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9150908 Method for detecting the presence of a nucleic acid in a sample  
An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes...
9039993 Microfluidic device  
Microfluidic devices of the present disclosure relate to quick and inexpensive microfluidic manipulation/handling. A number of channels may be supplied with fluid ingredient(s). In some...
9034606 Detection of an amplification reaction product using pH-sensitive dyes  
Methods are provided for a rapid, low cost approach to monitoring an amplification reaction. This includes monitoring the progress of isothermal or PCR amplification reactions to completion using...
9034603 Dried composition for hot-start PCR with long-term stability  
The present invention relates to a dried composition for hot-start PCR, more precisely a dried composition for hot-start PCR with improved stability and long-term storagability which is...
9034605 Reagents and methods for PCR  
Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least...
9034604 Composition comprising an oligonucleotide mixture for the detection of contaminations in cell cultures  
The present invention relates to a method for determining contaminations in a cell culture sample comprising the steps of: a) contacting a sample of a cell culture suspected to comprise...
9034635 Thermocycler and sample vessel for rapid amplification of DNA  
A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present...
9029103 Methods for sequencing polynucleotides  
Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first...
9029083 Vitro evolution in microfluidic systems  
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into...
9023602 Method for detecting cyst nematodes  
The present invention relates to a method for determining the presence of a cyst nematode in a sample comprising the steps of: providing a pair of bidirectional oligonucleotide primers or an...
9024006 Mutation detection assay  
A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant...
9017947 Soybean event MON89788 and methods for detection thereof  
The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also provides methods for detecting the...
9017972 DNA methylation analysis of regulatory T cells through DNA-methylation analysis of the TSDR region of the gene FOXP3  
The present invention relates to a method, in particular an in vitro method for identifying FoxP3-positive CD25+CD4+ regulatory T cells of a mammal, comprising analyzing the methylation status of...
9017970 RNA polyphosphatase compositions, kits, and uses thereof  
The present invention relates to the discovery of RNA 5′ polyphosphatase enzymes not previously described in the art, methods for discovery of said enzymes, compositions of said enzymes, methods...
9017971 Means and methods for investigating nucleic acid sequences  
The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.
9017973 Methods and compositions for incorporating nucleotides  
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of...
9017948 Assays and other reactions involving droplets  
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments,...
9017941 Microchip for analyzing nucleic acid and method of nucleic acid analysis using the same  
A method for nucleic acid analysis including injecting a slight amount of nucleic acid sample for analysis, characterized in that most of a nucleic acid sample which is not used, excluding the...
9012185 Thermal cycling device with phase changing fluids  
The invention provides systems, devices, and methods for heating and cooling chemical or biological samples, such as genetic materials during Polymerase Chain Reaction (“PCR”). The systems,...
9012184 End modification to prevent over-representation of fragments  
The invention relates to a method of preparing a 5′ and 3′ modified library of template polynucleotides and also the use of the 5′ and 3′ modified library of templates in methods of solid-phase...
9012142 Sequence-specific detection of nucleotide sequences  
A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a...
9012149 Methods for detection and quantitation of small RNAs  
Improved methods that increase the specificity and sensitivity of detection of small RNAs, including miRNAs, using oligonucleotide primers and nucleic acid amplification, are provided. Reaction...
9012183 Use of template switching for DNA synthesis  
A method of preparing a DNA copy of a target polynucleotide using template switching is described. The method includes mixing a double stranded template/primer substrate made up of a DNA primer...
9012208 Nucleic acid purification  
A self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, includes at least one input, and: (i) a...
9005894 Determination of KIR haplotypes associated with disease  
Disclosed is a method of determining KIR genotypes for one or more individuals in parallel, the method comprising: for each individual, amplifying the polymorphic exon sequences of the KIR genes,...
9005891 Methods for depleting RNA from nucleic acid samples  
The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA...
9005932 Mutational analysis  
A method for analysing genetic mutations, and in particular single nucleotide polymorphisms (SNPs) and/or somatic mutations, is described, as well as methods for preferentially amplifying one...
9005931 Programmable oligonucleotide micro array  
A programmable probe design of DNA micro array and detection methodology is provided. DNA probes, which are complemented with the target DNA, are designed and classified into groups according to...
9005933 Helicase dependent isothermal amplification using nicking enzymes  
The present invention relates to a method for amplifying a template nucleic acid, wherein the method comprises amplifying said template nucleic acid using the helicase dependent amplification...
8999676 Recombinant polymerases for improved single molecule sequencing  
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the...
8999673 Method for specifically producing a joined DNA fragment comprising a sequence derived from a target gene  
Provided is a method for selectively obtaining, for a given target gene, a “joined DNA fragment” wherein just a target gene fragment is joined with desired other DNA fragments, regardless of...
8999677 Method for differentiation of polynucleotide strands  
Objective of the present invention is to provide a method for keeping of directional information in double-stranded DNA. We suggest to convert polynucleotide into a hybrid double-stranded DNA. One...
8999675 Dengue virus assay  
Nucleic acid assays for detecting nucleic acids of Dengue virus serotypes 1-4 derived from 5′ NTR.
8999648 System and method for classification of patients  
A system (100) for classifying a biological test sample, including a database (112) populated with reference expression data. The reference expression data includes expression levels of a...
8999644 Method for detecting the presence of a DNA minor contributor in a DNA mixture  
The present invention concerns a method of detecting the presence of a DNA minor contributor in a DNA mixture by determining several haplotypes present in said one or more DNA samples.
8993232 Identification of the causative mutation for leopard complex spotting and congenital stationary night blindness in equines and a method for testing for same  
Methods are provided for determining whether or not a horse is genetically normal, is a carrier of, or is affected with or predisposed to Congenital Stationary Night Blindness and/or leopard...
8993242 Method for functional testing of site-specific DNA methylation  
Methods and kits are provided for testing the functional effect of methylating different cytosine residues, for testing patterns of DNA methylation on gene expression, and for site-specific...
8993270 Solid gel amplification method and apparatus for genotyping and pathogen detection  
The present invention provides for a novel system and method for amplification and detection of nucleic acids within a miniaturized device.
8993229 Method for detecting and distinguishing infectious norovirus from inactivated norovirus  
A method for extracting and distinguishing infectious norovirus from inactive norovirus using a solid support conjugated with a glycoprotein moiety capable of binding infectious norovirus wherein...
8993271 Method of nucleic acid amplification  
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer...
8993240 Hot start reverse transcription by primer design  
The present teachings provide methods, compositions, and kits for performing primer extension reactions. In some embodiments, a reverse transcription reaction is performed on a target...
8993237 Device and method for thermal cycling  
A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block...
8986958 Methods for generating target specific probes for solution based capture  
Provided herein are compositions and kits for single-stranded nucleic acid probes, and methods for making the single-stranded nucleic acid probes, where the single-stranded nucleic acid probes...
8986982 Apparatus and method for a continuous rapid thermal cycle system  
A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means...
8986959 Setting of multiple priming oligonucleotides for solid gel amplification in hydrogels  
The present invention provides for a novel system and method for amplification and detection of nucleic acids within a microfluidic device wherein multiple nucleotides capable of priming PCR are...
8986929 RGS2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication  
The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with...
8980584 System and methods for nucleic acid sequencing of single molecules by polymerase synthesis  
This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi...
8980551 Use of class IIB restriction endonucleases in 2nd generation sequencing applications  
The present invention relates to a method for genotyping DNA molecules contained in at least one DNA sample. The method includes: (a) digesting the DNA molecules contained in at least one DNA...
8980554 Genetic make-up modifies cancer outcome  
A frequent SNP A259G (K87E) genotype switch in the MMP8 gene in has been found to modify the clinical behavior of cancers. The modification varies based on the patient's genotype for the SNP, and...
8980563 Multiplex targeted amplification using flap nuclease  
Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe...