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5324503 |
Iodo-phenylated chelates for x-ray contrast
Hybrid agents for enhancing in vivo diagnostic imaging of body organs and tissues, and methods of preparing and using the same.
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5322682 |
Method for quantitatively measuring and mapping stored iron in tissue using MRI
The invention provides a specific measure of iron stores in vivo using magnetic resonance imaging. T 2 relaxation times in both lower-to-mid field strength magnetic resonance imaging instruments...
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5322934 |
Purification of a crude MRI agent using continuous deionization
The use of continuous deionization as an alternative or substitute method for the purification of a crude magnetic resonate.
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5320906 |
Delivery vehicles with amphiphile-associated active ingredient
Delivery vehicles comprising an outer biocompatible encapsulating layer, an inner amphiphilic active ingredient-associated layer and an active ingredient are described. The delivery vehicles are...
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5318031 |
Method and apparatus for determining chemical states of living animal or human tissue using nuclear magnetic resonance
In a method for determining chemical states of living animal or human tissue using nuclear magnetic resonance with a homogeneous constant magnetic field, the tissue is measured by means of a...
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5316756 |
NMR imaging using paramagnetic chelates having hydroxyalkyl-substituted amide groups
Compounds of the general formula I: ##STR1## R 1 signifies a COOX group or the group ##STR2## R 2 and R 3 are the same or different and signify a hydrogen atom, a lower straight- or...
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5314664 |
Sample supply system having integrated microwave disintegration
The flow-injection system includes a microwave oven having a flow-through reactor having a flow-through conduit located in windings around a conduit carrier for absorbing microwaves. The windings...
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5314827 |
Isotopic composition analyzer
An on-line mass spectrometric method and apparatus for the determination of the isotopic composition of at least oxygen, hydrogen and nitrogen in a compound or mixture of compounds. A mixture...
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5314681 |
Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
The invention relates to a modification of electron spin resonance enhanced magnetic resonance imaging (ESREMRI) in which two magnetically responsive materials (contrast agents) are introduced into...
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5314679 |
Vascular magnetic resonance imaging agent comprising nanoparticles
The preparation and isolation of biodegradable superparamagnetic MR imaging contrast agents for the vascular compartment is described. These aggregates are comprised of individual biodegradable...
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5314680 |
Polyazamacrocycles for magnetic resonance imaging
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized...
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5312755 |
Contrast resolution tissue mimicking phantoms for nuclear magnetic resonance imaging with stable NMR properties
Tissue mimicking phantoms for NMR imagers are produced having a base tissue mimicking material enclosed within a sealed container. The base tissue mimicking material is a gel solidified from a...
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5306640 |
Method for determining preselected properties of a crude oil
Methods are provided for using Nuclear Magnetic Resonance (NMR) spectroscopy to measure the bulk volume of oil and water in the polyurethane liner of sponge core. The method is accurate, rapid, and...
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5286651 |
Determining collective fluid inclusion volatiles compositions for inclusion composition mapping of earth's subsurface
A collective fluid inclusions volatiles sample is released from each of a plurality of sedimentary rock samples and analyzed as it is being released to determine composition thereof. Compositions...
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5283199 |
Chlorine dioxide monitor based on ion mobility spectrometry with selective dopant chemistry
An improved ion mobility spectrometer (IMS) and method for operating the same which enables analysis of chlorine dioxide in a mixture of gases which also includes the interferant chlorine. A...
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5283036 |
Apparatus for coupled liquid chromatography and nuclear magnetic resonance spectroscopy measurements
Apparatus is provided for coupled liquid chromatography and nuclear magnetic resonance (NMR) spectroscopy measurements. The apparatus includes a liquid chromatograph, an intermediate storage device...
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5281538 |
Method of preparing a sample for analysis by laser desorption mass spectrometry
A sample for analysis by Laser Desorption Mass Spectrometry is prepared by dissolving the sample material in a solvent and applying the solution to a matrix material applied to a target for a mass...
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5277895 |
Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives
Tetraazacyclododecane compounds of general formula I ##STR1## in which E and Q are defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable...
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5277896 |
Clay enclosed transition and rare earth metal ions as contrast agents for the gastrointestinal tract
The invention relates to compositions and methods of using clay-enclosed paramagnetic ions as image brightening or image contrast agents. In particular, T 1 relaxivity measurements on Hectorite...
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5275801 |
13,17-propionic acid and propionic acid derivative substituted porphyrin complex compounds, process for their production and pharmaceutical agents containing them
Porphyrin complex compounds consisting of at least one porphyrin ligand, optionally at least one ion of an element of atomic numbers 5, 13, 21-32, 37-39, 42-44, 49, 50 or 57-83 as well as...
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5271929 |
Nuclear magnetic resonance imaging agent comprising a di-aldehyde complex
There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of...
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5268165 |
Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging
Compositions comprising a covalently bounded adduct of deferoxamine, ferric iron and polymer for image enhancement in magnetic resonance (MR) imaging are provided. A pharmaceutical composition...
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5266498 |
Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal
An assay for an analyte in a test sample that uses a ligand binding reaction between the analyte and a specific binding member or a binding member pair that includes one binding member having a...
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5264204 |
Hydrophilic free radicals for magnetic resonance imaging
Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance...
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5261405 |
Apparatus and method for detecting cancer using nuclear magnetic resonance
A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are...
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5260050 |
Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for...
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5258313 |
Process for the detection or determination of oxygen by EPR spectrometry using radical lithium phthalocyanines and composition usable for in vivo determination
The present invention relates to a process for the detection or determination of molecular oxygen by EPR spectrometry using radical lithium phthalocyanines and a composition usable for in vivo...
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5256399 |
Aromatic pentadentate expanded porphyrins in magnetic resonance imaging
The present invention involves a novel tripyrrole dimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded...
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5256532 |
Methods, reagents and test kits for determination of subpopulations of biological entities
Analytes, having a characteristic determinant that selectively interacts with a specific binding substance, are determined by coupling a reporter substance to the analyte, or to the specific...
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5256397 |
2,2,5,5-tetrasubstituted-pyrrolidine-1-oxyl compounds useful as MRI agents
Nitroxides useful as MRI enhancing agents are of the formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 each are alkyl of 1-4 carbon atoms; and R is --alk--COO - M + or --B--N + (Alk) 3 Hal - ...
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5254478 |
Use in magnetometry by electronic paramagnetic resonance (EPR) of tetracyanoquinodimethane derivatives
Use in magnetometry by electronic paramagnetic resonance (EPR) of tetracyanoquinodimethane derivatives in accordance with the formula: ##STR1## in which AH + is a cation derived from a...
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5254460 |
Solvent mediated relaxation assay system
A new ligand binding assay is based upon measurements of relaxation rates of the solvent, which are obtained with a magnetic resonance (MR) spectrometer. It is termed a solvent mediated relaxation...
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5250284 |
Method for increasing nuclear magnetic resonance signals in living biological tissue using zinc
A method of enhancing a magnetic resonance signal comprising the steps of administering a quantity of a selected magnetic isotope to a living biological tissue at a concentration greater than the...
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5250672 |
Contrast agent for NMR imaging
A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H 2 O relaxation times in NMR...
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5248492 |
Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
This invention relates to compositions comprising a colloidal or particulate metal oxide which are stabilized by low molecular weight carbohydrates. The carbohydrates are characterized by the fact...
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5248498 |
Fullerene compositions for magnetic resonance spectroscopy and imaging
Methods and compositions are disclosed for enhancing magnetic resonance imaging and spectroscopy which utilize derivatives of the even-numbered carbon clusters, known as "fullerenes."...
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5246865 |
Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
A protein microsequencing method for use in conjunction with the thiobenzoylation degradation of polypeptides and proteins is disclosed. The process involves reaction of the N-terminal amino acid...
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5246696 |
Compositions for enhancing magnetic resonance imaging
Substantially nontoxic manganese or gadolinium complexes of compounds of the formula: ##STR1## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3, and x is selected from the group consisting of S, CHOH and...
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5244814 |
Decay detection in wood
The presence of decay is determined in wood by testing a sample. The wood tested may be standing timber, cut timber or when coated in building structures. The testing occurs in very short time...
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5242683 |
Contrast media comprising a paramagnetic agent and an iodinated agent for X-ray and MRI
There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent. The contrast...
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5240859 |
Methods for amino acid sequencing of a polypeptide
The present invention provides methods and reagents for sequencing amino acids. One embodiment of the method for determining the terminal amino acid of a substantialy pure polypeptide comprises the...
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5236694 |
19F labelled dextrans and antibodies as NMR imaging and spectroscopy agents
19 F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a 19 F-containing sensor moiety, and a transport polymer or substrate,...
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5234838 |
Ammonia monitor based on ion mobility spectrometry with selective dopant chemistry
An improved ion mobility spectrometer (IMS) and method for operating the same which enables analysis of ammonia in a mixture of gases when air is used as the carrier gas and the drift gas in the...
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5234680 |
Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl...
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5231031 |
Method for assessing risk of diabetes-associated pathologic conditions and efficacy of therapies for such conditions
Concentrations of one or more carbohydrates phosphorylated at a secondary hydroxyl, including fructose-3-phosphate and sorbitol-3-phosphate, in biological tissue or cells of diabetic patients are...
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5230883 |
Method for localization and treatment of tumors using polylysine complexes
Improved methods of selectively localizing, imaging and/or treating tumors, which have a net negative charge, employ novel compositions containing non-immunogenic complexes having a net positive...
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5225282 |
Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The...
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5223243 |
Dipyridoxyl phosphate chelating compound intermediates useful as NMRI contrast agents
N,N'-bis-(pyridoxal-5-phosphate)-alkylenediamine-N,N'-diacet
ic acids, N,N'-bis-(pyridoxal-5-phosphate)-1,2-cycloalkylenediamine-N,
N'diacetic acids, and...
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5219553 |
Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
Magnetic resonance imaging contrast media used to affect the relaxation times of atoms in body tissues undergoing NMR diagnosis are disclosed. Such media comprise (1) a paramagnetic,...
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5219554 |
Hydrated biodegradable superparamagnetic metal oxides
This invention relates to materials exhibiting certain magnetic and biological properties which make them uniquely suitable for use as magnetic resonance imaging (MRI) agents to enhance MR images...
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