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5055288 |
Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable...
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5055389 |
Detection of appendicitis by measurement of uroerythrin
Appendicitis can be detected by determining a threshold presence of the urinary pigment uroerythrin, in the urine of persons suspected of having appendicitis. The threshold presence of uroerythrin...
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5053215 |
NMR-assayable ligand-labelled trifluorothymidine containing composition and method for diagnosis of HSV infection
A method for diagnosing HSV infections in human or non-human patients which involves intravenously administering to the patient a non-invasively assayable ligand-labelled anti-viral drug, wherein...
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5053343 |
Selective ionization of gas constituents using electrolytic reactions
An ion mobility spectrometer, ionization detector and mass spectrometer is described having a reaction region, and a region for introducing a sample gas, liquid or solid samples into the reaction...
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5045304 |
Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
A method and contrast agent for magnetic resonance imaging (MRI) of abscess. Granulocytes are separated from whole blood and incubated with an imaging vehicle such as magnetite. The granulocytes...
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5042488 |
Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
A method for in vivo and in situ NMR imaging of body organs or tissues employing direct, observable deuterium magnetic resonance images.
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5039512 |
NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes
In a method of imaging body tissue in a patient, comprising administering to the patient an effective amount of a pharmaceutical agent for effecting the relaxation times of atoms in body tissues...
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5036014 |
Deuterated cannabinoids as standards for the analysis of tetrahydrocannabinol and its metabolites in biological fluids
New internal standards for use in gas chromatography/mass spectrometry test methods, comprising deuterated cannabinoids, have been developed for the analysis of tetrahydrocannabinol and its...
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5023072 |
Paramagnetic/superparamagnetic/ferromagnetic sucrose sulfate compositions for magnetic resonance imaging of the gastrointestinal tract
The disclosure is directed to a sucrose sulfate composition useful for magnetic resonance imaging of the gastrointestinal tract. Paramagnetic/superparamagnetic/ferromagnetic ions or particles are...
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5023185 |
Method for determining resolution power or discrimination capacity of an NMR imaging apparatus
A phantom for diagnosis by nuclear magnetic resonance imaging comprises a container made of a synthetic resin and a hydrogel sealingly contained in the container. The container has at least one...
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5021236 |
Method of enhancing NMR imaging using chelated paramagnetic ions bound to biomolecules
Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic...
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5011925 |
Morpholinoamido EDTA derivatives
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with aminoalkylamide derivatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetraacetic acid...
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4996991 |
Method for following the distribution of particles in neurological or neuromuscular tissue and cells
A process for following the exact distribution of particles in living neurological or neuromuscular tissue and cells. The process includes introducing particles into the tissue and cells, and...
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4996041 |
Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system
A diagnostic imaging agent is provided for use in conjunction with a magnetic resonance imaging system for the imaging of spacial oxygen distribution in tissue. The imaging agent is comprised of a...
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4994259 |
Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
Manganese(II) chelates of N,N'-bis-(pyridoxal)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N'-diacetic acids,...
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4988628 |
Method of drug detection
Disclosed are methods of rapidly and accurately detecting a compound-of interest, such as a toxic drug, in a body fluid. A liquid sample containing various native constituents and an anticipated...
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4986256 |
Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging
Water-soluble paramagnetic metalloporphyrins are used as contrast enhancing agents for magnetic resonance imaging. These agents exhibit excellent localization, non-toxicity and suprisingly high...
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4986980 |
Water-soluble, carrier-bound paramagnetic metal containing diagnostic agents
There is disclosed a diagnostic agent containing a non-radioactive paramagnetic metal species which agent comprises a physiologically tolerable, water-soluble, hydroxyl group-containing...
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4985233 |
A diagnostic agent containing a non-radioactive paramagnetic metal species in a macromolecular carrier
A paramagnetic metal species-containing diagnostic agent is disclosed which comprises a non-radioactive paramagnetic metal species and, as a carrier therefor, a physiologically tolerable,...
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4984573 |
Method of electron spin resonance enhanced magnetic resonance imaging
A method of generating a magnetic resonance image of a sample comprising introducing into the sample a contrast medium comprising a paramagnetic material having an electron spin resonance...
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4983376 |
Triazamacrocyclic NMR contrast agents and methods for their use
Compositions for the enhancement of NMR contrast are disclosed which include a complex of a paramagnetic metal selected from the group consisting of gadolinium, manganese, iron, and chromium, with...
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4978852 |
Hadamard transform measurement of MSN Fourier-transform mass spectra
The simultaneous collection of multiple spectra using tandem and multidimensional mass spectrometry from multiple precursors yields correspondingly enhanced sensitivity through Hadamard transform...
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4975576 |
Method and apparatus for measuring concentrations of gas mixtures
For identifying the concentration of individual types of molecules in a gas mixture, the gas mixture to be investigated is subjected to a selective pre-treatment and the product of this...
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4973841 |
Precision ultra-sensitive trace detector for carbon-14 when it is at concentration close to that present in recent organic materials
A method of detecting the amount of C-14 in a sample, comprising the following steps: ionizing the sample to form a negative-ion beam; deflecting said beam in a magnetic field and directing the...
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4963344 |
Method to enhance NMR imaging using chelated paramagnetic ions
Agents useful for influencing the relaxation times in NMR diagnostics, contain at least one paramagnetic, physiologically compatible complex salt comprising a chelate from an open-chain or cyclic...
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4951675 |
Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images...
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4945234 |
Method and apparatus for producing an arbitrary excitation spectrum for Fourier transform mass spectrometry
A desired mass domain excitation profile is selected and converted to a frequency domain excitation spectrum in which the frequency of excitation is generally proportional to the inverse of the...
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4940658 |
Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency
Method for determining levels of sulfhydryl amino acids, particularly total homocysteine levels in samples of body tissue from warm-blooded animals, methods of detecting cobalamin and folic acid...
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4935518 |
Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof
Managanese(II) chelates of N,N'-bis-(pyridoxal)-alkylenediamine-N,N'-diacetic acids, N,N'-bis-(pyridoxal)-1,2-cycloalkylenediamine-N,N'-diacetic acids,...
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4933844 |
Measurement of blood lipoprotein constituents by analysis of data acquired from an NMR spectrometer
A method and apparatus for analyzing blood plasma to determine the concentration of its lipoprotein constituents, VLDL, LDL, HDL and proteins includes obtaining the NMR chemical shift spectrum of a...
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4933441 |
Contrast enhancing agents for magnetic resonance images
A nonionic contrast enhancing agent for magnetic resonance. In a preferred embodiment a chelating agent, for example, EDTA or DTPA, binds a metal, preferrably Gd, having at least one unpaired...
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4931639 |
Multiplication measurement of ion mass spectra
A method for increasing the signal to noise and/or the speed of data collection for obtaining a collective secondary ion spectrum from selected combinations of primary ions is disclosed. The...
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4927624 |
Clay magnetic resonance contrast agents for gastrointestinal comsumption or introduction
Contrast medium compositions for delineation of bowel during magnetic resonance imaging (MRI) of the abdomen are provided for oral or rectal administration. The compositions consist of aqueous...
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4925652 |
Nitroxyl compounds, and diagnostic media based thereon useful for enhancing NmR imaging
Diagnostic media suitable for NMR diagnoses contain compounds of Formula I ##STR1## wherein is a single bond or a double bond, X is the grouping --(CH 2 ) n -- or , if is a single bond,...
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4920264 |
Method for preparing samples for mass analysis by desorption from a frozen solution
A method is disclosed for the processing and preparation of a sample of one or more nonvolatile or thermally labile molecules for mass spectral analysis which comprises providing a solution of such...
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4918021 |
Process for the detection of cancer
A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are...
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4916313 |
Method and apparatus for the determination of isotopic composition
The invention provides a method and apparatus for the mass spectrometric determination of the isotopic composition of an element comprised in a sample by gas chromatography-isotopic ratio mass...
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4915933 |
Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy
Mixed anionic complexes of the type (MW m Y n Z p ) r - wherein M is a paramagnetic ion; W, Y, and Z are each different ligands which chelate M; and m+n+p≥2 but preferably less than 5, with the...
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4912050 |
Process for the screening of cancer using nuclear magnetic resonance
A technique is disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and...
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4909257 |
Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging
A method is provided for obtaining in vivo diferentiation of tissues in an animal by nuclear magnetic resonance imaging comprising the steps of introducing into the animal a complex comprising a...
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4902627 |
Method for detecting amine-containing drugs in body fluids by sims
A method of analyzing a sample for selected molecules which consists of reacting the molecule with a reagent that produces a charged derivative which can be desorbed and analyzed using Secondary...
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4893627 |
Method for nuclear magnetic resonance imaging using deuterum as a contrast agent
A method for in vivo NMR imaging of the blood vessels and organs of a patient characterized by using a dark dye-like imaging substance consisting essentially of a stable, high-purity concentration...
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4880007 |
Contrast agent for NMR scanning
Complexes formed between (a) an amino di- or poly-phosphonate in which phosphonate groups comprise separate carbon atoms and (b) a paramagnetic metal ion such as Gd 3 +, have calcified tissue...
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4871716 |
Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
Novel magnetically responsive hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide and particulate magnetically...
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4867963 |
Enhancement of NMR imaging of tissue by paramagnetic pyrophosphate contrast agent
Nuclear magnetic resonance imaging of animal or human tissue is enhanced when a paramagnetic pyrophosphate compound is administered intraveneously as a contrast agent. The contrast agent is...
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4863716 |
Determination of fallopian tubal patency by magnetic resonance imaging
This invention is a method for obtaining improved NMR images of the uterine cavity and fallopian tubes comprising imjecting a physiologically acceptable solution of a chelate of a parmagnetic...
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4863715 |
Method of NMK imaging using a contrast agent comprising particles of a ferromagnetic material
Ferromagnetic particles, conveniently embedded in or coated by a biotolerable polymer and held in dispersion in a physiologically acceptable dispersion medium, may be used as contrast agents in nmr...
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4863717 |
Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
Nitroxide contrast agents for MRI have a long useful life and can be administered in low concentration doses. Such agents include nitroxide-doped liposomes that encapsulate an oxidant and large...
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4859449 |
Modified antibodies for enhanced hepatocyte clearance
Antibodies and antibody conjugates which have been modified by conjugation to, or exposure thereon, of glycoside residues that bind to the human hepatic asialoglycoprotein receptor clear rapidly...
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4859451 |
Paramagnetic contrast agents for MR imaging
In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through...
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