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7041812 |
Labeled nucleoside polyphosphates
The present invention describes new compositions of matter in the form of labeled nucleoside polyphosphates with four or more phosphates. In addition compositions of nucleoside polyphosphates with...
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7041452 |
Method of detecting the presence of absence of mixed varieties in grains, and identifying the mixed varieties
Provided is a DNA-level grain variety discrimination method of detecting the presence or absence of any other varieties of grains in object grains of a certain variety through multiplex PCR that...
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7041450 |
Method for diagnosing GH deficiency
The present invention relates to a method and kit for diagnosing GH (growth hormone) deficiency, in particular isolated growth hormone deficiency II (IGHD II). The method comprises the steps of...
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7041451 |
Electrochemiluminescence helicase assay
The present invention relates to electrochemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput...
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7041454 |
Genomic sequence of the purH gene and purH-related biallelic markers
The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer,...
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7037674 |
Cytochrome P450 reductases from poppy plants
The present invention relates to production of alkaloids from poppy plants and in particular togenes encoding enzymes in the alkaloid pathway, to proteins encoded by the gens, to plants transformed...
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7037661 |
Compositions and methods for labeling of nucleic acid molecules
The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such...
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7037688 |
Method for using unequal primer concentrations for generating nucleic acid amplification products
The method provided herein is a method for detecting a target sequence in a test sample. Generally, the method comprises forming a reaction mixture comprising a test sample, amplification reagents,...
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7037649 |
Immobilized nucleic acid and method for detecting nucleic acid
A nucleic acid to be immobilized and used for hybridization of nucleic acids using an immobilized nucleic acid, which has a polymer comprising a compound having an unsaturated bond, said polymer...
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7037687 |
Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases,...
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7037726 |
Methods for forming recombined nucleic acids
Described herein are methods for generating recombined nucleic acids. In one method, fragments of a sequence are provided wherein the fragments have non-extendable 3′ ends. A primer is provided...
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7033763 |
Pyrophosphorolysis activated polymerization (PAP)
A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification...
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7033755 |
Diagnostics and therapeutics for glaucoma
Methods and compositions for diagnosing and treating glaucoma are disclosed.
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7033758 |
Highly sensitive gene detection and localization using in situ branched-DNA hybridization
Methods are provided for highly sensitive and rapid in situ detection of a nucleic acid analyte of a known sequence. The method employs oligonucleotide probes in a series of optimized steps to...
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7029854 |
Methods designing multiple mRNA transcript nucleic acid probe sequences for use in nucleic acid arrays
Methods of identifying a sequence of a nucleic acid that is suitable for use as a surface immobilized probe for two or more mRNA transcripts encoded by the same gene are provided. In practicing the...
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7030220 |
Thermostable enzyme promoting the fidelity of thermostable DNA polymerases-for improvement of nucleic acid synthesis and amplification in vitro
A purified thermostable enzyme is derived from the thermophilic archaebacterium Archaeoglobus fulgidus . The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double...
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7029881 |
Methods for constructing DNA library and support carrying DNA library immobilized thereon
Method and apparatus for constructing a cDNA library by hybridizing mRNA with oligo (dT) on a support and treating with a reverse transcriptase to immobilized complementary DNA, or for constructing...
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7030216 |
Peptoids incorporating chemoselective functionalities
Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are...
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7029842 |
Signal sequence trapping
The present invention allows the screening of previously established genebanks or libraries by proxy for genes encoding secreted, partially secreted, or cell surface-displayed polypeptides of...
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7026141 |
Topoisomerase-based reagents and methods for molecular cloning
This invention provides a modified vaccinia topoisomerase enzyme containing an affinity tag which is capable of facilitating purification of protein-DNA complexes away from unbound DNA. This...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7026120 |
Probes for detecting tumor cells
Probes are provided that are useful for detecting CK19 target sequence in a test sample.
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7026137 |
Hepatitis
A screening method of identifying a compound for treating hepatitis. Also disclosed is a method for evaluating responsiveness of a subject having hepatitis to a drug.
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7026113 |
EIA vaccine and diagnostic
The invention provides an equine infectious anemia (EIA) vaccine that provides immunity to mammals, especially equines, from infection with equine infectious anemia virus (EIAV) and which allows...
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7022475 |
Genotyping assay to predict CYP3A5 phenotype
Genetic polymorphisms responsible or associated with altered expression of cytochrome P450 CYP3A5 enzyme are described. Single nucleotide polymorphisms are provided. Methods for identifying...
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7022830 |
Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed...
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7022473 |
Substrates for immobilizing and amplifying DNA and DNA-immobilized chips
Substrates for producing a DNA library are produced by immobilizing DNA onto a suitable substrate having excellent thermal conductivity. A surface of the substrate is chemically modified with a...
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7022501 |
Ligation of double-stranded DNAs
The present invention relates to a DNA ligation method. Specifically, a DNA complex comprising a three-stranded structure in each of the ends of double-stranded DNAs, one of which has...
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7019127 |
Solution phase synthesis of oligonucleotides
A process for the synthesis in solution phase of a phosphorothioate triester is provided. The process comprises the solution phase coupling of an H-phosphonate with an alcohol in the presence of a...
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7018833 |
Linear and circular expression elements
The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention...
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7015030 |
Microfluidic devices and uses thereof in biochemical processes
Provided is a microfluidic device comprising a microfluidic substrate comprising at least one pathway for sample flow; and at least one thermal transfer member which is capable of cycling between...
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7015018 |
Amplification method for detection of target nucleic acids involving-fluorescence energy transfer
A method for detecting the presence of a target nucleic acid sequence in a sample, said method comprising subjecting said sample to an amplification reaction using a set of nucleotides, at least...
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7015372 |
Plant artificial chromosome compositions and methods
The present invention provides for the identification and cloning of functional plant centromeres in Arabidopsis . This will permit construction of stably inherited plant artificial chromosomes...
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7014994 |
Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in...
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7014814 |
Support for substances for detection, apparatus for processing same, method of processing same, apparatus for making same, and method of making same
The present invention relates to a support for substances for detection, an apparatus for processing same, a method of processing same, an apparatus for making same, and a method of making same....
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7014997 |
Chromosome structural abnormality localization with single copy probes
Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of...
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7011944 |
Invasive cleavage of nucleic acids
The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to...
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7008768 |
Method for detecting radiation exposure
A method is disclosed for detecting exposure of organisms to biologically significant or hazardous amounts of ionizing radiation. The method uses nucleic acid microarray hybridization to evaluate...
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7008771 |
Multiplex amplification of short tandem repeat loci
Methods and materials are disclosed for use in simultaneously amplifying at least thirteen loci of genomic DNA in a single multiplex reaction, as are methods and materials for use in the analysis...
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RE39007 |
Isothermal strand displacement nucleic acid amplification
Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5′ exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The...
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7005293 |
Multiple axis printhead adjuster for non-contact fluid deposition devices
Non-contact fluid deposition devices having multiple axis printhead adjusters are provided. The subject printhead adjusters are made up of a single rigid frame that holds at least one printhead...
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7005267 |
Internal positive control for probe-based nucleic acid molecule assays and methods of making and using thereof
Disclosed herein are isolated nucleic acid molecules that may be used as an internal positive controls in probe-based nucleic acid assays such as TaqMan® based assays. Also disclosed are probes...
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7005264 |
Method and apparatus for nucleic acid sequencing and identification
The methods and apparatus 100 disclosed herein are of use for sequencing and/or identifying nucleic acids 230, 310 . Nucleic acids 230, 310 containing labeled nucleotides 235, 245, 315 may...
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7005260 |
Tenascin-C nucleic acid ligands
Methods are described for the identification and preparation of nucleic acid ligands to tenascin-C. Included in the invention are specific RNA ligands to tenascin-C identified by the SELEX method....
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7005277 |
Defective adenoviruses and corresponding complementation lines
Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the...
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7001723 |
Catalytic RNAs with aminoacylation activity
The present invention provides catalytic RNA molecules having cis or trans aminoacylation activity. The catalytic RNA molecules having cis aminoacylation activity comprise a catalytic domain and an...
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7001890 |
Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination
The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable...
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7001726 |
Enzymatically catalysed signal amplification
The present invention concerns detection of target molecules using methods of enzymatically catalysed amplification of target associated detectable structures.
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7001722 |
Parallel primer extension approach to nucleic acid sequence analysis
A method of analyzing a polynucleotide of interest, comprising providing one or more sets of consecutive oligonucleotide primers differing within each set by one base at the growing end therof;...
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6994969 |
Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
The present invention is in the field of nucleic acid-based diagnostic assays. More particularly, it relates to methods useful for the “diagnostic sequencing” of regions of sample nucleic acids...
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