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7442556 |
Microfluidic-based electrospray source for analytical devices with a rotary fluid flow channel for sample preparation
This invention provides microfluidic devices and methods for using the same. Microfluidic devices of the present invention comprises a first elastic layer, a fluid flow channel within the elastic...
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7439074 |
Method of analysis of alcohol by mass spectrometry
Method of identification and quantitative analysis of alcohol(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by...
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7435385 |
Label-free high-throughput optical technique for detecting biomolecular interactions
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7429727 |
Method, apparatus, and program product for quickly selecting complex molecules from a data base of molecules
The disclosed technology relates to the analysis of dissociation spectrum data that includes spectral peaks that represent fragments of a parent ion. The parent ion includes molecular subunits that...
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7419830 |
Plural reaction chamber catalytic testing device and method for its use in catalyst testing
A catalytic testing device comprising
a reaction block comprising a set of reaction chambers, each chamber comprising a fluid inlet and outlet connected to an outgoing fluid duct connected...
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7416900 |
Sample introduction system
A sample introduction system includes at least two, and preferably three, syringe pumps. The flow rates of two of the syringe pumps are varied, while keeping the overall flow rate constant. The...
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7413906 |
Quantitative, high-throughput screening method for protein stability
In proteomic research, it is often necessary to screen a large number of polypeptides for the presence of stable structure. Described herein are methods (referred to as MALDI MS-HX and SUPREX) for...
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7413907 |
Carbon nanotubes and their derivatives as matrix elements for the matrix-assisted laser desorption mass spectrometry of biomolecules and sequencing using associated fragmentation
The present invention is directed toward novel matrix elements, generally comprising functionalized carbon nanotubes, for matrix-assisted laser desorption ionization (MALDI)-mass spectroscopy (MS),...
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7409296 |
System and method for scoring peptide matches
The present invention relates to a system and method for scoring peptide matches. Embodiments of the present invention improves identification of peptides and proteins by introducing an appropriate...
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7402438 |
Automated identification of carbohydrates in mass spectra
Disclosed is a computerized method for identifying peaks corresponding to glycans from a mass spectrum. At least one glycan spectrum is received from a mass spectrometer, with each glycan spectrum...
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7402437 |
Method and device for analyzing the intracellular chemical state of living cells by nuclear magnetic resonance
The invention concerns a method for analysing the intracellular chemical state of living cells by nuclear magnetic resonance (NMR). Said method comprises a step which consists in preparing the cell...
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7399640 |
Structured biosample support plates for mass spectroscopic analyses and procedures for use
The invention relates to sample support plates with hydrophilic anchors in a strongly hydrophobic environment for mass spectroscopic analysis of biosubstances with ionization by matrix-assisted...
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7399641 |
Mass spectrometric immunoassay
Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for...
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7396688 |
Mass spectrometric analysis of biopolymers
The present invention makes use of unique tags of a specific biopolymer that can be exploited for determining the concentration the biopolymer in crude solutions. In preferred embodiments the...
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7397026 |
Efficient electron transfer dissociation for mass spectrometry
The present invention relates to, inter alia, methods and apparatuses for electron transfer dissociation (ETD) that vary the internal energy of precursor ions for ETD. The methods and apparatuses...
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7396685 |
Phase sensitively-detected reduced dimensionality nuclear magnetic resonance spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins
The present invention discloses eleven reduced dimensionality (RD) triple resonance nuclear magnetic resonance (NMR) experiments for measuring chemical shift values of certain nuclei in a protein...
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7396686 |
Biopolymer sequences by MALDI granddaughter ion spectra
The invention relates to the acquisition of spectra of biopolymers, especially of proteins, in tandem mass spectrometers with ionization using matrix-assisted laser desorption (MALDI) for the...
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7396687 |
Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids
Presented herein is the construction of pipettor tips (termed MSIA-Tips) containing porous solid supports that are constructed, covalently derivatized with affinity ligand, and used to extract...
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7395160 |
Quality assurance/quality control for electrospray ionization processes
The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing...
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7390672 |
Matrix-assisted laser desorption ionization mass spectrometry substrates having low volume matrix array elements
Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte.
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7390671 |
Method of selective excitation for improving contrast in magnetic resonance imaging
A method of magnetic resonance analysis of at least one type of molecules present in a solvent, the method comprises (a) applying a first radiofrequency pulse sequence selected so as to initially...
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7387880 |
Method for monitoring resting and activated platelets in unfixed blood samples
The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the...
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7385395 |
Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis
The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which...
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7385185 |
Molecular activation for tandem mass spectroscopy
In a tandem mass spectrometer means are provided for molecular activation of ions prior to fragmentation. An embodiment of a tandem mass spectrometer comprises a first collision cell receiving...
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7381568 |
Mass defect filter
A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species....
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7377894 |
Methods for creating a compound library and identifying lead chemical templates and ligands for target molecules
A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for...
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7374942 |
Process and apparatus for the combinatorial production and testing of catalyst material libraries by using at least two analytical methods
A process and apparatus for testing material libraries, in particular catalysts, by means of coupled use of at least two analytical methods, preferably IR thermography and mass spectrometry. Owing...
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7364913 |
Direct flow injection analysis nebulization electrospray and APCI mass spectrometry
A method and apparatus for Flow Injection Analysis (FIA) into Atmospheric Pressure Ion sources (API) including Electrospray (ES) and Atmospheric Pressure Chemical Ionization (APCI) sources whereby...
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7365311 |
Alignment of mass spectrometry data
Methods, systems and mediums are disclosed for aligning mass spectrometry data before the analysis of the mass spectrometry data. The mass spectrometry data may be received from a mass spectrometry...
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7364911 |
Methods for isolating and labeling sample molecules
The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more...
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7364919 |
Nanoparticles
Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or...
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7359574 |
System for optimizing alignment of laser beam with selected points on samples in maldi mass spectrometer
A mass spectrometry apparatus uses image processing of output signals of a camera in a mass spectrometer to provide feedback for directing the laser. The present invention provides for the...
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7358092 |
Method for the determination of 25-hydroxycholecalciferol in feed
A method for quantitative determination of 25-hydroxycholecalciferol in feed is described. The method includes the steps of adding a defined amount of an internal standard which has a mass...
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7357917 |
Diagnostic procedures using 129Xe spectroscopy characterstic chemical shift to detect pathology in vivo
An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized 129 Xe spectroscopy is disclosed. Generally stated, the method includes determining the...
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7351590 |
Methods and compositions for directed microwave chemistry
The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to...
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7351402 |
Polarizing agents for dynamic nuclear polarization
We describe polarizing agents for use in enhancing NMR and MRI signals via dynamic nuclear polarization (DNP). The polarizing agents include two or more paramagnetic centers, preferably two...
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7348182 |
Directed microwave chemistry
The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that...
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7341874 |
Method for detecting post-translation modifications of peptides
This invention provides for novel methods of identifying covalent modifications of an amino acid residue in a polypeptide chain by detecting mass differences.
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7335511 |
Magnetic resonance spectroscopy to classify tissue
Robust classification methods analyze magnetic resonance spectroscopy (MRS) data (spectra) of fine needle aspirates taken from breast tumors. The resultant data when compared with the...
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7333896 |
Quality assurance/quality control for high throughput bioassay process
The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing...
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7332613 |
Capture and release based isotope tagged peptides and methods for using the same
The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for...
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7332296 |
Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry
The invention provides methods for quantifying enzymatic activity of an enzyme with a known substrate. The methods employ SELDI-TOF mass spectrometry, and are suitable, in particular, for assaying...
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7332275 |
Methods for detecting methylated nucleotides
A method for detecting methylated nucleotides within a nucleic acid sample is provided. The method includes the steps of splitting a nucleic acid sample into separate reaction vessels; contacting...
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7332345 |
Chemical sensor system
A chemical sensing apparatus and method for the detection of sub parts-per-trillion concentrations of molecules in a sample by optimizing electron utilization in the formation of negative ions is...
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7329484 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7326926 |
Corona discharge ionization sources for mass spectrometric and ion mobility spectrometric analysis of gas-phase chemical species
A corona discharge mass spectrometer or an ion mobility spectrometer is provided with a robust corona discharge ionization source. The corona discharge ionization source, which can be operated at...
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7323341 |
Stable isotopic identification and method for identifying products by isotopic concentration
A stable isotopic identification comprising a mathematical array of concentrations of isotopes found in a product, said mathematical array being presented in a machine readable form and comparable...
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7323344 |
Method of measuring the concentration of hydrogen and methane in nitrogen by ion mobility spectrometry
A method is provided for the quantitative analysis of the contents, in nitrogen, of hydrogen and methane by ionic mobility spectrometry. The method includes the steps of: a) performing a...
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7319040 |
Process control using on-line instrumentation and process models
A method for providing improved estimates of properties of a chemical manufacturing process is disclosed. The method employs a process model that includes, or is modified by, scores or other gains...
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7316931 |
Mass defect labeling for the determination of oligomer sequences
Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for...
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