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8980558 Methods, compositions and kits for the improved detection of small RNA molecules  
The present invention provides compositions, methods and kits for use in the detection of small RNA sequences, which allow for rapid and robust amplification and detection. The methods provide...
8980580 Heterologous expression of fungal polyketide synthetic gene in yeast and a method of preparing a compound produced by a protean encoded by the polyketide synthetic gene by the heterologous expression  
The present invention relates to a method of removing an intron contained in a gene from a eukaryotic gene, and linking only the exon sequences to prepare an expression vector comprising the...
8980333 Development of novel detergents for use in PCR systems  
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for...
8980555 Rapid genotyping analysis and devices thereof  
The present invention discloses methods, primer, probes, and kits for genotyping various mutations or disease-causing agent. In one embodiment, the present invention is applied to detecting the...
8975018 Method of detecting expanded CAG repeat region in spinocerebellar ataxia-2 gene  
The present invention provides isolated nucleic acids encoding human SCA2 protein, or fragments thereof, and isolated SCA2 proteins encoded thereby. Further provided are vectors containing...
8975216 Articles having localized molecules disposed thereon and methods of producing same  
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the...
8975027 Methods and compositions related to continuous flow thermal gradient PCR  
Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.
8975025 Method and system for nucleic acid detection using electroconductive or electrochemically active labels  
A method for electrochemically or electrically detecting nucleic acids, utilizes electrochemically active or electrically conductive reporter materials. An electric voltage is applied and electric...
8975024 Methods for sequencing polynucleotides  
The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are...
8975022 Genetic polymorphisms associated with psoriasis, methdos of detection and uses thereof  
The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid...
8975028 Method for the identification of the clonal source of a restriction fragment  
The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising...
8975020 Methods of detecting Charcot-Marie Tooth disease type 2A  
Methods are described for screening a subject for risk of Charcot-Marie-Tooth Disease Type 2A or for diagnosing Charcot-Marie-Tooth disease or a predisposition for developing Charcot-Marie-Tooth...
8969046 Methods for detecting epigenetic modifications  
A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4,...
8969047 Solid support assay systems and methods utilizing non-standard bases  
Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In...
8969045 Method for detecting pyrophosphate by means of bioluminescence detection  
The invention relates to methods for detecting pyrophosphate by means of bioluminescence detection. In addition, methods for measuring chemical, especially enzyme-catalyzed, reactions in which...
8968999 Methods for in vitro joining and combinatorial assembly of nucleic acid molecules  
The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule...
8969006 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Soybean event MON89788 and methods for detection thereof
 
The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also provides methods for detecting the...
8962279 Solid-phase chelators and electronic biosensors  
Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified...
8962280 Methods for detecting DNA orginating from different individuals  
In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate...
8962278 Compositions and methods for production of immunoglobulins  
Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of a heavy...
8962255 Recombinase polymerase amplification  
This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade...
8962253 Methods and compositions for detection of small RNAs  
Currently, the circularization of small RNAs is broadly regarded as an obstacle in ligation-related assays and explicitly avoided while short lengths of linear RNA targets is broadly recognized as...
8962254 Analyzing messenger RNA and micro RNA in the same reaction mixture  
The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a...
8962820 Combination of fluorescent dyes for the detection of nucleic acids  
The present invention relates to combinations of fluorescent dyes used in molecular biology, particularly in multiplex PCR. In particular, the present invention relates to a combination of dyes...
8962241 Triggered molecular geometry based bioimaging probes  
The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable...
8956821 Methods and compositions for detecting Aspergillus terreus, Aspergillus niger, and mycotoxins  
The invention relates to a method of identifying an Aspergillus terreus or an Aspergillus niger fungal species in patient tissue or body fluid and to primers and probes for use in such a method.
8956817 Identification of microRNAs (miRNAs) in fecal samples as biomarkers for gastroenterological cancers  
A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool...
8956814 Methods and compositions for detecting serotypes of Chlamydia trachomatis capable of causing lymphogranuloma venereum  
Disclosed are methods and compositions for conducting assays utilizing real-time polymerase chain reactions (“PCRs”) in detection of serotypes L I, L II, and L III, but not stereotype B, of...
8951733 Methods of polynucleotide detection  
The present invention provides methods of detecting for the presence of a polynucleotide in vivo. These methods are particularly useful for performing identification and/or analysis of samples or...
8951725 Diagnostic methods for determining prognosis of non-small cell lung cancer  
The invention provides methods for identifying early stage non-small cell lung cancer (NSCLC) patients who will have a favorable prognosis for the recurrence of lung cancer after surgical...
8951731 Sequence analysis using decorated nucleic acids  
The present invention provides a sequence interrogation chemistry that combines the accuracy and haplotype integrity of long-read sequencing with improved methods of preparing genomic nucleic...
8945880 Thermal cycling by positioning relative to fixed-temperature heat source  
The thermal cycling system for performing a biological reaction at two or more different temperatures comprises: a) a heat source for setting at a fixed temperature; b) a reaction vessel...
8945486 Microwell device  
A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and...
8945845 Recombinase polymerase amplification  
This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade...
8945843 Thermocooler with thermal breaks that thermally isolate a thermocycling region from at least one guard heat region  
A sample processing apparatus includes a sample carrier receiving region configured to receive a sample carrier carrying at least one sample, at least one sample processing station that processes...
8945883 In situ cloning from pathological tissue specimens  
The present invention pertains to methods related to cloning nucleic acids from biological samples, particularly pathological tissue samples. This method includes hybridizing a population of...
8945850 Detection, identification and differentiation of Staphylococcus using a hybridization assay  
The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived...
8945912 DNA sequencing and amplification systems using nanoscale field effect sensor arrays  
In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another...
8945831 Compositions and methods for detecting juvenile renal dysplasia or calcium oxalate stones in dogs  
The application relates to Canine Cox2 allelic variants associated with Juvenile Renal Dysplasia, primer and probe compositions and methods and kits useful in detecting, monitoring and diagnosing...
8945882 DNA polymerases with improved activity  
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer...
8945881 Localized temperature control for spatial arrays of reaction media  
Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each...
8936921 Methods of isothermal amplification using blocked primers  
Methods for rapidly detecting clinically relevant mutations in the infectious genome of an agent are disclosed. The methods include use of a novel target and temperature dependent RNase H mediated...
8936919 Method for the detection and diagnosis of cancer involving primers and probes for the specific detection of the MAGE-A3-marker  
The present invention relates to MAGE-3 specific primers and probes for use new diagnostic kits and methods. The invention further relates to immunotherapeutic treatment of specific populations of...
8936911 Purified extended polymerase/template complex for sequencing  
Methods, Compositions, and Systems are provided for obtaining polymerase-template complex mixtures with improved levels of active polymerase. In some aspects, methods are described in which a...
8936920 Primers for detecting plasmodium  
The present invention provides an easy and rapid method for detecting/identifying the presence or absence of specific Plasmodium parasites and four species of malaria parasites in a human...
8932831 Insertion of sequence elements into nucleic acids  
The present invention concerns a method for inserting one or more tag sequences into a nucleic acid characterized by the following steps: (a) preparation of a template nucleic acid; (b)...
8932811 Genomic selection and sequencing using encoded microcarriers  
The present invention relates to a method for determining the sequence of a nucleic molecule. Herein a capture oligonucleotide probe is attached to an encoded microcarrier, wherein the code of...
8932808 Methods and compositions for determining a graft tolerant phenotype in a subject  
Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least one gene in a sample from the subject, e.g., a...
8932810 Identification of mutation and method for detecting lavender foal syndrome in the horse  
Provided is a method for determining whether a horse is normal, a carrier, or is affected with Lavender Foal Syndrome (LFS). The method entails, in a biological sample obtained or derived from a...
8932817 Methods for quantitative amplification and detection over a wide dynamic range  
Disclosed are compositions and methods for making differentiable amplicon species at unequal ratios using a single amplification system in a single vessel. The number of differentiable amplicons...