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7618821 |
Simulated blood components and methods
A control and a cellular fraction for use therein and methods for making the same, including a first cellular component including a plurality of a first group of processed animal red blood cells...
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7618587 |
Analyzers and methods of analyzing blood
Analyzers and methods of analysis are described for performing blood cell counting and immunoassay on a whole blood specimen in one measurement section. An assay sample is prepared by blending...
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7601539 |
Standard material for particle analyzer
A standard material that is used for judging an abnormal portion in a particle analyzer is described. The standard material comprises first standard particles to be fluorescence-stained by a...
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7598089 |
Methods and compositions for separating cells
The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover rare...
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7592179 |
Five-part differential white blood cell control and method for preparation of the same
The present invention provides a method for preparing a five-part differential white blood cell control and a white blood cell control prepared thereby. The white blood cell control obtained by the...
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7588905 |
Identification and monitoring of systemic lupus erythematosus
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to...
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7585640 |
Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
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7563584 |
Methods and compositions for detecting the activation state of multiple proteins in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
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7547554 |
Method and device for the detection of very small quantities of particles
The invention relates to a method and a device for detecting very small quantities of particles. The inventive method is based on a detection of antigen-antibody reaction products and provides a...
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7537907 |
Products and methods for single parameter and multiparameter phenotyping of cells
A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are...
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7531357 |
Preparation of platelet analogs
Erythrocytes from a vertebrate animal other than a human that have been size reduced and treated with a fixing agent by conventional methods to resemble human platelets are further treated to...
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7527978 |
Flow cytometry based micronucleus assays and kits
The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis...
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7527924 |
Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation
A rapid method for the quantitation of various live cell types is described. The method may include a variety of steps including: 1) suspending the cells in a detergent-like compound, 2) isolating...
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7521243 |
Enumeration of white blood cells
A sample acquiring device for volumetric enumeration of white blood cells in a blood sample that includes a measurement cavity for receiving a blood sample. The measurement cavity has a...
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7507548 |
Multidimensional detection of aberrant phenotypes in neoplastic cells to be used to monitor minimal disease levels using flow cytometry measurements
A method for detecting aberrant phenotypes expressed by neoplastic cells includes the steps of: 1) staining one or more normal/reactive samples and one neoplastic sample with multiple combinations...
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7491502 |
In vivo flow cytometry system and method
The present invention provides methods and systems for performing in vivo flow cytometry. In one embodiments, selected circulating cells of interest of a subject are labeled with fluorescent probe...
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7487660 |
Method and system for monitoring the functional capability of a particle detector
A method and a system for monitoring the functional capability of a particle detector connected downstream, in the flow direction, of a particle filter, in which particles occurring upon the...
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7485472 |
Simple method for quantitative measuring the adhesion of platelets ex vivo
The invention relates to measuring of the adhesion of platelets ex vivo. In this method, monodisperse polymer particles are added to blood, and the number of platelets in the blood are measured...
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7482165 |
Method of preventing white blood cell interferences to red blood cell measurements of a blood sample
Methods of prevention and correction of white blood cell interferences to the measurements of mean cell volume (MCV), red blood cell concentration (RBC) and hematocrit (Hct) of a blood sample are...
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7482161 |
Preparation of a red blood cell component for a hematology control
Red blood cells from a vertebrate are treated to make them effective components of a hematology control, allowing the control to be used for detecting all blood cell components, including white...
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7465584 |
Method and reagent for classifying leukocytes in animal blood
A method for classifying leukocytes in animal blood is described. In the method, a measurement sample is prepared by mixing a canine or feline blood sample with a lysing reagent. Erythrocytes are...
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7449337 |
Lytic reagent and method for leukocytes differential in whole blood
A lytic reagent composition and methods for differential analysis of leukocytes are disclosed. In embodiments, the analysis may utilize optical measurements in flow cytometry based hematology...
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7432105 |
Self-calibration system for a magnetic binding assay
A self-calibrated, magnetic binding assay (e.g., sandwich, competitive, etc.) for detecting the presence or quantity of an analyte residing in a test sample is provided. The magnetic binding assay...
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7416891 |
Reagent and method for classifying leucocytes
A reagent for classifying leucocytes, including: a) at least one of surfactant selected from a cationic surfactant, an amphoteric surfactant, and the combination thereof; b) an organic compound...
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7413905 |
Reagents and methods for classifying leukocytes
The present invention relates to a reagent for classifying leukocytes including (a) at least one surfactant capable of lysing erythrocytes and partly damaging the cell membrane of leukocytes, (b)...
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7405082 |
Methods and devices for measuring reticulocytes
Methods and devices are described for monitoring a therapeutic effect in a red blood cell-related disease by detecting the size of a reticulocyte using a full-automatic blood cell counting device.
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7393688 |
Method of using a hematology reference control for measurement of immature granulocytes
A method of using a reference control for measurement of immature granulocytes on a blood analyzer is disclosed. The method includes analyzing a reference control that contains an immature...
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7393656 |
Methods and compositions for risk stratification
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
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7390677 |
Immunoassay and immunoassay apparatus
An immunoassay comprises the steps of: (a) mixing a whole blood sample with sensitized insoluble carrier particles smaller than erythrocytes to cause an immune agglutination reaction; (b)...
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7390662 |
Method and apparatus for performing platelet measurement
The present invention relates to a hematology instrument system that discriminates platelets from red blood cells, debris and other particles within a blood sample. The instrument system uses an...
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7390631 |
Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7361512 |
Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency
A method of producing low hemoglobin concentration cell percentage (LHCC %) and the method of use for detection of iron deficiency have been disclosed. LHCC % is a sigmoid function of mean cell...
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7361510 |
Methods of detection of iron deficiency
New diagnostic indexes and the method of use for detection of iron deficiency have been disclosed. These include a logistic function of mean cell hemoglobin (MCH) and mean cell volume (MCV), and a...
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7358059 |
Simultaneous quantification of PIG-A associated proteins in red cells, platelets and leukocyte subsets using a single measurement
A single measurement can quantify phosphatidyl-inositol glycan complementation class A (PIG-A) associated proteins in red cells, platelets and the major leukocyte subsets present in blood...
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7354767 |
Reference control composition containing a nucleated red blood cell component made of non-nucleated blood cells
A reference control composition containing a nucleated red blood cell component and the method of making are disclosed. The reference control composition includes a nucleated red blood cell...
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7344890 |
Method for discriminating platelets from red blood cells
A method for discriminating and quantifying platelets within an analyzed blood sample involves initially diluting the blood sample with a ghosting reagent that causes a change in the index of...
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7338809 |
Method for assaying whole blood
In a method for measuring an analyte, which comprises a reaction step of forming a reaction system including a sample containing whole blood, a first substance carried by a solid carrier and...
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7332295 |
Multidimensional leukocyte differential analysis
This invention relates to an improved procedure for the multiparameter analysis of leukocyte subpopulations from peripheral blood, bone marrow or any body fluid containing blood nucleated cells,...
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7283217 |
Sample analyzer and computer product
A sample analyzer including a detection unit for irradiating a biological sample with light and obtaining optical information; a cell classification processor for classifying cells contained in the...
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7271009 |
Multi-analyte diagnostic test for thyroid disorders
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and...
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7256048 |
Method for detection of malaria and other parasite infections
A method of detecting parasite infection, particularly malaria, includes mixing a blood sample with a lytic reagent system to lyse red blood cells, and to form a sample mixture; performing a...
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7247483 |
Method for determining the volume of a liquid sample
A method, a device, and a test kit for performing this method for determining the volume of a sample of the liquid. In the method, a specific concentration of a chromophoric indicator is provided...
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7235404 |
Cyanide-free lytic reagent composition and method of use for hemoglobin and white blood cell measurement
A cyanide-free lytic reagent composition and method of use for measuring the total hemoglobin concentration and white blood cells in a blood sample are disclosed. The lytic reagent composition...
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7214541 |
Variable rate particle counter and method of use
A variable rate particle counter for adjusting the volumetric delivery rate of fluid to a flow cell based upon an initial particle count rate in order to effectively “tune” the final dilution...
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7208319 |
Method of measurement of nucleated red blood cells
Methods are provided for measurement of nucleated red blood cells in a blood sample. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells,...
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7198953 |
Method of using a reference control composition for measurement of nucleated red blood cells
Methods of using a reference control composition containing a nucleated red blood cell component for measurement of nucleated red blood cells are disclosed. The nucleated red blood cell component...
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7195920 |
Collection systems for cytometer sorting of sperm
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a...
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7195919 |
Hematology controls for reticulocytes and nucleated red blood cells
The present invention is drawn to a hematology control made from particles a particle having a biopolymer attached to a surface of the particle. The particle simulates a component of a blood...
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