Match Document Document Title
9040238 Polynucleotides for use in medicine  
The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a...
9040626 Nanofibers and morphology shifting micelles  
The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.
9034608 Polypeptides with permease activity  
The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO:...
9034577 Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
9029342 Compositions of matter that reduce pain, shock, and inflammation by blocking linoleic acid metabolites and uses thereof  
A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or...
9029103 Methods for sequencing polynucleotides  
Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first...
9029338 Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus  
The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
9023600 Highly selective pyrophosphate sensor  
A dinuclear zinc complex PPi sensor is provided, that may be represented by the formula where X is hydrogen, —COOEt, —CH═CH2, —OR, or —NR2, wherein X is a monovalent organic group having from 1 to...
9017970 RNA polyphosphatase compositions, kits, and uses thereof  
The present invention relates to the discovery of RNA 5′ polyphosphatase enzymes not previously described in the art, methods for discovery of said enzymes, compositions of said enzymes, methods...
9017971 Means and methods for investigating nucleic acid sequences  
The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid.
9017973 Methods and compositions for incorporating nucleotides  
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of...
9012197 Production of hemagglutinin-neuraminidase protein in microalgae  
The present invention is directed to recombinant microalgal cells and their use in production of heterologous hemagglutinin-neuraminidase (HN) polypeptides, as well as compositions and uses thereof.
9012149 Methods for detection and quantitation of small RNAs  
Improved methods that increase the specificity and sensitivity of detection of small RNAs, including miRNAs, using oligonucleotide primers and nucleic acid amplification, are provided. Reaction...
9012183 Use of template switching for DNA synthesis  
A method of preparing a DNA copy of a target polynucleotide using template switching is described. The method includes mixing a double stranded template/primer substrate made up of a DNA primer...
9005929 Multibase delivery for long reads in sequencing by synthesis protocols  
A method for obtaining nucleic acid sequence information that can include steps of (a) providing a first sequencing reagent to a target nucleic acid, wherein the first sequencing reagent comprises...
9006199 Methods and compositions for treating prostate cancer  
Treatment of prostate cancer by regional and prolonged release of one or more nucleotide-based RNAi agents is provided.
9005891 Methods for depleting RNA from nucleic acid samples  
The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA...
9005930 Kits and methods for generating 5′ capped RNA  
The present invention relates to kits and methods for efficiently generating 5′ capped RNA having a modified cap nucleotide and for use of such modified-nucleotide-capped RNA molecules. In...
9005938 Aldolases, nucleic acids encoding them and methods for making and using them  
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these...
9006191 Silencing of polo-like kinase expression using interfering RNA  
The present invention provides compositions comprising interfering RNA (e.g., siRNA, aiRNA, miRNA) that target polo-like kinase 1 (PLK-1) expression and methods of using such compositions to...
9000145 Control of insect pests through RNAi of pheromone biosynthesis activating neuropeptide receptor  
Disclosed are dsRNA constructs and methods to control insects via double stranded RNA interference of insect PBAN receptor genes.
8999672 Compositions and processes for improved plasmid DNA production  
Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is...
8999673 Method for specifically producing a joined DNA fragment comprising a sequence derived from a target gene  
Provided is a method for selectively obtaining, for a given target gene, a “joined DNA fragment” wherein just a target gene fragment is joined with desired other DNA fragments, regardless of...
8999635 Filaggrin  
The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases...
8999674 Methods and apparatus for single molecule sequencing using energy transfer detection  
Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy...
8993232 Identification of the causative mutation for leopard complex spotting and congenital stationary night blindness in equines and a method for testing for same  
Methods are provided for determining whether or not a horse is genetically normal, is a carrier of, or is affected with or predisposed to Congenital Stationary Night Blindness and/or leopard...
8993784 Polymethine compounds and their use as fluorescent labels  
The present disclosure relates to new polymethine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing...
8993271 Method of nucleic acid amplification  
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer...
8993276 Chimeric enzymes with improved cellulase activities  
Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids...
8986976 Method for isolation of nucleic acids and a kit thereof  
The present disclosure provides a method to isolate natural & artificial nucleic acids like deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and peptide nucleic acid (PNA) from a solid or...
8986982 Apparatus and method for a continuous rapid thermal cycle system  
A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means...
8986931 Multiplex branched-chain DNA assays  
Methods of detecting two or more nucleic acids in a multiplex branched-chain DNA assay are provided. Different nucleic acids are captured through cooperative hybridization events on different,...
8980584 System and methods for nucleic acid sequencing of single molecules by polymerase synthesis  
This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi...
8980558 Methods, compositions and kits for the improved detection of small RNA molecules  
The present invention provides compositions, methods and kits for use in the detection of small RNA sequences, which allow for rapid and robust amplification and detection. The methods provide...
8975018 Method of detecting expanded CAG repeat region in spinocerebellar ataxia-2 gene  
The present invention provides isolated nucleic acids encoding human SCA2 protein, or fragments thereof, and isolated SCA2 proteins encoded thereby. Further provided are vectors containing...
8975059 Polypeptides having endoglucanase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
8975044 Polynucleotides encoding for frizzled-binding agents and uses thereof  
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as...
8975026 Method for generating aptamers with improved off-rates  
The present disclosure describes the identification and use of aptamers and photoaptamers having slower dissociation rate constants than those obtained using previously described methods....
8975384 Tag peptide and use thereof  
The present invention provides a tag peptide comprising an amino acid sequence represented by the following formula (I): X1-Tyr-X2-Gly-Gln-X3 (I) (wherein X1, X2 and X3 are the same or different...
8975024 Methods for sequencing polynucleotides  
The invention relates to methods and systems for sequencing and constructing a high resolution physical map of a polynucleotide. In accordance with the invention, nucleotide sequences are...
8969046 Methods for detecting epigenetic modifications  
A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4,...
8969047 Solid support assay systems and methods utilizing non-standard bases  
Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In...
8969044 Method for recovering sperm nucleic acid from a forensic sample  
A method for selectively recovering nucleic acid from a sperm cell in a sample containing cells of at least a sperm cell and an epithelial cell, and a cell suspension medium comprising...
8969003 Functionalized 3-alkynyl pyrazolopyrimidine analogues as universal bases and methods of use  
3-alkynyl inosine analogs and their uses as universal bases are provided. The inosine analogs can be incorporated into nucleic acid primers and probes. They do not significantly destabilize...
8969076 Method for expression of small RNA molecules within a cell  
The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA...
8962581 Methods and kits to identify invasive glioblastoma  
The invention encompasses methods and kits used in the detection of invasive glioblastoma based upon the expression of NHERF-1. The methods and kits also allow prediction of disease outcome as...
8962280 Methods for detecting DNA orginating from different individuals  
In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate...
8962296 Isoprene synthase and gene encoding the same, and method for producing isoprene monomer  
The present invention provides means useful for establishing an excellent isoprene monomer production system. Specifically, the present invention provides a polynucleotide of the following (a),...
8962293 DNA polymerases and related methods  
Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer...
8962583 Treatment of inflammatory diseases using miR-124  
Methods of treating, reducing the risk of developing, or delaying the onset of an inflammatory disease are disclosed. The methods involved providing a subject with or at risk of developing an...