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8173385 |
Method for stabilization of peptides in a biological sample
The present invention provides a simple method for the stabilization of a peptide in a biological sample and a reagent for the stabilization, a simple method for the preservation of a biological...
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8168402 |
Diagnostic tests of substance use disorders
The present invention relates to compositions and methods for identifying and quantifying platelet proteins that relate to various bodily states. The present invention further provides methods and...
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8168945 |
Method for generation and use of isotopic patterns in mass spectral data of simple organisms
A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control...
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8158429 |
Multicolor reagents containing compensation controls
The present invention provides multicolor reagent formulations containing in a single container both fluorescently labeled detection reagents and single-color compensation control reagents, wherein...
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8148157 |
Reference, calibrator, or control composition of PIGF-1 and sFlt-1
Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such...
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8119407 |
Hemoglobin based bilirubin reference material
What is described is a single reference material and method of making useful for calibrating or qualifying instruments that are diagnostic spectroscopically for bilirubin, hemoglobin, and...
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8114633 |
Methods for differentiating plasma-derived protein from recombinant protein in a sample
The present invention relates, in general, to methods for detecting and quantitating plasma-derived protein and recombinant protein in a sample based on the difference in protein glycosylation,...
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8071723 |
Stable D-dimer liquid preparation
The invention is in the field of coagulation diagnosis and relates to a liquid, buffer-based D-dimer composition, which additionally contains fibrinogen and which is suitable as a standard material...
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8071384 |
Control and calibration solutions and methods for their use
Control and calibration solutions are described that provide control and calibration data that is recognized by a test meter allowing the meter to segregate the control and calibration data from...
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8066958 |
Device and kit for calibrating bodily fluid sampling devices
A control solution packet for calibrating a bodily fluid sampling device includes a container, a control solution pressurized within the container, and a membrane for covering and sealing the...
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8053239 |
Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
A method for extracting proteins from heterogeneous fluids by precipitation using microfluidics. The method uses an automated protocol for precipitation of proteins onto surfaces, rinsing the...
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7977063 |
Method for determining an allergic response
The present invention concerns a method for determining an allergic response by determining the extent of degranulation of human IgE sensitized cells upon activation by allergens in food products.
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7968350 |
Characterization of molecules
The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize...
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7939342 |
Diagnostic test kits employing an internal calibration system
A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection...
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7919745 |
Methods and systems for background correction in tandem mass spectrometry based quantitation
A corrected reporter ion intensity is calculated in tandem mass spectrometry based quantitation using isobaric labels. An analyte in each of two or more samples of a mixture of samples is labeled...
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7820444 |
Method for sample identification in a mammal as well as a kit for performing this method
Method as well a kit for the performance of the method for the investigation of biological samples from a mammal for at least one component, wherein the method includes the following steps: (a)...
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7820963 |
Method for generation and use of isotopic patterns in mass spectral data of simple organisms
A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control...
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7759130 |
Mass spectrometric quantitation method for biomolecules based on metabolically labeled internal standards
An object of the present invention is to quantitate with good accuracy, furthermore, quantitate absolutely, one or a plurality of biological molecules in a sample such as a tissue, a biological...
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7754436 |
Diagnostic assay for stroke
Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using a anti-H-FABP...
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7727769 |
Measurement result correction method, urine analysis system, and urine analyzer
A urine analysis system includes a urinary particle analyzer and a computer. The urinary particle analyzer has a measuring unit that measures a cast concentration from the urine and an electric...
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7722858 |
Prevention and treatment of atherosclerosis by reducing carbamylation of LDL or the effects of carbamylated LDL
The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of measuring the level of cLDL and/or autoantibody to cLDL in a...
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7709457 |
Methods and compositions for delivery of pharmaceutical agents
Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a...
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7695973 |
Determination of glycated protein
The present invention provides methods for quantitation of glycated protein in a biological sample using a solid support matrix by making a first bound protein measurement total bound protein under...
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7674623 |
Method of stabilizing human natriuretic peptides
The present invention relates to methods for making stable test samples that can be used in ligand-binding assays for measuring natriuretic peptides.
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7655421 |
Cytometer on a chip
An assay technique for label-free, highly parallel, qualitative and quantitative detection of specific cell populations in a sample and for assessing cell functional status, cell-cell interactions...
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7595199 |
Method of detecting amyloid-like fibrils or protein aggregates
The present invention relates to methods of detecting the presence of detergent- or urea-insoluble amyloid-like fibrils or protein aggregates on filters. Preferably, said fibrils or aggregates are...
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7572434 |
Method for assessing the effect of a drug on long term memory formation
Methods of assessing the effect of a drug on long term memory and for screening a pharmaceutical agent for its ability to modulate long term memory are disclosed.
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7560283 |
Storage-stable cellular whole blood composition containing elevated amounts of D-dimer
The present invention provides a cellular whole-blood D-dimer composition for use with diagnostic test procedures for D-dimer, and a method of its preparation. The composition comprises human...
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7547552 |
Indication composition for surgical instrument cleaning evaluation
The present invention provides an indicator composition for evaluating cleaning of a medical instrument that includes an extracellular matrix component and hemoglobin, as a contamination model...
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7544513 |
Hemoglobin assay for neonatal screening
The present invention provides an assay, suitable for neonatal screening of hemoglobinopathies by quantitatively determining the presence of at least one pair of hemoglobin (Hb) variants,...
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7534580 |
PSP94 diagnostic reagents and assays
In the serum, PSP94 occurs as a free form or is associated with a carrier protein. PSP94 in its bound form has been quantified in the blood of prostate cancer patients and these measurements have...
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7521244 |
Standard reference solutions
Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated...
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7501499 |
Modified hemoglobin and methods of making same
The present invention provides a hemoglobin molecule (Hb) having six ± one PEG chains, wherein two of said PEG chains are bound to Cys-93 (β) of Hb, and the remaining PEG chains are bound to t...
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7501232 |
Method for cell selection
The invention relates to a method for the non-invasive selection of single living cells under gentle conditions from mixtures of cells or cell cultures with respect to a specific production...
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7485433 |
Determination and quantification of red blood cell populations in samples
The invention relates to the detection and determination of erythrocytopathies and hemoglobinopathies. The invention provides a method for distinguishing between subsets of red blood cells in a...
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7476551 |
Diagnosing atherosclerosis risk by measuring carbamylated low density lipoprotein levels
The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of: measuring the level of carbamylated LDL in a sample obtained...
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7462495 |
Methods and compositions for use in diagnosing and characterizing chronic immune disease
Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to...
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7445933 |
Stable calibrators or controls for measuring human natriuretic peptides
The present invention relates to a stable liquid calibrator or control for use in ligand-binding assays wherein the calibrator or control comprises at least one human synthetic natriuretic peptide...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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7368288 |
Detection and recognition of analytes based on their crystallization patterns
The invention contemplates a method for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets...
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7361513 |
Cellular controls for glycated hemoglobin Hb A1c
Disclosed are cellular hemoglobin A1c (Hb A1c) normal and abnormal (high) controls for use in detecting Hb A1c levels. The present invention also relates to methods for generating cellular Hb A1c...
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7351586 |
Method of making stable calibrators or controls for measuring human natriuretic peptides
The present invention relates methods for making stable calibrators and controls that can be used in ligand-binding assays.
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7316931 |
Mass defect labeling for the determination of oligomer sequences
Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for...
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7291501 |
Stable compositions for measuring human natriuretic peptides
The present invention relates to methods for making stable compositions, such as, but not limited to, test samples, that can be used in ligand-binding assays.
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7285418 |
Method and kit for the diagnosis of troponin I
The invention provides a method for assaying for troponin I in a sample such as serum, the method comprising a determination of the troponin I concentration in a sample using a standard preparation...
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7262018 |
Agents that bind to and inhibit human cytochrome P450 2C19
The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of...
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7250306 |
Method for distinguishing between protein variants
Disclosed is a method for distinguishing between protein variants using high field asymmetric waveform ion mobility spectrometry (FAIMS). A method according to the instant invention includes the...
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7235368 |
CHP for use as marker for sepsis-type inflammatory diseases
Use of calcineurin B homologous protein (CHP) from body fluids or body tissues as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or...
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7232689 |
Calibration procedure for investigating biological systems
Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly...
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