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7560256 |
Automated process for detecting the presence of a target nucleic acid in a sample
An automated process for detecting the presence of a target nucleic acid in a sample. The process includes separating the target nucleic acid from other material present in the sample at a first...
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7560260 |
Compositions with polymerase activity
The invention provides novel compositions with polymerase activity and methods of using the compositions.
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7560254 |
Allele specific primer extension
A method of characterizing a nucleic acid sample is provided that includes the steps of: (a) conducting a DNA polymerase reaction that includes the reaction of a template, an allele specific...
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7560236 |
Microbial community analysis
The present invention provides a method which can enhance the precision of identification of bacterial species using a T-RFLP method and achieve, by itself, the identification of bacteria...
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7556944 |
Methods and compositions for use in preparing siRNAs
Methods and compositions for producing siRNAs, e.g., in the form of a d-siRNA composition, from dsRNAs are provided. In the subject methods, a dsRNA is contacted with a composition that includes an...
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7556943 |
Linear amplification of short nucleic acids
The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly amplifying a collection of micro RNAs...
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7553943 |
Polynucleotide arrays
The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a...
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7553627 |
Process for high throughput DNA methylation analysis
There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting...
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7553643 |
Method for amplifying target nucleic acid sequences using a primer comprising an AP endonuclease-cleavable linker
The present invention provides a novel method for nucleic acid amplification. The method includes contacting the sample with at least one forward primer and at least one reverse primer, an AP...
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7550261 |
Method of screening for drug hypersensitivity reaction
Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for...
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7550276 |
Method of detecting nucleic acid
The present invention relates to a method of detecting or quantifying a target nucleic acid present in a specimen. The present invention provides a method of detecting or quantifying a target...
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7547511 |
Antisense inhibition of laminin-8 expression to inhibit human gliomas
Using gene array technology, we observed that an increase of the α4 chain-containing Laminin-8 correlated with poor prognosis for patients with brain gliomas. We established that inhibition of...
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7541142 |
Pancreatic cancer genes
The present invention provides the art with the DNA coding sequences of polynucleotides that are up- or down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or...
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7541146 |
Biomolecule retaining material and methods for attaching biomolecules to a surface
The present invention provides a method and material for attachment of biomolecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides, silicon wafers or...
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7541444 |
Modified nucleotides
The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group...
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7541165 |
Molecular detection systems utilizing reiterative oligonucleotide synthesis
The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis...
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7537895 |
Comparative genomic hybridization
Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple...
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7534564 |
Methods and compositions for polypeptide engineering
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are...
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7534561 |
Nucleic acid array in situ fabrication methods and arrays produced using the same
Methods and devices for producing a nucleic acid arrays using in situ nucleic acid array synthesis protocols are provided. A feature of certain embodiments of the invention is that control probes...
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7534592 |
Crystallization of carboxyltransferase domain of Acetyl-CoEnzyme A Carboxylase 2 with a ligand
Provided are crystals relating to the carboxyltransferase domain of human Acetyl-Coenzyme A Carboxylase 2 and its various uses.
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7534587 |
Microsatellite markers for plants of the genus Triticeae and use thereof
The invention relates to novel microsatellite markers for wheats ( Triticum aestivum ) and closely related species (Genus Triticeae ) and to the use of said markers for the genetic analysis of...
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7531309 |
PCR based capsular typing method
The present invention relates to molecular diagnostics. In particular, the present invention relates to PCR based diagnostics for the typing of Group B streptococci.
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7531522 |
Antibodies, recombinant antibodies, recombinant antibody fragments and fusions mediated plant disease resistance against fungi
A method for the production of fungus resistant transgenic plants, plant cells or plant tissue comprising the introduction of an Ab, rAb, rAb fragment or fusion or vector of the invention or the...
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7531524 |
Modulators of coagulation factors with enhanced stability
The invention provides improved nucleic acid ligands with enhanced stability that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These...
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7531307 |
Use of representations of DNA for genetic analysis
It is an object of the present invention to provide a solution to problems associated with the use of microarray technology for the analysis DNA. The present invention provides compositions and...
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7527928 |
Reactions on a solid surface
The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to...
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7528117 |
High efficacy antisense RIαPKA poly-DNP oligoribonucleotides
The present invention discloses antisense poly-2′-O-(2,4-dinitrophenyl) oligoribonucleotides which are capable of down regulating the expression of the RI α subunit of protein kinase A. An...
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7527931 |
Identification of a gene associated with spinocerebellar ataxia type 5 and methods of use
The present invention provides methods that include analyzing an SCA5 polynucleotide, and determining whether the SCA5 polynucleotide includes a mutation. The methods may be used to identify a...
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7524629 |
Method for detecting cytosine methylation in DNA samples
Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting...
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7524942 |
Labeled nucleotide composition
Embodiments of labeled nucleotide compositions are described. Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a...
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7521213 |
Sample processing for nucleic acid amplification
Methods are described for the processing of biological samples for direct use in nucleic acid amplification without extracting or isolating the nucleic acids from the sample. In preferred...
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7521185 |
Assay for SARS coronavirus by amplification and detection of the replicase sequence
Primers and probes derived from SARS-CoV nucleic acid that facilitate detection and/or quantification of the replicase gene are disclosed. The disclosed sequences may be used in a variety of...
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7521187 |
Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
This invention relates generally to the freeze-drying of formulations comprising a polynucleotide, a block copolymer and a cationic surfactant. In the presence of a cryoprotectant or bulking agent,...
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7521178 |
Method for synthesizing DNA
A DNA synthesis reaction-enhancer comprising at least one kind selected from the group consisting of acidic substances and cationic complexes; a DNA synthesis method in which during a DNA synthesis...
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7517866 |
LIM mineralization protein splice variants
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
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7517977 |
Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification
An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length...
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7517668 |
Process for the production of protein products in aspergillus
A process for expression of a protein product in Aspergillus oryzae is disclosed. The process comprises transforming Aspergillus oryzae with a vector system comprising DNA-sequences encoding...
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7517646 |
Functional molecule and process for producing the same
A process for producing a functional molecule includes a forming step which forms a modified nucleotide n-mer (where, n represents an integer) containing a modified nucleoside prepared by...
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7517650 |
Method of diagnosing breast cancer and compositions therefor
A method of diagnosing breast cancer in an individual aged younger than 41 or older than 54 is provided. The method comprises obtaining a nucleic acid from the individual and determining a...
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7514211 |
Genomic DNAs participating in rheumatoid arthritis, method of diagnosing the same, method of judging onset risk and diagnostic kit for detecting the same
A genomic DNA involved in rheumatoid arthritis, a method of diagnosing rheumatoid arthritis or a method of judging onset risk of rheumatoid arthritis, and a diagnostic kit for diagnosing rheumatoid...
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7514253 |
URA5 gene and methods for stable genetic integration in yeast
A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous...
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7514545 |
Inducible eukaryotic expression system
Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a...
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7514210 |
Compartmentalised self replication method for in vitro evolution of molecular libraries
We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a...
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7510868 |
Chimeric adenoviruses for use in cancer treatment
The present invention relates to oncolytic adenoviruses having therapeutic applications. Recombinant chimeric adenoviruses, and methods to produce them are provided. The chimeric adenoviruses of...
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7510835 |
Methods for identifying risk of breast cancer and treatments thereof
Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying...
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7510869 |
Promoter and plasmid system for genetic engineering
This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a...
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7510836 |
Alpha arteether resistance domain
The present invention relates to an alpha-arteether resistance domain (ADR) of Sequence ID No.1 and a method of identifying ADR in alpha-arteether resistant pathogens and lastly, it relates to set...
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7510839 |
Method for the combined isolation of magnet-beads from a liquid sample and subsequent thermocyclisation for the polymerase chain reaction (PCR) and associated arrangement
Embodiments generally relate to a PCR wherein a magnetic field is focused in a localized area and also to the possibility of a cyclic transfer of heat. According to at least one embodiment of the...
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7507531 |
Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
Linkage of Myocardial Infarction (MI) to a locus on chromosome 13q12-13 is disclosed. In particular, the FLAP gene within this locus is shown by association analysis to be a susceptibility gene for...
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7507411 |
Attenuated influenza NS1 variants
Attenuated influenza virus variants comprising substitutions in NS1 that interfere with viral replication and phosphatidylinositol 3-kinase activation are described. NS1 variant polypeptides,...
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