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7148343 |
Compositions and methods for using a solid support to purify RNA
Reagents, methods and kits for the purification of RNA from biological materials are provided.
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7148005 |
Nucleic acid-based methods of detecting bacterial o-antigens
The present invention relates to method of testing a sample for the presence of nucleic acids encoding E. coli polysaccharide O-antigen serotype O111, S. enterica polysaccharide O-antigen...
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7144999 |
Modulation of hypoxia-inducible factor 1 alpha expression
Compounds, compositions and methods are provided for modulating the expression of hypoxia-inducible factor 1 alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding...
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7144702 |
Method for detecting target plant genus
A method for detecting species in a target plant genus comprises the steps of conducting PCR using at least one member selected from the group consisting of primers (A) and (B), which can hybridize...
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7144713 |
Method for precipitating nucleic acid with visible carrier
A suitable carrier molecule useful in a nucleic acid precipitation method is modified by coupling a suitable visualizable indicator molecule to the carrier molecule. The conjugated carrier...
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7141371 |
Methods for detecting and localizing DNA mutations by microarray
This disclosure provides methods for detecting and localizing DNA mutations by DNA microarray. In various embodiments, the described methods include use of restriction endonuclease(s) and/or...
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7141375 |
Methods and compositions for treatment of tumors using nucleic acid ligands to platelet-derived growth factor
A method is provided for treating solid tumors comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using...
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7141665 |
Enzymatic DNA molecules
The present invention discloses deoxyribonucleic acid enzymes—catalytic or enzymatic DNA molecules—capable of cleaving nucleic acid sequences or molecules, particularly RNA, in a site-specific...
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7141377 |
Process for discrimination of nucleic acid sequence variants
A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from...
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7138378 |
Genetic suppression and replacement
A strategy for suppressing specifically or partially specifically an endogenous gene and introducing a replacement gene, said strategy comprising the steps of:
1. providing suppressing nucleic...
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7138234 |
Gene involved in CADASIL, method of diagnosis and therapeutic application
The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which...
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7138254 |
Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
Methods for preparing nanoscale reactions using nucleic acids or proteins are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber,...
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7135312 |
Circular DNA vectors for synthesis of RNA and DNA
The present invention provides methods for synthesis and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides are synthesized using a small, circular DNA template which...
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7135310 |
Method to amplify variable sequences without imposing primer sequences
The present invention provides methods of amplifying target sequences without including regions flanking the target sequence in the amplified product or imposing amplification primer sequences on...
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7135284 |
Primer extension methods for production of high specific activity nucleic acid probes
The present invention provides novel nucleic acid labeling techniques that generate nucleic acid probes with specific activities at least ten fold higher than the levels obtained using standard...
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7135563 |
Compositions for detecting target sequences
The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays.
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7132529 |
Antisense modulation of stearoyl-CoA desaturase expression
Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense...
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7132235 |
Reagent kit for determining specific nucleotide variations
Detection of variable nucleotide(s) is based on primer extension and incorporation of detectable nucleoside triphosphates. By selecting the detection step primers from the region immediately...
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7132265 |
Circular site-directed mutagenesis
The invention provides improved methods of introducing site-directed mutations into circular DNA molecules of interest by means of mutagenic primer pairs. The mutagenic primer pairs are also...
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7132238 |
Method of determining a chemotherapeutic regimen based on ERCC1 expression
The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression...
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7132240 |
Use of methylated nucleic acid segments for isolating centromere DNA
The invention provides efficient methods for the isolation of centromeres from potentially any organism. Using the methods of the invention, methylated centromere DNA may be isolated from...
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7132266 |
Method and kit for analyzing target nucleic acid fragment
A method of analyzing a target nucleic acid fragment is provided that is capable of being performed simply and promptly, by anyone, using a compact device without requirement of specific technique...
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7129222 |
Immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7129049 |
Method of detecting equine glycogen storage disease IV
The present invention relates to diagnosing glycogen storage diseases in mammals.
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7129043 |
Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease
A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3...
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7129050 |
Method for distinguishing different-sequence polynucleotides
Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target...
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7129344 |
Nucleic acid isolation
A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a...
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7125982 |
Microbial production of nuclease resistant DNA, RNA, and oligo mixtures
The present method describes the use of thio-phosphate as a feed source for micro-organisms and multi-cellular organisms. This compound enters into nucleotide pools and ultimately into polymers of...
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7125717 |
Metabolically activated recombinant viral vectors and methods for their preparation and use
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
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7125671 |
Nucleic acid amplification with terminal-phosphate labeled nucleotides
The present invention relates generally to the use of terminal-phosphate-labeled nucleotides having three or more phosphates as substrates for nucleic acid polymerases and their use in DNA...
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7122313 |
Methods and kits for identifying and quantifying RNAs and DNAs associated with RNA and DNA binding proteins
Methods and kits for identifying RNAs and DNAs associated with an RNA or DNA binding protein via a detector specific for the binding protein or protein bound thereto which is linked to an...
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7122303 |
Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
Methods for substantially improved detection and analysis in nucleic acid hybridization assays are described. The methods provide the reliable estimation of background signal which derives...
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7122355 |
Composition and method for hot start nucleic acid amplification
The present invention is directed to a new composition for performing a nucleic acid amplification reaction comprising (i) a thermostable DNA-Polymerase, (ii) a thermostable 3′-5′ Exonuclease,...
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7122304 |
Methods for the storage and synthesis of nucleic acids using a solid support
The invention relates to storage of nucleic acid (particularly mRNA) on a solid support and to using such nucleic acid in nucleic acid synthesis or amplification reactions. In a preferred aspect,...
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7122383 |
Fluorescent polymer superquenching-based bioassays
A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering...
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7122653 |
Reagents and methods useful for detecting diseases of the prostate
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for...
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7122354 |
Nucleic acid encoding a chimeric polypeptide
DNA molecules comprising a sequence encoding the signal peptide of hGH linked to a heterologous protein and related cells, methods and fusion proteins.
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7119167 |
Fragment of L. lactis plasmid conferring antiphage activity and uses thereof
The present invention relates to a 2227-bp DNA fragment that confers antiphage activity. Two proteins encoded by this DNA sequence are responsible for the phage resistance phenotype. When...
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7119194 |
Nucleic acid-bondable magnetic carrier and method for isolating nucleic acid using the same
A nucleic acid-bondable magnetic carrier of the present invention is a magnetic silica particle comprising a superparamagnetic metal oxide, wherein the magnetic silica particle has a specific...
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7118892 |
Automated process for preparing and amplifying a target nucleic acid sequence
An automated process for preparing and amplifying a target nucleic acid sequence within a stand-alone unit.
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7118870 |
Detection of fecal contamination using nucleic acid molecules that recognize bacterial 16S rDNA sequences
Herein disclosed are nucleic acid sequences that can be used to detect fecal contamination in a sample. In one embodiment, the probes and primers disclosed herein can be used to identify the host...
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7118868 |
Method for detecting cytosine methylations
A method is described for the detection of 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, whereby 5-methylcytosine and...
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7119078 |
Technology of intracellular delivery of DNA oligonucleotides to improve drug activity
The present invention relates to methods of intracellular delivery of oligonucleotides. More particularly, the present invention relates to the use of the delivery system to deliver G-quartet...
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7115719 |
Formulations and methods for denaturing proteins
Reagents, methods and kits for denaturation of protein are provided.
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7115400 |
Methods of nucleic acid amplification and sequencing
Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified...
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7115376 |
Method for distinguishing different-sequence polynucleotides
Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In one embodiment of the invention, a plurality of different-sequence probe pairs are...
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7115581 |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide...
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7115725 |
Multi-mutant diphtheria toxin vaccines
Disclosed is DNA encoding diphtheria toxin polypeptides having multiple mutations, which render the polypeptides useful as vaccines.
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7115583 |
Microbubble compositions and methods for oligonucleotide delivery
The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several...
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7112422 |
Fluorometric assay for detecting nucleic acid cleavage
A method of detecting an enzyme-mediated DNA cleavage reaction in a fluorometric assay is provided. The method can be used to detect DNA cleavage caused by restriction endonucleases, retroviral...
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