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7144738 |
Materials for enhancing staining of biopolymers in matrices
Methods for detecting biopolymers such as proteins, peptides, and nucleic acids in a matrix are provided, in which the methods include contacting the matrix with a sensitizing reagent that includes...
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7141432 |
Method of using reduced dimensionality nuclear magnetic resonance spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins
The present invention discloses eight new reduced dimensionality (RD) triple resonance nuclear magnetic resonance (NMR) experiments for measuring chemical shift values of certain nuclei in a...
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7132295 |
Isotopically coded affinity markers 3
This application relates to isotopically labeled affinity markers of the formula (II)
for mass spectrometric analysis of proteins. In formula (II), the groups A, PRG, S, Z, L', Z', R, R',...
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7132244 |
Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7127092 |
Reduction of motion artifact in NMR images using spherical navigator signals
A series of fMRI image frames are acquired along with interleaved navigator signals. The navigator signals are acquired while three orthogonal readout gradients are applied such that a spherical...
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7125721 |
Method and apparatus for rapid fat content determination
A sample for NMR measurement of moisture and fat and oil contents is disclosed. The sample includes an organic portion containing at least some fats and oils, a pad that is substantially...
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7125965 |
MRI probes of membrane potential
The invention provides methods and compositions for molecular resonance imaging of membrane potential. The compositions comprise an indicator moiety attached through an optional linker to a...
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7125678 |
Protein biopolymer markers predictive of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7122327 |
Biopolymer markers indicative of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7122379 |
Determining the reaction progress of graft polymerization reactions
A method of using Raman Spectra for determining the progress of a graft polymerization reaction is disclosed. The method entails (a) measuring at the beginning of the reaction and at a plurality of...
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7122323 |
Apparatus and method for synthesizing combinatorial libraries
An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library...
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RE39353 |
Mass spectrometer system and method for matrix-assisted laser desorption measurements
The system for analyzing multiple samples includes a plurality of portable of sample supports each for accommodating a plurality of samples thereon, and an identification mechanism for identifying...
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7112453 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7109038 |
Occult blood detection in biological samples by laser desorption and matrix-assisted laser desorption/ionization mass spectrometry for biomedical applications
Methods are described for detecting and quantifying occult blood in a biological sample using laser desorption mass spectrometry (LD MS). Biological samples that can be analyzed using various...
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7108985 |
Methods and kits useful for the simplification of complex peptide mixtures
Methods and reagents for obtaining simplified mixtures of peptides from a sample containing a number of peptides are disclosed. The simplified sample can be easier to analyze than the original...
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7109040 |
Modular isotope coding approach to proteomic analysis
The present invention provides methods for analyzing a peptide or peptides of interest in a protein sample using a combination of a relatively generic isotope tag with a decoupled selection...
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7101718 |
Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation...
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7097989 |
Complement C3 precursor biopolymer markers predictive of type II diabetes
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7094549 |
Fibronectin biopolymer marker indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time- of-flight detection procedures to maximize the diversity of biopolymers...
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7091046 |
Multiplexed protein expression and activity assay
A system for analyzing expression levels and activity of a plurality of proteins is provided. A bio-displayed polypeptide binding component associated with a predetermined marker is used to bind...
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7090975 |
Pyrophosphorolysis and incorporation of nucleotide method for nucleic acid detection
Processes are disclosed using the depolymerization of a nucleic acid hybrid and incorporation of a suitable nucleotide to qualitatively and quantitatively analyze for the presence of predetermined...
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7087436 |
Membrane countercurrent exchanger and membrane inlet mass spectrometer for the analysis of gas partial pressure in liquid samples
A method and apparatus for the analysis of blood or other liquids by mass spectrometry to determine the partial pressures of gases and other volatile substances dissolved in the blood or other...
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7081366 |
Uniform bead dosing from a stable dispersion
A primary antibody bead suspension for an enzyme-linked immunoassay (“ELISA”) procedure is formed of a quantity of primary antibody coated magnetic beads ( 3 ) uniformly dispersed and held in...
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7076383 |
Method of resonance spectroscopy for the analysis of statistical properties of samples
The invention refers to a method of resonance spectroscopy for the analysis of statistical properties of samples, comprising the following steps: a) recording of a complex resonance frequency...
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7071003 |
Surface-enhanced laser desorption/Ionization for desorption and detection of analytes
This invention is directed to probes that are removably insertable into mass spectrometers. The probes have sample presenting surfaces, at least, that contain non-metallic materials. The probes are...
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7071000 |
Method for sampling reaction products
A method for sampling reaction products includes delivering a reactant through a sampling probe to contact a substance deposited on a substrate and reacting the reactant to form a reaction product....
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7063982 |
Process of vaporizing and reacting a liquid feed
A process for evaporating a liquid feed and reacting said feed in the presence of catalyst to make product within a reactor having both an evaporation zone and a reaction zone comprises the steps...
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7052916 |
Polypeptide analyses using stable isotope labeling
Methods for incorporating a stable isotope into a protein or peptide fragment are disclosed. The methods include providing isolated isotope-labeled protein or peptide fragments and analyzing the...
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7052915 |
Selective labeling and isolation of phosphopeptides and applications to proteome analysis
A method for selective labeling of phosphate groups in natural and synthetic oligomers and polymers in the presence of chemically related groups such as carboxylic acid groups. The method is...
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7052914 |
Automated method for examining catalytic and spectroscopic properties of the components of combinatorial libraries
The invention relates to an automated method for carrying out reactions with high spatial resolution on libraries of different materials and for analysis of the products obtained using a simple...
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7052849 |
Protein biopolymer markers predictive of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7053366 |
Desalting plate for MALDI mass spectrometry
A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample...
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7053365 |
Chromatograph mass spectrometric apparatus and method of calibrating the same
First, normal calibration is executed by introducing a standards sample to an MS portion, thereafter, an adjusting sample is introduced to a GC portion, and a mass spectrum is acquired by executing...
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7049149 |
Biological marker for stress states
The object of the invention is to propose a novel biomarker for stress states, which biomarker is highly meaningful and capable of enabling quantitative measurements to be made of stress levels. To...
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7046357 |
Apparatus for microfluidic processing and reading of biochip arrays
A method and a device for detecting an analyte, including a substrate having a chemically selective surface; and a fluidic system disposed on the substrate, the manifold having at least one fluid...
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7045296 |
Process for analyzing protein samples
Methods using gel electrophoresis and mass spectrometry for the rapid, quantitative analysis of proteins or protein function in mixtures of proteins derived from two or more samples in one unit...
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7038036 |
Oligonucleotides labeled with stable isotopes and a method for detecting the same
Antisense oligonucleotide sequences which enable the measurement of the distribution and structure of antisense oligonucleotide drugs in the body, with lapse of time, and a method of detecting...
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7033841 |
Process and compounds for use in detecting analytes by measurement of residual magnetism, and the use of the said compounds
The invention relates to a process for quantitative detection of analytes in liquid and solid phases with the aid of binding remanence measurement, compounds that are suitable for this purpose, and...
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7028537 |
Coupling electrochemistry to mass spectrometry and high performance liquid chromatography
A hyphenated technique based on the combination of high performance liquid chromatography (HPLC), electrochemical (coulometric) oxidation (EC) and electrospray ionization (ESI)- or atmospheric...
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7026167 |
Systems and methods for the analysis of protein phosphorylation
The present invention relates to a method of applying mass spectrometry to analyzing peptides or proteins, especially in the proteome setting. More particularly, the invention relates to a mass...
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7026129 |
IG lambda biopolymer markers predictive of Alzheimers disease
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7022491 |
Method for determining molecule—molecule interaction analysis
The invention relates to a method for monitoring interactions to a target biomolecule comprising the steps of: providing a biomolecule of interest having specificity for the target biomolecule;...
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7015044 |
Diagnostic for early stage Alzheimer's disease
A method for diagnosing Alzheimer's disease even at early stages by assessing the levels of sulfatides or its metabolites in biological fluids is disclosed.
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7015004 |
Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7011977 |
Quantification of carnitine levels in dialysis patients
Disclosed herein are methods for diagnosing carnitine deficiency in patients and quantifying that deficiency such that carnitine concentrations can be easily and accurately tracked within a given...
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7008800 |
Biopolymer marker indicative of disease state having a molecular weight of 1077 daltons
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7001738 |
Method for assaying protein nitrosylation
Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain...
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6979574 |
Process for detecting binding reactions with use of the measurement of the relaxation of the double refraction of magnetic particles
The invention relates to a new process for detecting analytes or binding reactions using measurement of the double refraction, as well as the use of the compounds in analytical chemistry that are...
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6977370 |
Off-resonance mid-IR laser desorption ionization
Methods for producing a preponderance of gas phase ions having higher order charge states during laser desorption ionization of an analyte are presented, the methods comprising irradiating the...
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6963807 |
Automated identification of peptides
A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a...
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