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6630614 |
Rad21 orthologue and uses thereof
The invention provides isolated Rad21 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to altering Rad21 levels in plants in order to...
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6623965 |
Simplified use of 5′ ends of RNAs for cloning and cDNA library construction
A method of directional cloning using the 5′ ends of RNAs for use, for example, in cloning and cDNA library construction is provided.
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6623957 |
Secretion of T cell receptor fragments from recombinant host cells
Variable domain murine T-cell receptor genes have been isolated and used to construct cloning and expression vectors. V α , V β , and single chain V α -V β fragments have been expressed as...
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6620617 |
Polymeric gene delivery system
A means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed. The gene, under control of an appropriate promoter for...
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6613749 |
Papovavirus pseudocapsids and use thereof for exogenous material transfer
The present invention relates to biologically useful material in the form of a pseudocapsid formed from papovavirus major capsid antigen and excluding minor capsid antigens, which pseudocapsid...
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6607911 |
Compositions and methods relating to control DNA construct
The invention relates to novel control DNA constructs, and methods and kits for using and making the same, which provide comprehensive controls useful for quality assurance in the diagnostic...
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6602506 |
Delivery of proteins into eukaryotic cells with recombinant Yersinia
The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.
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6599739 |
Infectious papillomavirus pseudoviral particles
The invention provides an infectious papillomavirus pseudoviral particle useful in gene transfer comprising: (a) a papillomavirus vector DNA which comprises an E2 binding site and an expression...
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6599719 |
Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed...
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6599737 |
Adenoviral vectors with tandem fiber proteins
The present invention provides an adenoviral gene transfer vector comprising a first fiber gene and a second fiber gene, wherein the fiber genes are different. The present invention also provides...
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6593113 |
In vitro method for providing templates for DNA sequencing
The present invention relates to an in vitro method for providing unique templates for DNA sequencing and to a kit, which can be used, when employing the selection method of this invention. The...
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6582694 |
Method for preparing a viral aerosol
A method for preparing a viral aerosol from a dilute viral suspension prepared by dissolving a virus in an aqueous solution containing 6-12 g/l of a monovalent cation salt, or 50-100 g/l of a...
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6572863 |
Constitutive expression of non-infectious HIV-like particles
Non-infectious, non-replicating immunogenic HIV-like particles are produced by stable long-term constitutive expression in mammalian cells by eliminating elements toxic to the mammalian cells. An...
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6573073 |
CFTR gene regulator
The invention relates to a novel CFTR gene regulatory element capable of increasing the activity of the CFTR gene promoter, and to nucleic acid constructs comprising the element together with the...
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6569641 |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein by recombinant DNA technique
The present invention is directed to a process for the production of a peptide, polypeptide, or protein having a predetermined property. In accordance with one embodiment, the process begins by...
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6565845 |
Method for gene transfer to the central nervous system
The present invention relates to a method for implanting producer cells into the mammalian brain. The producer cells are engineered with a retroviral based recombinant vector encoding a tumorcidal...
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6565844 |
Protein production and protein delivery
The present invention relates to DNA constructs that alter the expression of a targeted gene in a cell when the DNA construct is homologously recombined with a target site within the chromosomal...
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6566342 |
Gene therapy by secretory gland expression
Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect...
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6559355 |
Rad3 orthologues and uses thereof
The invention provides isolated Rad3 nucleic acids and their encoded proteins. The present invention provides methods and compositions relating to pyrimidine excision activity, altering Rad3 levels...
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6551618 |
Compositions and methods for delivery of agents for neuronal regeneration and survival
Devices useful in the delivery of DNA encoding neurotrophic agents, anti-fibrotic agents, and related compositions are disclosed herein for use in the treatment of central and/or peripheral nervous...
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6551587 |
Vectors for tissue-specific replication
The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and...
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6544786 |
Method and vector for producing and transferring trans-spliced peptides
A method for trans-splicing peptides is provided. In the method, at least two extein peptides are provided, or are synthesized by recombinant methods, the extein peptides having co-reacting...
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6544507 |
Anti-neoplastic viral agents
A viral DNA construct, and virus encoded thereby, is provided having one or more tumor specific transcription factor binding sites in place of one or more wild type transcription factor binding...
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6544748 |
Preparation of erythropoietin by endogenous gene activation
The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a...
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6544957 |
Methods and reagents for facilitating transcription
A previously unknown histone acetylase inhibitor, 6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide, termed “scriptaid,” can be used to enhance transcription. Scriptaid...
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6541248 |
Anti-viral vectors
A viral vector production system is provided which system comprises: (i) a viral genome comprising at least one first nucleotide sequence encoding a gene product capable of binding to and...
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6541245 |
Adenoviral helper vectors
The present invention is directed to improved helper vectors and cell lines for the production of pseudoadenoviral (PAV) vectors containing substantially reduced levels of contaminating helper...
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6537784 |
Self-regulated apoptosis of inflammatory cells by gene therapy
This invention relates to chimeric nucleic acids and to the therapeutic induction of apoptosis in activated inflammatory cells, or cells at a site of inflammation, by introducing into those cells...
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6531313 |
Invasive bacterial vectors for expressing alphavirus replicons
The present invention is directed to a bacterial delivery system for delivering alphavirus replicon DNA into an animal or animal cells with the replicon encoding one or more heterologous genes to...
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6524851 |
Hybrid nucleic acid molecules and vectors including β-globin regulatory elements
The invention relates to hybrid nucleic acid molecules for gene therapy in cells of the erythroid lineage, and in particular α-, β-, δ-, ε, γ-, or ζ-globin nucleotide sequences operably...
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6524812 |
Genes encoding resistance to DNA alkylating agents
The invention provides genes encoding resistance to DNA bioreductive alkylating or cleaving agents and methods of identifying and using those genes.
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6521458 |
Compositions and methods for improved plant transformation
The present invention provides methods for eliminating plants containing non-T-DNA sequences derived from a T-DNA vector. More specifically, the present invention provides a method for killing...
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6521427 |
Method for the complete chemical synthesis and assembly of genes and genomes
The present invention relates generally to the fields of oligonucleotide synthesis. More particularly, it concerns the assembly of genes and genomes of completely synthetic artificial organisms....
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6518064 |
Pink bollworm expression system for commercially valuable protein production
The present invention is directed to a method for transforming insects, in particular Lepidoptera. The invention provides promoters and vectors, as well as methods for transforming insect cells and...
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6505126 |
Method to identify fungal genes useful as antifungal targets
The invention provides methods for identifying nucleic acids and polypeptides derived from fungi that are useful as antifungal targets for diagnosis and/or treatment of fungal diseases. The...
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6503540 |
Cloning and characterization of bves, a novel gene expressed in heart and uses thereof
The present invention is directed to cloning and characterization of bves (blood vessel/epicardial substance), a cDNA expressed in developing and adult heart and skeletal muscle cells in chick,...
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6500619 |
Method for making an improved cloning vector containing marker inactivation system
Provided are lacZα gene fragments which have been modified to introduce multiple restriction enzyme sites. Vectors according to the present invention include at least one promoter operatively...
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6500644 |
Method for in vivo production of a mutant library in cells
A method for in vivo production of a library in cells comprising a multitude of mutated genetic elements, wherein an error-prone polymerase is used in each ancestral cell to replicate all or a part...
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6498011 |
Method for transformation of animal cells
The present invention relates to a method for introducing nucleic acids into cells for e.g. producing transiently transfected or stably transformed animal cells by using a specifically designed...
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6498033 |
Lentiviral vectors
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of...
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6498023 |
Generation of single-strand circular DNA from linear self-annealing segments
The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed...
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6495349 |
Chimeric gene constructs
Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the...
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6491920 |
Polypeptides and DNA encoding same
Proteins from the merozoite stage of the malaria parasite, fragments and derivatives thereof, DNA coding for the said proteins, and processes for the preparation of the proteins and plasmid and...
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6489141 |
Nucleic acid sequence and methods for selectively expressing a protein in a target cell or tissue
A synthetic polynucleotide and a method are disclosed for selectively expressing a protein in a target cell or tissue of a mammal. Selective expression is effected by replacing at least one...
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6489304 |
Hyperstructure-forming carriers
Disclosed are bioactive substances useful for the delivery of effector units in animals. Also disclosed are methods for utilizing the bioactive substances of the invention.
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6486134 |
Gene treatment to enhance feed efficiency and growth rate of livestock
This invention relates to the enhancement of feed efficiency and growth rate, and the reduction of fat accumulation to produce better quality meat by administration of an exogenous gene sequence...
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6482616 |
RCA-free adenoviral vector system and propagation method
The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic...
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6482617 |
Viable contaminant particle free adenoviruses, their preparation and use
Novel adenovirus-derived viral vectors, the preparation thereof, and their use in gene therapy, are disclosed. In particular, recombinant adenoviruses including an adenovirus genome wherein (i) the...
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6479290 |
Chimeric adenoviral vectors
The invention concerns adenoviral vectors having the characteristic of containing a region essential for heterologous packaging with respect to the adenoviral genome from which they are derived....
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6479281 |
Infectious pseudotyped lentiviral vectors lacking matrix protein and uses thereof
Vector systems that encode viral proteins that will assemble into an infectious lentivirus particle having a deletion of the lentiviral matrix are described. In one embodiment the vectors encode a...
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