapten trysin...
4426453 Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds  
Novel amides of an iodothyronine compound such as tri-iodothyronine (T3) or thyroxine (T4) with an aminoacetic acid compound such as nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid...
4410634 Method of passively adsorbing immuno-reactive haptens to solid phases  
The method comprises covalently binding an immuno-reactive to a selected macromolecular carrier and then contacting the resulting hapten-carrier conjugate at a selected concentration in a liquid...
4410633 Method for the measurement of free thyroxine or 3,5,3'-triiodothyronine in a liquid sample  
An immunoassay for the measurement of free thyroid hormone, i.e., thyroxine or 3,5,3'-triiodothyronine, in a liquid sample in which the thyroid hormone is present in both free and combined states,...
4401764 Immunoassays employing labeled reagent and a conjugate having two binding sites  
In the immunoassay of antigens in liquids, a reaction mixture is formed containing the liquid under assay, labelled antigen, and a mixed binding reagent which contains an antigen-binding site and a...
4391795 Assay for free thyroid hormone  
Sample containing free and bound thyroid hormone; in particular, thyroxine, is contacted with immobilized binder; in particular, supported on a solid support, to bind the free thyroxine. After...
4390517 Method, composition and kit for stabilizing radiolabeled compounds  
A method of stabilizing a solution of a radiolabeled compound comprising adding to such solution a compound having a substantially insoluble backbone, to which has been bound a quaternary ammonium...
4385126 Double tagged immunoassay  
Immunoassays are performed with two different ligands tagged with two different tagging constituents which are independent of each other and the two tagged ligands are immunologically bound...
4381291 Measurement of free ligands  
A method for indirect measurement of the concentration of a free ligand in a liquid sample also containing the ligand bound to endogenous binding material, comprising the steps of performing two...
4380580 Heterogenous chemiluminescent specific binding assay  
A heterogeneous specific binding assay which employs a substance having reactant activity, i.e., a reactant, in a chemiluminescent reaction as a labeling substance in the detection of a ligand in a...
4378428 Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays  
A highly sensitive, immunoassay method for determining the amount of an analyte in a sample containing a known analyte in an unknown concentration is provided. Sample; a polypeptide-labeled analog...
4378344 Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system  
A method for performing multiple, simultaneous in vitro diagnostic tests is provided. The method utilizes a solid phase device comprising a receptacle and an insert. The receptacle has one or more...
4352751 Species-linked diamine triacetic acids and their chelates  
Species-linked diamine triacetic acids of the formula ##STR1## wherein T is an organic species containing at least one amine, hydroxyl, or thiol functional group, L is the residue of at least one...
4347058 Thyroid polarization fluoroimmunoassay  
A polarization fluoroimmunoassay for T 3 or T 4 thyroid hormones where a serum sample is assayed by contacting the sample with a base to denature the thyroxine binding globulins and thereby form...
4347059 T.sub.3 Uptake polarization fluoroimmunoassay  
A T 3 uptake polarization fluoroimmunoassay where a sample is assayed by contacting a serum sample with T 3 to form a solution, contacting the solution with a separating agent and incubating the...
4341865 Determination of thyroxine binding globulin  
This invention encompasses a method for measuring unsaturated thyroxine binding globulin in serum comprising intermixing with the serum: (i) thyroxine irreversible enzyme inhibitor conjugate...
4337063 Competitive immunoassay using spectral sensitizer label  
Method for immunological analysis of a trace component(s) by labelling an antigen or antibody with a marker comprising causing an immune reaction using an antigen or antibody labelled with a...
4332784 Dual isotope assays  
Dual isotope assays for thyroid function are performed by carrying out a radio-immunoassay for two of thyroxine (T4), tri-iodothyronine (T3), thyroid stimulating hormone (TSH), and thyroxine...
4329461 Fluorescent thyroid hormone conjugates and their uses  
Novel polyhalothyronines or immunogenic mimetic analogs are provided conjugated to a fluorescer compound with the resulting conjugate being highly fluorescent. Specifically, the compounds have at...
4312854 Immunoassay for thyroid stimulating hormone employing florisil adsorbent as separating agent  
An improved immunoassay method for determining thyroid stimulating hormone (TSH) in a liquid sample wherein the bound- and free-species of the labelled, preferably radio-labelled, TSH are separated...
4311690 Test set and method for the determination of free hormones  
Disclosed is a process for determining the concentration of unbound hormone, e.g., thyroxine, cortisol, or testosterone, in a liquid sample containing hormone and protein capable of binding the...
4311687 Radiometric assay of dialysates  
An improved radiometric assay of dialysates from equilibrium dialysis procedures which involves using immobilized antibody specific for a given hapten to separate free hapten (including...
4310504 Dry radioimmunoassay test composition containing stabilized label/antibody mixture  
A dry radioimmunoassay test composition comprising a mixture of a radiolabelled form of a ligand, i.e., a hapten or an antigen, an antibody for the ligand, and a heavy metal cation, e.g., cupric...
4307071 Analytical reagent and method  
A reagent is disclosed for determining the concentration of a ligand in blood serum. The reagent includes a protenaceous, three-dimensional, serum-insoluble complex which is readily collected by...
4307070 Methods and apparatuses for performing immunoassays  
Methods and apparatuses are featured for preconcentrating immunological reactants prior to their contact and reaction to enhance the rate of reaction for separating reacted and unreacted reactants...
4301139 Multilayer column chromatography specific binding assay method, test device and test kit  
A specific binding assay method, and a test device and test kit for use therein, for determining a liqand, such as an antigen or antibody, in, or the ligand binding capacity of, a liquid medium,...
4299812 Immunoassay of thyroxine in neonates using dried blood samples  
In the immunoassay of thyroxine using dried blood samples spotted on filter paper, the assay in this invention is run at a pH of 9.2 to 10.0, preferably at about 9.5, rather than the pH range of...
4297337 Solid-phase immunoassays using magnetic glass  
Solid-phase immunoassay procedures employing magnetic glass or crystal-containing material, or a superparamagnetic material formed of magnetic particles dispersed in a non-magnetic matrix, as...
Matches 151 - 200 out of 326 < 1 2 3 4 5 6 7 >