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8182996 |
Compositions and methods for detecting Klebsiella pneumoniae
Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to...
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8182994 |
Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is...
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8182993 |
Methods and processes for calling bases in sequence by incorporation methods
Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from...
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8182992 |
Compositions for use in identification of adventitious viruses
The present invention provides compositions, kits and methods for rapid identification and quantification of adventitious contaminant viruses by molecular mass and base composition analysis.
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8183015 |
Biological reagents and methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection
This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites,...
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8182995 |
Real time gene expression profiling
The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the...
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8178297 |
Method of detecting canine exercise-induced collapse
The present invention relates to diagnosing Canine Exercise-Induced Collapse (EIC).
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8178360 |
Dye compounds and the use of their labelled conjugates
Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a...
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8180572 |
High-resolution melting analysis
The present invention relates to methods and systems for the analysis of the dissociation behavior of nucleic acids and the identification of nucleic acids. In one aspect, methods and systems are...
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8178294 |
Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes
Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to...
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8178299 |
Method to determine the risk for side effects of an SSRI treatment in a person
A new method is found to determine an increased risk for side effects of an SSRI treatment in a person by genotyping the person for the presence of the 102 C/C DNA sequence in the 5-HT2A receptor...
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8178300 |
Method for the identification of the clonal source of a restriction fragment
The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising...
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RE43365 |
Apparatus for chemical amplification based on fluid partitioning in an immiscible liquid
A system for nucleic acid amplification of a sample comprises partitioning the sample into partitioned sections and performing PCR on the partitioned sections of the sample. Another embodiment of...
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8173365 |
Method for inhibiting signal transduction, signal transduction inhibitor to be used therein and use thereof
An object of the present invention is to provide a method for inhibiting activation of signaling pathway mediated by erbB1 or erbB2 in human cell and a signaling inhibitor to be used therefor. The...
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8173401 |
Method for direct amplification from crude nucleic acid samples
The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the...
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8173400 |
Method of detecting or quantitating endogenous wheat DNA and method of determining contamination rate of genetically modified wheat in test sample
An object of the present invention is to discover an endogenous wheat sequence satisfying the conditions of: a) it is universally present in varieties of wheat, b) the amount present (detected...
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8173071 |
Micro-fluidic test apparatus and method
An apparatus, system, and method for determining the osmolarity of a fluid. The apparatus includes at least one micro-fluidic circuit and at least one electrical circuit disposed in communication...
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8173371 |
Serial coupling of nucleic acid metabolism and extension for nucleic acid amplification
A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification...
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8173602 |
Detecting CYP24 expression level as a marker for predisposition to cancer
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer...
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8168384 |
Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy
The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease....
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8168387 |
Oligonucleotides, use thereof, detecting method and kit for diagnosing the presence of H5 and N1 genes of the Influenza A virus
The present invention relates to a double pair of oligonucleotides for amplifying two target sequences located, respectively, in the H5 and N1 genes of the genome of the Influenza A virus, said...
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8168390 |
Method and apparatus for diagnosing age-related macular degeneration
Disclosed is a method for identifying an individual who has an altered risk for developing age-related macular degeneration comprising detecting an insertion/deletion polymorphism in the ARMS2 gene.
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8168442 |
Cartridge for conducting a chemical reaction
A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a...
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8168388 |
Preparation of nucleic acid templates for solid phase amplification
The invention relates to a method of preparing template constructs for solid-phase nucleic acid amplification and to use of the templates in methods of solid-phase nucleic acid amplification. The...
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8163485 |
Differential enzymatic fragmentation
The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.
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8163524 |
Comparative analysis of extracellular RNA species
The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA,...
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8163484 |
Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic...
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8163895 |
Compositions for use in identification of orthopoxviruses
Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass...
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8163483 |
Compositions and methods for spinocerebellar ataxia
Mutations in the KCNC3 (Kv3.3) voltage-gated potassium channel gene result in spinocerebellar ataxia.
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8163486 |
Probe, probe set, probe carrier, and testing method
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
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8163480 |
Nucleic acid size detection method
The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an...
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8158353 |
Species-specific and quantitative detection of CNS tissue in meat and meat products
The present invention concerns a method for the species-specific and quantitative detection of CNS tissue in meat and meat products of the ruminant species bovine, ovine and caprine or porcine by a...
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8158352 |
Screening of a novel hepatic syndrome and its uses
The invention concerns methods of screening for a hepatic syndrome occurring in the young adult and associating cholesterol biliary microlithiasis, intrahepatic cholestasis and several mutations of...
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8158341 |
Efficient algorithm for PCR testing of blood samples
A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an...
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8158346 |
Labelled nucleotides
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
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8158388 |
Repair of nucleic acids for improved amplification
Methods and compositions are provided for repairing a polynucleotide so that it can be copied with improved fidelity and/or yield in, for example, an amplification reaction. This involves the use...
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8153366 |
Methods and compositions for predicting drug responses
The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized...
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8153373 |
Capture and characterized co-localized chromatin (4C) technology
The present invention relates in one aspect to a method for analyzing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (e.g., one or...
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8153403 |
Process for identifying existence of single nucleotide polymorphism without DNA sequencing
A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a...
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8153372 |
Method for simultaneously determining in a single multiplex reaction gender of donors and quantities of genomic DNA and ratios thereof, presence and extent of DNA degradation, and PCR inhibition within a human DNA sample
Methods are provided for determining, in a single polymerase chain reaction (PCR) reaction, the quantity, quality, and gender of origin of DNA in a sample, and whether or not the sample contains...
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8153402 |
Emulsion compositions
An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a...
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8153371 |
Probe, probe set, probe carrier, and testing method
A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of...
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8153401 |
Method for direct amplification from crude nucleic acid samples
The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the...
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8153365 |
Oligonucleotide analogues
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked...
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8153773 |
Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap
New RNA cap analogs are disclosed containing one or more phosphorothioates groups. The analogs also contain modifications at the 2′-O position of 7-methylguanosine that prevent them from being i...
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8153375 |
Compositions and methods for nucleic acid sequencing
Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant...
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8148115 |
Device and method for extraction and analysis of nucleic acids from biological samples
Device and methods for extracting and analyzing nucleic acids from biological samples.
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8148062 |
Detection of disease related genes
The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA...
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8148511 |
Methods and compositions for the detection and quantification of E. coli and Enterococcus
The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in...
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8148516 |
Flowcell systems for single molecule detection
The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule...
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