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6479464 |
Compositions and methods for highly efficient transfection
The invention encompasses a transfection complex comprising a polypeptide comprising the contiguous 29 amino acids: 6G's, 2F's, 2L's, 1W, 4R's, 2E's, 2N's, 3K's, 1T, 1S, 1A, 1Y, 1M, 1C, and 1I, and...
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6475757 |
Plasmids for construction of eukaryotic viral vectors
The present invention provides a dual selection cassette (DSC) comprising first and second DNA segments having homology to a eukaryotic viral vector, positive and negative selection genes, each...
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6475781 |
Trans-dominant suppressor genes for oligomeric proteins
The invention features two methods for making eucaryotic trans-dominant suppressor genes encoding polypeptide translation products capable of suppressing the activity of a growth factor that...
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6475994 |
Method and articles for transfection of genetic material
A gene transfection particle includes a polymer, a support particle conjugated with the dendritic polymer, and genetic material conjugated with the dendritic polymer. The gene transfection...
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6475770 |
Processes for preparation of Marek's Disease using continuous mammalian cell lines
The present invention relates to mammalian cell lines which efficiently support the growth and productive infection of Marek's Disease Virus at high titers. The present invention also relates to...
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6468771 |
Adeno-associated virus and adenovirus chimeric recombinant viruses useful for the integration of foreign genetic information into the chromosomal DNA of target cells
The present invention provides chimeric viral vectors which have both the capacity to infect host cells efficiently and the capacity to integrate their genomic material into the host cell's genome....
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6468745 |
Method for expressing a library of nucleic acid sequence variants and selecting desired traits
The present invention relates to a method for using viral vectors to bear populations of sequence variants and using plant hosts to select the sequences that exhibit the desired traits.
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6465246 |
Oncogene- or virus-controlled expression systems
Nucleic acid constructs for expressing an effector gene, with the nucleic acid construct comprising a promoter I (component a) which controls the expression of a transcription factor gene...
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6458939 |
Compositions and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation
The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers (e.g., colon cancer) in mammals, e.g., humans. The invention is based on...
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6451769 |
Compositions and methods for administering Borrelia DNA
Disclosed is a vaccine against Lyme Disease or its causative agent Borrelia burgdorferi (sensu stricto or sensu lato) containing a plasmid a DNA encoding a promoter for driving expression in a...
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6447769 |
Compositions and methods for enhanced tumor cell immunity in vivo
The invention provides a method of preventing or reducing the severity of a cancer in a subject by stimulating the subject's immune response against the cancer. The invention provides, for example,...
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6444421 |
Methods for detecting intermolecular interactions in vivo and in vitro
Methods for assessing intermolecular interactions in vivo and in vitro are provided. Methods are provided for detecting protein-DNA interactions in vivo, in which a cell having a chimeric guide...
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6436410 |
DNA encoding neospora dihydrofolate reductase-thymidylate synthase
The present invention provides isolated polynucleotide molecules comprising a nucleotide sequence encoding the DHFR-TS protein of Neospora which polynucleotide molecules are useful in preparing...
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6436694 |
Regulable gene expression in gram-positive bacteria
A system has been constructed which is suitable for tetracycline-inducible gene expression in Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis . The replicon/host gene...
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6436638 |
Cryptosporidium detection method
A method for selectively detecting the presence of C. parvum organisms in a sample. A method for selectively detecting the presence of C. parvum organisms and for detecting the presence of G....
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6432699 |
Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A
The invention involves viral vectors that can be used to transduce a target cell, i.e., to introduce genetic material into the cell. The targets of interest are eukaryotic cells and particularly...
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6432927 |
Compositions and methods for inducing gene expression
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of...
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6428953 |
Method and means for producing high titer, safe, recombinant lentivirus vectors
Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a...
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6428988 |
Methods using cre-lox for production of recombinant adeno-associated viruses
Methods for efficient production of recombinant AAV are described. In one aspect, three vectors are introduced into a host cell. A first vector directs expression of cre recombinase, a second...
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6410314 |
Episomally replicating vector, its preparation and use
The present invention relates to stably episomally replicating vectors, comprising at least one scaffold/matrix attached region (S/MAR) and at least one viral or eukaryotic origin of replication...
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6403336 |
Process for the production of α-human atrial natriuretic polypeptide
DNA fragments which contain a sequence of DNA which encodes a protective peptide-fused α-hANP in which the protective peptide has a C-terminus lysine residue which is directly fused to the...
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6395473 |
Adenoviral based promoter assay
Adenoviral vectors are used to transfer a promoter/reporter gene construct to mammalian cell cultures. The promoter/reporter gene construct is used to determine if a candidate inducing agent has...
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6395519 |
Means and methods for nucleic acid delivery vehicle design and nucleic acid transfer
Cells capable of at least, in part, complementing adenovirus E2A function of an adenovirus defective in E2A function. Such cells include a nucleic acid encoding adenovirus E2A or a functional part,...
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6392124 |
Infectious vectors and clones of plants derived from the turnip mosaic virus (TUMV)
The infectious clone comprises: a) a complete copy of the complementary DNA (cDNA) to the genomic RNA of the turnip mosaic virus (TuMV), in the form of double stranded DNA, b) a transcription...
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6391580 |
Ras proteins
The invention provides seven human Ras proteins (RASP) and polynucleotides which identify and encode RASP. The invention also provides expression vectors, host cells, antibodies, agonists, and...
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6391594 |
Modified modular PKS with retained scaffold
Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The...
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6391552 |
Enhancing transfection efficiency of vectors by recursive recombination
The invention provides a number of strategies for transferring and/or evolving gene(s) associated with cellular DNA uptake so that they confer or enhance DNA-uptake capacity of a recipient cell....
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6388170 |
Bidirectional promoters and methods related thereto
The present invention comprises artificial nucleic acid constructs comprising a bidirectional promoter having minimal promoter and a common promoter, wherein said minimal promoters is operably...
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6387368 |
Hybrid adenovirus-AAV virus and methods of use thereof
The present invention provides a hybrid vector construct which comprises a portion of an adenovirus, 5′ and 3′ ITR sequences from an AAV, and a selected transgene. Other hybrid vectors form a...
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6387620 |
Transcription-free selex
Methods are provided for the production of nucleic acid ligands against target molecules using a procedure known as Transcription-free Systematic Evolution of Ligands by EXponential enrichment...
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6368589 |
Use of autologous promoters to express gene products in Bordetella
Autologous promoters are used to effect expression of gene products in Bordetella strains. Hybrid Bordetella genes are constructed comprising a Bordetella gene, particularly one encoding a...
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6358702 |
Polynucleotides encoding human Hox C10
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such...
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6355412 |
Methods and compositions for directed cloning and subcloning using homologous recombination
The present invention is directed to methods and compositions for DNA subcloning using bacterial recombinase-mediated homologous recombination. The invention relates to methods for cloning,...
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6350866 |
Streptococcus pneumoniae gene sequence FtsZ
The invention provides isolated nucleic acid compounds encoding FtsZ of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a...
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6344446 |
Cationic lipid:DNA complexes for gene targeting
This invention herein describes pharmaceutical compositions and methods for targeted delivery of functional genes into cells and tissues in vivo. The invention discloses DNA:lipid complexes,...
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6335185 |
Bacteriophage vectors generated by bacteriophage/plasmid recombination
The present invention relates to methods for the generation of lambda (λ) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins,...
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6332897 |
Assay methods
The present invention relates to an automated format for the yeast two hybrid assay for protein-protein interactions.
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6331397 |
Method for producing long DNA constructs in agarose
The invention relates to a method for producing a DNA construct, whereby two or several DNAs are recombined in melted agarose. The invention also relates to vectors which can be used therefor, in...
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6329190 |
Targetting adenovirus with use of constrained peptide motifs
The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a...
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6329181 |
Helper functions for recombinant vector production
The present invention provides methods and compositions for preparations of recombinant parvovirus virions with a reduced number of replication competent particles. The compositions of the present...
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6322781 |
Production of recombinant baculoviruses
This invention pertains to methods that facilitate production of recombinant baculoviruses that have been engineered for use as biological control agents. More specifically, this invention pertains...
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6323019 |
Design of novel highly efficient HIV based packaging systems for gene therapy
By transducing cells with an HIV-1-MN molecular clone deleted in the major packaging sequence, a stable HIV-1 packaging cell line, ψ422 was produced. ψ422 cells form syncytia with CD4 positive...
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6319692 |
Methods for transferring gene into chromosome
Methods for transferring a foreign gene into a host chromosome by integrating the foreign gene into a vector by utilizing a lysogenic phage, for the purpose of deleting unnecessary genes derived...
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6312925 |
Methods and compositions to facilitate D-loop formation by oligonucleotides
Methods and compositions for efficient targeting and modification of target sequences in duplex DNA are provided, utilizing oligonucleotides or oligonucleotide compositions containing two domains....
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6303345 |
Use of a virus DNA as promoter
Described is the characterization and the use of strong viral promoters for expressing genes, in bacteria and fungi, in particular yeasts. The invention is based on the surprising finding that CFDV...
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6303116 |
Genetically engineered retroviral vector particles capable of infecting non-dividing cells
The present invention is a method of generating retroviral vector particles derived from retroviruses and capable of transducing therapeutic genes into non-dividing cells.
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6303362 |
Adenoviral vector and methods for making and using the same
In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods,...
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6297030 |
Human Wnt-7a polynucleotides
Wnt-7a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7a polypeptides and...
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6291214 |
System for generating recombinant viruses
The present invention provides a system for simple generation of recombinant animal viruses. The system includes a virus homing vector and can further comprise a transfer vector. These components...
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6287557 |
Methods of gene therapy using herpes viral vectors expressing GM-CSF
A genetically disabled mutant virus has a genome which is defective in respect of a selected gene that is essential for the production of infectious new virus particles, and which carries...
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