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7115719 |
Formulations and methods for denaturing proteins
Reagents, methods and kits for denaturation of protein are provided.
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7115400 |
Methods of nucleic acid amplification and sequencing
Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified...
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7115376 |
Method for distinguishing different-sequence polynucleotides
Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In one embodiment of the invention, a plurality of different-sequence probe pairs are...
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7115581 |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7115725 |
Multi-mutant diphtheria toxin vaccines
Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
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7115583 |
Microbubble compositions and methods for oligonucleotide delivery
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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7112422 |
Fluorometric assay for detecting nucleic acid cleavage
A method of detecting an enzyme-mediated DNA cleavage reaction in a fluorometric assay is provided. The method can be used to detect DNA cleavage caused by restriction endonucleases, retroviral...
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7112406 |
Polynomial amplification of nucleic acids
The invention provides methods and compositions for the amplification and replication of nucleic acid molecules. In particular, novel amplification methods, referred to herein as polynomial...
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7108976 |
Complexity management of genomic DNA by locus specific amplification
The present invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample to interrogate a collection of target sequences. In one embodiment complexity...
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7108974 |
Method for rapid detection and identification of bioagents
Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers...
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7109322 |
Process for the depletion or removal of endotoxins
A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering...
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7105300 |
Sequencing by incorporation
Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible...
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RE39282 |
Nucleic acid derivatives
This invention relates to a methodology for assessing the sensitivity of an HIV-1 sample to zidovudine and to diagnostic assays for use in such assessment.
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7105298 |
Serial coupling of restriction cleavage and extension for nucleic acid amplification
A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification...
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7101666 |
Involvement of the BDNF gene in mood disorders
Methods and kits for determining susceptibility of a patient to mood disorders are described. The method involves analyzing a sample comprising nucleic acids from a patient for a polymorphism in...
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7101992 |
Nucleic acid base pair
A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static...
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7101697 |
Restriction endonucleases, method of synthesis and use thereof
A restriction endonuclease having one DNA binding site is proposed, synthesized from a restriction endonuclease that has one C-terminal domain and one N-terminal domain and two DNA binding sites,...
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7101673 |
Method for detecting a nucleic acid comprising asymmetrical amplification
A method for detecting amplified nucleic acid fragments is provided. The method comprises the steps of carrying out amplification reaction to amplify a predetermined region of a nucleic acid in a...
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7097980 |
Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
The present invention relates to the detection of nucleic acid sequence differences using coupled ligase detection reaction and polymerase chain reaction. One aspect of the present invention...
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7097966 |
Detection of survivin in the biological fluids of cancer patients
The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising...
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7097976 |
Methods of analysis of allelic imbalance
Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance....
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7094544 |
Genetic test for the identification of carriers of complex vertebral malformations in cattle
Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers BM4129, INRAA003,...
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7094541 |
Assay for detection of human parvovirus B19 nucleic acid
Nucleic acid oligomers specific for human parvovirus B19 genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus B19 nucleic acid in biological specimens is disclosed....
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7094536 |
Methods and compositions for amplification of RNA sequences
The invention provides methods for linear and exponential amplification of RNA. They are particularly suitable for amplifying a plurality of RNA species in a sample. The methods are based on...
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7094568 |
Method for producing proteins tagged at the N- or C-terminus
The present invention relates to novel methods of producing proteins in which one or more domains are full length and correctly folded and which are each tagged at either the N- or C-terminus with...
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7094538 |
Diagnostic assay for cancer susceptibility
The lifetime probability of a person developing cancer can now be determined based on an allelic variation found in the 3′UTR of the prohibitin gene. The probability is dependent on the sequence...
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7094539 |
Bacillus stearothermophilus reverse transcription compositions and kits
The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus...
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7091026 |
Artificial endonuclease
The present invention provides artificial endonucleases and methods to prepare and use those endonucleases.
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7090804 |
Amplification of nucleic acids with electronic detection
The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification....
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7087744 |
Fluorescent nucleotides and labeling methods using the same
Fluorescent nucleotides useful for labeling nucleic acids which are represented by the formula: X—Y—Z wherein X represents a residue of natural or non-natural nucleotide and the like and binds...
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7087415 |
Methods and compositions for directed gene assembly
The present invention is directed to methods and compositions for use of homologous recombination for directed evolution, gene reassembly, and directed mutagenesis. One aspect of the present...
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7087580 |
Neuropilin antisense oligonucleotide sequences and methods of using same to modulate cell growth
This invention relates to oligonucleotides complementary to the neuropilin genes which modulate tumor cell growth and angiogenesis in mammals. This invention is also related to methods of using...
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7087414 |
Methods and devices for multiplexing amplification reactions
The present invention provides a two-step multiplex amplification reaction wherein the first step truncates the standard initial multiplex amplification round to “boost” the sample copy number...
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7083924 |
Diagnostic method for the identification of foetal DNA in a material sample
A method for the identification of foetal DNA in a maternal DNA-containing sample such as a blood or vaginal sample, said method comprising (a) isolating DNA from said sample, (b) subjecting said...
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7083926 |
Method for identifying accessible binding sites on RNA
A method for identifying sites on a target RNA which are accessible to pairing by antisense DNA, ribozymes or DNAzymes. Native or in vitro-synthesized target RNA is incubated with defined ODNs and...
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7083929 |
Parallel polynucleotide sequencing method
The invention is directed to a method for sequencing multiple target polynucleotide segments in parallel, and to compositions and kits therefor. In the method, a plurality of sample polynucleotide...
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7081363 |
Better emergence characteristics and improved seedling growth under low-light environments
This invention relates to seedlings which demonstrate better emergence characteristics when grown in darkness and improved seedling growth when grown under low-light levels. More specifically, the...
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7081527 |
Compositions, methods and kits for determining the presence of Cryptosporidium parvum organisms in a test sample
The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are...
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7081337 |
Methods for modulating transcriptional activation using mint proteins
The present invention is directed to isolated nucleic acids encoding Mint protein variants having enhanced abilities to modulate the transcriptional activation mediated by the cytoplasmic tail of...
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7078196 |
RNA interference mediating small RNA molecules
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
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7078501 |
Topoisomerase linker-mediated amplification methods
A Vaccinia topoisomerase-adapted linker, which contains an oligonucleotide primer binding site of known sequence, useful for specifically joining the linker to the end of a polynucleotide of...
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7078168 |
Method for determining allele frequencies
The present invention related to a method of determining the frequency of an allele in a population of nucleic acid molecules. The method comprises pooling the nucleic acid molecules of a...
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7078170 |
Reaction mixtures for target amplification of nucleic acid with mutant RNA polymerase
This invention provides a reaction mixture to amplify a nucleic acid. The mixture includes a double stranded DNA molecule with one or more primer recognition sites and a mutant RNA polymerase...
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7078208 |
Thermostable reverse transcriptases and uses thereof
The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic...
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7074596 |
Synthesis and use of anti-reverse mRNA cap analogues
The ability to synthesize capped RNA transcripts in vitro has been of considerable value in a variety of applications. However, one-third to one-half of the caps have, until now, been incorporated...
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7074597 |
Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry
This invention provides methods for detecting single nucleotide polymorphisms and multiplex genotyping using dideoxynucleotides and mass spectrometry.
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7074556 |
cDNA synthesis improvements
The present invention generally relates to methods of making cDNA molecules and cDNA libraries. The invention also relates to cDNA molecules and cDNA libraries produced according to these methods,...
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7074598 |
Detection of vancomycin-resistant enterococcus spp.
The invention provides methods to detect vancomycin-resistant enterococci in biological samples using real-time PCR. Primers and probes for the detection of vancomycin-resistant enterococci are...
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7074599 |
Detection of mecA-containing Staphylococcus spp.
The invention provides methods to detect mecA-containing Staphylococcus spp. in biological samples using real-time PCR. Primers and probes for the detection of S. aureus are provided by the...
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7070929 |
Genetic markers for improved disease resistance in animals (BPI)
A method for determining improved disease resistance in animals is disclosed. The method assays for a novel genetic alleles of the BPI gene of the animal. The alleles are correlated with superior...
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