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7391017 |
Mass scale alignment of time-of-flight mass spectra
The invention generates mass scale comparability between mass spectra which are acquired in time-of-flight mass spectrometers, particularly with ionization by matrix-assisted laser desorption....
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7390621 |
Methods and compositions for detecting telomerase activity
A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and...
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7387887 |
Nucleic acid melting analysis with saturation dyes
Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A...
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7387878 |
Methods for DNA amplification and sequencing
The osmoprotectants proline, 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine (“THP(B)”, and 2-methyl-4-carboxy-5-hydroxy-3,4,5,6,-tetrahydropyrimidine (“THP(A)”) are capable of increasing...
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7384739 |
Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof
The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA...
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7384737 |
Synthesis of spatially addressed molecular arrays
Methods are disclosed for forming spatially addressable arrays of polynucleotides of known squence, by using blocking groups that prevent the incorporation of multiple nucleotides during each...
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7381819 |
Composition for treatment or prevention of endometrial cancer and method of preventing or treating endometrial cancer using the composition
Provided are a composition for the treatment or prevention of an endometrial cancer including a nuclear acid molecule inducing RNA interference against human syndecan-1 gene expression and a...
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7381808 |
Method and nucleic acids for the differentiation of prostate tumors
The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method...
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7381708 |
Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye
The present invention provides methods for preventing retinal ganglion cell death in the glaucomatous eye and methods for suppressing apoptosis-specific eIF5A1 expression through the use of...
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7381528 |
Methods for detection of mutations in myostatin variants
Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a...
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7378260 |
Products and methods for reducing dye artifacts
The present invention provides products and methods of reducing dye artifacts from chain extension reactions.
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7378259 |
Fluid processing device
A fluid processing device and method of using the device are provided. The fluid processing device can include a substrate with a fluid processing pathway at least partially formed in or on the...
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7378242 |
DNA sequence detection by limited primer extension
A novel limited primer extension reaction improves detection sensitivity and specificity in a variety of hybridization platforms. In the invention, a sequence of target DNA that lacks one of the...
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7374927 |
Methods of analysis of degraded nucleic acid samples
The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these...
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7374885 |
Single-primer nucleic acid amplification methods
The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to...
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7374884 |
Diabetes gene
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus...
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7374883 |
Method and kit for the detection of a novel coronoavirus associated with the severe acute respiratory syndrome (SARS)
The instant invention relates to a quantitative real time RT-PCR method for detecting Severe Acute Respiratory Syndrome-associated virus (SARS-associated virus) and to oligonucleotides and kits for...
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7374882 |
Method for base sequencing and biologically active nucleic acids
Aptamers are nucleic acids and similar molecules, such as peptide-nucleic acids, that specifically bind to a ligand such as a protein or peptide. The present invention provides aptamers comprising...
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7374879 |
Method for detecting product of nucleic acid synthesizing reaction
A method for detecting the occurrence of nucleic acid syntheses using an enzyme through the use of a generated insoluble substance as an indicator.
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7371830 |
Method for separating biological material from a fluid using magnetic particles
Magnetic particles are prepared containing a magnetic core coated with a glass layer having a substantially pore-free glass surface or having pores with a diameter of less than 10 nm. The particles...
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7371530 |
Micro PCR device, method for amplifying nucleic acids using the micro PCR device, and method for measuring concentration of PCR products using the micro PCR device
Provided is a micro PCR device. The micro PCR device includes a PCR chamber having electrodes. First primers of PCR primer sets are immobilized on the surfaces of the electrodes and second primers...
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7371522 |
Use of polymorphism of the serotonin transporter gene promoter as a predictor of disease risk
The present invention provides a method of screening subjects for disease risk. The method comprises determining the serotonin transporter gene promoter genotype of a subject. The serotonin...
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7371521 |
Methods
Methods for determining the KIT genotype of pigs are provided. These methods are useful in determining coat colour genotype, breed determination and for screening pigs to determine those likely to...
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7368263 |
Chemically assembled nano-scale circuit elements
The present invention provides nano-scale devices, including electronic circuits, using DNA molecules as a support structure. DNA binding proteins are used to mask regions of the DNA as a material,...
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7364891 |
Mutated alkaline cellulase
A mutated alkaline cellulase derived from a cellulase having the amino acid sequence represented by SEQ ID NO: 1 or one having a homology of at least 90% therewith by deleting one or more amino...
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7364854 |
Nucleotide mixture for improved nucleic acid amplification performance
The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification In...
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7364846 |
Gene expression profiling from FFPE samples
Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and...
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7361489 |
Nucleic acid amplification methods
The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention...
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7361488 |
Nucleic acid detection methods using universal priming
The present invention is directed to providing sensitive and accurate assays for gene detection, genome-wide gene expression profiling and alternative splice monitoring with a minimum or absence of...
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7361468 |
Methods for genotyping polymorphisms in humans
Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two...
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7361465 |
Methods and compositions for tailing and amplifying RNA
The present invention provides methods and compositions that enable tagging and amplification of targeted RNA molecules. A targeted RNA molecule is any non-polyadenylated RNA molecule including,...
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7361464 |
Method, systems and kits for immuno-detection of epitopes expressed on molecules
Methods, systems and kits are provided for detecting molecules expressing a selected epitope in a sample through use of an epitope detector containing a single chain Fv for the selected epitope or...
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7358351 |
Endothelial cell expression patterns
To gain a better understanding of tumor angiogenesis, new techniques for isolating endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from ECs derived...
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7358349 |
Nucleic acids having expression differentials between hepatoblastoma and normal liver
A nucleic acid comprising any one of base sequences set forth in SEQ ID NO:1 to NO:104 in the Sequence Listing and a protein encoded by the nucleic acid, particularly a nucleic acid displaying...
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7358347 |
MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is...
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7358068 |
Antiviral oligonucleotides
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length....
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7358049 |
Gene chip technology for determining memory genes
The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during...
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7358047 |
Methods of forming circular nucleic acid probes and uses thereof
The present invention relates generally to a method of amplifying closed circular nucleic acid probes and, more particularly, to a method of amplifying closed circular nucleic acid probes by...
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7355022 |
Gene functionally related to dyslexia
The present invention describes a novel human gene, DYXC1, which is functionally related to dyslexia. DYXC1 gene encodes a 420-amino acid residue protein. DYXC1 is expressed in several tissues,...
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7354742 |
Method for generating amplified RNA
The present invention provides a new method for producing amplified RNA from a selected set of cells. This method combines and utilizes known methods in a novel way to produce the gene expression...
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7354708 |
Invasion assays
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7354707 |
Nucleic acid probes, method for determining concentrations of nucleic acid by using the probes, and method for analyzing data obtained by the method
Nucleic acid probes are provided, each of which is formed of a single-stranded oligonucleotide which can hybridize to a target nucleic acid and is labeled with a fluorescent dye or with a...
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7351557 |
Amplification of RNA sequences using composite RNA-DNA primers and strand displacement
The invention provides methods for linear amplification of RNA that has an RNA sequence of interest. The methods are based on using a first DNA primer with a 3′ portion that is complementary to...
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7351528 |
Probing of specific nucleic acids
The present invention relates to improved methods for probing of specific nucleic acids using circularizable probes designed such that they report the presence of a target sequence by allowing a...
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7348146 |
Single nucleotide polymorphism analysis of highly polymorphic target sequences
Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.
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7345025 |
Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of...
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7344863 |
Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides...
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7341837 |
Soluble analyte detection and amplification
The present invention relates to a method of detection of a compound of interest that is present at low levels in a sample. In particular, the present invention relates to a method of detection of...
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7341835 |
Methods of analysis of alternative splicing in mouse
The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of mouse genes. The invention provides the sequences in such a way as to make them...
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7338765 |
Representational fragment amplification
Methods and kits are provided for non-preferential amplification of a population of nucleic acids. The methods allow for a high degree of amplification, where representation in the final population...
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