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7371568 |
Method for modifying chromosomes
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign...
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7354761 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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7339050 |
Stress-induced promoter and method of using the same
This invention provides a stress-inducible promoter that effectively functions in monocotyledonous plants such as rice, and environmental stress-tolerant plants using the promoter. Such promoter is...
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7332307 |
Antibacterial therapy with bacteriophage physico-chemically altered by pegylation to delay inactivation by the host defense system
The present invention is directed to bacteriophage therapy, using methods which enable the bacteriophage to delay inactivation by any and all parts of the host defense system (HDS) against foreign...
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7319001 |
High throughput system for producing recombinant viruses using site-specific recombination
Disclosed are the methods for producing recombinant viruses using site-specific recombination in vitro. In the present invention, circular viral genomic DNAs are digested with restriction enzymes...
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7314912 |
AAv scleroprotein, production and use thereof
The invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one mutation which brings about an increase in the infectivity of the virus.
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7303898 |
Defective sindbis viral vectors
Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus...
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7297542 |
Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention...
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7297533 |
Recombinant feline herpesvirus type 1 and polyvalent vaccine using the same
An attenuated feline recombinant herpesvirus 1 (FHV-1), which is prepared by identifying gene regions in the genome wherein inserted foreign genes can be expressed without affecting the replication...
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7297520 |
Large circular sense molecule array
Large circular (LC)-sense molecules in an array is disclosed. The LC-sense molecules array is combined with cDNA hybridization to detect differences in expression profile between different cells....
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7291498 |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing...
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7285657 |
Rubisco small subunit promotes from Brassica rapa and uses thereof
The present invention is related to a family of novel spatiotemporally active Rubisco promoters (SEQ ID NO: 1, 2, 3) obtainable from light grown Brassica seedlings. Furthermore the invention is...
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7285414 |
Viruses targeted to hypoxic cells and tissues
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
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7285399 |
Compositions and methods using the yeast YMR107W promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7276359 |
Polynucleotide composition, method of preparation, and use thereof
A lyophilized polynucleotide composition contains at least one polynucleotide and at least one cryoprotectant, wherein the ratio of the polynucleotide to cryoprotectant is from about 0.001 to about...
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7273931 |
Plant promoter
This disclosure provides gene sequence of a novel gene DaRub1 of Deschampsia antarctica expressed at low temperatures. The promoter sequence of this gene is identified and characterized. The...
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7262033 |
Cell lines for the propagation of mutated herpes viruses
A process for propagating a mutant herpes virus having a mutation in its endogenous HSV VP16 gene or a homologue thereof, which process comprises infecting a cell line with the mutant herpes virus...
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7256036 |
Modified adenoviral fiber and target adenoviruses
The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said...
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7244609 |
Synthetic genes and bacterial plasmids devoid of CpG
The invention relates to a new series of bacterial plasmid vectors which are fully devoid of CpG and which can express synthetic genes which do not contain CpG in the bacteria Escherichia coli.
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7244588 |
Cold-induced expression vector
A vector having a region encoding a cold shock protein gene mRNA-origin 5′-nontranslated region, characterized in that the 5′-nontranslated region has a mutation having been transferred therein...
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7244585 |
3′ Sequence of the GB virus B (GBV-B) genome
The present invention relates generally to the fields of biochemistry, molecular biology, and virology. More particularly, it relates to the identification of 259 nucleotides located at the 3′...
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7229813 |
Everninomicin biosynthetic proteins
This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds...
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7229761 |
Method of constructing a synthetic polynucleotide
A method of constructing a synthetic polynucleotide, the method including selecting a first codon of a parent polynucleotide that encodes a polypeptide for replacement with a synonymous codon,...
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7220565 |
Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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7214515 |
Viral delivery system for infectious transfer of large genomic DNA inserts
The present invention relates to HSV-based amplicon vectors carrying a genomic DNA fragment, and methods of constructing and using the same. Included within the present invention is a method of...
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7196183 |
Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
The present invention relates to genomic nucleotide sequences and amino acid sequences corresponding to the non-coding and coding region of a new type of HCV. The invention relates to new HCV types...
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7196066 |
DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
Methods of eliciting an immune response in a subject by administering one or more large genomic DNA fragments are provided. Also provided are methods of identifying sequences encoding antigenic...
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7195896 |
Complementary adenoviral vector systems and cell lines
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic...
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7192720 |
Array-based epitope-captured antibody display
Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is...
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7189561 |
Production of adenovirus vectors with reduced levels of replication competent adenovirus contamination
Methods, cells and recombinant adenoviral vectors are disclosed that permit the production of recombinant adenoviral vector stocks with reduced levels of contamination by replication competent...
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7183107 |
Enhanced replication of HCV RNA
This invention provides methods of generating cells that stably replicate sub-genomic virus replicons. This invention also provides methods of generating cells that have disabled PKR activity and...
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7166287 |
Viral agent
The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts...
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7163791 |
α,2,8-sialyltransferase
The invention provides a novel α-2,8-sialyltransferase expressed by a gene cloned from animal cells, a cDNA coding for the α-2,8-sialyltransferase, a method of detecting, or suppressing the...
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7144712 |
Human hepatitis B virus core proteins as vaccine platforms and methods of use thereof
The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core...
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7115733 |
Rubisco promoters and uses thereof
The present invention is related to a family of novel spatiotemporally active Rubisco promoters (SEQ ID NO: 1, 2, 3) obtainable from light grown Brassica seedlings. Furthermore the invention is...
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7112434 |
Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for...
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7105346 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with...
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7098025 |
Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the...
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7087415 |
Methods and compositions for directed gene assembly
The present invention is directed to methods and compositions for use of homologous recombination for directed evolution, gene reassembly, and directed mutagenesis. One aspect of the present...
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7083970 |
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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7078190 |
Compositions and methods utilizing the yeast ZE01 promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7070992 |
Retroviral vectors with foreign-sequence insertion between retroviral primer binding site and retroviral splice donor
The subject of the invention is retroviral gene transfer vectors in which foreign sequences are introduced between the retroviral primer binding site (PBS) and the retroviral splice donor (SD). The...
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7070989 |
Escherichia coli strain secreting human granulocyte colony stimulating factor (G-CSF)
The present invention provides a recombinant plasmid vector comprising a kanamycin resistance gene, a promoter, an endoxylanase signal sequence, a nucleotide sequence coding for an oligopeptide...
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7067282 |
Compositions and methods using the yeast YLR110C promoter
The invention provides novel yeast promoters useful for controlling the expression of homologous and heterologous nucleic acid molecules in yeast cells. The yeast promoters are induced by a...
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7060467 |
Recombinant proteins containing repeating units
Methods for the production of recombinant proteins containing repeating units are disclosed. Also disclosed are methods for the production of degenerate polynucleotides encoding said recombinant...
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7052881 |
Packaging systems for human recombinant adenovirus to be used in gene therapy
Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with...
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7045348 |
Adenoviral vector incorporating zipper peptide-modified fiber protein and uses thereof
The present invention provides a recombinant adenovirus vector targeted by zipper peptides. The vector contains a fiber protein modified by insertion of a first zipper peptide that can crosslink to...
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7045344 |
Adenoviral vector and methods for making and using the same
In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods,...
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7045337 |
In vivo incorporation of unnatural amino acids
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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7045313 |
Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
Methods and compositions are provided for the use of vaccinia virus or other poxviruses as vectors for expression of foreign genes. Expression of foreign genes is obtained by combining vaccinia...
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