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7371542 |
Gene expression system
The present invention relates to nucleic acid molecules and in particular to vectors, comprising at least one gene of interest, at least one scaffold/matrix attached region (S/MAR), at least one...
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7368235 |
Method for identifying reading frame mutations
The invention relates to a simple and rapid method for identifying mutations in a gene of interest indicating an alteration in the reading frame of the proteins derived therefrom. The inventive...
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7297533 |
Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same
An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication...
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7297520 |
Large circular sense molecule array
Large circular (LC)-sense molecules in an array is disclosed. The LC-sense molecules array is combined with cDNA hybridization to detect differences in expression profile between different cells....
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7291498 |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing...
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7285414 |
Viruses targeted to hypoxic cells and tissues
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
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7285399 |
Compositions and methods using the yeast YMR107W promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7262056 |
Enhancing intermolecular integration of nucleic acids using integrator complexes
We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is...
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7262032 |
Allele-specific mutation detection assay using an enzyme-disabling agent
The present invention relates to a method of detecting a base at a pre-determined position in a nucleic acid molecule by performing enzymatic detection reactions using base-specific detection...
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7256324 |
Plant regulatory sequences for selective control of gene expression
Promoters from male reproductive tissues were isolated from corn ( Zea mays ). These promoters can be used in plants to regulate transcription of target genes including genes for control of...
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7220578 |
Single LTR lentivirus vector
The present invention provides an isolated nucleic acid comprising a single retroviral LTR, a polypurine tract, a packaging signal, a primer binding site and a rev responsive element. Further...
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7214515 |
Viral delivery system for infectious transfer of large genomic DNA inserts
The present invention relates to HSV-based amplicon vectors carrying a genomic DNA fragment, and methods of constructing and using the same. Included within the present invention is a method of...
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7205130 |
Bi-directionally cloned random cDNA expression vector libraries, compositions and methods of use
The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for...
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7172882 |
Method and materials for producing deletion derivatives of polypeptides
The present invention describes an in vitro transposition-based methodology for generation of deletion derivatives of polypeptides. An artificial transposon containing at least partly within its...
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7169585 |
Papillomavirus vaccine
A method of providing papillomavirus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections causd by papillomavirus. The method...
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7160702 |
Methods and nucleic acid vectors for rapid expression and screening of CDNA clones
Recombinant DNA vectors and methods for cloning and expressing nucleic acid molecules by using a combination of site-specific recombination and end-to-end joining or linking of nucleic acid...
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7150874 |
Vector for integration of heterologous sequences into poxviral genomes
A new DNA vector is disclosed comprising a nucleic acid sequence useful for inserting heterologous sequences into the genome of poxviruses by homologous recombination. Also disclosed are...
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7144712 |
Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7144579 |
Paramyxoviruses comprising modified transcription start sequence
The present invention provides virus vectors of the family Paramyxoviridae in which the transcription start (S) sequence has been modified so as to modify the expression of genes located downstream...
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7115391 |
Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these...
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7112434 |
Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for...
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7109178 |
Method for ligating nucleic acids and molecular cloning
The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector...
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7105343 |
Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac
The present invention provides efficient transfer of genes into host cells or embryos to transform the cells or embryos by transposition vectors using the minimal amount of nucleotide sequences in...
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7078190 |
Compositions and methods utilizing the yeast ZE01 promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7078029 |
Herpes simplex virus strains
The present invention provides an HSV having a genome with a mutation of a TAATGARAT sequence such that, in the presence of a ICP4 gene product, a native immediate early gene is expressed from the...
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7067310 |
Method for the preparation of a viral vector by inter-molecular homologous recombination
The present invention encompasses methods of preparing a recombinant viral vector, within a procaryotic cell, by intermolecular homologous recombination, methods of preparing an infectious viral...
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7067282 |
Compositions and methods using the yeast YLR110C promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7064246 |
Use of transposable elements for altering gene expression
Methods of repressing expression of a recombinant gene in a cell are provided. The methods include the steps of introducing a transposase DNA binding motif into or adjacent to the gene, and...
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7045313 |
Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
Methods and compositions are provided for the use of vaccinia virus or other poxviruses as vectors for expression of foreign genes. Expression of foreign genes is obtained by combining vaccinia...
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7041483 |
Expression modulating sequences
The present invention provides a method for modulating expression of a genetic sequence by introducing, creating or deleting one or more pseudo-translation initiation sites in the nucleotide...
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7033801 |
Compositions and methods for rapidly generating recombinant nucleic acid molecules
A method of generating a double stranded (ds) recombinant nucleic acid molecule covalently linked in both strands by contacting two or more ds nucleotide sequences with a topoisomerase under...
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7026113 |
EIA vaccine and diagnostic
The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows...
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6998252 |
Recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus...
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6994999 |
Isolated DNA molecule comprising the promoter sequence of a bovine myostatin gene
The present invention relates to a novel promoter sequence which encodes an isolated DNA molecule comprising the polynucleotide sequence of SEQ ID NO: 1 and which encodes the promoter region of the...
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6979568 |
Vector for the expression of two foreign genes
A vector expressing two foreign genes by using RRE sequence and controlling the ratio of the expression doses of these genes owing to the modification is provided. This vector, which can be...
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6977165 |
Sequence specific recombinase-based methods for producing intron containing vectors and compositions for use in practicing the same
Methods are provided for producing a vector that includes at least one splicable intron. In the subject methods, intron containing vectors are produced from donor and acceptor vectors that each...
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6962815 |
AAV2 vectors and methods
The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation...
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6953689 |
Cloning system for construction of recombinant expression vectors
Cloning systems are provided for constructing expression vectors. In one aspect of the invention, a kit is provided for constructing one or more recombinant expression vectors. The kit comprises: a...
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6908762 |
Method of preparing a eukaryotic viral vector
The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage...
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6908751 |
Methods for enhancing the expression of a protein of interest by recombinant host cells
The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in eukaryotic cells. A strategy is provided for...
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6872813 |
Genes coding for tomato β-galactosidase polypeptides
Novel DNA sequences derived from a family of genes encoding β-galactosidases in tomato are disclosed. β-Galactosidase II has demonstrated enzyme activity in cell wall disassembly, leading to loss...
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6838285 |
Site specific recombinase based method for producing adenoviral vectors
Site-specific recombinase based methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In...
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6825011 |
Methods for insertion of nucleic acids into circular vectors
The present invention provides vectors and methods which improve the efficiency of nucleic acid insertion into circular vectors, which generally facilitate nucleic acid cloning and specifically...
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6821759 |
Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof
A simple method for modifying genes in a recombination deficient host cell is disclosed. Such modifications include generating insertions, deletions, substitutions, and/or point mutations at any...
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6818209 |
Retroviral delivery system
A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope...
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6783979 |
Vectors encoding HCN channels and MiRP1
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac...
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6780618 |
Method for improving genetic stability of foreign insert nucleotide sequence in recombinant poliovirus
The present invention relates to (a) methods for improving a genetic stability of an insert nucleotide sequence in a recombinant single-stranded RNA virus vector, which comprises performing a...
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6733970 |
Screening system for zinc finger polypeptides for a desired binding ability
This invention relates to a method for producing a zinc finger nucleic acid binding protein comprising preparing a zinc finger protein according design rules, varying the protein at one or more...
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6730483 |
Phagemid for antibody screening
A phagemid has been constructed that expresses an antibody fused to coliphage pIII protein. The phagemid is suitable for selecting specific antibodies from large gene libraries with small...
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6723504 |
Method for generating a gene library
The present invention relates to a method of generating a gene library from an environmental pool of organisms, which gene library is enriched in DNA encoding a polypeptide with an activity of...
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