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7358069 Vector constructs  
Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo.
7354718 Molecular dissection method using trans-splicing to designed spliced leader sequences, genes, and constructs thereof  
The presently disclosed subject matter generally relates to a method for detectably labeling ribonucleic acid molecules expressed in cells of interest. Also provided are methods for isolating...
7341852 Methods of decoupling reaction scale and protein synthesis yield in batch mode  
Biological macromolecules are synthesized in vitro in a thin film that provides for high surface area/volume ratio, allowing improved yield in scaled up reactions.
7338789 Methods of in vitro protein synthesis  
Biological macromolecules are synthesized in vitro under conditions and in a reaction composition wherein oxidative phosphorylation is activated and protein folding is improved.
7335471 Polypeptides derived from RNA polymerases and use thereof  
Mutant RNA polymerases of phagic origin in which the peptide chain is modified by substitution, deletion or addition of at least one amino acid, the modification having the effect of reducing the...
7323319 RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use  
Materials and methods for incorporating adenosine derivatives into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives include naturally occurring compounds such as Coenzyme A,...
7319024 C. elegans p21-activated kinase (PAK) gene and associated loss-of-function phenotypes that facilitate screening for small molecule modulators of PAK activity in the nematode, caenorhabditis elegans  
The invention refers to a novel C. elegans p21-activated kinase gene, the pak-3 gene, and associated loss-of-function phenotypes. These phenotypes can be used to elucidate PAK signaling pathways...
7217517 Nucleic acids, polypeptides, and methods for modulating apoptosis  
The present invention provides methods of identifying an incidence of ischemia in mammalian tissue, particularly mammalian heart tissue. Further, a method of reducing apoptosis in mammalian tissue,...
7198923 Method for the preparation of purified HCV RNA by exosome separation  
The invention relates to a method for the isolation of hepatitis C virus. The method comprises the separation of particles termed exosomes from the blood plasma of an individual infected with...
7179457 Modified nodavirus RNA for gene delivery  
The invention provides a nodavirus RNA1 molecule modified to include a heterologous insertion which is downstream of its replicase ORF and, preferably, its B2 ORF. The insertion preferably...
7148343 Compositions and methods for using a solid support to purify RNA  
Reagents, methods and kits for the purification of RNA from biological materials are provided.
7119194 Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same  
A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific...
7026301 Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil  
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
RE39031 RNA amplification method requiring only one manipulation step  
An RNA amplification method is particularly useful for diagnosing bacterial or viral infections or genetic disorders and for cell typing. The method includes the steps of denaturing a solution...
6995258 Nucleolar targeting of therapeutics against HIV  
The HIV regulatory proteins Tat and Rev accumulate in nucleoli of human cells. No functional role has been attributed to this localization. Recently it was demonstrated that expression of Rev...
6887707 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA  
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates...
6872818 Ammonium sulfate for neutralization of inhibitory effects  
The present invention provides RNA purification and/or analysis methods that use ammonium sulfate to mitigate or neutralize inhibitory effects of certain molecules. Exemplary inhibitory molecules...
6869780 Nodavirus-like DNA expression vector and uses therefor  
The present invention describes the production of a nodavirus-based DNA vector that drives abundant expression of foreign genes in a wide variety of cell types. The DNA plasmid is initially...
6855520 Cell volume-regulated human kinase h-sgk  
The present invention relates to the cloning and characterization of a human serine/threonine kinase (h-sgk: serum and glucocorticoid dependent kinase). The invention furthermore relates to...
6828127 Method of amplifying an RNA target sequence using an RNA polymerase functioning preferably on RNA template  
Disclosed is a process for transcribing RNA using a nucleotide reagent as the promoter. Such a reagent enables any type of RNA to be transcribed without sequence specification and without protein...
6790642 Method for reducing the amount of nucleic acid adhering to a hydrophobic surface  
The present invention provides a method for isolating nucleic acid from a sample, preferably from a biological sample. This method involves applying the biological sample to a hydrophobic organic...
6787133 Using purified telomerase to identify telomerase activators and inhibitors  
This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative...
6770633 Ribozyme therapy for the treatment of proliferative skin and eye diseases  
As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which...
6740750 Expression systems for functional nucleic acid expression  
A ribozyme comprising the following base sequence (I) or (II): base sequence (I)(SEQ ID No. 1): 5′-ACCGUUGGUUUCCGUAGUGUAGU GGUUAUCACGUUCGCCUAACACGCGAAAGGUCCCCGGUUCGAAACCGGGCACU...
6716627 Antisense modulation of mucin 1, transmembrane expression  
Antisense compounds, compositions and methods are provided for modulating the expression of mucin 1, transmembrane. The compositions comprise antisense compounds, particularly antisense...
6706498 Method for isolating DNA  
The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled...
6699987 Formulations and method for isolating nucleic acids from optional complex starting material and subsequent complex gene analytics  
The subject of the invention are formulations not containing chaotropic components for isolating nucleic acids with binding to a solid phase, in particular of DNA, from optional complex starting...
6692959 Antisense modulation of IL-1 receptor-associated kinase-4 expression  
Antisense compounds, compositions and methods are provided for modulating the expression of IL-1 receptor-associated kinase-4. The compositions comprise antisense compounds, particularly antisense...
6680301 Transfer of molecules into the cytosol of cells  
The present invention relates to a method for introducing molecules in cells by disrupting endosomal and lysosomal membranes using photodynamic treatment, without killing the majority of the cells...
6653133 Antisense modulation of Fas mediated signaling  
Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods...
6646117 Polyribozyme capable of conferring on plants resistance to viruses and resistant plants producing this polyribozyme  
The invention relates to a nucleic acid sequence, called “polyribozyme”, which has an endoribonuclease activity and is capable of inactivating the gene for the capsid protein of a virus,...
6635423 Informative nucleic acid arrays and methods for making same  
The present invention is directed to methods for making and using informative nucleic acid arrays (e.g., DNA including cDNA, RNA, PNA) for research and other applications in various disciplines or...
6633818 Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations  
An improved method for the simultaneous sequence-specific identification of mRNAs in a mRNA population allows the visualization of nearly every mRNA expressed by a tissue as a distinct band on a...
6623962 Enzymatic nucleic acid treatment of diseases of conditions related to levels of epidermal growth factor receptors  
Enzymatic nucleic acid molecules which cleave EGFR RNA.
6593133 Neurotrophic factors  
The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as...
6582936 Methods for making nucleic acids  
Nucleic acids are made by converting a primed single-stranded DNA to a double-stranded DNA by a method comprising the step contacting the single-stranded DNA with a DNA polymerase having 5′...
6582922 Method of extracting nucleic acids using particulate carrier  
The present invention provides a method of extracting and isolating nucleic acids from a material containing nucleic acids using a nucleic acid-binding particulate carrier. More specifically, the...
6576419 Assay procedure using fluorogenic tracers  
Fluorescent energy transfer dyes capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to...
6544755 Method and reagent for treatment of diseases by expression of the c-Myc gene  
An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of Burkitt's lymphoma or acute lymphocytic leukemia.
6537754 Association of kinesin with sensitivity to chemotherapeutic drugs  
The invention provides diagnostic assays for assessing the sensitivity or resistance to DNA damaging agents and microtubule-directed chemotherapeutic drugs of malignant cells in a tumor or tissue....
6531300 Target amplification of nucleic acid with mutant RNA polymerase  
This invention provides for a novel amplification procedure for nucleic acid. The method uses a mutant RNA polymerase designed to transcribe deoxynucleotides. Using primers that bind to target...
6528639 Base-modified enzymatic nucleic acid  
Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
6524854 Antisense inhibition of PKA regulatory subunit RII alpha expression  
Antisense compounds, compositions and methods are provided for modulating the expression of PKA regulatory subunit RII alpha. The compositions comprise antisense compounds, particularly antisense...
6517834 Purified telomerase  
This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative...
6498033 Lentiviral vectors  
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of...
6498023 Generation of single-strand circular DNA from linear self-annealing segments  
The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed...
6492512 Method and reagent for treatment of lung cancer and other malignancies caused by the deregulation of L-MYC gene expression  
An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.
6479465 Methods of treating colitis using STAT-4 anti-sense oligonucleotides  
The present invention provides a method of treating or preventing the inflammatory response of an inflammatory bowel disease in a subject, comprising administering to the subject an amount of a...
6444421 Methods for detecting intermolecular interactions in vivo and in vitro  
Methods for assessing intermolecular interactions in vivo and in vitro are provided. Methods are provided for detecting protein-DNA interactions in vivo, in which a cell having a chimeric guide...
6436909 Antisense inhibition of transforming growth factor-β expression  
Compositions and methods are provided for modulating the expression of TGF-β. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TGF-β are preferred....
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