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5217706 |
Complexes and compositions for magnetic resonance imaging
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized...
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5215680 |
Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
This invention relates to a large scale method for the production of medical grade lipid-coated microbubbles, to the paramagnetic labeling of such microbubbles and to therapeutic applications for...
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5213101 |
Process for the detection of cancer using nuclear magnetic resonance
A technique is disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and...
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5213788 |
Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for...
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5207715 |
Method of detecting cancer by measuring lipid-peroxidation using NMR
A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are...
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5208324 |
Paramagnetic compounds
There are provided paramagnetic compounds comprising a paramagnetic metal species chelated by a chelating moiety bound by an amide group to a linker group itself bound by an ester group to a...
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5200178 |
Method for tumor detection
The invention relates to a method of detecting an Fc receptor-expressing tumor site in an individual by administering to the individual a diagnostically effective amount of detectably-labeled...
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5200345 |
Methods and apparatus for quantifying tissue damage, determining tissue type, monitoring neural activity, and determining hematocrit
Tissue damage may be quantified, tissue type identified, neural activity monitored or blood hematocrit determined by measuring the difference between the total tissue sodium and potassium...
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5196348 |
Perfluoro-crown ethers in fluorine magnetic resonance spectroscopy of biopsied tissue
A method is disclosed for nuclear magnetic resonance spectroscopy wherein the improvement is the use of perfluoro 15-crown-5 ether which has 20 magnetically similar fluorine providing a superior...
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5190882 |
Method for quantitatively determining the amount of saturates, olefins, and aromatics in a mixture thereof
A quantitative method including separating a mixture of olefins, aromatics, and saturates by supercritical fluid chromatography to obtain an eluent stream that over a first time period contains a...
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5188816 |
Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
The present invention relates to a method of using a polyazamacrocyclic compound or a salt thereof to measure intracellular metal ions formula ##STR1## where x is 2, 3 or a combination of p 2(s)...
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5185267 |
Method for detecting maternally transferred drug metabolites in newborn infants
An improved method for detecting the presence of durg metabolites in the meconium of newborn infants is described. The method involves a single step extraction of the drug metabolites from meconium...
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5183045 |
NMR measuring method and measuring apparatus for tissue of a living body
There is carried out an NMR measurement in which a receiver coil (7) for receiving an NMR free induction signal comes in contact with or in close vicinity to one side of tissue of a living body (1)...
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5174987 |
Method of using iron containing preparation for NMR imaging
There is described an iron containing preparation for NMR imaging comprising, as necessary ingredients, the prescribed amounts of an iron containing compound, sodium carbonate or sodium...
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5169944 |
Methods and compositions for the enteral administration of hepatobiliary MRI contrast agents
Hepatobiliary magnetic resonance imaging of a human or animal subject is enhanced by enterally administering to the subject an effective amount of a lipophilic contrast enhancing agent....
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5169785 |
Method for detecting fuel dilution of marine lubricating oils
Vanadium in marine diesel lubricating oils resulting from raw fuel dilution is detected and quantified by way of an analytical technique employing electron spin resonance (ESR). Dilution of the...
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5162103 |
Sample holder compactor for industrial NMR analysis
A sample holder and compactor system (10), for use in an industrial NMR (or like) instrument, wherein particulate non-uniform samples can be loaded and compacted. The system comprises a tubular...
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5160726 |
Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
An improvement is provided to a method for obtaining an in vivo MR image of an organ or tissue of an animal or human subject, of the type including administering to the subject as a contrast agent...
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5160725 |
Magnetic liquid compositions
Magnetic liquid compositions are prepared from physiologically tolerated dispersions of stabilized superparamegnetic particles in water or aqueous salt solution and reactive stabilizer substances...
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5154914 |
Methods of diagnostic image analysis using lipophilic contrast agents
The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these...
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5145661 |
Method and contrast agent for use in magnetic resonance imaging of abscess
A method and contrast agent for magnetic resonance imaging (MRI) of abscesses. Granulocytes are separated from whole blood and incubated with an imaging vehicle such as polymer-coated magnetite....
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5143716 |
Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region
Methods of providing an image of the gastrointestional region of a patient and diagnosing the presence of any tumorous tissue in that region using contrast media comprising a combination of at...
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5142143 |
Method and apparatus for preconcentration for analysis purposes of trace constitutes in gases
A preconcentrator for analyzing trace constituents in gases wherein a sample gas is introduced to a confined sorbent which thereafter is evacuated by a vacuum pump and a low-pressure carrier gas...
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5137711 |
Paramagnetic DTPA and EDTA alkoxyalkylamide complexes as MRI agents
Novel magnetic resonance imaging agents methods utilize complexes of paramagnetic ions with alkoxyalkylamide deriviatives of diethylenetriaminepentaacetic acid ("DTPA") or...
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5135737 |
Amplifier molecules for enhancement of diagnosis and therapy
Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number...
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5135870 |
Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
A sample containing one or more compounds of high molecular weight is analyzed by irradiating, with a pulsed laser in vacuum, a substrate coated with a thin frozen film of a solution containing the...
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5130119 |
Method of using fluorosubstituted benzene derivatives in F-NMR imaging
Fluorosubstituted benzene derivatives of Formula I ##STR1## wherein Y, R 2 , R 3 and R 4 are defined herein, are NMR diagnostic agents.
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5128121 |
Mixture of a positive and negative contrast agent for magnetic resonance imaging
There is provided a method of generating enhanced images of the human or non-human animal body, for example for use in medical diagnosis, which involves administering to the body a positive MRI...
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5124267 |
Method for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material
The invention relates to a process for the determination of small substance quantities of medicines, of endogenous or other chemical compounds in biological material, characterized by either...
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5122472 |
Chalcogen-based chiral reagents and method for nuclear magnetic resonance detection of stereochemical assignments and enantiomeric ratios
Selenium reagents when coupled to a compound containing an asymmetric carbon atom can be used in a highly sensitive method for determination of enantiomeric purity and for stereochemical...
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5122363 |
Zeolite-enclosed transistion and rare earth metal ions as contrast agents for the gastrointestinal tract
The invention relates to a method of using zeolite enclosed paramagnetic ions as image brightening or image contrast agents. In particular, zeolite enclosed trivalent gadolinium is useful in MRI...
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5120527 |
Paramagnetic oil emulsions as MRI contrast agents
A paramagnetic oil emulsion for magnetic resonance imaging composed of about 5 to about 30 volume percent oil and about 70 to about 95 volume percent aqueous-based paramagnetic agent carrier, at...
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5104641 |
Nitroxide NMR contrast enhancing agents and their use in NMR imaging
Nitroxides useful as NMR contrast enhancing agents for organs are of the formula ##STR1## wherein in the above formulae, R 1 , R 2 , R 3 and R 4 are, g., CH 3 ; R is --B--COO--M + or...
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5100646 |
NMR glomerular filtration test
A method of determining the glomerular filtration rate of a subject comprises (1) obtaining a serum sample S pre and a urine sample U pre from a subject; (2) administering to the subject an...
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5098692 |
Calcium chelate and gadolinium pharmaceutical composition and methods of X-ray and NMR imaging
Improved metal complex-containing pharmaceutical agents are described which, as an additive, contain one or more complexing agents and/or one or more weak metal complex(es) or mixtures thereof.
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5096826 |
Method of measuring specific surface area
A method for determining the specific surface of a porous or a powdery substance includes measuring the spin-lattice relaxation rate of impregnating agent protons, in which the impregnating agent...
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5094837 |
Method for use of magnetic resonance imaging to image pancreas using secretin
Structural and functional imaging of the pancreas can be achieved with magnetic resonance imaging and a secretin solution. An amount of secretin is placed in solution and administered to a patient...
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5091169 |
Dipyridoxyl phosphate NMRI contrast agent compositions
N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacet
ic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,
N'-diacetic acids, and...
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5089644 |
Preparation of oxamine complexes
A process for making a solution of a complex of an oxamine and a polyvalent paramagnetic metal comprising contacting a solution of the oxamine with (a) the insoluble hydroxide of the polyvalent...
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5087439 |
Paramagnetic metal-diethylenetriamine-pentaacetic acid partial amide complexes for magnetic resonance imaging
Complexes of a highly paramagnetic polyvalent metal, e.g., a lanthanide such as gadolinium, or of a less paramagnetic metal, e.g., iron, manganese, copper, cobalt, chromium or nickel, with a...
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5087440 |
Heterocyclic derivatives of DTPA used for magnetic resonance imaging
Gadolinium and calcium chelates of DTPA (diethylenetriaminepentaacetic acid) bisamides, such as a composition comprising a gadolinium chelate of a 6-carboxymethyl-3,9-bis...
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5084266 |
Method for tumor imaging utilizing a labelled tumor specific antibody and a non-tumor reactive antibody
A method for identifying and/or determining the location of a tumor which produces or is associated with a cytoplasmic, intra-cellular or cell surface marker substance, is disclosed, which...
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5080885 |
Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
A non-toxic, brominated perfluorocarbon emulsion for internal and intravenous use in animals (including humans) is disclosed, for use as an oxygen transport medium and as a contrast enhancement...
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5078986 |
Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
Nuclear magnetic resonance (NMR) imaging of body organs and tissues is enhanced by administering to a living animal body a substantially nontoxic paramagnetic image altering agent comprised of a...
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5070213 |
Perfluoro-4,4'-bis(2,2-dimethyl-1,3-dioxolane) and its preparation and use
The novel compound perfluoro-4,4'-bis(2,2-dimethyl-1,3-dioxolane) is disclosed. Its preparation by fluorination of 4,4'-bis[2,2-bis(trifluoromethyl)-1,3-dioxolane using UV radiation or by reaction...
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5064754 |
Genomic sequencing method
A method of determining the nucleotide sequence of a DNA molecule of arbitrary length as a single procedure by sequencing portions of the molecule in a fashion such that the sequence of the 5' end...
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5064636 |
Paramagnetic oil emulsions as enteric MRI contrast agents
A paramagnetic oil emulsion for enteric administration composed of about 5 to about 30 volume percent oil and about 70 to about 95 volume percent aqueous-based paramagnetic carrier, the...
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5064638 |
Simultaneous multinuclear magnetic resonance imaging and spectroscopy
A method of simultaneous multinuclear magnetic resonance imaging and spatially localized NMR spectroscopy is disclosed. Clinical implementation of the disclosed method allows routine in vivo NMR...
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5059415 |
Method for diagnostically imaging lesions in the brain inside a blood-brain barrier
An improved method for diagnosing and characterizing brain lesions is described which first involves chemically modifying the blood-brain barrier (BBB) in order to increase BBB permeability....
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5055288 |
Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides
The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable...
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