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7067310 |
Method for the preparation of a viral vector by inter-molecular homologous recombination
The present invention encompasses methods of preparing a recombinant viral vector, within a procaryotic cell, by intermolecular homologous recombination, methods of preparing an infectious viral...
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7063978 |
Coated film laminate having an electrically conductive surface
Articles including a polymeric substrate and an electrically conductive surface are provided. Methods of making and using such articles also are provided.
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7060814 |
Probe for constructing probe-polymer method of constructing probe-polymer and utilization thereof
The present invention provides a method for measuring a target gene under isothermal conditions without using enzyme. A pair of probes each having n (n≧3) base sequence regions complementary to...
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7060467 |
Recombinant proteins containing repeating units
Methods for the production of recombinant proteins containing repeating units are disclosed. Also disclosed are methods for the production of degenerate polynucleotides encoding said recombinant...
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7060434 |
Probes for myctophid fish and a method for developing the same
The DNA probes produced by molecular cloning and the characterization of specific gene region sequences is provided, these can be used as genetic markers for the genes such as Cytochrome b (cyt b);...
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7060455 |
Broad specificity DNA damage endonuclease
The present disclosure describes DNA damage endonucleases which exhibit broad specificity with respect to the types of structural aberrations in double stranded DNA. These enzymes recognize double...
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7060809 |
LNA compositions and uses thereof
Modified LNA units are provided that comprises unique base groups. Desirable nucleobase and nucleosidic base substitutions can mediate universal hybridization when incorporated into nucleic acid...
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7060816 |
Detection of fungal pathogens using the polymerase chain reaction
The present invention relates to the use of primers in polymerase chain reaction assays for the detection of fungal pathogens Colletotrichum acutatum, Alternaria spp., and Cladosporium...
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7058515 |
Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
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7056674 |
Prediction of likelihood of cancer recurrence
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
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7057026 |
Labelled nucleotides
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
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7056662 |
Method of diagnosing a risk of developing insulin resistance
The invention provides compositions and methods of inhibiting Mal1 expression or function to treat lipid metabolisms disorders.
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7056659 |
Characterizing nucleic acids
A method for characterizing DNA, which comprises: (i) providing a population of DNA fragments, each fragment having cleavably attached thereto a mass label for identifying a feature of that...
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7056705 |
Multiplex PCR primer set for human glucokinase gene amplification
The present invention provides a primer pooi for amplifying a target sequence of a human glucokinase gene including at least one set of primers or variant primers thereof, each set of primers being...
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7056675 |
Method of forming an electrically conductive connection utilizing a polynucleotide/conductive polymer complex
A conductive polymer is formed enzymatically in the presence of a polynucleotide template. The method includes combining at least one redox monomer with a polynucleotide template and a redox...
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7056665 |
Screening methods involving the detection of short-lived proteins
A method is provided for screening for agents that affect protein degradation rates, the method comprising: taking a library of cells, the cells expressing a fusion protein comprising a reporter...
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7056670 |
Sequencing method
Disclosed is a single molecule sequencing method comprising the steps of: a) attaching a molecule to a solid phase; b) incubating the molecule with a first composition comprising a first reporter...
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7056703 |
Polypeptides having polymerase activity and methods of use thereof
The invention relates to thermostable polymerases that have polymerase activity temperatures in the range from 90° C. up to 113° C., such as those derived from Pyrolobus fumaria , and to...
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7056716 |
High fidelity reverse transcriptases and uses thereof
The invention relates to reverse transcriptases which have increased fidelity (or reduced misincorporation rate) and/or terminal deoxynucleotidyl transferase activity. In particular, the invention...
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7056696 |
Expression vector containing a drug-resistance gene having a destabilizing sequence as selection marker
The present invention provides a process for preparing a retrovirus to be expressed at a high titer by specifically transferring a desired foreign gene into target cells. A pseudotyped retrovirus...
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7056706 |
Shot-gun sequencing and amplification without cloning
Disclosed is a method for sequencing and amplifying nucleic acid templates wherein a degenerate primer with a fixed sequence region and a random sequence region is utilized. By determining the...
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7056666 |
Analysis of surface immobilized polymers utilizing microfluorescence detection
Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine...
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7056704 |
RNA interference mediating small RNA molecules
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
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7057031 |
Nucleotide compositions comprising photocleavable markers and methods of preparation thereof
Labelled nucleotides and polynucleotides useful in the sequencing of nucleic acids are described. Methods of preparing photocleavable marker nucleotides and photocleavable marker-polynucleotide...
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7056660 |
Method for characterizing disseminated and micrometastasized cancer cells
The invention relates to a diagnostic method and related compositions for characterizing disseminated and micrometastasized cancer cells in body fluids using DNA, mRNA and/or protein. According to...
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7056661 |
Method for sequencing nucleic acid molecules
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the...
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7056671 |
Isothermal chimeric primer nucleic acid amplification methods using blocking oglionucleotide
Methods of amplifying a target nucleic acid whereby the target nucleic acid is amplified in the presence of a deoxyribonucleotide triphosphate, a DNA polymerase having strand displacement activity,...
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7057025 |
Binary probe and clamp composition
Binary probe and clamp compositions conduct methods for target hybridization detection. Where the probe is a substrate for exonuclease cleavage, the composition provides quantitation and detection...
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7052878 |
Serotype and dengue group specific flurogenic probe based PCR (TaqMan) assays against the respective C and NS5 genomic and 3′ non-coding regions of dengue virus
Five fluorogenic probe hydrolysis reverse transcriptase-polymerase chain reaction (RT-PCR) (TaqMan™) assays are described for serotype-specific detection of dengue 1–4 and group-specific...
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7052837 |
Histoplasma capsulatum catalase sequences and their use in the detection of Histoplamsa capsulatum and histoplasmosis
The present invention describes Histoplasmosis capsulatum catalase A and catalase P nucleic acid and protein sequences as reagents for the detection of H. capsulatum infection. Specifically,...
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7053206 |
Methods and compositions for multiplex amplification of nucleic acids
A method is described for predetermining ratios of primer pairs present in a single reaction vessel so as to achieve approximately equimolar yield of products. The ratios are determined as a...
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7052875 |
Stable gene preparations
The invention is directed to the retention of the stability of formulations useful for a gene therapy during the preparation and preservation. In the invention, at least one saccharide and/or at...
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7052877 |
Thermus brockianus nucleic acid polymerases
The invention provides nucleic acids and polypeptides for nucleic acid polymerases from a thermophilic organism, Thermus brockianus . The invention also provides methods for using these nucleic...
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7052876 |
Combinatorial method for producing nucleic acids
A method of generating novel nucleic acid molecules, by applying a combinatorial approach to the assembly of blocks of nucleic acid sequence, is described. By using restriction endonucleases having...
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7052846 |
Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
Tags and linkers specifically designed for a wide variety of nucleic acid reactions are disclosed, which are suitable for a wide variety of nucleic acid reactions wherein separation of nucleic acid...
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7052845 |
Polymorphisms in the region of the human hemochromatosis gene
Polymorphic sites in the region surrounding the HH gene are provided. These polymorphisms are useful as surrogate markers in diagnostic assays for hemochromatosis.
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7052836 |
Nucleic acids for detecting fusarium species
Nucleic acids for detecting Aspergillus species and other filamentous fungi are provided. Unique internal transcribed space 2 coding regions permit the development of nucleic acid probes specific...
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7049070 |
Materials and methods for detection and characterization of nucleic acid sequence variability
A method for influencing the separation mobility of single stranded nucleic acids in native conditions is disclosed. Temperature changes during the separation of single stranded nucleic acids under...
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7049102 |
Multi-gene expression profile
This invention relates to the use of promoters for ribonucleic acid amplification and other genetic manipulations. Processes are provided wherein complementary deoxyribonucleic acid (cDNA) is...
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7049431 |
Antisense antibacterial cell division composition and method
Antisense oligomers directed to bacterial cell division and cell cycle-encoding nucleic acids are capable of selectively modulating the biological activity thereof, and are useful in treatment and...
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7049103 |
Method of evaluating drug efficacy and toxicity
A method of assaying the efficacy and/or toxicity of a test substance by expression of a specific gene in a cell or a microorganism, which comprises treating the cell or the microorganism with the...
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7049066 |
Diagnosis and treatment of myocardial failure
The present invention provides methods of diagnosing myocardial failure in a human. The methods comprise obtaining a sample of myocardial tissue from a ventricle of the heart. In one embodiment,...
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7049101 |
Enzymes having high temperature polymerase activity and methods of use thereof
The invention relates to thermostable polymerases that have polymerase activity temperatures in the range from 90° C. up to 113° C., such as those derived from Pyrolobus fumaria , and to...
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7049065 |
Method of preparing normalized and/or subtracted cDNA
A method of preparing normalized and/or subtracted cDNA; a method in which the cDNA that is normalized and/or subtracted is in the form of uncloned cDNA (cDNA tester); a method of preparing...
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7049104 |
Genetic analysis method
The present invention relates to a quick and simple method for genetic testing, particularly for SNP testing, using two kinds of primers which are complementary to a mutant target and a wild-type...
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7049062 |
Assay for methylation in the GST-Pi gene
A diagnostic or prognostic assay is disclosed for a disease of condition characterized by abnormal methylation of cytosine at side or sites within the glutathione-S-transferase (GST) Pi gene and/or...
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7045293 |
Alteration of sequence of a target molecule
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that...
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7047136 |
Interferometric technique for quantitating biological indicators
A technique is described for quantitating biological indicators, such as viral load, using interferometric interactions such as quantum resonance interferometry. A diffusion curve for the...
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7045288 |
Apparatus for the automation of chemical reaction kinetics studies
The present invention relates to an apparatus designed to perform chemical reaction kinetics studies and more particularly to an apparatus which is capable of conducting accelerated automated...
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7045610 |
Modified oligonucleotides for mismatch discrimination
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor...
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