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8148608 |
Systems and methods for clonal expression in plants
The present invention provides systems and methods for generating clonal root lines, clonal root cell lines, clonal plant cell lines, and clonal plants and for expressing gene products in such cell...
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8101385 |
Materials and methods for the generation of transcripts comprising modified nucleotides
Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.
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8097418 |
Methods and kits for sense RNA synthesis
Methods and kits are provided for performing multiple rounds of sense RNA synthesis. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression...
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8097409 |
Kits for detecting group B Streptococci
Compositions, methods and kits for detecting Group B streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very...
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8043834 |
Universal reagents for rolling circle amplification and methods of use
Disclosed are compositions and methods useful for labeling and detection of analytes. The compositions generally are associations of three components: reporter binding agents, amplification target...
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8012686 |
Risk assessment for adverse drug reactions
The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is...
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7998707 |
Quantitative measurement of gene expression from fixed paraffin embedded tissue
Methods are disclosed for rapid, reliable and simple isolation of RNA, DNA and proteins from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene...
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7960147 |
Quantitative measurement of gene expression based on isolation of RNA from formalin-fixed paraffin-embedded tissue specimens
Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used for quantitative measurement gene...
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7947477 |
Emulsion PCR and amplicon capture
Compositions and methods of use are disclosed for clonally amplifying target polynucleotide sequences in solution and attaching the amplicons to a surface by activation of a masked binding moiety....
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7943310 |
Methods for assessing response to therapy in subjects having ulcerative colitis
A method for prognostic or diagnostic assessment of a gastrointestinal-related disorder, such as ulcerative colitis, in a subject correlates the presence, absence, and/or magnitude of a gene in a...
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7943347 |
Nucleic acid amplification method
Provided is a simple and highly sensitive nucleic acid amplification method including hybridizing two types of oligonucleotide probes with a target gene and ligating the oligonucleotide probes with...
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7939255 |
Diagnostic methods for colorectal cancer
The present application discloses a diagnostic method and a kit for prognosis assessment of colorectal cancer (CRC) and a novel tumor suppressor gene to be used for diagnosis of colorectal cancer...
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7932032 |
Method for diagnosing esophageal cancer
This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal...
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7919280 |
Method for isolation of DNA, RNA and proteins from formalin-fixed paraffin-embedded tissue specimens
Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene expression...
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7906490 |
Circular DNA vectors for synthesis of RNA and DNA
The present invention provides methods for synthesis and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides are synthesized using a small, circular DNA template which...
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7888017 |
Non-invasive fetal genetic screening by digital analysis
The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample....
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7883871 |
Compositions and methods for reverse transcriptase-polymerase chain reaction (RT-PCR)
The present invention is directed to compositions and methods useful for the amplification of nucleic acid molecules by reverse transcriptase-polymerase chain reaction (RT-PCR). Specifically, the...
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7838270 |
Target-dependent transcription using deletion mutants of N4 RNA polymerase
The present invention comprises novel methods, compositions and kits that use N4 vRNAP deletion mutants to detect and quantify analytes comprising one or multiple target nucleic acid sequences,...
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7829285 |
Circulating mRNA as diagnostic markers
Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclampsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for...
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7829312 |
Methods for relative quantification of specific nucleic acid sequences
This invention relates generally to a method for quantifying the number of occurrences of a specific nucleic acid sequence within a nucleic acid sample in order to circumvent the shortcomings of...
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7794986 |
Method for amplification of RNA sequences
The invention relates to a method for amplification of a target RNA sequence, wherein the first primer comprises a hybridizing sequence of 7 to 14 nucleotides, which is capable of binding to a...
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7794984 |
Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks
A novel use of a template-dependent polymerase. The novel use is effected by employing the template-dependent polymerase for incorporating at least one oligonucleotide triphosphate onto a nascent...
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7705138 |
Hepatitis C virus variants
The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV...
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7700286 |
Method for the detection of cancer
The present invention relates to a method for the diagnosis and/or the follow up of the evolution of cancer, which includes the analysis and quantification of over expressed and amplified genes in...
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7655397 |
Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers
A method of diagnosing a disease that includes obtaining experimental data on gene selections. The gene selection functions to characterize a cancer when the expression of that gene selection is...
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7648967 |
Mutagenic nucleoside analogs for the treatment of viral disease
The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides isoguanosine nucleosides and derivatives thereof as well...
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7550264 |
Methods and kits for sense RNA synthesis
Methods and kits are provided for performing multiple rounds of sense RNA synthesis. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression...
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7507528 |
Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells
This invention relates to a method for selecting and/or for qualitative and/or quantitative detection of predetermined biological cells from or in a sample containing biological cells, the sample...
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7470515 |
Compositions and methods for cDNA synthesis
Methods for making cDNA molecules, for amplification of RNA by PCR and for preparation of cDNA libraries are provided. Kits for making cDNA molecules also are provided. Compositions are also...
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7465561 |
Probes and methods for hepatitis C virus typing using single probe analysis
This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at...
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7455995 |
BAALC expression as a diagnostic marker for acute leukemia
Overexpression of the gene, BAALC, in biological samples from a patient is prognostic for tumor aggressiveness and unfavorable patient outcome. The present invention provides polynucleotide primers...
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7432084 |
Methods for preparing nucleic acid samples
In one aspect the present invention provides methods of synthesizing a preparation of nucleic acid molecules, the methods comprising the steps of: (a) utilizing an RNA template to enzymatically...
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7422849 |
Method for determining expression of a PI3 kinase gene
This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways...
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7323319 |
RNA containing coenzymes, biotin, or fluorophores, and methods for their preparation and use
Materials and methods for incorporating adenosine derivatives into the 5′ end of transcribed RNA are disclosed. Adenosine derivatives include naturally occurring compounds such as Coenzyme A, N...
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7270982 |
Helicobacter pylori antigens in blood
The present invention provides methods for detecting Helicobacter pylori (H. pylori) DNA and/or fragments thereof in blood. The first method involves extracting DNA from a blood sample, preferably...
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7202022 |
Method for identification, separation and quantitative measurement of nucleic acid fragments
The invention relates to a new method for sequence-specific identification, separation and quantitative measurement of nucleic acid fragments. The invention is based on the use of restriction...
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7189505 |
Methods of assessing HIV integrase inhibitor therapy
The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic...
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7186507 |
Fluorescent in situ RT-PCR
The present invention describes an in situ reverse transcriptase PCR method in which the background fluorescence is greatly reduced as compared to traditional in situ PCR.
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7179590 |
High temperature reverse transcription using mutant DNA polymerases
The present invention relates to improved reverse transcription methods using a modified thermostable DNA polymerases, particularly in a magnesium ion buffer. These methods are particularly useful...
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7176002 |
Universal-tagged oligonucleotide primers and methods of use
The present invention relates to universal-tagged oligonucleotide primers, and to methods of using the primers for amplifying the genome.
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7163789 |
Cancer diagnosis method
The invention concerns a method for the diagnosis and/or the follow up of the evolution of cancer comprising the analysis of the RNA components of the telomerase enzyme present in the plasma or...
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7135302 |
Method for predicting transplant rejection
The present invention relates to a method for predicting whether or not transplant recipients are likely to reject tissue allografts. It is based, at least in part, on the discovery that, based on...
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7112404 |
Process for high throughput DNA methylation analysis
There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting...
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7083922 |
Detection of HIV
The present invention relates to oligonucleotides for use in amplifying and detecting HIV nucleic acid in a sample.
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7074558 |
Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products
This invention provides for a novel amplification procedure for nucleic acid. The method uses a wild type or mutant RNA polymerase designed to transcribe both deoxyribonucleotides and ribonucleotides.
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7052890 |
Transglutaminase gene products
The invention provides a nucleotide sequence comprising at least a portion of the nucleotide sequence of FIG. 10A, FIG. 6B or FIG. 10A or FIG. 10B; nucleotides which hybridise to the nucleotide...
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7049067 |
Oligonucleotide for detection of HIV-1 and detection method
An oligonucleotide useful for detection of an RNA derived from HIV-1 consisting of at least 10 consecutive bases in any of SEQ ID NOS:1, 2, 4 to 10 and 13 to 17, which can bind to a specific site...
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RE39031 |
RNA amplification method requiring only one manipulation step
An RNA amplification method is particularly useful for diagnosing bacterial or viral infections or genetic disorders and for cell typing. The method includes the steps of denaturing a solution...
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7005278 |
Method of determining dihydropyrimidine dehydrogenase gene expression
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine...
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6986988 |
Method for enrichment of natural antisense messenger RNA
A method for enrichment of natural antisense mRNA which involves hybridization of cDNA obtained from sense RNA with cDNA obtained from antisense RNA, followed by DNA polymerase treatment of the...
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