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7309573 |
Methods for detection of a nucleic acid by sequential amplification
The invention relates to methods and compositions for detecting a target nucleic acid. The methods include subjecting a target, template, cleavage agent, polymerase and first, second and third...
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7309570 |
Methods for using double-mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
A method and kit for synthesizing a nucleic acid molecule comprising at least one non-canonical nucleoside triphosphate using a double-mutant polymerase having a reduced discrimination between...
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7309588 |
Nucleic acid assays
The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the...
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7309693 |
Preventives and remedies for pulmonary hypertension
The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a...
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7306913 |
Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules...
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7306935 |
Polypeptides having alpha-amylase activity and polypeptides encoding same
The present invention relates to polypeptides having alpha-amylase activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to a...
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7303897 |
Method of preparing polynucleotide fragments for use in shuffling, and shuffling of same
The invention relates to a fragmentation process that depends on mismatches between two strands of parental polynucleotides. One embodiment, comprises a method for preparing polynucleotide...
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7304041 |
Modulators of coagulation factors
The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids...
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7303882 |
Utilization of nucleotide probes in ELISA procedure for the quantitative determination of baculovirus titer
To maximize the yield of protein from a baculovirus system, optimal infection of the host cell culture must be achieved; in order to obtain such optimal infection, the titer of the virus...
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7300788 |
Method for genotyping polymorphisms in humans
The invention provides nucleic acid sequences that are complementary, in one embodiment, to a wide variety of human polymorphisms. The invention provides the sequences in such a way as to make them...
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7300658 |
Recombinant poxvirus comprising at least two compox ATI promoters
Recombinant poxvirus are disclosed comprising in the viral genome at least two expression cassettes, each comprising a cowpox ATI promoter according to SEQ ID NO:1, a polynucleotide sequence in...
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7300757 |
Electronic systems and component devices for macroscopic and microscopic molecular biological reaction, analyses, and diagnostics
This invention pertains to the design, fabrication, and uses of an electronic system which can actively carry out and control multi-step and multiplex reactions in macroscopic or microscopic...
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7301016 |
Human transferase family members and uses thereof
The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid...
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7300752 |
Compositions and methods for determining canine gender
The present invention provides methods to determine gender of a canine subject, that include contacting a nucleic acid sample from the canine subject with at least one probe or primer specific for...
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7297518 |
Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
The invention provides methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension. Some applications of the invention utilize total internal reflection fluorescence...
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7297479 |
DNA-based analog neural networks
This invention is an oligomer-based analog neural network (ANN) comprising weight and saturation oligomers, the concentrations of which are selected such that activation of the ANN by a set of...
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7297517 |
Oligonucleotides and method for detection of meca gene of methicillin-resistant Staphylococcus aureus
An oligonucleotide for cleavage, detection or amplification of the mecA gene, a gene element of methicillin-resistant Staphylococcus aureus (MRSA), or RNA derived from said gene is provided....
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7297542 |
Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention...
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7297490 |
Authentication of biologic materials using DNA-DNA hybridization on a solid support
Provided are a method for preparing an array for authenticating biological samples and a method for authenticating the biological samples based on analysis of variable sequences of ribosomal RNA...
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7297488 |
Identifying and testing antisense oligonucleotides that inhibit telomerase reverse transcriptase
This disclosure provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer,...
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7297487 |
Desmin gene having novel point mutation causative of dilated cardiomyopathy
The present invention is intended to elucidate the cause of severe cardiomyopathy in subline (T) not manifesting the macroscopic cardiac hypertrophy, which has been separated from a hamster (B)...
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RE39920 |
Methods for detection of nucleic acid sequences in urine
Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of...
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7294465 |
Polycystic kidney disease PKD2 gene and uses thereof
The present invention provides a purified and isolated wild type PKD2 gene, as well as mutated forms of this gene. The present invention also provides one or more single-stranded nucleic acid...
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7294709 |
Detection of Giardia
Oligonucleotide molecules for the detection of Giardia lamblia ( G. lamblia which molecules hybridise under medium to high stringency conditions to unique 18S rDNA/rRNA sequences of G. lamblia,...
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7294713 |
Antisense IAP oligonucleotides and uses thereof
The present invention feature antisense IAP oligonucleotides and other negative regulators of the IAP anti-apoptotic pathway, and methods for using them to enhance apoptosis.
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7294487 |
Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of...
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7291465 |
Method for direct detection of fungal pathogens
The present invention relates to a method and diagnostic kit for directly detecting the presence of a specific species of mold/fungi in a sample, particularly a species which is toxic to humans or...
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7291468 |
Systems and methods of analyzing nucleic acid polymers and related components
Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.
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7291469 |
Mutant met and uses therefor
The present invention provides compositions and methods for detecting mutations in the proto-oncogene Met.
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7291470 |
Primer composition and method of using the same in the detection of Shigella sonnei
The invention provides a new primer composition for detecting the presence of Shigella sonnei and a method of using the same. The primer composition and method have high specificity and...
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7291487 |
Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
A method for synthesizing a nucleic acid molecule comprising at least one non-canonical nucleoside triphosphate using a mutant polymerase having a reduced discrimination between canonical and...
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7291724 |
Oligonucleotides for rapidly identifying microbial DNA or RNA
An oligonucoeotide selected from the group consisting of ISN2 (SEQ ID NO: 43), ISN2* (SEQ ID NO: 44), ISN (SEQ ID NO: 34), ISP2 (SEQ ID NO: 46), ISP2* (SEQ ID NO: 45) and ISP (SEQ ID NO: 33).
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7288377 |
ADH1C
The present invention relates to a method for identifying individuals with Parkinson's disease and/or individuals at risk for developing Parkinson's disease, comprising screening nucleic acids from...
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7288641 |
Sulfotransferase 1E1 sequence variants
Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes....
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7288642 |
Sulfotransferase 2B1 pharmacogenetics
Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are sulfotransferase allozymes. Methods...
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7288378 |
Compositions and methods for TIGR genotyping assays
Methods and compositions are described for use in the rapid and simultaneous screening of one or more samples for one or more polymorphisms in the TIGR gene. The methods and compositions of the...
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7285649 |
Isolated nucleic acids, vectors and host cells encoding ErbB3 antibodies
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein...
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7285288 |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The...
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7285388 |
Methods for identification of alport syndrome
Animals with mutations in COL4a4 present with autosomal recessive Alport Syndrome (ARAS). Through sequencing of COL4a4, the mutation causative for ARAS in the English Cocker Spaniel (ECS) has been...
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7285242 |
Biochemical analysis unit and biochemical analyzing method using the same
A biochemical analysis unit includes a substrate made of a material capable of attenuating radiation energy and/or light energy and formed with a plurality of holes, and a plurality of absorptive...
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7285401 |
Method and reagents for detecting nucleic acid sequences
The present invention is directed to a method for detecting an amplification product. Amplification is accomplished through the use of a plurality of detection probes. The present invention is also...
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7282355 |
Nucleic acid detection method
Disclosed are methods for detecting a target nucleic acid molecule having a known sequence among a plurality of nucleic acid molecules. The method includes hybridizing two oligonucleotides to...
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7279277 |
Methods for clinical diagnosis
A method for the identification of human foetal cell nuclei is provided wherein the method involves subjecting chromosomes of cell nuclei to exonucleolytic digestion by an enzyme so as to remove...
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7279311 |
Use of nucleic acids bound to carrier macromolecules
A nucleic acid primer is bound to a soluble carrier macromolecule, a multitude of primer molecules thus being carried by each carrier macromolecule, and hybridisation of the primer to a template...
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7279275 |
Methods and compositions for detection of segmented negative strand RNA viruses
The present invention provides compositions and methods for the detection of the presence, absence, or quantity of a segmented negative strand RNA virus such as an influenza virus. A genetically...
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7279566 |
Centrosome proteins and uses thereof
The invention includes nucleic acids and polypeptides that play important roles in centrosomes and cellular functions involving centrosomes. In addition, the invention encompasses antibodies,...
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7279282 |
Methods for identifying a candidate for treatment of obesity
Methods of identifying human subjects for treatment of obesity or an obesity-related condition with ciliary neurotrophic factor (CNTF) or a CNTF-related molecule, such as Axokine®, based on the...
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7276340 |
Age determination from biological stains using messenger RNA profiling analysis
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, systems, methods and kits for the age determination of an individual from bloodstains or samples of unknown origin....
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7276356 |
Recombinant negative strand RNA virus expression systems and vaccines
Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells...
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7276338 |
Nucleotide sequencing via repetitive single molecule hybridization
Methods of obtaining sequence information about target oligonucleotides by repetitive single molecule hybridization are disclosed. The methods include exposing a target oligonucleotide to one or...
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