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6960447 |
Isolation of membrane bound ligand-specific complexes
A method to recover receptors without removing microenvironmental components associated with them is described. The membranes containing the receptors are first associated with ligand-coupled solid...
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6958244 |
Low-conductivity buffers for magnetic resonance measurements
An NMR buffer is particularly useful for biomolecules that require a certain amount of salt in the buffer solution. A primary buffer component and a titrating component are selected based on low...
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6943033 |
MAGNETIC RESONANCE METHOD FOR ASSESING AMIDE PROTON TRANSFER EFFECTS BETWEEN AMIDE PROTONS OF ENDOGENOUS MOBILE PROTEINS AND PEPTIDES AND TISSUE WATER IN SITU AND ITS USE FOR IMAGING PH AND MOBILE PROTEIN/PEPTIDE CONTENT
Featured is an MRI/NMR methodology or process to detect amide protons of endogenous mobile proteins and peptides via the water signal. Such methods and processes can be used for the purposes of...
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6939686 |
Methodology of using raman imaging microscopy for evaluating drug action within living cells
A method of using Raman imaging microscopy to evaluate drug actions in living cells is disclosed. Specifically the invention describes the methods of using Raman imaging microscopy to detect drug...
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6939718 |
Mass spectrometry of prostaglandins
A liquid chromatography-electrospray ionization mass spectrometry method is capable of separating and identifying different prostaglandin isomers, including PGD 2 and PGE 2 . Unlike traditional...
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6939716 |
Method for detecting conditions indicative of sepsis
The disclosure describes a method for detecting conditions indicative of sepsis. In one embodiment of the invention, an increase in the level of 3-chlorotyrosine or 3-bromotyrosine from the normal...
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6924150 |
Magnetic resonance imaging contrast system
A method for improving the magnetic resonance imaging contrast of a selected portion of a sample. A selected ferrimagnetic constituent is associated with the sample portion, by molecular or...
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6921667 |
Methods for direct detection of individual methotrexate metabolites
The present invention provides a method for determining a level of a methotrexate polyglutamate (MTXPG) in a cellular extract by resolving at least one MTXPG in a cellular extract obtained from a...
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6917037 |
Mass spectrum analyzing system
The measurement throughput and the precision in sample identification are improved in a tandem type mass spectrograph. Thus, in a mass spectrum analyzing system utilizing a tandem type mass...
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6906320 |
Mass spectrometry data analysis techniques
The present invention features mass spectrometry data analysis techniques that can be employed to selectively identify analytes differing in abundance between different sample sets. The employed...
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6905879 |
Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry
Arginine-containing cysteine-modifying compounds useful for MALDI-MS analysis of proteins are provided. These compounds termed isotope-coded ionization enhancement reagents (ICIER) can provide...
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6902938 |
Chemical analysis method for multiplexed samples
Analyzing a plurality of fluid specimens with a single analyzing instrument comprising introducing different combinations of specimens into a homogenizing volume to create a homogenized specimen...
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6902936 |
Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures
The method of the invention provides novel compounds, termed acid-labile isotope-coded extractants (ALICE), for quantitative mass spectrometric analysis of protein mixtures. The compounds contain a...
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6900061 |
MALDI plate and process for making a MALDI plate
A sample plate for a MALDI process is provided which comprises an electrically conductive substrate having a hydrophobic coating whose thickness and hydrophobic character can be modified by...
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6890722 |
HP biopolymer markers predictive of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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6887713 |
Bioactive chip mass spectrometry
The present invention is directed to a bioactive probe or chip (BC) that allows for the isolation of analytes, such as biomolecules, followed by modification or bioreaction on these said analytes....
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6881588 |
Fluid treatment device
A fluid treatment device is disclosed for mixing first and second fluids. The first fluid may be a treatment liquid that is contained in a container and that is used to change a property, such as...
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6875616 |
Process for determining the status of an organism by peptide measurement
A method for detecting the condition of an organism through the measurement of peptides from a sample of said organism containing high- and low-molecular weight peptides, as an indication of the...
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6875618 |
Method for phosphorus quantitation
A method of detecting and measuring phosphorus in samples is disclosed. The measurement of phosphorylation is made with an inductively coupled plasma mass spectrometer (ICP-MS), coupled to a...
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6872575 |
Affinity selected signature peptides for protein identification and quantification
A method for protein identification in complex mixtures that utilizes affinity selection of constituent proteolytic peptide fragments unique to a protein analyte. These “signature peptides”...
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6869803 |
Method to quantitatively analyze conjugated dienes in hydrocarbon feeds and products as an indicator of fouling potential
A method to quantify the conjugated dienes in a feedstream including the steps of dissolving 4-methyl-1,2,4-trazoline-3,5-dione (MTAD) in said feedstream, and determining the molar concentration of...
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6864098 |
Quantitative MALDI-time of flight mass spectrometry of peptides and proteins
A method of quantitatively analyzing a sample analyte involves performing matrix-assisted laser desorption ionization mass spectrometry on the sample analyte and an internal standard, and comparing...
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6864091 |
Sampling probe
A sampling probe for delivering a reactant to a substance deposited on a substrate to form a reaction product and for transporting the reaction product to a product analyzer for analysis. The probe...
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6864089 |
Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing
This invention related to methods useful in the labeling of multiple polypeptide samples and subsequent analysis of these samples by mass spectrometry, particularly in the high throughput proteomic...
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6861647 |
Method and apparatus for mass spectrometric analysis of samples
An MALDI mass spectrometer for the composition analysis of large batch sizes of samples includes a mass spectrometer having an ionization chamber and a sample chamber coupled to the ionization...
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6858435 |
Method and system for peak parking in liquid chromatography-mass spectrometer (LC-MS) analysis
A reconfigurable multi-mode post-column analysis system improves resolution of liquid chromatography detection data by providing a parking or MS/MS detection mode in which flow of column eluent is...
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6846679 |
Characterizing polypeptides through cleavage and mass spectrometry
Provided is a method for characterizing a polypeptide or a population of polypeptides, which method comprises: (a) contacting a sample comprising one or more polypeptides with a first cleavage...
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6844199 |
Direct detection of bacteria-antibody complexes via UV resonance Raman spectroscopy
A system for the detection of bacteria based on bacteria-antibody complexes. Bacteria attached to antibody are detected with resonance Raman spectroscopy. The bacteria are detected directly in a...
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6841773 |
Portable time-of-flight mass spectrometer system
A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The...
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6835572 |
Magnetic resonance spectroscopy of breast biopsy to determine pathology, vascularization and nodal involvement
Robust classification methods analyse magnetic resonance spectroscopy (MRS) data (spectra) of fine needle aspirates taken from breast tumours. The resultant data when compared with the...
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6825045 |
System and method of infrared matrix-assisted laser desorption/ionization mass spectrometry in polyacrylamide gels
A system and method for desorption and ionization of analytes in an ablation medium. In one embodiment, the method includes the steps of preparing a sample having analytes in a medium including at...
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6821784 |
Method of diagnosing colorectal adenomas and cancer using proton magnetic resonance spectroscopy
Two dimensional COSY magnetic resonance spectroscopy of human stool can be used in a non-invasive method of detecting the presence of colorectal cancer. The spectrum of a patient's stool is...
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6818112 |
Protein separation via multidimensional electrophoresis
The present method provides methods and apparatus for separating proteins using a series of electrophoretic methods that utilize controlled fractionation and labeling techniques to resolve mixtures...
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6818202 |
Enhancement of NMR and MRI in the presence of hyperpolarized noble gases
The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which...
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6818454 |
Phosphoprotein binding agents and methods of their use
The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified...
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6815212 |
Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
Methods are provided for detecting the binding of a first member to a second member of a ligand pair, comprising the steps of (a) combining a set of first tagged members with a biological sample...
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6815213 |
Method for analyzing a sample of a complex molecule relatively to a reference batch of the same complex molecule
The invention concerns a method for analyzing a sample of a complex molecule relatively to a reference batch of the same complex molecule. Said method is characterized in that it consists in...
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6815214 |
Pharmaceutical uses and synthesis of diketopiperazines
The synthesis of novel diketopiperazines, their use in inhibiting cellular events such as those involving NFK-α, NFK-β and in the treatment of inflammation events, a combinatorial library of...
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6811977 |
Rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping
The invention provides methods of identifying one or more nucleic acids in a sample. The nucleic acids, for example, expressed genes in a cell, can be identified by contacting the nucleic acids...
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6808933 |
Methods of enhancing confidence in assays for analytes
Methods are disclosed for enhancing the confidence index in detecting the presence and/or amount of an analyte suspected of being in a sample. In the method, a combination of at least two...
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6806090 |
Process for quality control and standardization of medicinal plant products
A process for establishing a standard specification for a medicinal plant material comprises: (i) preparing a test solution or test extract of a sample of the medicinal plant material which is...
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6800489 |
Electrospray tandem mass spectrometry of transition metal diimine complexes of amino acids, α-hydroxyketones and hexose phosphates for newborn screening
Tandem mass spectrometry (MS/MS) has been used extensively for solving various biological problems, such as structure identification of oligopeptides, nucleic acids, and nucleotides. One of the...
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6800449 |
High throughput functional proteomics
A method is disclosed which provides a high throughput method for assigning plausible functions to unknown sequence entries in a particular database. The method was used herein to identify lectin...
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6797516 |
Mass spectrometric screening of catalysts
Screening methods to identify catalysts or to identify improved catalysts using mass spectrometric analysis of products of catalysis, particularly catalyst-bound intermediate products in the...
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6797256 |
Composition for determining pyrimidine metabolizing activity
The present invention provide a method for assessing the sensitivity to a pyrimidine drug such as 5-FU which is degraded in the pyrimidine metabolic pathway, specifically in vivo pyrimidine...
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6797482 |
Methods for the high-resolution identification of solvent-accessible amide hydrogens in protein binding sites
The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The...
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6790673 |
Speciated isotope dilution mass spectrometry of reactive species and related methods
A method of speciated isotope dilution mass spectrometry (SIDMS) which will permit determination of concentrations of one or more species from a sample even if the sample has been subjected to...
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6783751 |
Method for labeling biopolymers using isotopes
The invention relates to a novel method for the in-vivo labeling of biopolymers such as proteins, nucleic acids, lipids, carbohydrates and biodegradable plastic using isotopes, especially stabile...
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6770486 |
Optimization of ligand affinity for RNA targets using mass spectrometry
The present invention provides methods for the identification ligand compounds that bind to target molecules such as proteins or structured RNA with as little as millimolar (mM) affinity using mass...
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6767715 |
Nitroso compounds and their use as spin traps
A compound of the formula wherein X is Cl or CH 3 , or a salt thereof, is useful as a spin trap in various assays.
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