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7608432 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7601519 |
Method for producing purine nucleoside by fermentation
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia...
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7592152 |
Chondroitinase ABC I and methods of analyzing therewith
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
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7507570 |
Recombinant chondroitinase ABC I and uses thereof
The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The...
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7482133 |
Catalytic domains of β(1,4)-galactosyltransferase I having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use
Disclosed are methods and compositions that can be used to synthesize oligosaccharides; mutants of galactosyltransferases having altered donor and acceptor specificity; methods for increasing the...
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7445921 |
Transglycosylation method and protein having transglycosylation activity
The present invention provides a transglycosylation method and a protein catalyzing a transglycosylation reaction. A reaction of transferring a galactosylβ1→3N-acetylgalactosaminyl group from a...
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7405267 |
Method for purifying teicoplanin A2
Disclosed is a method for purifying teicoplanin A 2 comprising: (i) a primary pre-purification step of purifying a filtrate of fermentation broth of a strain using a synthetic adsorbent; (ii) a...
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7335500 |
Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose
This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and...
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7329514 |
Process for producing n-acetylneuraminic acid
In the process for producing N-acetylneuraminic acid by using a microorganism having the ability to produce N-acetylneuraminic acid, the present invention provides economical and efficient process...
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7270980 |
Compounds for immunodiagnosis of prostate cancer and methods for their use
Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides...
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7241587 |
Method of uncoupling the catabolic pathway of glycolysis from the oxidative membrane bound pathway of glucose conversion
The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention...
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7232675 |
Sulfotransferase, its polypeptide and DNA encoding the same
A glycosaminoglycan sulfotransferase, a peptide thereof, a nucleic acid comprising a nucleotide sequence encoding the same, an enzyme agent for the synthesis of a glycosaminoglycan, which comprises...
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7217558 |
Microorganism producing 5'xanthylic acid
The invention relates to Corynebacterium ammoniagenes CJXOL 0201 KCCM 10447 producing 5′-xanthylic acid. More specifically, the invention relates to Corynebacterium ammoniagenes CJXOL 0201...
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7198932 |
Gdp-4-keto-6-deoxy-d-mannose-3,5-epimerase-4-reductase gene derived from arabidopsis thaliana
The present invention relates to a gene for an enzyme involving in the synthesis of GDP-L-fucose. Particularly, the present invention relates to a GDP-4-keto-6-deoxy-D-mannose-3,...
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7138262 |
High mannose proteins and methods of making high mannose proteins
The invention features a method of producing a high mannose glucocerebrosidase (hmGCB) which includes: providing a cell which is capable of expressing glucocerebrosidase (GCB), and allowing...
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7122653 |
Reagents and methods useful for detecting diseases of the prostate
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for...
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7094582 |
Cell-free production of glucosamine
Methods for cell-free production of glucosamine from starch, maltodextrin or glycogen or from fructose and a source of amino groups are disclosed. Also disclosed are cellular extracts comprising...
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7078195 |
Antibiotics AA-896
This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896-A4, AA-896-A5, AA-896-A6, AA-896-Bl, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7,...
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6887979 |
Method of preventing decrease in the activity of protein due to freezing and use of polypeptide in the production of protein activity decrease preventing agent
An objective of the present invention is to provide a means to prevent freeze-induced decrease in protein activity. The present invention relates to a method for preventing freeze-induced decrease...
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6780616 |
Antibiotic caprazamycins and process for producing the same
There have been obtained, by cultivation of Streptomyces sp. MK730-62F2 (deposit number of FERM BP-7218), antibiotic caprazamycins A to F having by the following general formula (I) wherein R is...
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6753154 |
Human AZU-1 gene, variants thereof and expressed gene products
A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of...
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6709834 |
Lipopolysaccharide α-2,3 sialytransferase of campylobacter jejuni and its uses
The structure and specificity of a recombinant α2,3-sialyltransferase from Campylobacter spp., is disclosed. Also provided are methods for using the α2,3-sialyltransferase in the production of...
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6649753 |
Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
This invention relates to the production of new & stable salts of S-adenosyl-L-methionine SAMe). The source of SAMe used in the salt formation is from chemical process wherein stereoselective...
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6316184 |
Method for judging the possibility of the onset of sheep leukemia
There is provided a method for convenient judgement of a possibility of the onset of leukemia of an ovine individual caused by the bovine leukemia virus (BLV) by means of genetic engineering...
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6197552 |
Process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine
A process for preparing 2,6-diaminopurine-2'-deoxyriboside and 2'-deoxyguanosine. These compounds may be used as materials for pharmaceuticals, such as antiviral agents and the like, and...
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6190888 |
Process for making riboflavin glucoside
A process for producing riboflavin glucoside comprises cultivating a microorganism belonging to the genus Bacillus, such as Bacillus brevis, Bacillus cereus, Bacillus circulans, Bacillus coagulans,...
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6168934 |
Oligosaccharide enzyme substrates and inhibitors: methods and compositions
Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is...
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6130072 |
Osmotically controlled fermentation process for the preparation of acarbose
The invention relates to a novel fermentative process for the preparation of acarbose. By monitoring and controlling the osmolality in the fermentation solution, a substantial improvement in yield...
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6127152 |
Process for producing nucleoside derivatives
There is disclosed a process for producing a nucleoside derivative of the formula [I]: ##STR1## characterized by contacting 2',3',5'-O-triacylribonucleoside derivative of the formula [II]: ##STR2##...
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6087132 |
Multi-functional enzymes including derivable 2'3'-dideoxyribofuranoside triprosphates
The invention relates to a multifunctional nucleoside didesoxyribosyl or nucleoside deoxyribosyl transferase which has one or more of the following additional activities (desoxy) nucleoside kinase,...
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6040158 |
Process for preparing sugar nucleotide
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6017736 |
Method of preparing purine nucleoside compound
The present invention provides a method of preparing stably and at a high yield a purine nucleoside compound by utilizing an exchange reaction of a nucleic acid base which is carried out in the...
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5968783 |
Process for the preparation of sugar nucleotides
The present invention relates to a process for preparing sugar nucleotides from nucleotides and sugar derivatives by the use of yeast, characterized in that the reactions are conducted at 20° C....
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5939290 |
Modified sialyl Lewis.sup.x compounds
The present invention is drawn to methods for the synthesis of sialyl Lewis x derivatives modified at the C-2 and/or C-6 position of GlcNAc employing chemoenzymatic synthesis. The derivatives find...
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5866377 |
Aminooligosaccharide derivative and process for preparing the same
The present invention relates to novel aminooligosaccharide derivative and pharmaceutically acceptable non-toxic salts thereof, which possess potent saccharide hydrolase inhibition and...
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5834251 |
Methods of modifying carbohydrate moieties
The invention is directed to methods of converting high mannose type glycosylation patterns to hybrid or complex type glycosylation patterns.
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5789204 |
Biosorbent for heavy metals prepared from biomass
The object of this invention is to provide a biosorbent for heavy metals having polyaminosaccharide sodiumphosphate as main ingredient prepared from microbial biomass using Aspergillus,...
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5759823 |
Ogligosaccharide enzyme substrates and inhibitors: methods and compostions
Oligosaccharide compounds that are substrates and inhibitors of glycosyltransferase and glycosidase enzymes and compositions containing such compounds are disclosed. A method of glycosylation is...
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5674715 |
Method for producing uridine diphosphate N-acetylgluosamine
A method for producing uridine diphosphate N-acetylglucosamine comprising culturing osmo-tolerant yeasts in aerobic conditions in a medium having inorganic salt concentration of about 2-8%.
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5643760 |
Microbial process for preparation of indolopyrrolocarbazole derivatives
Indolopyrrolocarbazole derivatives, such as, for example, 12,13-dihydro-1,11-dihydroxy-13-(β-D-glucopyranosyl)-5H-ind
olo[2,3-a] pyrrolo[3,4-c]carbazole-5,7-(6H)-dione or 6-amino derivative...
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5612203 |
Process for producing saccharides
Disclosed is a method for producing saccarides of definite chain length, such as glucose, maltose, malto-oligosaccharides and isomalto-oligosaccharides with a high purity. Saccharides such as...
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5610040 |
Enzymatic synthesis of ceramides and hybrid ceramides
The present invention provides an efficient method for the production of ceramides and hybrid ceramides via the selective N-acylation of glycosphingolipids by reacting an organic acid or ester...
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5589365 |
Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
A compound of formula (VIII) ##STR1## is added to a culture media containing Microtetraspora sp. A34549 or Saccharothrix aerocolonigenes ATCC 39243. The compound is glycosylated to form an...
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5585252 |
Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective...
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5494790 |
α-3 sialyltransferase
There are provided a novel α2➝3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the α2➝3 sialyltransferase, a method for detecting or suppressing the...
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5468849 |
Rebeccamycin analogs by tryptophan analogs feeding
Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin...
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5442051 |
Anhydrous crystal of 4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-oleate
Anhydrous crystals of 4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-olate are disclosed. The crystals possess (1) water content of 0.5% by weight or less (the Karl Fisher method), and (2) specific...
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5395757 |
Method for the hydrolysis of sugar compounds and reagent therefor
A method for the hydrolysis of only the lacto-N-biosidic (Galβ1-3GlcNAcβ1-) linkages at the non-reducing termini of sugar compounds, characterized by the use of glycosidase that is specific for...
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5384249 |
α2➝3 sialyltransferase
There are provided a novel α2➝3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the α2➝3 sialyltransferase, a method for detecting or suppressing the...
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5344823 |
Antitumor antibiotic BMY-41219
A new antitumor antibiotic designated BMY-41219 is produced by fermentation of Saccharothrix aerocolonigenes ATCC 39243. The BMY-41219 antibiotic exhibits antitumor activity.
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