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8133495 |
Live attenuated antigenically marked classical swine fever virus
Classical swine fever virus is a world-wide distributed highly-contagious disease affecting swine. The two main strategies for diseases control are prophylactic vaccination and non-vaccination...
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8067560 |
SRSV detection kit
This invention relates to an SRSV detection kit comprising all antibodies against SRSV-related virus constituting peptides selected from the following peptide groups (a) to (k), respectively: (a) a...
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8039687 |
Method for screening genomic DNA fragments
The present invention provides a method for selecting genomic DNA fragments which are useful for providing a plant with an agriculturally advantageous improvement. The method of the present...
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7833987 |
Small synthetic RNA, a method of preparing the same and uses thereof
Translation of the hepatitis C virus (HCV) RNA is mediated by the interaction of ribosomes and cellular proteins with an internal ribosome entry site (IRES) located within the 5′untranslated r...
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7803582 |
Recombinant vector and use in gene therapy
A recombinant vector for delivering A3G genes into human cells comprising (i) a gene expression block including an A3G gene selected from a wild type A3G gene represented by SEQ ID NO: 1 and a...
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7718365 |
Microarray analysis of RNA
In certain embodiments, the invention provides a method of performing an array analysis, the method including contacting a sample of RNA with an analogous DNA set to provide a DNA/RNA duplex,...
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7566532 |
Methods for detecting retroviruses
Disclosed is a method for detecting human retroviral nucleic acids such as human immunodeficiency virus type I (HIV-1) nucleic acid, human T-cell leukemia virus type I (HTLV-I) nucleic acid, and...
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7524651 |
Assay methods for detection of a virus in an avian tissue sample
The invention relates to methods of detecting a virus in an avian tissue sample wherein genetic material derived from feathers is tested for the presence of genetic material from the virus.
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7504227 |
Drug targets for the treatment of neurodegenerative disorders
Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for...
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7501129 |
Vectors comprising guinea pig CMV regulatory elements
The invention comprises novel polynucleotides, and related vectors, host cells, methods, and compositions, containing transcriptional enhancers providing very high levels of expression of...
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7435539 |
Typing of human enteroviruses
The present invention discloses a method for detecting the presence of an enterovirus in a clinical sample. The invention additionally discloses a method for typing an enterovirus in a clinical...
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7179457 |
Modified nodavirus RNA for gene delivery
The invention provides a nodavirus RNA1 molecule modified to include a heterologous insertion which is downstream of its replicase ORF and, preferably, its B2 ORF. The insertion preferably...
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7166287 |
Viral agent
The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts...
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RE39282 |
Nucleic acid derivatives
This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment.
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6908762 |
Method of preparing a eukaryotic viral vector
The inventive method of producing a eukaryotic viral vector comprises contacting a eukaryotic cell, which comprises a unique enzyme that nicks or cleaves a DNA molecule, with a recombinant phage...
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6887707 |
Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates...
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6869780 |
Nodavirus-like DNA expression vector and uses therefor
The present invention describes the production of a nodavirus-based DNA vector that drives abundant expression of foreign genes in a wide variety of cell types. The DNA plasmid is initially...
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6866853 |
Interferon inducing genetically engineered attenuated viruses
The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses...
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6849431 |
Non-B, non-C, non-G hepatitis virus gene, polynucleotide, polypeptide, virus particle, method for isolating virus particle, and method for detecting virus
By isolating a so far unknown novel hepatitis virus and determining the gene sequence thereof, genes, polynucleotides, polypeptides, methods for isolating virus particles, virus particles, and...
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6818209 |
Retroviral delivery system
A retroviral delivery system capable of transducing a target site is described. The retroviral delivery system comprises a first nucleotide sequence coding for at least a part of an envelope...
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6803194 |
Use of ribozymes for functionating genes
Double stranded DNAs, expression vectors and methods for their use are provided in which the intracellular expression of the double stranded DNAs is used to alter the phenotype of a target cell so...
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6723321 |
Autoinducer synthase modulating compounds and uses thereof
Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also...
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6699987 |
Formulations and method for isolating nucleic acids from optional complex starting material and subsequent complex gene analytics
The subject of the invention are formulations not containing chaotropic components for isolating nucleic acids with binding to a solid phase, in particular of DNA, from optional complex starting...
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6660264 |
Treatment of intracellular infection
An agent for combating an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery...
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6613516 |
Preparation of nucleic acid samples
The presently claimed invention provides methods, compositions, and apparatus for studying nucleic acids. Specifically, the present invention provides a novel enrichment and labeling strategy for...
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6514694 |
Methods for the detection of encysted parasites
The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such...
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6392124 |
Infectious vectors and clones of plants derived from the turnip mosaic virus (TUMV)
The infectious clone comprises: a) a complete copy of the complementary DNA (cDNA) to the genomic RNA of the turnip mosaic virus (TuMV), in the form of double stranded DNA, b) a transcription...
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6331417 |
Detection and quantification of human herpes virus 7 by enzymic amplification
The present invention relates to an isolated nucleic acid molecule comprising: (i) a primer protion consisting of a contiguous sequence of from 10 to 50 nucleotides capable of hybridizing to (a)...
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6284249 |
Fusion polypeptide having the C protein and E1 protein of hepatitis C virus
The invention concerns a pharmaceutical composition for treating or preventing C hepatitis (HCV), induced infections, which in a preferred embodiment, comprises a main active principle, (i) a...
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6245528 |
Latent baculovirus expression system
The invention relates to a baculovirus including a disruption in its endogenous p35 gene and its use in establishing latent baculovirus infections. In some embodiments, the baculovirus can also...
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6218105 |
High throughput papilloma virus in vitro infectivity assay
A high throughput virus in vitro infectivity assay method comprising growing cells in a multi-well format, infecting the cells with intact virion incubated with a test agent, and measuring...
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6197944 |
DNA molecules stabilized by modifications of the 3'-terminal phosphodiester linkage
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a...
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5973137 |
Low pH RNA isolation reagents, method, and kit
The present invention describes an RNA isolation process which utilizes low pH reagents. In addition, the reagents are less hazardous and are more stable than those used in prior art methods. This...
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5962274 |
Viral vector directed to predetermined target cells
Disclosed are compositions comprising viral vectors derived from the paramyxovirus, simian virus 5 (SV5). The SV5 vectors of the present invention are designed so that the HN protein that binds to...
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5959092 |
HCV isolates
Two new isolates of the Hepatitis C virus (HCV), J1 and J7, are disclosed. These new isolates comprise nucleotide and amino acid sequences which are distinct from the prototype HCV isolate, HCV1....
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5942389 |
Genes and genetic elements associated with sensitivity to cisplatin
The invention provides genetic suppressor elements that confer upon a cell resistance to platinum-based drugs, including cisplatin, methods for identifying and obtaining such elements, and methods...
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5882852 |
Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the...
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5869634 |
Method of making an RNA particle for use in cleaving nucleic acid molecules and inserting a nucleic acid molecule into the cleavage site
The present invention provides new methods, employing a nucleotide integrase, for cleaving double-stranded and single stranded DNA substrates at specific sites and for attaching nucleic acid...
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5856157 |
Δ9 14:0-ACP fatty acid desaturase and gene therefor
Isolation and characterization of a novel plant fatty acid desaturase cDNA that encodes a Δ9 14:0-ACP desaturase. Expression of the Δ9 14:0-ACP desaturase is a critical factor for pest resistance i...
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5674723 |
Nucleic acid molecules which immortalize human or animal cells and uses thereof
The present invention concerns DNA sequences which are suitable for immortalizing human or animal cells, processes for isolating such DNA sequences as well as processes for producing immortalized...
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5639600 |
Diagnosis and treatment of cell proliferative disease having clonal macrophage involvement
The presence of clonal macrophages in pre-cancerous and cancerous tissue represents an early stage of the disease in which clonal expansion of macrophages occurs due to HIV integration or other...
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5595869 |
Diagnostic methods for detecting lymphomas in humans
The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms...
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5585254 |
Autonomous parvovirus gene delivery vehicles and expression vectors
The present invention relates to novel recombinant autonomous parvovirus vectors, novel recombinant virus particles, and novel gene delivery vehicles that can be used to selectively target...
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5582993 |
Compositions and methods for the detection of bacteria in the genus vibrio
The nucleic acid compositions and methods are presented which are capable of preferentially hybridizing to rRNA or rDNA of Vibrio bacteria over rRNA or rDNA of non-Vibrio bacteria having utility...
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5580761 |
Method of conferring resistance to immunodeficiency viral infection
In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes...
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5578468 |
Site-specific RNA cleavage
The present invention relates to a method of effecting site-specific cleavage of RNA and to an element and a factor responsible for such cleavage.
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5550018 |
Test for virulent genomic nucleotide 472 revertants in attenuated live poliovirus type 3 vaccines
The present invention comprises the method of evaluation of the safety of live attenuated vaccines based on detection and measurement of the incidence of genetic changes associated with reversion...
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5545536 |
Colony-stimulating factor derivatives
Novel proteins possessing substantially the same biological activity as human GM-CSF, as well as proteins having a higher specific activity than native human GM-CSF, are disclosed. The proteins may...
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5512430 |
Diagnostic array for virus infection
The use of nucleic acid to diagnose disease is disclosed. The use of nucleic acid from at least one hair follicle to diagnose the presence of a human immunodeficiency virus infection is demonstrated.
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5503979 |
Method of using replicatable hybridzable recombinant RNA probes
The present invention provides a replicatable and hybridizable recombinant single-stranded RNA probe molecule comprising: a recognition sequence for the binding of an RNA-directed RNA polymerase; a...
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