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7391017 |
Mass scale alignment of time-of-flight mass spectra
The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption....
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7390621 |
Methods and compositions for detecting telomerase activity
A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and...
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7388093 |
Gene for identifying individuals with familial dysautonomia
This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is...
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7387887 |
Nucleic acid melting analysis with saturation dyes
Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A...
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7387876 |
Amplification of trace amounts of nucleic acids
Methods of reducing background during amplification of small amounts of nucleic acids employ careful analysis of sources of low level contamination. Ultraviolet light can be used to reduce nucleic...
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7384770 |
Rapid quantification of acetic acid-producing bacteria using real-time PCR
A set of primer pairs for amplifying a nucleic acid of an acetic acid-producing bacteria, each primer containing an oligonucleotide selected from the ackA gene region of the acetic acid-producing...
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7384743 |
BRCA1/BCRA2 screening panel
A method for analyzing a biological sample is performed by analyzing a biological sample for the presence of one or more mutations or polymorphisms in the BCRA1 and/or BCRA2 genes.
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7384741 |
Molecular identification of Aspergillus species
Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the...
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7384740 |
Polynucleotide and protein involved in synaptogenesis variants thereof and their therapeutic and diagnostic uses
The present invention provides a method of diagnosing autism linked to a mutation in the polynucleotide of SEQ ID NO: 12 or the polypeptide of SEQ ID NO: 14, or a propensity therefor, in a human,...
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7381818 |
Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof
Minor groove binder-oligonucleotide probes are provided along with methods for their use wherein the probes have an attached fluorophore which, in an unhybridized form exhibits very low background...
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7381808 |
Method and nucleic acids for the differentiation of prostate tumors
The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method...
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7381547 |
Methods and compositions to detect bacteria using multiplex PCR
Multiplex polymerase chain reaction assays for detecting a bacteria (e.g. Helicobacter pylori ) in a specimen use multiple oligonucleotide primer pairs based on the sequences of multiple loci of...
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7381528 |
Methods for detection of mutations in myostatin variants
Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a...
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7381527 |
Method of detection of SP-A2 gene variants
The invention provides a method for predicting the susceptibility of an individual to pulmonary tuberculosis, the method comprising amplifying genomic DNA of pulmonary tuberculosis patients and...
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7378260 |
Products and methods for reducing dye artifacts
The present invention provides products and methods of reducing dye artifacts from chain extension reactions.
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7378241 |
Method for determining the efficiency of nucleic acid amplifications
The present invention concerns a method for determining the efficiency of the amplification of a target nucleic acid comprising the following steps: (i) preparation of a dilution series of the...
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7378233 |
BRAF mutation T1796A in thyroid cancers
The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27...
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7375210 |
PCR primer set for detecting severe acute respiratory syndrome (SARS)-Coronavirus, method and kit for detecting SARS-Coronavirus using the same
Provided are SARS-CoV detection PCR primers having nucleotide sequences as set forth in SEQ ID NOS: 1-46, a method for detecting SARS-CoV using the primers, and a SARS-CoV detection kit including...
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7374914 |
Method of detection of alterations in MSH5
We have now discovered that mammals have a DNA gene analogous to that existing in bacteria. MSH5 defects or alterations in this mismatch repair pathway in a mammal, such as a human, can be...
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7374913 |
Method for synthesizing polynucleotides
The present invention realized isothermal and rapid polynucleotide synthesis by using as templates polynucleotides having a structure capable of forming loops, and combining a plurality of primers...
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7374885 |
Single-primer nucleic acid amplification methods
The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to...
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7374883 |
Method and kit for the detection of a novel coronoavirus associated with the severe acute respiratory syndrome (SARS)
The instant invention relates to a quantitative real time RT-PCR method for detecting Severe Acute Respiratory Syndrome-associated virus (SARS-associated virus) and to oligonucleotides and kits for...
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7374882 |
Method for base sequencing and biologically active nucleic acids
Aptamers are nucleic acids and similar molecules, such as peptide-nucleic acids, that specifically bind to a ligand such as a protein or peptide. The present invention provides aptamers comprising...
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7374879 |
Method for detecting product of nucleic acid synthesizing reaction
A method for detecting the occurrence of nucleic acid syntheses using an enzyme through the use of a generated insoluble substance as an indicator.
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7373253 |
Multi-test analysis of real-time nucleic acid amplification
A method and device are described for analyzing a sample for the presence of a nucleic acid wherein the sample is amplified, illustratively using PCR, in the presence of a fluorescent probe capable...
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7371849 |
Methods of constructing camel antibody libraries
The present invention provides camel antibody libraries that maintain in vivo diversity of camelid antibody variable region genes. The in vivo diversity of antibody variable region genes can be...
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7371545 |
Method for determining the amount of template nucleic acid present in a sample
A method for determining the amount of template nucleic acid present in a sample comprising the steps of: I) bringing into association with the sample all the components necessary for nucleic acid...
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7371544 |
Homogenous method for the detection of a polynucleotide, with e.g. cleavable lanthanide chelate label
The present invention relates to a homogenous method for detecting at least one target polynucleotide in a sample comprising the steps of
contacting a sample comprising said polynucleotide...
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7371530 |
Micro PCR device, method for amplifying nucleic acids using the micro PCR device, and method for measuring concentration of PCR products using the micro PCR device
Provided is a micro PCR device. The micro PCR device includes a PCR chamber having electrodes. First primers of PCR primer sets are immobilized on the surfaces of the electrodes and second primers...
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7371522 |
Use of polymorphism of the serotonin transporter gene promoter as a predictor of disease risk
The present invention provides a method of screening subjects for disease risk. The method comprises determining the serotonin transporter gene promoter genotype of a subject. The serotonin...
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7371521 |
Methods
Methods for determining the KIT genotype of pigs are provided. These methods are useful in determining coat colour genotype, breed determination and for screening pigs to determine those likely to...
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7368560 |
Intercalation-mediated synthesis of polymers
Methods and compositions for synthesizing biopolymers using an intercalator are provided. Aspects provide compositions and methods for synthesizing biopolymers with non-natural backbones or...
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7368265 |
Selective genome amplification
The invention provides methods and compositions for amplifying selected polynucleotides, especially selected subsets of restriction fragments. Generally, methods of the invention are implemented by...
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7368264 |
SLC1A1 marker for anxiety disorder
The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for...
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7368246 |
Quantitative gene expression profiling
Described herein are approaches to the measurement of gene expression for chosen genes in a biological sample. The methods permit the quantitation of target nucleic acids, e.g., DNAs or RNAs in a...
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7368243 |
Detection of nucleic acids to assess risk for bovine spongiform encephalopathy
The present invention provides a method of detecting abnormal serum nucleic acid profiles to assess the risk of a transmissible spongiform encephalopathy, e.g., BSE.
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7368241 |
Cotton event PV-GHBK04 (757) and compositions and methods for detection thereof
The present invention provides a cotton event PV-GHBK04 (757), a cotton plant that contains PV-GHBK04 (757) DNA molecules and its progeny thereof, and methods for producing cotton event PV-GHBK04...
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7368236 |
Methods of producing nucleic acid ligands
The present invention includes methods for the identification and production of improved nucleic acid ligands based on the SELEX process. Also included are nucleic acid ligands to the HIV-RT...
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7365187 |
DNA amplification method and kit therefor
In a method for amplifying a DNA, comprising performing PCR using a sense primer and an antisense primer, PCR is performed in the presence of an additional sense primer comprising the sense primer...
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7364854 |
Nucleotide mixture for improved nucleic acid amplification performance
The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In...
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7364853 |
Detection of microsatellite instability and its use in diagnosis of tumors
Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA...
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7364844 |
Use of the Krit1 gene in the field of angiogenesis
The invention concerns a method for diagnosing cavernous angiomas for detecting mutations in the Krit1 gene. More particularly, said detection is performed by using nucleotide sequences. The...
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7361746 |
Methods and compositions for detection of Mycobacterium avium complex species
Methods of detecting Mycobacterium avium complex (MAC) organisms using in vitro nucleic acid amplification with amplification oligonucleotides specific for 16S rRNA or DNA sequences encoding 16S...
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7361489 |
Nucleic acid amplification methods
The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention...
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7361488 |
Nucleic acid detection methods using universal priming
The present invention is directed to providing sensitive and accurate assays for gene detection, genome-wide gene expression profiling and alternative splice monitoring with a minimum or absence of...
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7361471 |
Nucleic acid archiving
This invention is directed to a process for tightly binding nucleic acid to solid phase and corresponding processes for the utilization thereof. Nucleic acid is bound to solid phase matrices...
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7361466 |
Nucleic acid analysis using terminal-phosphate-labeled nucleotides
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the...
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7358347 |
MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is...
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7358048 |
Method for detection of promoter methylation status
The present invention relates to the detection of promoter methylation status using a combination of either modification of methylated DNA or restriction endonuclease digestion, multiplex...
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7358047 |
Methods of forming circular nucleic acid probes and uses thereof
The present invention relates generally to a method of amplifying closed circular nucleic acid probes and, more particularly, to a method of amplifying closed circular nucleic acid probes by...
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