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7316931 |
Mass defect labeling for the determination of oligomer sequences
Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for...
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7309608 |
Method of analysis of aldehyde and ketone by mass spectrometry
A method of identification and quantitative analysis of aldehydes and/or ketones in a sample by mass spectrometry using stable isotope labeled oxime internal standards or stable isotope labeled...
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7309858 |
Method and apparatus for de-convoluting a convoluted spectrum
Embodiments of the present invention relate to methods, systems, and apparatus suitable for performing a survey scan of one or more analytes or labeled fragments of analytes to obtain a convoluted...
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7306953 |
Detection of disease by analysis of emissions
A method of determining the cause of disease is described, which method uses the detection of “signature” or “fingerprint” volatile compounds in an emission, especially flatus, from a patient.
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7306952 |
Molecular fingerprinting of triglycerides in biological samples by electrospray ionization tandem mass spectrometry
A method for determination of at least one of the triglyceride molecular species in a biological sample comprising the subjecting sample to lipid extraction to obtain a lipid extract and subjecting...
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7297547 |
Analysis of metals in acidic solutions
In one embodiment, a method of neutralizing the matrix of an acidic solution including at least one metal using a weak anion exchange resin is provided. The method includes the acts of: activating...
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7299134 |
Method for correlating gene expression profiles with protein expression profiles
The present invention relates to methods for correlating gene and protein expression in a cell.
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7297940 |
Method, apparatus, and program product for classifying ionized molecular fragments
Apparatus, methods, and program products are disclosed that classify spectral peaks in dissociation spectrum data and thereby improves the efficiency of molecular sequencing.
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7291476 |
O-acetyltranferases
A post-translational modification of a predetermined protein expressed by a cell is detected by specifically detecting an O-acetylation of a serine, threonine or tyrosine residue of the protein as...
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7288411 |
Process for simultaneously evaluating a plurality of catalysts
A process for simultaneously testing a plurality of catalysts using combinatorial chemistry has been developed. The process involves containing the plurality of catalysts in an array of parallel...
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7287391 |
Automated modular hyperpolarizers and related devices and methods
Modular expandable hyperpolarizers include a central control module and at least one optical pumping module that can be expandable to a plurality of optical pumping modules that can be separately...
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7287390 |
Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems and related devices and methods
Hyperpolarizers for producing polarized noble gases can include: (a) a control module configured to direct the operation of a hyperpolarizer to produce polarized noble gas via spin-exchange...
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7285422 |
Systems and methods for preparing and analyzing low volume analyte array elements
The invention provides methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or...
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7276381 |
Monomers and polymers having energy absorbing moieties of use in desorption/ionization of analytes
The present invention provides polymerizable monomers that incorporate moieties derived from energy absorbing molecules (EAM). The invention also provides polymers that are based on the monomers....
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7277807 |
Method for processing a set of spectra, particularly NMR spectra
A method for processing a set of spectra, particularly NMR spectra, by selecting a principle spectral range, recording a plurality of principle spectra in the principal spectral range, obtaining a...
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7276378 |
Increasing ionization efficiency in mass spectrometry
A system for the analysis of polyionic molecules by mass spectrometry is provided. The polyionic molecule is attached to a charged tag which neutralizes some of the charge on the polyionic analyte....
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7273588 |
Methods of sampling halosilanes for metal analytes
Methods for determining the amount of at least one metal analyte present in a liquid or gas sample of a halosilane supply (e.g., a chlorosilane supply) are disclosed herein. A sample of a...
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7267796 |
Preparative liquid chromatograph using plural detectors
The preparative liquid chromatograph uses a plurality of detectors including a mass spectrometer, and a chromatogram generator is provided for generating a plurality of chromatograms each...
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7267994 |
Element-coded affinity tags
The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a...
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7259018 |
Ion mobility analysis of lipoproteins
A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation...
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7256047 |
Measurement of gluconeogenesis and intermediary metabolism using stable isotopes
The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a...
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7250306 |
Method for distinguishing between protein variants
Disclosed is a method for distinguishing between protein variants using high field asymmetric waveform ion mobility spectrometry (FAIMS). A method according to the instant invention includes the...
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7250304 |
Functional assay of high-density lipoprotein
This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components...
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7247495 |
Mass spectrometer method and apparatus for analyzing a sample in a solution
The invention provides a mass spectrometric method for analyzing a sample in a solution, including the steps of directing a flow of a solution containing sample compounds to be analyzed towards a...
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7235361 |
Biological applications of quantum dots
The present invention provides a composition comprising fluorescent semiconductor nanocrystals associated to a compound, wherein the nanocrystals have a characteristic spectral emission, wherein...
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7235368 |
CHP for use as marker for sepsis-type inflammatory diseases
Use of calcineurin B homologous protein (CHP) from body fluids or body tissues as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or...
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7232992 |
Charged droplet sprayers
Charged droplet spray is formed from a solution with all or a portion of the charged droplet spray current generated from reduction or oxidation (redox) reactions occurring on surfaces removed from...
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7230235 |
Automatic detection of quality spectra
The present application provides systems and/or methods for accessing a portion of a mass-fragment spectrum, constructing a vector that is responsive to an intensity-balance of the spectrum, and...
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7229834 |
Method for interpreting tandem mass spectrometry data for clinical diagnosis
A method for interpreting data that is produced after a group of amino acids and acylcarnitines are derivatized from blood spots taken from newborn babies and scanned by a tandem mass spectrometer....
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7229832 |
Heat activated membrane introduction apparatus and method for screening materials
A process and apparatus for rapidly screening materials using, for example, mass spectrometry has been developed. More specifically, an array of materials on a fluid permeable support contained...
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7220383 |
Method and instrument for automated analysis of fluid-based processing systems
An analytical apparatus to monitor fluid systems has at least one extraction module having a raw-sample reservoir connected by input fluid conduit to individual ones of said fluid systems, to...
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7220591 |
Method and apparatus for rapid fat content determination
A method and apparatus for rapidly and accurately determining the fat and oil content of a sample using microwave drying and NMR analysis is disclosed. The method and apparatus incorporate a low...
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7214353 |
Peptide or protein-capturing surfaces for high throughput MALDI mass spectrometry
Methods and compositions useful for capturing proteins or peptides from a sample mixture and analyzing the captured proteins or peptides via high throughput electrospray ionization (ESI) or...
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7211376 |
Polypeptide fingerprinting methods
The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.
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7202093 |
Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds
Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated...
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7192781 |
Methods for stabilizing 5-azacytidine in plasma
The invention provides methods for stabilizing 5-azacytidine against hydrolysis in plasma. By extracting the 5-azacytidine into acetonitrile and zinc sulfate, the 5-azacytidine can be stored for at...
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7192779 |
Diagnosis of Smith-Lemli-Optiz syndrome
The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3)...
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7188033 |
Method and system of computing and rendering the nature of the chemical bond of hydrogen-type molecules and molecular ions
Provided is a system of computing and rendering a nature of a chemical bond based on physical, Maxwellian solutions of charge, mass, and current density functions of hydrogen-type molecules and...
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7184813 |
Method and apparatus for improved metabolite signal separation in MR spectroscopy
A technique is set forth for MR spectroscopy that is capable of reducing signal overlap between metabolite signals for improved clinical analysis of metabolite content. The technique includes...
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7183116 |
Methods for isolation and labeling of sample molecules
The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more...
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7183118 |
Methods for quantitative proteome analysis of glycoproteins
The invention provides a method for identifying and quantifying polyglycopeptides in a sample. The method can include the steps of immobilizing glycopolypeptides to a solid support; cleaving the...
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7179655 |
Protein profiling platform
Methods and compositions are described for analyzing complex protein mixtures, such as proteomes, using activity-based probes. In particular, probes that specifically react with and bind to the...
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7181348 |
Automatic identification of compounds in a sample mixture by means of NMR spectroscopy
A computer implemented process for producing a representation of a reference spectrum for a hypothetical solution having a first pH condition, for use in determining the composition of a test...
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7179606 |
IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7179610 |
Complement C3 precursor biopolymer markers indicative of insulin resistance
The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers...
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7166474 |
Method for the ESR-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing samples, ESR-spectrometer for carrying out said method, and use of the method for diagnostic purposes and for controlling albumin-containing preparations
The invention relates to method for the ESR-spectroscopic detection of changes in the transport properties of albumin in an albumin-containing sample. Said method can be used in the medical,...
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7166437 |
Measurement of elastic fiber breakdown products in sputum
The subject invention is directed to the measurement of elastic fiber breakdown products in human sputum obtained from patients with emphysema and other lung diseases. Measurement of elastic fiber...
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7167819 |
Method of determining the three-dimensional shape of a macromolecule
The present invention provides a fast and efficient method for determining the three-dimensional conformation of a protein. The steps of the method of the invention include: 1) formation of...
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7158862 |
Method and system for mining mass spectral data
A method, system, and computer program product for mining mass spectral data to detect chemical-specific characteristic features in large databases and/or files, including specifying spectral...
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7153694 |
Quantitative method for hydrocarbon analysis
A method for quantitative determination of hydrocarbon species in a hydrocarbon sample is disclosed. The method uses Townsend Discharge Nitric Oxide Chemical Ionization Gas Chromatography/Mass...
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