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8420317 Alkaline shock-based method of processing a biological sample  
Method of processing a biological sample to yield nucleic acid appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to...
8420323 Nucleic acid amplification method  
An object to be achieved by the present invention is to provide a nucleic acid amplification method by which a nucleic acid can be amplified using oligonucleotide primers and DNA polymerase. The...
8415095 Use of nucleoside derivatives comprising a citrate group for the production of antibodies having an affinity for triphosphorylated nucleosides  
Nucleoside analogues comprising a citrate group can be used to obtain immunogens designed to produce antibodies having an affinity for triphosphorylated nucleosides. Such antibodies are useful for...
8409807 NMR systems and methods for the rapid detection of analytes  
This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
8409799 Diagnostic test for cardiomyopathy  
Methods and compositions relating to diagnosing and treating cardiomyopathy and particularly relating to methods and compositions for diagnosing and treating arrhythmogenic right ventricular...
8409806 Allelic ladder loci  
Disclosed are rare short tandem repeat (STR) alleles within the D10S1248 and D12S391 loci in humans. Provided are representative allelic ladders for each locus, methods and assays using these...
8409848 System and method for rapid thermal cycling  
At least one exemplary embodiment is directed to an apparatus that includes a microfluidic channel and at least one energy absorbing element, where the energy absorbing element is configured to...
8409829 Methods for analysis of molecular events  
Methods and compositions are provided for detecting the presence of nucleic acid sequence variants in a subpopulation of nucleic acid molecules in a biological sample. These methods are...
8409804 Isolation of CpG islands by thermal segregation and enzymatic selection-amplification method  
The present invention concerns isolation, library preparation and selective amplification from a compositionally heterogeneous pool of DNA fragments of a fraction of molecules, such as those...
8409805 Method of amplification of GC-rich DNA templates  
Methods are provided for increasing the processivity of DNA polymerases on GC-rich templates. The methods relate to providing enhancers and biased ratios of dNTPs, and may be used in DNA...
8409802 Format of probes to detect nucleic acid differences  
The invention provides, inter alia, novel probes, methods, reaction mixtures, and kits for detecting the presence or absence of a target nucleic acid sequence.
8404446 DNA in the presence of gellan  
A method is provided for nucleic acid amplification with enhanced sensitivity. The method for enhanced sensitivity involves carrying out the amplification reaction in the presence of gellan. For...
8404822 Probe, probe set, probe-immobilized carrier, and genetic testing method  
A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other...
8404443 Hot start nucleic acid amplification  
Methods and compositions for performing nucleic acid duplication and amplification reactions are provided. A single-stranded nucleic acid binding protein is selected and provided in the reaction...
8404438 Probes for detection of SULT1A1 gene, reagent containing the same, and the uses thereof  
A primer set for amplifying a region including sites to be detected of SULT1A1*2 and SULT1A1*3 in the SULT1A1 gene by a gene amplification method is provided, wherein the primer set can amplify...
8404463 DNA assays using amplicon probes on encoded particles  
Encoded bead multiplex assays for chromosomal gains and losses are provided that provide the benefits of complex, large template DNA sources, such as BAC DNA, as the probe material without bead...
8404464 Methods of using stabilized compositions of thermostable DNA polymerase and anionic detergent  
The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to...
8399192 Using populations of beads for the fabrication of arrays on surfaces  
The present invention provides a method of creating an array of features. The method can include steps of (a) providing a plurality of beads, wherein each bead in the plurality of beads includes...
8399189 Primers for melting analysis  
Methods and kits are provided for nucleic acid analysis. In an illustrative method a target nucleic acid is amplified using a first primer and a second primer, wherein the first primer comprises a...
8399222 Compositions and methods for detecting small RNAs, and uses thereof  
Compositions and methods are provided for the detection of small RNA target nucleic acids, preferably miRNA target nucleic acids, wherein the compositions and methods provide for sensitive and...
8399195 Detecting genetic abnormalities  
The present invention is directed to compositions and methods for detecting genetic abnormalities. The present invention encompasses methods and compositions for comparing alleles in a sample...
8399199 Use of stem-loop oligonucleotides in the preparation of nucleic acid molecules  
The present invention concerns preparation of DNA molecules, such as a library, using a stem-loop oligonucleotide. In particular embodiments, the invention employs a single reaction mixture and...
8399221 Methods for detection and quantitation of small RNAs  
Improved methods that increase the specificity and sensitivity of detection of small RNAs, including miRNAs, using oligonucleotide primers and nucleic acid amplification, are provided. Reaction...
8399196 Nucleic acid sequencing methods, kits and reagents  
The present invention relates to nucleic acid sequencing methods, kits and reagents, and more particularly to methods of sequencing nucleic acid which employ a nucleic acid processing enzyme and...
8394591 Method for the identification of the clonal source of a restriction fragment  
The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising...
8394587 Single nucleotide polymorphisms and use of same predicting male-specific prenatal loss  
The present invention is directed to a panel of single nucleotide polymorphisms (SNPs) in specific genes that serve as biomarkers for sex-specific prenatal loss of a conceptus or embryo. There is...
8394608 Self-contained biological analysis  
Devices, containers, and methods are provided for performing biological analysis in a closed environment. Illustrative biological analysis include nucleic acid amplification and detection and...
8394944 Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation  
The present invention provides primers and probes to be used in a method of enhancing hybridization of a probe to a target nucleotide sequence when the target sequence is capable of forming...
8394586 Labelled nucleotides  
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
8394609 Primers and methods for the detection and discrimination of nucleic acids  
The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular...
8394324 Microchip large-volume PCR with integrated real-time CE detection  
A microfluidic device is provided with appropriate integrated structures to conduct large volume PCR and end-point or real-time capillary electrophoresis detection. The microfluidic device...
8389221 Method of detecting H5 or H7 avian influenza virus  
The present invention provides oligonucleotide primers specifically hybridizing to an arbitrary nucleotide sequence designed from the nucleotide sequence of hemagglutinin of an H5 or H7 avian...
8389246 Method for nucleic acid quantitation  
It is intended to provide a novel convenient approach for DNA quantitative analysis that overcomes the disadvantages of conventional formulations. A standard DNA sample is prepared by introducing...
8389245 Detection of HPV  
The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits...
8389216 Methods for nucleic acid manipulation  
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing...
8389701 Multisignaling oligomeric or polymeric compositions comprising labeled moieties and binding partners  
The present invention provides multisignal labeling reagents and these are useful in a number of biochemical applications, including the manufacture of biomolecular probes and their use in...
8389247 Physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs  
The invention is generally directed to a physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs. In one embodiment, the invention relates to the use of...
8389244 Methods and kits for synthesis of siRNA expression cassettes  
Amplification-based methods and kits for rapidly producing siRNA expression cassettes are provided. Also provided are methods for expressing amplified siRNA expression cassettes in cells.
8383335 Method for diagnosis and monitoring of viral infection by analysis of viral transrenal nucleic acids in urine  
The present invention relates to methods for diagnosis or monitoring of viral infection by detecting the presence of transrenal viral nucleic acids or nucleic acids of viral origin in urine...
8383338 Methods and systems for uniform enrichment of genomic regions  
The present invention provides methods and compositions for the enrichment of target nucleic acids in a microarray system. In particular, the present invention provides methods and compositions...
8383345 Sequence tag directed subassembly of short sequencing reads into long sequencing reads  
The invention provides methods for preparing DNA sequencing libraries for assembling short read sequencing data into longer contiguous sequences and providing for genome assembly, full length cDNA...
8383347 Method of diagnosing or assessing risk for Parkinson's disease or Alzheimer's disease using TCR clonality  
Changes in adaptive immune system were identified and correlated as a predictor of Aβ40 and Aβ42 and AD progression. T-cell, B-cell, TCR and BCR profiles were used to correlate clinical...
8383346 Combined automated parallel synthesis of polynucleotide variants  
The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide...
8386184 Systems and methods for determining an amount of starting reagent using the polymerase chain reaction  
Systems and methods for calculating an initial amount of target nucleic acid N0 in a sample are provided. A plurality of fluorescent measurements is received. Each respective fluorescent...
8383369 Intermittent detection during analytical reactions  
Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times....
8377656 Compositions and methods for detecting Cryptococcus neoformans  
Disclosed are oligonucleotides useful in methods for determining whether a sample contains Cryptococcus neoformans, a causative agent for human cryptococcosis. These oligonucleotides, which have...
8377657 Primers for analyzing methylated sequences and methods of use thereof  
Primers having abasic regions or mismatches for amplifying sequences suspected of having methylation. Primers having abasic regions or mismatches for amplifying sequences adjacent to suspected or...
8377655 Assay for the measurement of IGF type 1 receptor and insulin receptor expression  
This invention relates to a quantitative PCR assay that differentiates between IR-A, IR-B and IGF-IR mRNAs and compares expression of the three receptors on the same scale.
8372340 Apparatus and methods for integrated sample preparation, reaction and detection  
Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and...
8372605 Immuno-amplification  
A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and...