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7622306 |
Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies
The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins...
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7619216 |
Charged droplet sprayers
Charged droplet spray is formed from a solution with all or a portion of the charged droplet spray current generated from reduction or oxidation (redox) reactions occurring on surfaces removed from...
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7618827 |
Thyroid hormone analysis by mass spectrometry
Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation...
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7615377 |
Fluorescein-based metal sensors
The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same.
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7605003 |
Use of biomarkers for detecting ovarian cancer
The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the...
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7605001 |
Method of multidimensional NMR with simultaneous plural magnetization transfer, and NMR pulse sequence thereof
There is disclosed an NMR measurement method of observing plural magnetization transfer patterns in one experiment and observing their respective time-modulated, evolved chemical shifts. In an...
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7605000 |
Cold shock inducible expression and production of heterologous polypeptides
The present invention relates to a DNA molecule or vector and a host cell containing this DNA molecule or vector which can be used to produce a heterologous polypeptide under conditions that elicit...
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7604998 |
Fingerprint analysis for a plurality of oligonucleotides
The invention provides a method for evaluating the accuracy of an oligonucleotide sample, specifically a sample containing a variety of oligonucleotides of potentially varying size and sequence....
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7604948 |
Biomarkers for diagnosing an autism spectrum disorder
The present invention provides methods of identifying biomarkers indicative of the presence of a neurodevelopmental disorder, including an autism spectrum disorder, in an individual, using...
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7595485 |
Data analysis to provide a revised data set for use in peptide sequencing determination
In one aspect of the present invention, the less “useful” spectral data is disregarded from the spectral data resulting from the fragmentation by ETD and candidate charge states for the...
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7595198 |
Photocleavable isotope-coded affinity tags
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as proteins and protein fragments from biological samples from in...
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7589318 |
Mass defect triggered information dependent acquisition
Systems and methods for analyzing compounds in a sample. In one embodiment, a mass spectrometer includes an ion source for emitting a plurality of ions from a sample together with a detector...
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7588944 |
Method of analyzing C-terminal amino acid sequence of peptide
An analyte peptide is selectively degraded sequentially by using an alkanoic anhydride (S 101 ). The original peptide and a series of degradation reaction products having peptide in which one or...
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7588943 |
Method for quantitative monitoring of a gas injected in a reservoir in particular in a natural environment
A method for quantitative monitoring of a gas injected into a reservoir and likely to react chemically with the injection medium includes injecting into a reservoir a mixture of the potentially...
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7582282 |
Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics
The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the...
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7575935 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7572596 |
Modulation of the neuroendoctrine system as a therapy for motor neuron disease
The invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject. The method comprises administering to the nervous system of the subject a composition comprising a...
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7564028 |
Vacuum housing system for MALDI-TOF mass spectrometry
The present invention is directed to ion source and vacuum housings for use in MALDI-TOF mass spectrometry which operates with any type of mass analyzer including linear, reflector, or tandem...
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7560286 |
Mass spectrometric method for structural analysis of chain nitrogen-containing compounds using sqauric acid
A method for effectively causing charge-remote fragmentation (CRF) when the structural analysis of an nitrogen-containing organic compound is performed using a high-energy collisional-induced...
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7557577 |
Water-soluble paramagnetic substance reducing the relaxation time of the coolant in an MRI system
The invention relates to the use of a water-soluble paramagnetic substance, in particular a magnetic resonance contrast medium, to reduce the magnetic resonance relaxation time of a coolant for...
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7556969 |
Intensified neutral loss tags and use thereof in mass spectrometry
Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a...
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7550301 |
MALDI analysis based on derivatized matrices forming covalent bonds with analyte molecules
Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for laser desorption/ionization mass spectrometry....
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7547555 |
Use of temperature and flow profiles in gradient elution based analytical process
A method and apparatus are provided for optimizing a liquid chromatography/mass spectrometry system for gradient elution. A temperature profile is determined according to which a gas is flowed into...
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7547536 |
Method for detecting bacterial spores
A method of detecting the presence and quantity of bacterial spores, which includes adding an electrophilic alcohol and an acid anhydride to a sample, admixing the sample with a solvent, and...
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7544518 |
Rapid quantitative analysis of proteins or protein function in complex mixtures
Analytical reagents and mass spectrometry-based methods using these reagents for the rapid, and quantitative analysis of proteins or protein function in mixtures of proteins. The methods employ...
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7534622 |
Electron transfer dissociation for biopolymer sequence mass spectrometric analysis
The present invention relates to a new method for fragmenting ions in a mass spectrometer through the use of electron transfer dissociation, and for performing sequence analysis of peptides and...
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7531134 |
Method and apparatus for automated analysis and characterization of chemical constituents of process solutions
A method of directed automated analysis of a plurality of analytes of a process solution includes providing a sample of the process solution containing a plurality of the analytes, admixing an...
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7521249 |
Method and composition for the preparation of a sample for analysis
The present invention relates to the preparation of a sample. Preferably, the sample is a sample to be analyzed, for example for ingredient content, etc. Preferred samples include foods, cosmetics,...
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7518103 |
Pulsed flow modulation gas chromatography mass spectrometry with supersonic molecular beams method and apparatus
There is provided a pulsed flow modulation gas chromatograph mass spectrometer with supersonic molecular beams apparatus and method for improved sample analysis. The apparatus includes a gas...
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7514269 |
Precision adaptable chemical spectrometer
The invention is directed to a spectrometer for measuring submillimeter absorption. The spectrometer may include a solid state exciter generating a submillimeter wave and sweeping a predetermined...
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7514268 |
Method for identifying contaminants
A method is provided for identifying contaminants on a surface. In one embodiment, an infrared beam is transmitted onto a sample. A first infrared absorbance of the sample is determined at a first...
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7510880 |
Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts
A method for determination of at least one of the lipid species in a biological sample comprising subjecting the sample to lipid extraction to obtain a lipid extract and subjecting the resulting...
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7501286 |
Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
The invention provides reagents, kits and methods for detecting and/or quantifying proteins in complex mixtures, such as a cell lysate. The methods can be used in high throughput assays to profile...
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7494822 |
Method of quantification of carboxylic acids by mass spectrometry
Method of identification and quantitative analysis of carboxylic acid(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is...
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7494815 |
Method and apparatus for analyzing compounds with amino group
The present invention provides a method and apparatus for analyzing compounds with amino group(s) contained in biological organisms. In this method, a compound with amino group(s) is derivatized...
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7491549 |
Apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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7479631 |
Probes for a gas phase ion spectrometer
The invention provides a probe and a method of making the probe that is removably insertable into a gas phase ion spectrometer, the probe comprising a substrate having a surface and a hydrogel...
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7473560 |
Steroid hormone analysis by mass spectrometry
Methods, systems and kits for the simultaneous or sequential analysis of a multitude of steroid hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal...
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7470543 |
Methods for identifying ligands using competitive binding 1H NMR experiments
A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a 1D 1 H nuclear magnetic resonance spectrum...
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7465586 |
Oral detection test for cannabinoid use
A method for confirming the active intake of marijuana and its active component Δ 9 -tetrahydrocannabinol (“Δ 9 -THC”) by detecting the amount of 11-nor-Δ 9 -THC carboxylic acid (“THCA”)...
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7462824 |
Combined ambient desorption and ionization source for mass spectrometry
Combined desorption and ionization sources are provided to generate molecular ions form a sample disposed on a substrate surface. A heated gas-jet probe or heated solvent stream probe desorbs...
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7462494 |
Method for laser desorption mass spectrometry using porous polymeric substrates with particle fillers
Articles and methods for the high-energy desorption/ionization of various compositions are disclosed. Methods of the invention utilize porous substrates, optionally in combination with one or more...
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7457708 |
Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components
Described are techniques for processing data sets produced by analyzing a sample. The input data set is represented as rows of intensities over time for a particular mass to charge (m/z) range. A...
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7449171 |
Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolic products
Methods of determining rate of biosynthesis or breakdown of biological molecules from metabolic derivatives and catabolic products are disclosed herein. In particular, methods of measuring the...
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7449170 |
Materials and methods for controlling isotope effects during fractionation of analytes
Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy...
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7449150 |
Probe and apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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7446309 |
In-plane distribution measurement method
In plane distribution of a target object contained in a sample is measured. The sample dispersedly placed on a substrate is treated to promote ionization of the target object. Then, the mass and...
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7445937 |
Methods for synthesis and evaluation of hydrogen storage compositions
A method for identification and evaluation of the hydrogen storage capacity of materials is presented, the method comprising providing a plurality of materials, wherein the plurality of materials...
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7442556 |
Microfluidic-based electrospray source for analytical devices with a rotary fluid flow channel for sample preparation
This invention provides microfluidic devices and methods for using the same. Microfluidic devices of the present invention comprises a first elastic layer, a fluid flow channel within the elastic...
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7439074 |
Method of analysis of alcohol by mass spectrometry
Method of identification and quantitative analysis of alcohol(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by...
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