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6524860 |
Methods for improving sheath fluids and collection systems for sex-specific cytometer sorting of sperm
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a...
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6514763 |
Hematology blood control and method for preparation of same
The control of the present invention involves a gentle chemical removal of red cells, leaving an intact white cell preparation. The preservation steps, namely the use of cross-linking agents as...
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6509192 |
Quality control method
A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an...
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6472215 |
Method of analyzing nucleated red blood cells in a blood sample
A method of analyzing nucleated red blood cells (NRBCs) in a blood sample and further enumerating NRBCs is disclosed. The method includes lysing a first aliquot and a second aliquot of a blood...
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6448085 |
Quality control material and calibrator for nucleated red blood cell tested on hematology analyzer
A method for the quality control of nucleated red blood cells on a hematology analyzer using a mixture of human and animal blood, particularly chicken blood and fixed human blood with nucleated red...
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6444471 |
Reticulocyte containing complete blood control
A control composition, and method of preparing a control composition, that includes stabilized, maturation-arrested reticulocytes, and a complete blood count base including mature erythrocytes,...
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6406915 |
Hematology control and system for multi-parameter hematology measurements
Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for...
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6403378 |
Cell viability assay reagent
A kit for labeling cells to determine their viability which includes a first dye for labeling non-viable cells and a second dye for labeling all cells, including non-viable cells in which the dyes...
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6368864 |
Dyes and methods of reticulocyte enumeration
A dye compound having the formula I: wherein, n is 0, 1, 2, or 3; R1 is H, alkyl, or an alkoxy group; R2 is CH 2 (CH 2 ) m OH, wherein m is 0, 1, 2, or 3; X is O, S, or C(CH 3 ) 2 ; R is CH 3 ,...
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6362003 |
Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof
A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an...
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6350613 |
Determination of white blood cell differential and reticulocyte counts
Target nucleated cells, and target cells containing remnant ribosomal material, which are present in a quiescent anticoagulated whole blood sample are optically detected, enumerated, and analyzed...
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6350619 |
Control particles for cell counting and instrument linearity
This invention describes methods and kits for determining instrument linearity of a flow cytometer and is particularly useful as a control particle for use in conjunction with absolute cell...
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6342391 |
Erythrocyte sedimentation rate control
A three-phase suspension suitable for use as an erythrocyte sedimentation rate (ESR) control having the following three components: (1) a synthetic plasma base, (2) an aggregating agent such as a...
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6271035 |
Methods and compositions for rapid staining of nucleic acids in whole cells
A rapid fluorescence staining method for facilitating flow cytometry analysis of reticulocytes is described. The method comprises contacting cells with a cocktail containing a detergent, sphering...
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6268217 |
Erythrocyte parameters in hemochromatosis
The invention provides a method of diagnosing hemochromatosis or a predisposition thereto by detecting an increase in erythrocyte parameters such as mean corpuscular volume or mean corpuscular...
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6254787 |
Method for establishing a fluid containing size-controlled particles
Provided is a method for preparing a fluid containing size-controlled particles that is optimized with respect to use of a target fluid as a matrix fluid under conditions approximating actual...
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6251684 |
Dried chemical compositions
The present invention provides dried chemical compositions comprising dried beads. Typically, the beads comprise reagents suitable for analysis of biological samples, in particular analysis of...
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6232125 |
Method and apparatus for differentiating and enumerating leukocytes
A method and apparatus for differentiating and enumerating the five major sub-populations of leukocytes in a blood sample (i.e., lymphocytes, monocytes, eosinophils, neutrophils and basophils) uses...
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6228652 |
Method and apparatus for analyzing cells in a whole blood sample
A blood analyzing instrument includes a single transducer for simultaneously measuring the DC volume, RF conductivity, light scattering and fluorescence characteristics of blood cells passing...
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6225124 |
Diluting reagent and method compelling time-independent consistency in MCV assay
Aqueous blood-sample diluting reagent and method of its use for compelling a morphological change in a blood sample to yield an MCV value assayed at elapsed time after the sample is drawn to be...
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6214625 |
Composition and method for differentiation of basophils and eosinophils in blood
This invention relates to lytic reagents and methods of using the lytic reagents for automatically determining leukocyte subpopulations in blood. More specifically, the new lytic reagents...
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6210969 |
Composition and method for differentiation of basophil and eosinophil subpopulations of leukocytes in blood
This invention relates to lytic reagents and methods of using the lytic reagents for automatically determining leukocyte subpopulations in blood. More specifically, the new lytic reagents...
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6197539 |
Method for preparing a stabilized blood cell preparation using aged transition metal ion solution
The invention is directed to novel methods of stabilizing blood compositions for use in the quality control of analytical techniques. The novel method comprises removing leucocytes from a blood...
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6187590 |
Hematology reference control and method of preparation
Hematology reference control cells and method of manufacture. The invention relates to the methods of preparing stable white blood cell ("WBC") and nucleated red blood cell ("NRBC") fractions and...
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6174728 |
Control or calibration standard for use with instruments for optical measurement of hemoglobin concentration in blood samples
A control or calibration standard for use with instruments for the optical measurement of the hemoglobin content in blood samples, features scattering particles or beads dispersed in aqueous...
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6149867 |
Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a...
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6146901 |
Composition for manipulating optical and electrical properties of particles to achieve target values for such properties and methods for using the composition
A composition and a method for using the composition for manipulating the electronic and optical properties of biological particles are disclosed. The composition generally has a hypotonic...
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6143567 |
Reagents and a method for the lysis of erythrocytes
The lysis of erythrocytes is accomplished by subjecting whole blood treated with an anticoagulant at a pH between 4 and 9 with a nitrogenous heterocyclic compound, most preferably pyrrolidine...
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6127187 |
Apparatus and method for analyzing blood samples
Apparatus for analyzing blood or the like has a centrifuge rotor (10) with a means for visibly holding a sample, and a scanning arm (32) which traverses the rotor and includes a means (38) for...
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6114173 |
Fully automated method and reagent composition therefor for rapid identification and characterization of reticulocytes erythrocytes and platelets in whole blood
The invention provides a very fast and reliable method and reagent composition for determining reticulocyte and erythrocyte counts, identification and characterization, as well as platelet counts,...
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6074879 |
Synthetic polymer particles for use as standards and calibrators in flow cytometry
The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for...
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6060322 |
Method for identification of reticulated cells
A reagent composition and method is provided for identification of reticulated cells from other cell types in a blood cell sample by using optical measurement. More particularly, the reagent...
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6010911 |
Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
An apparatus and method for performing activated clotting time tests, including their use for evaluating platelet functionality of a blood sample. The apparatus includes a plurality of test cells....
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6008052 |
Preservation of cells as controls or standards in cellular analysis
Cells fixed with a fixative, reduced with a Schiff's base reducing agent and then dried in the presence of α-α-trehalose retain their light scatter and fluorescence properties and may be used,...
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6004816 |
Reagent and method for classification and counting of leukocytes
A reagent for classification and counting of leukocytes, the reagent containing at least one dye which has the following structural formula ##STR1## where R 1 is a hydrogen atom or an alkyl group,...
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5994138 |
Staining reagent for the determination of blood cells
The invention concerns a staining reagent for the determination of blood cells, in particular reticulocytes, which contains a stain capable of labelling cells after incubation, as well as an...
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5994139 |
Stable hematology control composition and method of use
The present invention relates to a hematology control product for automated hematology instruments containing an aqueous solution of at least one blood cell analog, an absorbance agent in an amount...
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5972712 |
Heparin-independent, high sensitivity platelet function evaluation technique
An method for performing activated clotting time tests, including a method for evaluating platelet functionality of a blood sample. The method includes the steps of combining a heparin-inactivating...
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5958776 |
Method for classifying and counting immature leukocytes
A hematological sample is treated with a hemolytic agent that maintains immature leukocytes in a viable state and damages other leukocytes. The damaged leukocytes are stained with a fluorochrome...
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5945340 |
Reticulocyte assay control
A pre-determined concentration of stabilized, maturation-arrested porcine reticulocytes in a red blood cell base, useful as a reticulocyte control composition. The composition can be provided in...
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5935857 |
Blood diluent
An improved isotonic multipurpose blood diluent, and a method for use of this diluent is provided. The diluent is especially suitable for electronic enumeration and sizing of blood cells,...
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5932428 |
Method for preparing a sample in a scan capillary for immunofluorescent interrogation
An assay and sample mixture for the enumeration of fluorescently stained target components of a whole blood sample by an imaging instrument. The sample preparation method ensures that the amount of...
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5906772 |
Styrene-divinyl benzene copolymer and stabilization and enhanced dilution of standard turbidity/nephelometry test samples
The use of a unique styrene-divinylbenzene copolymer and an improved more highly diluted suspension for preparing standard turbidity test equipment calibration samples of very low turbidity levels...
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5906942 |
Method for preparing stable coagulation controls
A method for preparing a coagulation control sample which is stable in the absence of buffer and which has a clotting time within the range of normal human clotting times for reproducibly...
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5891731 |
Reagent for measuring reticulocytes and a method of measuring them
A reagent for measuring reticulocytes which has at least one dye which specifically stains reticulocytes and at least one dye which specifically stains leukocytes.
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5891733 |
Reagent for analyzing solid components in urine and method for analyzing solid components by employing the same
A reagent for analyzing solid components in urine comprising: (i) a buffer agent for maintaining pH at 5.0 to 9.0, (ii) an osmotic pressure compensating agent for maintaining osmotic pressure at...
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5891394 |
Apparatus for rapid and ultrasensitive detection and counting of microorganisms by fluorescence
Apparatus for rapid, ultra sensitive and automatic counting of flourescent biological cells such as microorganisms, carried by a solid support such as a filter.
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5888823 |
Standard fluid for flow cytometer
A standard fluid for a flow cytometer which shows, after staining, almost the same fluorescence intensity and scattered light intensity as those of the cells to be assayed.
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5882933 |
Method for determination of leukocytes and hemoglobin concentration in blood
A method is provided for differentiating leukocyte subpopulations, immunophenotyping of lymphocytes and counting white blood cells. The method preserves leukocyte morphology and surface markers...
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5882934 |
Composition and method for hemoglobin and cell analysis
A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of...
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