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8168608 |
Promoter and plasmid system for genetic engineering
This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a...
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8163557 |
Chimaeric human papillomavirus 16 L1 virus-like particles and a method for preparing the particles
A method for producing a chimaeric human papillomavirus (HPV) L1 polypeptide containing a heterologous peptide, and in particular, a HPV L2 peptide comprising the steps of introducing a DNA...
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8163548 |
Recombinant bicistronic flaviviruses and methods of use thereof
The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5′ to 3′, a viral 5′UTR, an ORF e...
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8153598 |
PKD ligands and polynucleotides encoding PKD ligands
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The...
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8148155 |
Methods for increasing homologous recombination of a nucleic acid sequence
The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous...
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8143039 |
Use of genetically modified organisms to generate biomass degrading enzymes
The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of...
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8142770 |
Drug comprising as the active ingredient proliferative vector containing survivin promoter
It is intended to provide a drug to be used in gene therapy which specifically targets abnormal cells such as tumor cells and destroys the same for healing. Namely, a drug comprising, as the active...
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8133700 |
Latent phase viral interleukin-10-(VII-10) and uses thereof
The present invention relates to a purified nucleic acid sequence encoding a homologue of human interleukin 10 (IL-10), wherein said IL-10 homologue is expressed during the latent phase of...
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8129119 |
System for manipulating nucleic acids
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be...
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8124406 |
Method for modifying chromosomes
The present invention relates to a method for producing a modified foreign chromosome(s) or a fragment(s) thereof, which comprises the steps of: (a) preparing a microcell comprising a foreign...
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8119146 |
Expressing hepatitis B virus surface antigen for vaccine preparation
HBsAg is expressed in a Saccharomyces cerevisiae host, carrying a plasmid having a HBsAg coding sequence, wherein the plasmid includes: (1) an upstream promoter from a glyceraldehyde-3-phosphate...
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8114637 |
Packaging cells for recombinant adenovirus
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low...
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8092791 |
Method of producing herpes simplex virus amplicons, resulting amplicons, and their use
The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector...
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8093021 |
Defective sindbis viral vectors
Disclosed herein are new defective Sindbis viral vectors made from a novel Helper plasmid, with differences in envelope proteins between JT vectors and consensus Sindbis virus sequences, and also...
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8076100 |
Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes
Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV env genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host...
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8067377 |
Peptide compositions for targeting adipose tissue
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed....
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8053569 |
Nucleic acids encoding and methods of producing fusion proteins
The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier while allowing their activity once across the barrier to remain...
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8034589 |
Method of preparing a proliferation-regulated recombinant adenoviral vector efficiently and kit for preparing the same
Provided is a method of preparing a proliferation-regulated recombinant adenoviral vector effectively, comprising preparing a proliferation-regulated vector plasmid by preparing a restriction...
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8034587 |
Prokaryotic DNA repair ligases
The present invention relates to the cloning and characterization of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of...
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7981669 |
Viral vectors
The present invention provides a herpes virus which lacks a functional ICP34.5 encoding gene and which comprises two or more of—(i) a gene encoding a prodrug converting enzyme; (ii) a gene e...
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7977470 |
Human Ron-related gene variant associated with cancers
The invention relates to the nucleic acid and polypeptide sequences of three novel human Ron-related gene variants (Ron-V1, Ron-V2, and Ron-V3). The invention also provides a process for producing...
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7968316 |
Method for the mass production of immunoglobulin Fc region deleted initial methionine residues
Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide...
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7947493 |
Compositions and methods for regulating mRNA transcription and translation
The invention relates to compositions, specifically novel nucleic acid constructs encoding a cardiovirus 2A polypeptide operably linked to suitable promoters. Also, disclosed are methods whereby...
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7943373 |
Telomelysin/GFP-expressing recombinant virus
The present invention provides a reagent for cancer cell detection or cancer diagnosis. The present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a...
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7935505 |
Plasmid DNA preparations and methods for producing same
The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations.
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7919682 |
Plants with reduced activity of a starch phosphorylating enzyme
The present invention relates to plant cells and plants, which are genetically modified, wherein the genetic modification leads to the reduction of the activity of a starch phosphorylating OK1...
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7901890 |
Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation
Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The...
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7902347 |
Human Ron-related gene variant associated with cancers
The invention relates to the nucleic acid and polypeptide sequences of three novel human Ron-related gene variants (Ron-V1, Ron-V2, and Ron-V3). The invention also provides a process for producing...
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7897344 |
Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs
Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another. The...
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7888076 |
Collagen-like protein CLAC, precursor thereof and genes encoding the same
A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific...
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7879582 |
Method for the recombination of genetic elements
A method for the recombination of a gene is disclosed. The method involves the design of unpaired forward and reverse primers having homology to the 5′ end of one template and to the 3′ end of ano...
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7838294 |
Inhibitors of the JNK signal transduction pathway and methods of use
JNK-interacting protein 1 (JIP-1), an inhibitor of the JNK1 protein, and methods of treating a pathological condition or of preventing the occurrence of a pathological condition in a patient by the...
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7816104 |
Packaging cells for recombinant adenovirus
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low...
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7812133 |
Anti-OX40L antibodies and methods using same
The invention provides anti-OX40L antibodies, and compositions comprising and methods of using these antibodies.
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7803582 |
Recombinant vector and use in gene therapy
A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a...
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7790866 |
Cancer-associated gene
The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent...
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7790154 |
Duplexed parvovirus vectors
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
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7790419 |
Antiviral vectors
A viral vector production system is provided which system comprises: (i) a viral genome comprising at least one first nucleotide sequence encoding a gene product capable of binding to and effecting...
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7790420 |
Method for determining protein solubility
The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate...
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7785872 |
Nucleic acids for enhancing gene expression and use thereof
The present invention relates to a method for producing a protein, novel nucleic acid fragment, an expression vector, and a method for enhancing the protein production in Pichia. The present...
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7781190 |
Method for constructing and modifying large DNA molecules
This invention provides a method for combining overlapping DNA molecules comprising: (a) providing first and second DNA fragments, the first having a region homologous to a region in the second;...
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7745603 |
Plant promoter and uses therefor
The present invention relates generally to a novel plant promoter. More particularly, the present invention provides a plant promoter capable of induction by physical and/or environmental stimuli...
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7745179 |
Lentiviral vectors featuring liver specific transcriptional enhancer and methods of using same
Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral...
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7740837 |
Genetically modified cells expressing a TGF beta inhibitor, the cells being lung cancer cells
The present invention relates to compositions comprising a therapeutically effective amount of genetically modified cells containing a genetic construct expressing a TGFβ inhibitor effective to ...
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7741042 |
Method for preparing a DNA chip and use thereof
The present invention relates to a method for producing a DNA chip, which comprises the steps of: (a) cloning a probe, where a linker is coupled to one or both ends of an oligonucleotide to be...
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7718398 |
Promoters having a modified transcription efficiency and derived from methyltrophic yeast
The present invention relates to a deoxyribonucleic acid (DNA) comprising at least one promoter sequence, which is derived from a wild-type promoter of a methyltrophic yeast, whose transcription...
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7714119 |
AAV vector compositions and methods for enhanced expression of immunoglobulins using the same
Single AAV vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a self-processing...
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7700117 |
Camp factor of Streptococcus uberis
The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. Also disclosed are chimeric CAMP factor constructs, including...
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7695939 |
Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions
The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of...
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7666623 |
Method for producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose
Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch...
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