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5272066 |
Synthetic method for enhancing glycoprotein stability
A method for modifying eukaryotic and prokaryotic proteins to extend their in vivo circulatory lifetimes. In the preferred embodiment, enzymatic and/or chemical treatments are used to produce a...
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5264352 |
Process for the enzymatic synthesis of 2-deoxy-β-D-galactosides
The invention relates to a process for the enzymatic synthesis of 2-deoxy-β-D-galactosides. The enzyme galactosyltransferase is able to catalyze the transfer of 2-deoxygalactose residues from the...
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5262310 |
Enzymatic decomposition method of chitin-containing materials
Chitin-containing material is heat-treated in organic solvent or in the solvent with water, and then β-1, 4 glycoside decomposing enzyme is added for decomposing the chitin-containing material by...
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5217882 |
Microbial transformation process for producing antihypertensive N.sub.2 -glucuronide products
Fermentation of the microorganism Streptomyces sp. MA6751 (ATCC No. 55043) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields an N2-glucuronide analog which is also an...
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5210023 |
Method of purifying ferment-produced riboflavin
A method of purifying ferment-produced riboflavin, wherein the impure riboflavin is suspended in water or dilute aqueous acid, and the suspension is heated at a temperature of from 75° to 130° C....
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5198352 |
Preparation of antibacterial compositions from glycopeptides
Antibacterially active compositions are prepared from a proteolytic enzymatic digestate of glycopeptides obtained from a protein isolate enriched with soya glycoprotein 7S or with bean glycoprotein...
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5177004 |
Enzymatic deacylation of acyl-aminosorboses
The present invention relates to an improved process for the preparation of 1-desoxynojirimycin. 1-Desoxynojirimycin can be reacted by alkylation on the nitrogen atom to give various saccharase...
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5166327 |
Process for producing 3'-deoxy-3-'-fluorothymidine
This invention provides a process for producing 3'-deoxy-'-fluorothymidine, which comprises allowing 3'-deoxy-'-fluoro-5'-mesylthymidine (the stating material) to react with an acetylating agent,...
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5158938 |
Rebeccamycin
Addition of bromine to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of a new rebeccamycin derivative having...
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5145780 |
Method of decomposing nucleic acids with a heat stable nuclease from Trichoderma or Fusarium
An enzyme preparation is obtained containing a nuclease that is produced by a fungus such as Trichoderma, Aspergillus and Fusarium and which remains active even after heating at 100° C. for 30...
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5093244 |
Production of a deoxyribonucleoside
A process for the fermentative production of the deoxyribonucleoside thymidine and/or its corresponding base thymine by aerobically cultivating a strain of the genus Brevibacterium, in particular...
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5091524 |
Glycosidase inhibitor salbostatin, process for its preparation, and its use
Salbostatin, a compound of the formula I ##STR1## acts as a glycosidase inhibitor and is suitable for use in pharmacy and in plant protection.
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5071750 |
Enzymatic process for preparing N-acetylneuraminic acid
A process for obtaining N-acetylneuraminic acid from N-acetylglucosamine is disclosed. The process is carried out in a reactor which contains both N-acylglucosamine-2-epimerase (E.C. 5.1.3.8) which...
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5055553 |
Low molecular weight pulmonary surfactant proteins
This invention relates to novel proteins useful for enhancing pulmonary surfactant activity, methods and materials for obtaining said proteins and compositions containing one or more of the proteins.
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5026640 |
Process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids
The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth...
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5008188 |
Process for producing S-adenosyl-L-homocysteine
Process for producing S-adenosyl-L-homocysteine, which comprises reacting adenosine with homocysteine by contacting them in an aqueous medium in the presence of cells or treated cells of a...
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4968606 |
Methods for producing ribose-1-phosphoric acid and ribavirin
The present invention relates to methods for producing ribavirin utilizing microorganisms and a method for producing ribose-1-phosphoric acid which is a precursor of ribavirin. The methods involve...
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4918009 |
Method of controlling the regioselectivity of glycosidic bonds
A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of...
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4885163 |
Topical use of IGF-II for wound healing
There is herein described an invention for promoting the rate and improving the quality of wound healing by topically applying insulin-like growth factor-II to the wound.
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4840899 |
Method for the production of ribavirin using high robose donor concentrations
A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from...
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4840898 |
High temperature method for the production of ribavirin
A method for the production of a 1,2,4-triazole nucleoside comprising the step of reacting a ribose donor with a triazole compound in the presence of an enzyme preparation derived from...
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4835104 |
Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides
A biological process for producing a 2',3'-dideoxyncleoside from 2',3'-dideoxyuridine is disclosed. The 2',3'-dideoxynucleoside can be purified readily using a porous nonpolar resin adsorbent.
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4794081 |
Process for the preparation of riboflavin
Riboflavin is obtained directly from the culture in a high yield by cultivating a riboflavin-producing microorganism in a medium using a lower (C 1 to C 4 ) aliphatic compound, separating...
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4686185 |
Microorganism of new species of genus Streptomyces and use thereof for production of chitinase
A microorganism of a new species of the genus Streptomyces having an ability to produce chitinase has been found, and a method of producing chitinase using this microorganism is disclosed.
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4621056 |
Process for producing stable sulpho-adenosyl-L-methionine salts
A process is described for the large-scale industrial production of any stable SAMe salt at very high purity and with a yield of about 90% or more. The new process is characterized by the following...
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4614719 |
Process for producing ribavirin
There is disclosed a process for producing ribavirin from 1,2,4-triazole-carboxamide and a ribose donor by the enzymatic action of a microorganism belonging to specific genera, e.g. Brevebacterium....
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4565781 |
Antibiotic, Spicamycin
An antibiotic, Spicamycin, having the physicochemical properties set forth below is produced by aerobically cultivating a Spicamycin-producing Streptomyces strain in a suitable culture medium, and...
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4524145 |
4'-Deschlororebeccamycin pharmaceutical composition and method of use
A new antitumor antibiotic designated herein as 4'-deschlororebeccamycin is produced by fermentation of Nocardia aerocolonigenes ATCC 39243. The new compound possesses antibacterial activity and...
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4458016 |
Production of 1-β-D-ribofuranosyl-1,2,4-triazole
The production of a 1-β-D-ribofuranosyl-1,2,4-triazole of the formula ##STR1## wherein R is hydroxy, amino, or alkoxy, is carried out by reacting a 1,2,4 triazole of formula ##STR2## wherein R is...
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4407947 |
Process for obtaining metal-free corrinoids
A process for obtaining metal-free corrinoids consisting of inoculating a culture media free of added compounds of metals of the VIIIth group of the Periodic Table with a parent strain of...
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4396719 |
Method of estimating the insulation life of a resin insulator
Either a monitoring resin piece associated with an electrical appliance or a resin piece forming a part of the insulating components of the electrical appliance is taken out after the electrical...
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4181574 |
Production of antibiotics by fermentation of novel strains of Micropolyspora caesia
A novel antibiotic complex designated herein as Bu-2313 is produced by fermentation of Micropolyspora sp. A.T.C.C. 31295, 31296, 31297 and 31298. The complex is separated into two bioactive...
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4065557 |
Amino sugars and their use in improving the meat:fat ratio in animals
Glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-
en-1-ylamino)- α-D-glucopyranose, which are inhibitors of glycoside hydrolases of the...
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4062950 |
Amino sugar derivatives
New amino sugars which are glucopyranosyl and oligoglucosidyl derivatives of 4,6-bisdesoxy-4-(4,5,6-trihydroxy-3-hydroxymethylcyclohex-2-
en-1-ylamin o)-α-D-glucopyranose inhibit glycoside...
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4018972 |
Antibacterial agents cis-BM123γ.sub.1 and cis-BM123γ.sub.2
This disclosure describes two new antibacterial agents designated cis-BM123γ 1 and cis-BM123γ 2 produced by a novel photolytic process whereby trans-BM123γ 1 and trans-BM123γ 2 are...
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4011391 |
Validamycin C, D, E and F antibiotics
Novel antibiotics, termed validamycins C, D, E and F, and acid salts thereof, are prepared by cultivating a validamycin-producing strain of microorganism of the genus Streptomyces, and optionally...
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3988314 |
Compound U-50,228, derivatives thereof, and processes for preparation
New antiviral agent U-50,228 and derivatives thereof, produced by the controlled fermentation of the known microorganism Streptomyces platensis var. clarensis var nova, NRRL 8035. This antiviral...
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3976545 |
1,2,4-Triazol E-3-carboxamides as antiviral agents
The use of 1,2,4-triazole-3-carboxamide and 1,2,4-triazole-3-thiocarboxamide and physiologically compatible salts thereof as antiviral agents is disclosed. A process for synthesizing...
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3914158 |
Antibiotic production
Production of antibiotics cephamycin C and toyocamycin by fermentation of Streptomyces albogriseolus.
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3907643 |
Process for producing the antibiotic U-44,590
New antibiotic U-44,590 and derivatives thereof, produced by the controlled fermentation of the new microorganism Streptomyces platensis var. clarensis var nova, NRRL 8035. This antibiotic and its...
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3888843 |
4-Carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate
Bredinin, which is 4-carbamoyl-1-β-D-ribofuranosylimidazolium-5-olate, has immunosuppressive activity. For its production, microorganism Eupenicillium brefeldianum is cultivated in a nutrient...
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3625940 |
NOVEL ANTIBIOTICS OF AGRICULTURAL FUNGICIDES, POLYOXINS J, K AND L: AND PROCESS FOR PREPARING THE SAME
Polyoxins J, K and L are each a novel antibiotic to be used as an agricultural fungicide for the protection of plants. Said polyoxins J, K and L are recovered from a culture obtained by cultivating...
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3535207 |
METHOD OF CONVERTING HETEROCYCLIC BASES INTO THE CORRESPONDING NUCLEOSIDES BY BACTERIAL ACTION
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3505311 |
CORRINOID COMPOUNDS CONTAINING NO METAL
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3364198 |
Process for the production of n6-methyltubercidin and intermediate
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3271386 |
5-amino-4-imidazolecarboxamide riboside recovery process
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3264195 |
Process for the preparation of septacidin and derivatives
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3160560 |
Streptolydigin and production thereof
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3028314 |
Process for the continuous propagation of filamentous microorganisms
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2910408 |
Production of n-acetylglucosamine
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